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VTPRHPGGLSSIDSRPVARVGYGAMGLGPSVPADDAEALLRRALELGVNHIDTASFYDDGEVNRRIRGAL SPYPDDLVIVSKVGARPATGPVPLALAQRPAELRAAVERDLTELGVERIAVANLRRADIGPGLVATGDQV VDLDDQLAEMIALRDEGKIAAIGMSNIDLDTARRAAPAGIVCIQNAYNLLNRTGADVLEFARQQDIAFVP YFPLGSAFPGFPKVSQNAVVRAVAAETGAAPAQIGLAWLLAHAPNILLIAGTSSIDHLEQNVRCGDIRLS DTAIAALDAVPGEQSAHGDGVEAFLDEG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4686 | - | - | 100% (308) | putative oxidoreductase YdbC |
| M. smegmatis MC2 155 | MSMEG_2475 | - | 3e-53 | 47.10% (276) | putative oxidoreductase YdbC |
| M. smegmatis MC2 155 | MSMEG_6730 | - | 6e-35 | 35.47% (296) | putative oxidoreductase YdbC |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2320 | - | 1e-16 | 28.10% (306) | hypothetical protein Mb2320 |
| M. gilvum PYR-GCK | Mflv_1329 | - | 2e-57 | 48.25% (286) | aldo/keto reductase |
| M. tuberculosis H37Rv | Rv2298 | - | 1e-16 | 28.10% (306) | hypothetical protein Rv2298 |
| M. leprae Br4923 | MLBr_00458 | - | 1e-36 | 37.50% (280) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 6e-26 | 30.56% (324) | aldo/keto reductase |
| M. marinum M | MMAR_2086 | - | 8e-42 | 42.27% (291) | oxidoreductase |
| M. avium 104 | MAV_4594 | - | 1e-101 | 65.31% (294) | putative oxidoreductase YdbC |
| M. thermoresistible (build 8) | TH_1525 | - | 1e-11 | 26.87% (294) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_2745 | - | 6e-17 | 28.43% (306) | hypothetical protein MUL_2745 |
| M. vanbaalenii PYR-1 | Mvan_5463 | - | 6e-57 | 48.08% (287) | aldo/keto reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4686|M.smegmatis_MC2_155 ------------------MTPR-HPGGLSSIDSRPVARVGYGAMGL----
MAV_4594|M.avium_104 ------------------MTDKPRPGGIGDLGGLPVARVGYGAMQL----
Mflv_1329|M.gilvum_PYR-GCK ------------------MDTF-------PLGSHTVGRVGFGAMQLPGPG
Mvan_5463|M.vanbaalenii_PYR-1 ------------------MDSY-------QLGSYSVGRVGFGAMQLPGPG
MLBr_00458|M.leprae_Br4923 MRRFWRTVVEVTSQNSQALAQA--SGAFTLGGDLKVNRLGFGAMRLTGKG
MMAR_2086|M.marinum_M ------------------MAAA--SATLTLGGDLTVNRLGFGAMRLTGDG
MAB_4120c|M.abscessus_ATCC_199 ------------------MKHT-------WLGELSVSRIGLGAMSMSAYY
Mb2320|M.bovis_AF2122/97 ------------------MKYL------DVDGIGQVSRIGLGTWQFGSRE
Rv2298|M.tuberculosis_H37Rv ------------------MKYL------DVDGIGQVSRIGLGTWQFGSRE
MUL_2745|M.ulcerans_Agy99 ------------------MKHL------EVDGIGNVSRIGLGTWQFGSRE
TH_1525|M.thermoresistible__bu ----------------VNMTTVP---AITLNNGAQIPQVGFGVYQIP---
: . : ::* *. :
MSMEG_4686|M.smegmatis_MC2_155 -----GPSVPADDAEALLRRALELGVNHIDTASFYDDGEVNRRIRGALSP
MAV_4594|M.avium_104 -----FDTSP-DEAAAVLRRAVELGVNHIDTASFYGPGEVNRRIRAALAP
Mflv_1329|M.gilvum_PYR-GCK ---VFGPPRDHDQALAVLRRVVELGINHIDTAQIYGPNVANELIREALHP
Mvan_5463|M.vanbaalenii_PYR-1 ---VFGPPRDHDQAIAVLRRAVELGINHIDTAQIYGPNVANELIREALHP
MLBr_00458|M.leprae_Br4923 ---VWGPPVDRYEAVRVLRRAVELGVNFIDTADSYGPYVSEEIIAEALHP
MMAR_2086|M.marinum_M ---VWGPPADRAEAVRVLRRAAELGVNFIDTADSYGPYVSEEIIHEALHP
MAB_4120c|M.abscessus_ATCC_199 RAIGSESGPDEATSIDTLRRALDLGVSLIDTAEIYGPFVNEELVGRAIAG
Mb2320|M.bovis_AF2122/97 --WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGD
Rv2298|M.tuberculosis_H37Rv --WGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGD
MUL_2745|M.ulcerans_Agy99 --WGYGDRYASGAARDIVARACALGVTLFDTAEVYGLGKSERILGEALGD
TH_1525|M.thermoresistible__bu ----------PDQTAAAVRTALDAGYRHIDTAQMYGNERGVAEGIRDAGL
: : . * :***. *.
