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MMRSVKSWAAVGCAVAVTLSGCAFEGVNSLPLPGAEGRGGDAVTYHIQVPNVATLESNSPVMIDDVVVGS VGKMTVQNWHADVEVSIKPDVVIPANAVATVGQTSLLGSMHLALNPPLGESPSGRLQPGSTLPLNESSTY PTTEQTLSSLSTVANGGGLGQIGDIIHNMSTGLAGREDDARELLQRLDNFVGVLAEQREDIVASIQQLRR VAGTFANQQQVIDRALTEIPPAIDVLIQERPQFTTALDRLGTFSDTATQLVNDAGDDLVKNLENLGPILG ALADVGPDLNLALLWTSAFPYGPTFADRVTKGDYINLYAIFDITYPRLKKTLLLGTRWGDENAKLIPAPG DPYYLNYSYDPLKIGVAPPPAEAIPAPAEGAAATPALPPMSEPLLPVTPPPPAAPWLPQSQPITSGNIFA GPYGAEAAPAPVPPAAPTPGGGG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2512 | - | - | 100% (443) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4534 | - | e-131 | 55.69% (404) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_4164 | - | e-111 | 54.05% (370) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 1e-56 | 36.65% (322) | MCE-family lipoprotein LprK |
| M. tuberculosis H37Rv | Rv1970 | lprM | 2e-75 | 45.06% (324) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 1e-51 | 33.96% (321) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 8e-65 | 38.58% (337) | MCE-family protein LprN |
| M. marinum M | MMAR_4706 | - | 1e-135 | 60.00% (395) | MCE family lipoprotein |
| M. avium 104 | MAV_2536 | - | 2e-81 | 43.70% (373) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_4786 | - | 1e-154 | 60.48% (463) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_4487 | - | 1e-145 | 58.21% (469) | PUTATIVE virulence factor mce family protein |
| M. ulcerans Agy99 | MUL_2866 | lprM | 7e-78 | 45.31% (320) | MCE family lipoprotein LprM |
| M. vanbaalenii PYR-1 | Mvan_4146 | - | 0.0 | 79.55% (445) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2512|M.gilvum_PYR-GCK -----MMRSVKS-------WAAVGCAVAVTLSGCAFEGVNSLPLPGAEGR
Mvan_4146|M.vanbaalenii_PYR-1 -----MIRGVKQ-------LTVLGCSAALSLSGCAFQGVNSLPLPGAVGR
MSMEG_4786|M.smegmatis_MC2_155 ---MRIRKRIRL-------AVAAGTCVALTASGCAFQGVNSLPLPGAEGR
TH_4487|M.thermoresistible__bu --------MMRG-------VVAVGACVALTVSGCGFQGVNSLPLPGAVGR
MMAR_4706|M.marinum_M MTASTATPALRR-------LFVIGCCVMLAVTGCAFNGLNSLPLPGAVGR
MAB_4149c|M.abscessus_ATCC_199 -----MSRNVLR-------AAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
Rv1970|M.tuberculosis_H37Rv -----MRIG------------LTLVMIAAVVASCGWRGLNSLPLPGTQGN
MUL_2866|M.ulcerans_Agy99 -----MRVRQRRRVAPRLATVLVTMVTLAAVSGCGWRGLNSLPLPGTEGN
MAV_2536|M.avium_104 -----MSQSPLRR---RVMAALLAAVALATLSGCGFRGLNSFNLPGTKGG
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
:.* :.*:... :** *
Mflv_2512|M.gilvum_PYR-GCK GGDAVTYHIQVPNVATLESNSPVMIDDVVVGSVGKMTVQN-----WHADV
Mvan_4146|M.vanbaalenii_PYR-1 GPDAVSYNVQVPNVATLESNSPVMIDDVVVGSVGKMTVQN-----WHADV
MSMEG_4786|M.smegmatis_MC2_155 GADSVVYHVEIANVATLEPNSPVMMNDVVVGSVRRLAVRD-----WHADV
TH_4487|M.thermoresistible__bu GPGAETYTVEIENVATLEPNSPVMIGDVVVGSVRSMTVQD-----WHAKV
MMAR_4706|M.marinum_M GPGASVYHVEIANVGTLEANSPVMLNDVIVGSISKMTVRG-----WHADV
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQG-----WHALV
MUL_2866|M.ulcerans_Agy99 GPGSFVIQAQMPDVNNIQPNSRVRVADVTVGHVARIERQG-----WHALV
MAV_2536|M.avium_104 GPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQG-----WNALV
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKN-----WVATL
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKN-----WVATL
