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RVRQRRRVAPRLATVLVTMVTLAAVSGCGWRGLNSLPLPGTEGNGPGSFVIQAQMPDVNNIQPNSRVRVA DVTVGHVARIERQGWHALVTIRLDAGVALPANATARIGTTSLLGSYHIELAAPKHDAPQGRLRKGSLIPL SRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHEVRSLIAQLDSFTATLDDQSDDIIEA TESLNRLVGKFAEQQPVLDRALATIPDALAVLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELRQ LGPVLESLANAGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGLLTGTRWECHLTE LELQWGRTIGQFPSPCTAGYRGTPGNPLTVPYHWDQGP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2866 | lprM | - | 100% (389) | MCE family lipoprotein LprM |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | e-142 | 67.01% (385) | MCE family lipoprotein LprM |
| M. ulcerans Agy99 | MUL_1066 | lprK | 1e-70 | 38.83% (376) | MCE family lipoprotein LprK |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 1e-71 | 40.31% (387) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_2105 | - | 1e-146 | 68.46% (371) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 0.0 | 85.25% (373) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 5e-66 | 36.87% (358) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 1e-65 | 42.68% (321) | MCE-family protein LprN |
| M. marinum M | MMAR_2886 | lprM | 0.0 | 98.46% (389) | MCE family lipoprotein LprM |
| M. avium 104 | MAV_2536 | - | 1e-145 | 66.58% (377) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 1e-143 | 66.32% (383) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3635 | - | 1e-148 | 67.28% (379) | PUTATIVE AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_3978 | - | 1e-153 | 71.43% (385) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2866|M.ulcerans_Agy99 ----MRVRQRRRVAPRLATV-LVTMVTLAAVSGCG-WRGLNSLPLPGTEG
MMAR_2886|M.marinum_M ----MRVRHRRRVAPRLATV-LVTMVTLAAVSGCG-WRGLNSLPLPGTEG
Rv1970|M.tuberculosis_H37Rv ----MRIG-------------LTLVMIAAVVASCG-WRGLNSLPLPGTQG
MSMEG_0350|M.smegmatis_MC2_155 ----MT-HMRRVVACA-----ATVAALMIGVTGCSNWRGLNSVSLPGTEG
Mvan_3978|M.vanbaalenii_PYR-1 ----MSRTWRRRIMLS-----AATIAVVMGMSGCADWQGLNSLPMPGTEG
TH_3635|M.thermoresistible__bu ----MTYRWRIA---------LVLVVALAGVTGCADWRGVNTLSLPGTEG
Mflv_2105|M.gilvum_PYR-GCK ----MTAVRAS-ATMAL----AVTMAAAVTVSGCG-WRGLNSVPLPGTQG
MAV_2536|M.avium_104 ----MSQSPLRRRVMAA----LLAAVALATLSGCG-FRGLNSFNLPGTKG
MAB_4149c|M.abscessus_ATCC_199 ----MSRNVLRAAVMG--------VGVAVVVSGCQ-FNGLNSLNLPGTAG
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCG-WRGISNVAIPGGPG
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCG-WRGISNVSIPGGPG
* ::.* :.*:... :** *
MUL_2866|M.ulcerans_Agy99 NGPGSFVIQAQMPDVNNIQPNSRVRVADVTVGHVARIERQ-----GWHAL
MMAR_2886|M.marinum_M NGPGSFVIQAQMPDVNNIQPNSRVRVADVTVGHVARIERQ-----GWHAL
Rv1970|M.tuberculosis_H37Rv NGPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHAL
MSMEG_0350|M.smegmatis_MC2_155 GGPGAFDIQVQMPDITNLQPNSRVRVADVTVGTVTKVERQ-----GWHAL
Mvan_3978|M.vanbaalenii_PYR-1 GGPGSFVIQAQLPDVNNIQPNSRVRVGDVNVGTVTKVERQ-----GWHAL
TH_3635|M.thermoresistible__bu GGPGSFVVRAQMPDVNNLEPNARVRVDDVTVGAVTRIERQ-----GWHAL
Mflv_2105|M.gilvum_PYR-GCK GGPGSFTIQAQMPDVDNVEQNSRVRVGDVNVGTVSKIERQ-----GWNAL
MAV_2536|M.avium_104 GGPGAYTIRAQMPDVQNLQRNSRVRVNDVTVGNVIDIELQ-----GWNAL