MSMEG_4686|M.smegmatis_MC2_155 YPDDLVIVSKVGAR-PATGPVPLALAQRPAELRAAVERDLTELGVERIAV
MAV_4594|M.avium_104 YPDDLVIVSKVGARYTGEQPIPLASAQRPAELRAAVEDDLSQLGLDRIPV
Mflv_1329|M.gilvum_PYR-GCK YADGLALVSKVGGRRDEQG--NWLPAQDPDDLRRQLEENLSTLDTDRLAA
Mvan_5463|M.vanbaalenii_PYR-1 YPADLALVSKVGGKRDAQG--NWLPAQEPDDLYDQLEENLRTLDTDRLAA
MLBr_00458|M.leprae_Br4923 YKG-LVIATKAGLLRTGRD--VWIPLGNPSYLRQELEMSLRRLNVDTIDL
MMAR_2086|M.marinum_M YTG-LVIATKAGLLRTGPG--VWVPLGNPSYLRQECEMSLRRLGVDTIDL
MAB_4120c|M.abscessus_ATCC_199 RRDEVVLATKFGLVSHGNG-ASQVLDSTPGNISTAVEGSLRRLGVDHIDL
Mb2320|M.bovis_AF2122/97 DRTEVVVASK-----------VFPVAPFPAVIKNRERASARRLQLNRIPL
Rv2298|M.tuberculosis_H37Rv DRTEVVVASK-----------VFPVAPFPAVIKNRERASARRLQLNRIPL
MUL_2745|M.ulcerans_Agy99 ERAEVVVASK-----------IMPVAPFPAVVKQRERASARRLQLDRIPL
TH_1525|M.thermoresistible__bu DRGEVFITSKLN-----------NPYHRPDDARRAFDRTLTELGSDYVDL
: :.:* * * : :
MSMEG_4686|M.smegmatis_MC2_155 ANLRRADIGPGLVATGDQVVDLDDQLAEMIALRDEGKIAAIGMSNIDLDT
MAV_4594|M.avium_104 VNLRRMDLGPSAATGGDQDVDLDDQLAEMIALRDEGKIGGIGISSVPLEV
Mflv_1329|M.gilvum_PYR-GCK VNLRAFNHDDPSLPAVLDRDLFDRQLTAMIAARDEGLIAGIGLSNVSADH
Mvan_5463|M.vanbaalenii_PYR-1 VNLRVFGSAGGAGPADLNRALFDRQLSTMIRARDEGLIAGIGLSNIGVDH
MLBr_00458|M.leprae_Br4923 FQLHRIDPN----------FPLADQVGELFTLKNEGKIRHIGLSEINLDQ
MMAR_2086|M.marinum_M FQLHRIDRN----------YPLADQVGELLALKNEGKIRHIGLSEIDVDQ
MAB_4120c|M.abscessus_ATCC_199 YYQHRVDPN----------VAIEDTIGAVAELVQQGKVRYIGLSEAAAGT
Mb2320|M.bovis_AF2122/97 YQIHQPNPV----------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLAR
Rv2298|M.tuberculosis_H37Rv YQIHQPNPV----------VPDSVIMPGMRDLLDSGDIGAAGVSNYSLAR
MUL_2745|M.ulcerans_Agy99 YQIHQPNPV----------VPDSVIMPGIRELLDIGRIGAAGVSNYSLAR
TH_1525|M.thermoresistible__bu FLIHWPLPMHYDG-------DFVSTWKTLEEFAADGRARSIGVSNFEPAH
: : * *:*.
