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M. thermoresistible (build 8) TH_4487 (-)

annotation: virulence factor mce family protein
coordinates: 1109347 - 1110735
length: 463

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4487--100% (463)virulence factor mce family protein
M. thermoresistible (build 8)TH_2981-e-13259.26% (378) PUTATIVE virulence factor Mce family protein
M. thermoresistible (build 8)TH_3627-e-12353.53% (411) PUTATIVE virulence factor Mce family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3525clprN9e-6035.96% (356) MCE-family lipoprotein LprN
M. gilvum PYR-GCKMflv_2512-1e-14558.21% (469) virulence factor Mce family protein
M. tuberculosis H37RvRv1970lprM6e-7845.02% (331) MCE-family lipoprotein LprM
M. leprae Br4923MLBr_02593lprK1e-5232.93% (331) putative lipoprotein
M. abscessus ATCC 19977MAB_4149c-2e-6639.94% (328) MCE-family protein LprN
M. marinum MMMAR_4706-1e-13559.41% (409) MCE family lipoprotein
M. avium 104MAV_2536-1e-8042.40% (375) virulence factor Mce family protein
M. smegmatis MC2 155MSMEG_4786-1e-17266.31% (472) virulence factor mce family protein
M. ulcerans Agy99MUL_2866lprM6e-8146.67% (330) MCE family lipoprotein LprM
M. vanbaalenii PYR-1Mvan_4146-1e-14557.08% (466) virulence factor Mce family protein

CLUSTAL 2.0.9 multiple sequence alignment


Rv1970|M.tuberculosis_H37Rv         -----MRIG------------LTLVMIAAVVASCGWRGLNSLPLPGTQGN
MUL_2866|M.ulcerans_Agy99           -----MRVRQRRRVAPRLATVLVTMVTLAAVSGCGWRGLNSLPLPGTEGN
MAV_2536|M.avium_104                -----MSQSPLRR---RVMAALLAAVALATLSGCGFRGLNSFNLPGTKGG
Mb3525c|M.bovis_AF2122/97           -----MNRIWLR-------AIIL-TASSALLAGCQFGGLNSLPLPGTAGH
MAB_4149c|M.abscessus_ATCC_199      -----MSRNVLR-------AAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
TH_4487|M.thermoresistible__bu      --------MMRG-------VVAVGACVALTVSGCGFQGVNSLPLPGAVGR
MSMEG_4786|M.smegmatis_MC2_155      ---MRIRKRIRL-------AVAAGTCVALTASGCAFQGVNSLPLPGAEGR
MMAR_4706|M.marinum_M               MTASTATPALRR-------LFVIGCCVMLAVTGCAFNGLNSLPLPGAVGR
Mflv_2512|M.gilvum_PYR-GCK          -----MMRSVKS-------WAAVGCAVAVTLSGCAFEGVNSLPLPGAEGR
Mvan_4146|M.vanbaalenii_PYR-1       -----MIRGVKQ-------LTVLGCSAALSLSGCAFQGVNSLPLPGAVGR
MLBr_02593|M.leprae_Br4923          -MRRAMSVVHTSRVRHQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
                                                                   :.* : *:... :**  * 

Rv1970|M.tuberculosis_H37Rv         GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQG-----WHALV
MUL_2866|M.ulcerans_Agy99           GPGSFVIQAQMPDVNNIQPNSRVRVADVTVGHVARIERQG-----WHALV
MAV_2536|M.avium_104                GPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQG-----WNALV
Mb3525c|M.bovis_AF2122/97           GEGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAV
MAB_4149c|M.abscessus_ATCC_199      GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
TH_4487|M.thermoresistible__bu      GPGAETYTVEIENVATLEPNSPVMIGDVVVGSVRSMTVQD-----WHAKV
MSMEG_4786|M.smegmatis_MC2_155      GADSVVYHVEIANVATLEPNSPVMMNDVVVGSVRRLAVRD-----WHADV
MMAR_4706|M.marinum_M               GPGASVYHVEIANVGTLEANSPVMLNDVIVGSISKMTVRG-----WHADV
Mflv_2512|M.gilvum_PYR-GCK          GGDAVTYHIQVPNVATLESNSPVMIDDVVVGSVGKMTVQN-----WHADV
Mvan_4146|M.vanbaalenii_PYR-1       GPDAVSYNVQVPNVATLESNSPVMIDDVVVGSVGKMTVQN-----WHADV
MLBr_02593|M.leprae_Br4923          GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKN-----WVATL
                                    *  :     :: :.  :  ** * : ** ** :  :         : * :