MAB_4149c|M.abscessus_ATCC_199 HGSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAG
Mb0179|M.bovis_AF2122/97 TGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLK-----NWVAT
MLBr_02593|M.leprae_Br4923 SGKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVAT
* :: : .::** : *: * * ** ** : :. .* *
MUL_2866|M.ulcerans_Agy99 VTIRLDAGVALPANATARIGTTSLLGSYHIELAAPKHDAPQGRLRKGSLI
MMAR_2886|M.marinum_M VTIRLDAGVALPANATARIGTTSLLGSYHIELAAPKHEAPQGRLREGSLI
Rv1970|M.tuberculosis_H37Rv VTMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLI
MSMEG_0350|M.smegmatis_MC2_155 LTLRLNGDVNLPANCTATIGQTSLLGSLHVELAPPAAAPPQGRLHQGSLI
Mvan_3978|M.vanbaalenii_PYR-1 LTMRLNADVNLPENSTVTIGLTSILGSLHIELSPPAGAAPVGRLHDGSLI
TH_3635|M.thermoresistible__bu VTMRLDGSVRLPANATAKLGQTSILGSQHIELAPPEHTAPEGVLRDGSVI
Mflv_2105|M.gilvum_PYR-GCK VTMTLNGDVNLPANATAKVGQTSLLGSQHIELAAPADEAPQGRLEEGTLI
MAV_2536|M.avium_104 VTMTIDGDVDLPANATATLGQTSLLGSVHVELAPPAGVAPQGKLKNGSLI
MAB_4149c|M.abscessus_ATCC_199 VKVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATI
Mb0179|M.bovis_AF2122/97 LTLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPD-PSPVPLKDGDTI
MLBr_02593|M.leprae_Br4923 LTLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTI
:.: :. * ** * .. :. **:*** *:**:.* . * * *
MUL_2866|M.ulcerans_Agy99 PLSRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHEVRS
MMAR_2886|M.marinum_M PLSRGGAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFRGREHDVRS
Rv1970|M.tuberculosis_H37Rv ALSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRG
MSMEG_0350|M.smegmatis_MC2_155 PLADSTTHPTTEQTLAAVSMLLNGGGLGQMQDITKALSTALRGREADLRN
Mvan_3978|M.vanbaalenii_PYR-1 PLSSGGAFPSTEQTLAALSMVLNGGGLGQVQDITEAFSTAFDGREHDVRS
TH_3635|M.thermoresistible__bu ALENAGMYPTTEQTLASLSAVLNGGGIGQIYDITEALSLAFAGREDDLRN
Mflv_2105|M.gilvum_PYR-GCK PLASAGAYPSTEQALAAVALLLNGGGLGNIQDITDALSTAFSGRENDLRS
MAV_2536|M.avium_104 PLSSAGAYPSTERTLAAVSLLLNGGGLGQVQDITKTLSTAFSGREQDLRN
MAB_4149c|M.abscessus_ATCC_199 PLSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQ
Mb0179|M.bovis_AF2122/97 PLKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRA
MLBr_02593|M.leprae_Br4923 PLKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHA
.* .*:**..*:::: ::. *.: : : . . ** ::
MUL_2866|M.ulcerans_Agy99 LIAQLDSFTATLDDQSDDIIEATESLNRLVGKFAEQQPVLDRALATIPDA
MMAR_2886|M.marinum_M LIAQLDSFTATLDDQSDDIIEATESLNRLVGKFAEQQPVLDRALATIPDA
Rv1970|M.tuberculosis_H37Rv LIGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDA
MSMEG_0350|M.smegmatis_MC2_155 LIGQLETFVAKTNDQTGDIIEATEKLNRLTGKFAAQQPVVDKAVRTIPDA
Mvan_3978|M.vanbaalenii_PYR-1 LIGQLETFARNVNDQTGDIIAATESLNNLVGQFAAQRPVLDHALQTIPDA
TH_3635|M.thermoresistible__bu LVDQLDLFATQLNDQSGDIIAAAESLNDLIGRFAAQEPVLDRALTTIPDA
Mflv_2105|M.gilvum_PYR-GCK LIEQLDIAVGHLDDQTGDIIATSESLNNVVGQIAEQKPVVDKALRTIPDA
MAV_2536|M.avium_104 LLNQLDTFVGYLNDQKSDIIAATDHLNNLVGQFADQKPIIDKALKTIPQA
MAB_4149c|M.abscessus_ATCC_199 VLPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPA
Mb0179|M.bovis_AF2122/97 FLGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPL
MLBr_02593|M.leprae_Br4923 FLTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPL
.: :* :.* .** : : : . .. : ..: : :
MUL_2866|M.ulcerans_Agy99 LAVLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELRQLGPVLESL
MMAR_2886|M.marinum_M LTVLNDERDKLVTAADQLSKFSALTADSVNKTKANLVSELQQLGPVLESL
Rv1970|M.tuberculosis_H37Rv LAVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESL
MSMEG_0350|M.smegmatis_MC2_155 LEVLKDQRDNLTAALDQLGRFSALAADSTRQTKDSLVREFRNIGPVLESL
Mvan_3978|M.vanbaalenii_PYR-1 LAVLDGERQNLIETADQFGKFSALTVDTVNKTKDNLVKELNDVGPVLESL
TH_3635|M.thermoresistible__bu LAVLTEQRDSLVDSVDRLGRLGTLVTETVTETRHDLVRILEHSGPVLARL
Mflv_2105|M.gilvum_PYR-GCK LAVLRDQRDTLSEALVQLGRFSALAADSVTKTREALIQELKDLGPVLQSL
MAV_2536|M.avium_104 LTVLKDERENLANALGEVGQLSALAADSVNKTKENLIKELKDLGPVLQSL
MAB_4149c|M.abscessus_ATCC_199 LKVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRAL
Mb0179|M.bovis_AF2122/97 IKHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKEL
MLBr_02593|M.leprae_Br4923 IKHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLREL
: : : : : ...:. . : : :. : *
MUL_2866|M.ulcerans_Agy99 ANAGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGL
MMAR_2886|M.marinum_M ANAGPSLTRSLSLLATFPFPNETFQNFQRGDYANLTAIVDLTLSRIDQGL
Rv1970|M.tuberculosis_H37Rv ANSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGL
MSMEG_0350|M.smegmatis_MC2_155 ANAGPNMTRALSILTTYPFPNETLEKWLRGDYGNMTAIVDLTLSRIDAGF
Mvan_3978|M.vanbaalenii_PYR-1 ADAGPSMTRALSLIPTFPFPNETIEKWQRGDYANLTAIADLTLSRIDAGM
TH_3635|M.thermoresistible__bu ADAGPAMTRGLSGIVTYPFPFETIELWQRGDYANLTAVFDLTLSRLDAGF
Mflv_2105|M.gilvum_PYR-GCK ADAGPALTRALSFLPTFPFPKETLTNWMRGDYANLTLVVDLTLSRIDQGF
MAV_2536|M.avium_104 ADAGPALTRSLGFLGTFPFPAETLSKWIRGDYANLTAVIDLTLSRLDASF
MAB_4149c|M.abscessus_ATCC_199 AENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETL
Mb0179|M.bovis_AF2122/97 RRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAF
MLBr_02593|M.leprae_Br4923 GRGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAV
: .: : * *: . . **:* *: *:* :. .
MUL_2866|M.ulcerans_Agy99 LTGTRWECHLTELELQWGR-TIGQFPSP-CTAGYRGTPGNPLTVPYHWDQ
MMAR_2886|M.marinum_M LTGTRWECHLTELELQWGR-TIGQFPSP-CTAGYRGTPGNPLTVPYHWDQ
Rv1970|M.tuberculosis_H37Rv LTGTRWECHLTQLELQWGR-TIGQFPSP-CTAGYRGTPGNPLTIAYRWDQ
MSMEG_0350|M.smegmatis_MC2_155 FTGTRWEGDLTELEMQWGR-TIGQLPSP-YTA------VNPLVAPYRWDQ
Mvan_3978|M.vanbaalenii_PYR-1 FTGTRWEGDLTELELQWGR-TIGQFPSP-YTR------ANPLTVPYRWDQ
TH_3635|M.thermoresistible__bu FTGTRWECHLTWLEMQWGR-TIGQFPSP-CTAGGPGTPGNPLTIPYRWDQ
Mflv_2105|M.gilvum_PYR-GCK FTGTRFECNLTWLELQWGR-TIGQTPSP-CNHNVPPPGSNPLVAPYRWDQ
MAV_2536|M.avium_104 LTGTRFECNLTELELQWGR-TIGQLPSP-CTGGGPYNPGNPLVVPYHFDQ
MAB_4149c|M.abscessus_ATCC_199 FTTSFFDPNMQHFNDVVNP-PEWLIGSM-ANLNGKETSPFDLPAPAAPQG
Mb0179|M.bovis_AF2122/97 LTGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC
MLBr_02593|M.leprae_Br4923 LTGTGLSGALRALEQSFGRDPETMIPDVRYTTNPNDAPGGPLVERADRRC
:* : . : :: . . . . *
MUL_2866|M.ulcerans_Agy99 GP-
MMAR_2886|M.marinum_M GP-
Rv1970|M.tuberculosis_H37Rv GP-
MSMEG_0350|M.smegmatis_MC2_155 GR-
Mvan_3978|M.vanbaalenii_PYR-1 GP-
TH_3635|M.thermoresistible__bu GP-
Mflv_2105|M.gilvum_PYR-GCK GR-
MAV_2536|M.avium_104 GR-
MAB_4149c|M.abscessus_ATCC_199 GGR
Mb0179|M.bovis_AF2122/97 ---
MLBr_02593|M.leprae_Br4923 ---