* : :: :. : ** * : ** ** : : * * :
Mflv_2512|M.gilvum_PYR-GCK EVSIKPDVVIPANAVATVGQTSLLGSMHLALNPPLGESPSGRLQPGSTLP
Mvan_4146|M.vanbaalenii_PYR-1 EISVKPDVVIPANAVATVGQTSLLGSMHLALNPPLGDEPKGRLQPGSTLP
MSMEG_4786|M.smegmatis_MC2_155 EFSVEPGVVVPANAVATIGQTSLLGSMHLALNPPLGQEPQGRLTPGGTIP
TH_4487|M.thermoresistible__bu EISVEPGVEVPANAVASVGQTSLLGSMHLALDPPPGERPQGRLAPGSVIR
MMAR_4706|M.marinum_M EISVRRGAVIPDNAVASVGQTSLLGSMHLALNSPLGQVSDQRLQPGSTIP
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
MUL_2866|M.ulcerans_Agy99 TIRLDAGVALPANATARIGTTSLLGSYHIELAAPKHDAPQGRLRKGSLIP
MAV_2536|M.avium_104 TMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIP
Mb0179|M.bovis_AF2122/97 TLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPP-DPSPVPLKDGDTIP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPA-NPSLELLKNGDTIP
. : . :* *:.* :. ****** *: * .* * * :
Mflv_2512|M.gilvum_PYR-GCK LNESSTYPTTEQTLSSLSTVANGGGLGQIGDIIHNMSTGLAGREDDAREL
Mvan_4146|M.vanbaalenii_PYR-1 LNASSTYPTTEQTLASLSTVANGGGLGQIGDIVHNMNTALSGREPEVREL
MSMEG_4786|M.smegmatis_MC2_155 LNSASTYPTTEQTLSSLAAVVNGGGLGQIGEVIHNFSVALDGREADFRDL
TH_4487|M.thermoresistible__bu LDDSSTYPTTEQTLASLAAVVNGGGLGQIGDVIHNMSGALNGREQQIRDL
MMAR_4706|M.marinum_M LSRSSTYPSTEQTLSSLSVILNAGGLGQIGDIIHNFTAALSGRTSDIRDL
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
MUL_2866|M.ulcerans_Agy99 LSRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHEVRSL
MAV_2536|M.avium_104 LSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNL
Mb0179|M.bovis_AF2122/97 LKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAF
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
*. . :*:**..*:::: : . *.: : : . . ** : .
Mflv_2512|M.gilvum_PYR-GCK LQRLDNFVGVLAEQREDIVASIQQLRRVAGTFANQQQVIDRALTEIPPAI
Mvan_4146|M.vanbaalenii_PYR-1 LTRLDNFVGVLAEQRENIIASIQQLRRVAGTFANQREVIDRALKEIPPAI
MSMEG_4786|M.smegmatis_MC2_155 LTRLDNFVGTLDAQRDNIVSSIDSLNRLASTFAGQSEEITRALNKIPPAM
TH_4487|M.thermoresistible__bu LNRLDTFVGTLDAQRDNIVSSIESLNRLAARFAGERDDITRALERVPPAI
MMAR_4706|M.marinum_M LVRLDRFVGTFDEQRDNLVASIQALNRLAGTLAGQRDVITQALQKIPPAL
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
MUL_2866|M.ulcerans_Agy99 IAQLDSFTATLDDQSDDIIEATESLNRLVGKFAEQQPVLDRALATIPDAL
MAV_2536|M.avium_104 LNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQAL
Mb0179|M.bovis_AF2122/97 LGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
: :* : : * :: : : .. .. . : : : : :
Mflv_2512|M.gilvum_PYR-GCK DVLIQERPQFTTALDRLGTFSDTATQLVNDAGDDLVKNLENLGPILGALA
Mvan_4146|M.vanbaalenii_PYR-1 DVLIRERPNFTTALDRLGQFSNTATQLVNDAGDDLVKNLENLGPVLGALA
MSMEG_4786|M.smegmatis_MC2_155 DVLIQERPRFTTALQKLGTFGSTAHQLVNESQDDLVRNLRNLEPAIKALA
TH_4487|M.thermoresistible__bu EVLVRERPRLTAALERLGTFSDTTTRFVNDSQADLVRNLENLEPALKALA
MMAR_4706|M.marinum_M DVLIRERPRITAALDKLGTFSDTATRLVNDAGSDLVQNLQNLGPTISALA
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
MUL_2866|M.ulcerans_Agy99 AVLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELRQLGPVLESLA
MAV_2536|M.avium_104 TVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLA
Mb0179|M.bovis_AF2122/97 KHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELR
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
: : : * :. :. . : : : :*. * : *