Rv1970|M.tuberculosis_H37Rv         TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
MUL_2866|M.ulcerans_Agy99           TIRLDAGVALPANATARIGTTSLLGSYHIELAAPKHDAPQGRLRKGSLIP
MAV_2536|M.avium_104                TMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLIP
Mb3525c|M.bovis_AF2122/97           KLDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDRPPTGRLVDGSRIT
MAB_4149c|M.abscessus_ATCC_199      KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
TH_4487|M.thermoresistible__bu      EISVEPGVEVPANAVASVGQTSLLGSMHLALDPPPGERPQGRLAPGSVIR
MSMEG_4786|M.smegmatis_MC2_155      EFSVEPGVVVPANAVATIGQTSLLGSMHLALNPPLGQEPQGRLTPGGTIP
MMAR_4706|M.marinum_M               EISVRRGAVIPDNAVASVGQTSLLGSMHLALNSPLGQVSDQRLQPGSTIP
Mflv_2512|M.gilvum_PYR-GCK          EVSIKPDVVIPANAVATVGQTSLLGSMHLALNPPLGESPSGRLQPGSTLP
Mvan_4146|M.vanbaalenii_PYR-1       EISVKPDVVIPANAVATVGQTSLLGSMHLALNPPLGDEPKGRLQPGSTLP
MLBr_02593|M.leprae_Br4923          TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
                                     . :   . :* *:.* :. ****** *: * .*        *  *  : 

Rv1970|M.tuberculosis_H37Rv         LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
MUL_2866|M.ulcerans_Agy99           LSRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHEVRSL
MAV_2536|M.avium_104                LSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRNL
Mb3525c|M.bovis_AF2122/97           EANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNL
MAB_4149c|M.abscessus_ATCC_199      LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
TH_4487|M.thermoresistible__bu      LDDSSTYPTTEQTLASLAAVVNGGGLGQIGDVIHNMSGALNGREQQIRDL
MSMEG_4786|M.smegmatis_MC2_155      LNSASTYPTTEQTLSSLAAVVNGGGLGQIGEVIHNFSVALDGREADFRDL
MMAR_4706|M.marinum_M               LSRSSTYPSTEQTLSSLSVILNAGGLGQIGDIIHNFTAALSGRTSDIRDL
Mflv_2512|M.gilvum_PYR-GCK          LNESSTYPTTEQTLSSLSTVANGGGLGQIGDIIHNMSTGLAGREDDAREL
Mvan_4146|M.vanbaalenii_PYR-1       LNASSTYPTTEQTLASLSTVANGGGLGQIGDIVHNMNTALSGREPEVREL
MLBr_02593|M.leprae_Br4923          LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
                                        . :*:**..::::. : . *.:  :  : .     . **  :   .