MSMEG_4686|M.smegmatis_MC2_155 ARRAAP-AGIVCIQN--AYNLLNRTGA-DVLEFARQQDIAFVPYFPLGSA
MAV_4594|M.avium_104 LRRALP-AGIVCVQN--AYSLLDRSQE-AMVDVCAAEGIAWVPYFPLGSA
Mflv_1329|M.gilvum_PYR-GCK LRVALERTEIVCVQN--AYNLLDRTSQ-PVLDLSAEHGIAFVPFFPLGSG
Mvan_5463|M.vanbaalenii_PYR-1 LRIALERTEIVCVQN--AYNLVDRTSQ-PVLELCLEHGVAFVPFFPLGSG
MLBr_00458|M.leprae_Br4923 LTAAQQITEIVSVQN--MYNLSARAAE-PLLDAVTSRGIGFIPWSPLAAG
MMAR_2086|M.marinum_M LEAAQQITEIVSVQN--MYNLAARGAE-PLLEAATSQGIAFIPWFPLASG
MAB_4120c|M.abscessus_ATCC_199 IRRAHAVHPITALQN--EYSLWTRDIEDEILPTIRELGIGLVAYSPLGRG
Mb2320|M.bovis_AF2122/97 WRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQG
Rv2298|M.tuberculosis_H37Rv WRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQG
MUL_2745|M.ulcerans_Agy99 WKKADAALGRPVVSNQVHFSLAHPGPLDDLVPFAERENRIIIAYSPLAQG
TH_1525|M.thermoresistible__bu LDLLAAETSTVPAVN--QVEIHPYFGNNDVRRYCAEHGIAVEAWAPIAKG
* .: : . .: *:. .
MSMEG_4686|M.smegmatis_MC2_155 FPGFPK--------------------------VSQNAVVRAVAAETGAAP
MAV_4594|M.avium_104 FPGLPK--------------------------VTDNAVVVDIAGELGATP
Mflv_1329|M.gilvum_PYR-GCK FVADNP--------------------------VLKHPAVVREAEKLGRTP
Mvan_5463|M.vanbaalenii_PYR-1 FVPDNP--------------------------VLNHPAVVREARNLGRTP
MLBr_00458|M.leprae_Br4923 PLAAP------------------------------DGPLQRIAVNHHATP
MMAR_2086|M.marinum_M PLAAP------------------------------DGPLRKIADDHHATP
MAB_4120c|M.abscessus_ATCC_199 FLTGAIGSRDQLAEGDFRREQPRFSAENFDANLALVEEVRSVASSIGATS
Mb2320|M.bovis_AF2122/97 LLGGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKP
Rv2298|M.tuberculosis_H37Rv LLGGKYG--LENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKP
MUL_2745|M.ulcerans_Agy99 LLGGKYG--VDNRPAGVRAVNPLFGTENLRRIEPLLQTLRAVAIDVDAKP
TH_1525|M.thermoresistible__bu RVADDP-------------------------------VIAGIADRLGRTP
: * .
MSMEG_4686|M.smegmatis_MC2_155 AQIGLAWLLAHAPNILLIAGTSSIDHLEQNVRCGDIRLSDTAIAALDAVP
MAV_4594|M.avium_104 AQVGLAWILARAPHTLLIPGTRSITHLEENMGASGVTLSAEAIARLDAV-
Mflv_1329|M.gilvum_PYR-GCK AQIVLAWTLSVAPNVLLIPGTSSVAHLEQNTAVRDITLDDDTRRDLDAAA
Mvan_5463|M.vanbaalenii_PYR-1 AQIALAWTLSVAPNVLLIPGTSSVTHLEENTAVRDVELDDETRRELDEAA
MLBr_00458|M.leprae_Br4923 SQLALAWLLKRSPVMLPIPGTSRVAHLEENVAAAEISLSDDEFEMLSAAG
MMAR_2086|M.marinum_M SQLALAWLLKRSPVMLPIPGTSRVAHLQENVAAAEIVLSDQEFEALSVAG
MAB_4120c|M.abscessus_ATCC_199 AQVALAWLLARGDDIVPIPGTTKVSRVNENVGAVDIELLPEHLVRLECLA
Mb2320|M.bovis_AF2122/97 AQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAA
Rv2298|M.tuberculosis_H37Rv AQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAA
MUL_2745|M.ulcerans_Agy99 AQVALAWLIS-LPGVVAIPGASSVEQLEFNVAAADIELSADARAALTEAA
TH_1525|M.thermoresistible__bu AQVTLRWHIQ--RGDIVLPKSVTPERVRSNIALFDFELSDADMAAISALD
:*: * * : : :. : ::. * . * :
MSMEG_4686|M.smegmatis_MC2_155 GEQSAHGDGVEAFLDEG------
MAV_4594|M.avium_104 GSAAGHDYAVTGGHQ--------
Mflv_1329|M.gilvum_PYR-GCK -----------------------
Mvan_5463|M.vanbaalenii_PYR-1 H----------------------
MLBr_00458|M.leprae_Br4923 AQ---------------------
MMAR_2086|M.marinum_M AAHGG------------------
MAB_4120c|M.abscessus_ATCC_199 AAAGDRYNAEHLARLEG------
Mb2320|M.bovis_AF2122/97 RAFRPVSTGRFLTDMVREKVSRR
Rv2298|M.tuberculosis_H37Rv RAFRPVSTGRFLTDMVREKVSRR
MUL_2745|M.ulcerans_Agy99 RAFHPVSARRFLTDTVREKLGRR
TH_1525|M.thermoresistible__bu KGEAGRMGPHPDKFDMI------