Mflv_2512|M.gilvum_PYR-GCK DVGPDLNLALLWTSAFPYGPTFADRVTKGDYINLYAIFDITYPRLKKTLL
Mvan_4146|M.vanbaalenii_PYR-1 DIGPDLNEAVLWASAFPYGPTFADRITRGDYINLYAIFDLTYPRLKKTLL
MSMEG_4786|M.smegmatis_MC2_155 DVGPDLAGVLEYAGHFPFTQSFIDRAIRGDYWNLFATIDLTIPRLKRSLM
TH_4487|M.thermoresistible__bu DVGPSLNSVLEFAVHFPFTQNFIDRAIRGDYYNLFAIVDFTIPRLKRTLF
MMAR_4706|M.marinum_M DIGPDLDAAIAYAPTFPFTQGFIDRYIRGDYVNGYFIIDLTNAGLRKSIL
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
MUL_2866|M.ulcerans_Agy99 NAGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGLL
MAV_2536|M.avium_104 DAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFL
Mb0179|M.bovis_AF2122/97 RAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
: : *: . :*:* * .*.* : .:
Mflv_2512|M.gilvum_PYR-GCK LGTRWGDENAKLIPAPG-DPYYLNYSYDPLKIGVAP--------------
Mvan_4146|M.vanbaalenii_PYR-1 AGTRWGDQNAKLIPAPG-DPYYLNYAYNPMMVGITP--------------
MSMEG_4786|M.smegmatis_MC2_155 LGTRWEQEGAQLVPAPG-DPYYLNYTYDPLKAGVETPGPASFPPPFAD--
TH_4487|M.thermoresistible__bu LGTRWAQEGAQLVPAPG-DPQYLQYTYDPLRLGVDPP-PPQFVPPLGDEV
MMAR_4706|M.marinum_M LGTHWGRLGAEGVPAPG-DPEYLQFKFG----------------------
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVN-PPEWLIGSMANLN-------------------
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWG-RTIGQFPSPCTA--------------------
MUL_2866|M.ulcerans_Agy99 TGTRWECHLTELELQWG-RTIGQFPSPCTA--------------------
MAV_2536|M.avium_104 TGTRFECNLTELELQWG-RTIGQLPSPCTG--------------------
Mb0179|M.bovis_AF2122/97 TGTGFSGALRALEQSFGRDPETMIPDIRYTP-------------------
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFGRDPETMIPDVRYTT-------------------
: . .
Mflv_2512|M.gilvum_PYR-GCK --PPAEAIPAPAEG-AAATPALPPMSEPLLPVTPPPPAAPWLPQSQPITS
Mvan_4146|M.vanbaalenii_PYR-1 --PPEEALPPPAQG-GAPSSLTGVPAQPILPVVPPPPAAPWLPQAQPMAG
MSMEG_4786|M.smegmatis_MC2_155 --PPVPAAPVDQTTLPLPEAPPGPPPAYAGPVLPVAPPAPMTLPGVPAPV
TH_4487|M.thermoresistible__bu FPPAVPPEPPQAATAEQEALPLPPITEDVGPLLPAAPPAVVNFPGGPVTV
MMAR_4706|M.marinum_M --APIPPGPPPADAPPPGDPAPGPPPDSAVPIPGATPAEAAPTDGGP---
MAB_4149c|M.abscessus_ATCC_199 -------------------------GKETSPFDLPAPAAPQ---------
Rv1970|M.tuberculosis_H37Rv ----------------------GYRGTPGNPLTIAYRWDQGP--------
MUL_2866|M.ulcerans_Agy99 ----------------------GYRGTPGNPLTVPYHWDQGP--------
MAV_2536|M.avium_104 ----------------------GGPYNPGNPLVVPYHFDQGR--------
Mb0179|M.bovis_AF2122/97 ----------------------NPNDAPGGPLVERGNRQC----------
MLBr_02593|M.leprae_Br4923 ----------------------NPNDAPGGPLVERADRRC----------
*.
Mflv_2512|M.gilvum_PYR-GCK G----------NIFAGPYGAEAAP--APVPPAAPTPGGGG
Mvan_4146|M.vanbaalenii_PYR-1 D----------QIFAGPFGAPTPPPVAPPAPSVPTPGGGG
MSMEG_4786|M.smegmatis_MC2_155 T-TPGDP---TQIFAGPYGDQPNPPTEAPAPAQPTTGGGG
TH_4487|M.thermoresistible__bu RPTPPAPDGSTPIFAG-HPAQPPSPETAPS-----SGGGG
MMAR_4706|M.marinum_M ----------------------------------------
MAB_4149c|M.abscessus_ATCC_199 ------------------------------------GGGR
Rv1970|M.tuberculosis_H37Rv ----------------------------------------
MUL_2866|M.ulcerans_Agy99 ----------------------------------------
MAV_2536|M.avium_104 ----------------------------------------
Mb0179|M.bovis_AF2122/97 ----------------------------------------
MLBr_02593|M.leprae_Br4923 ----------------------------------------