Rv1970|M.tuberculosis_H37Rv         IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
MUL_2866|M.ulcerans_Agy99           IAQLDSFTATLDDQSDDIIEATESLNRLVGKFAEQQPVLDRALATIPDAL
MAV_2536|M.avium_104                LNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQAL
Mb3525c|M.bovis_AF2122/97           VPRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAV
MAB_4149c|M.abscessus_ATCC_199      LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
TH_4487|M.thermoresistible__bu      LNRLDTFVGTLDAQRDNIVSSIESLNRLAARFAGERDDITRALERVPPAI
MSMEG_4786|M.smegmatis_MC2_155      LTRLDNFVGTLDAQRDNIVSSIDSLNRLASTFAGQSEEITRALNKIPPAM
MMAR_4706|M.marinum_M               LVRLDRFVGTFDEQRDNLVASIQALNRLAGTLAGQRDVITQALQKIPPAL
Mflv_2512|M.gilvum_PYR-GCK          LQRLDNFVGVLAEQREDIVASIQQLRRVAGTFANQQQVIDRALTEIPPAI
Mvan_4146|M.vanbaalenii_PYR-1       LTRLDNFVGVLAEQRENIIASIQQLRRVAGTFANQREVIDRALKEIPPAI
MLBr_02593|M.leprae_Br4923          LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
                                    : :*  : . :  *  ::  : :   ..   ..     : : :  :   :

Rv1970|M.tuberculosis_H37Rv         AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
MUL_2866|M.ulcerans_Agy99           AVLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELRQLGPVLESLA
MAV_2536|M.avium_104                TVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSLA
Mb3525c|M.bovis_AF2122/97           RVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYSIVKALN
MAB_4149c|M.abscessus_ATCC_199      KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
TH_4487|M.thermoresistible__bu      EVLVRERPRLTAALERLGTFSDTTTRFVNDSQADLVRNLENLEPALKALA
MSMEG_4786|M.smegmatis_MC2_155      DVLIQERPRFTTALQKLGTFGSTAHQLVNESQDDLVRNLRNLEPAIKALA
MMAR_4706|M.marinum_M               DVLIRERPRITAALDKLGTFSDTATRLVNDAGSDLVQNLQNLGPTISALA
Mflv_2512|M.gilvum_PYR-GCK          DVLIQERPQFTTALDRLGTFSDTATQLVNDAGDDLVKNLENLGPILGALA
Mvan_4146|M.vanbaalenii_PYR-1       DVLIRERPNFTTALDRLGQFSNTATQLVNDAGDDLVKNLENLGPVLGALA
MLBr_02593|M.leprae_Br4923          KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
                                      :   :  :  *   :  :   .   :  :   :  :*. *   :  * 

Rv1970|M.tuberculosis_H37Rv         NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
MUL_2866|M.ulcerans_Agy99           NAGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGLL
MAV_2536|M.avium_104                DAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASFL
Mb3525c|M.bovis_AF2122/97           DDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFF
MAB_4149c|M.abscessus_ATCC_199      ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
TH_4487|M.thermoresistible__bu      DVGPSLNSVLEFAVHFPFTQNFIDRAIRGDYYNLFAIVDFTIPRLKRTLF
MSMEG_4786|M.smegmatis_MC2_155      DVGPDLAGVLEYAGHFPFTQSFIDRAIRGDYWNLFATIDLTIPRLKRSLM
MMAR_4706|M.marinum_M               DIGPDLDAAIAYAPTFPFTQGFIDRYIRGDYVNGYFIIDLTNAGLRKSIL
Mflv_2512|M.gilvum_PYR-GCK          DVGPDLNLALLWTSAFPYGPTFADRVTKGDYINLYAIFDITYPRLKKTLL
Mvan_4146|M.vanbaalenii_PYR-1       DIGPDLNEAVLWASAFPYGPTFADRITRGDYINLYAIFDLTYPRLKKTLL
MLBr_02593|M.leprae_Br4923          RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
                                         :   :      *:      .  :*:* *    .*.*   :   .:

Rv1970|M.tuberculosis_H37Rv         TGTRWECHLTQLELQWG---RTIGQFPS----------------------
MUL_2866|M.ulcerans_Agy99           TGTRWECHLTELELQWG---RTIGQFPS----------------------
MAV_2536|M.avium_104                TGTRFECNLTELELQWG---RTIGQLPS----------------------
Mb3525c|M.bovis_AF2122/97           TTAYFDPNMAHMDEILNPPDFLIGELAN----------------------
MAB_4149c|M.abscessus_ATCC_199      TTSFFDPNMQHFNDVVNPPEWLIGSMAN----------------------
TH_4487|M.thermoresistible__bu      LGTRWAQEGAQLVPAPGDPQYLQYTYDPLRLGVDPP-PPQFVPPLGDEVF
MSMEG_4786|M.smegmatis_MC2_155      LGTRWEQEGAQLVPAPGDPYYLNYTYDPLKAGVETPGPASFPPPFAD---
MMAR_4706|M.marinum_M               LGTHWGRLGAEGVPAPGDPEYLQFKFG-----------------------
Mflv_2512|M.gilvum_PYR-GCK          LGTRWGDENAKLIPAPGDPYYLNYSYDPLKIGVAP---------------
Mvan_4146|M.vanbaalenii_PYR-1       AGTRWGDQNAKLIPAPGDPYYLNYAYNPMMVGITP---------------
MLBr_02593|M.leprae_Br4923          TGTGLSGALRALEQSFGRDPETMIPDVR----------------------
                                      :             .                                 

Rv1970|M.tuberculosis_H37Rv         ----------------------PCTAGYRGTPGNPLTIAYRWDQGP----
MUL_2866|M.ulcerans_Agy99           ----------------------PCTAGYRGTPGNPLTVPYHWDQGP----
MAV_2536|M.avium_104                ----------------------PCTGGGPYNPGNPLVVPYHFDQGR----
Mb3525c|M.bovis_AF2122/97           ----------------------LSGQAADPFKIPPGTAS---GQ------
MAB_4149c|M.abscessus_ATCC_199      ----------------------LNGKETSPFDLPAPAAPQGGGR------
TH_4487|M.thermoresistible__bu      PPAVPPEPPQAATAEQEALPLPPITEDVGPLLPAAPPAVVNFPGGPVTVR
MSMEG_4786|M.smegmatis_MC2_155      -PPVPAAPVDQTTLPLPEAPPGPPPAYAGPVLPVAPPAPMTLPGVPAPVT
MMAR_4706|M.marinum_M               -APIPPGPPPADAPPPGDPAPGPPPDSAVPIPGATPAEAAPTDGGP----
Mflv_2512|M.gilvum_PYR-GCK          -PPAEAIPAPAEG-AAATPALPPMSEPLLPVTPPPPAAPWLPQSQPITSG
Mvan_4146|M.vanbaalenii_PYR-1       -PPEEALPPPAQG-GAPSSLTGVPAQPILPVVPPPPAAPWLPQAQPMAGD
MLBr_02593|M.leprae_Br4923          -----------------------YTTNPNDAPGGPLVERADRRC------
                                                                      .               

Rv1970|M.tuberculosis_H37Rv         ---------------------------------------
MUL_2866|M.ulcerans_Agy99           ---------------------------------------
MAV_2536|M.avium_104                ---------------------------------------
Mb3525c|M.bovis_AF2122/97           ---------------------------------------
MAB_4149c|M.abscessus_ATCC_199      ---------------------------------------
TH_4487|M.thermoresistible__bu      PTPPAPDGSTPIFAG-HPAQPPSPETAPS-----SGGGG
MSMEG_4786|M.smegmatis_MC2_155      -TPGDP---TQIFAGPYGDQPNPPTEAPAPAQPTTGGGG
MMAR_4706|M.marinum_M               ---------------------------------------
Mflv_2512|M.gilvum_PYR-GCK          ----------NIFAGPYGAEAAP--APVPPAAPTPGGGG
Mvan_4146|M.vanbaalenii_PYR-1       ----------QIFAGPFGAPTPPPVAPPAPSVPTPGGGG
MLBr_02593|M.leprae_Br4923          ---------------------------------------