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MADILIASHSPIGHIGPLLNVAYGLVGRGDRVTVLTSAQHTDAIRASGAAPVALPDAGDPDADRLDIENP KRARTSGIARINVDIVAFFVAPMAHQADALAKLLAQHRFDAVIADYGFFGILPFLLGNRADRPPFLTYST TPLMLSSRDTAPAGLGLPPPRHAVERLRNRALETLTHKVLLRASQRAVQEQLHRMNCRPLPVFLFDGAVL SERVIAPTVPQFDYHRSDLPKNVRYVGAVHPMPNQGFRRPMWWRLLDGDRPVVHVTQGTVDNTDLTRLLE PTLEALADEDVVVIASTGGRDLDVLRTPVPANTYVAKYIPHDLLMPKVDVLVTNGGYGTVQRALSCGVPL VVAGKTEDKPEVAARVAWSGAGIDLRTGTPTPAAIRDAVREVLTDKRYLSRARTLEAAFAQRDGVAEIIA LVDEVIAERRAEVGGELACEVTHEQR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4670 | - | - | 100% (446) | N-glycosylation |
| M. smegmatis MC2 155 | MSMEG_2342 | - | 4e-28 | 28.57% (434) | putative glycosyltransferase |
| M. smegmatis MC2 155 | MSMEG_2699 | - | 8e-15 | 27.21% (419) | hypothetical protein MSMEG_2699 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2986c | - | 1e-22 | 39.46% (185) | glycosyl transferase |
| M. gilvum PYR-GCK | Mflv_2592 | - | 1e-143 | 60.79% (431) | glycosyl transferase family protein |
| M. tuberculosis H37Rv | Rv2958c | - | 7e-23 | 36.26% (182) | glycosyl transferase |
| M. leprae Br4923 | MLBr_00128 | - | 7e-22 | 39.11% (179) | putative glycosyl transferase |
| M. abscessus ATCC 19977 | MAB_3062c | - | 8e-17 | 28.57% (420) | hypothetical protein MAB_3062c |
| M. marinum M | MMAR_1755 | - | 2e-20 | 36.07% (183) | glycosyl transferase |
| M. avium 104 | MAV_3631 | - | 4e-15 | 27.85% (438) | hypothetical protein MAV_3631 |
| M. thermoresistible (build 8) | TH_3465 | - | 3e-80 | 42.13% (432) | PUTATIVE UDP-glucuronosyl/UDP-glucosyltransferase |
| M. ulcerans Agy99 | MUL_3383 | - | 1e-16 | 27.36% (435) | glycosyl transferase |
| M. vanbaalenii PYR-1 | Mvan_4034 | - | 1e-148 | 62.00% (429) | glycosyl transferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2958c|M.tuberculosis_H37Rv ------------MEETSVAGDPGPDAGTSTAPNAAPEPVARRQRILFVGE
MLBr_00128|M.leprae_Br4923 ---------------------MGKDAGMSTAPDTVPECQSRRMRILFIAE
Mb2986c|M.bovis_AF2122/97 MRVSCVYATASRWGGPPVASEVRGDAAISTTPDAAPGLAARRRRILFVAE
MMAR_1755|M.marinum_M ---------------------------MSIATN-APQP-VRRQRVLFVAE
Mflv_2592|M.gilvum_PYR-GCK ---------------------------------------MNAMPDILITA
Mvan_4034|M.vanbaalenii_PYR-1 ------------------------------------------MPEILIAT
MSMEG_4670|M.smegmatis_MC2_155 ------------------------------------------MADILIAS
TH_3465|M.thermoresistible__bu ------------------VGGYGLTRTRLLGRRLSSGSEDEFLARYLLAA
MAV_3631|M.avium_104 -------------------------------------------MRVAVVA
MUL_3383|M.ulcerans_Agy99 -------------------------------------------MRVAVVA
MAB_3062c|M.abscessus_ATCC_199 -------------------------------------------MRVAVVA
:
Rv2958c|M.tuberculosis_H37Rv AATLAHVVRPFVLARSLDPSRYEVHFACDPRFNKLLGPLPFPHHPIHTVP
MLBr_00128|M.leprae_Br4923 AVTLSTVVRPFAVARLLDPSRYEVHFACDPRYNNLLGPLPFPHHPIHTVP
Mb2986c|M.bovis_AF2122/97 AVTLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLPFRHHAIHTIP
MMAR_1755|M.marinum_M ATTLAHVVRPFVVALSLDPSRYEVHFACDPRFNKLLGPIPFPHHPIYTIP
Mflv_2592|M.gilvum_PYR-GCK CPPVGHIGPLLNVAHGLVAHGHRVTVLTSARHADKIRAVGADPRPLPYGA
Mvan_4034|M.vanbaalenii_PYR-1 CPPVGHLSPLLNVARGLVARGDRVTVLTSARHADKIRAVGAEPRPLPHAA
MSMEG_4670|M.smegmatis_MC2_155 HSPIGHIGPLLNVAYGLVGRGDRVTVLTSAQHTDAIRASGAAPVALPDAG
TH_3465|M.thermoresistible__bu TPLSGHVAPLVQIGATLRSRGHTVTVLTTTEFADAVTRAGLRFTALPAGT
MAV_3631|M.avium_104 GPDPGHSFPAIALCRRFADAGDTPTLFTGAEWLDTARGAGVDAVELDGLA
MUL_3383|M.ulcerans_Agy99 GPDPGHSFPAIALCRRFLAAGDIPTLLTGVEWLDTARAAGVDAIELAGLV
MAB_3062c|M.abscessus_ATCC_199 GPDPGHAFPALALCLKFAAAGDDPVLLTGTRWLDQARAAGVESVELLGLQ
. . : : . . . :
Rv2958c|M.tuberculosis_H37Rv SEE-------------------VLLKIAQGRLFYNTRTLRKYIAADRKIL
MLBr_00128|M.leprae_Br4923 SEW-------------------VLTRIAQGRLFYTTRTLRKYVEEDSKLL
Mb2986c|M.bovis_AF2122/97 SER-------------------FFGNLTQGR-FYAMRTLRKYVEADLRVL
MMAR_1755|M.marinum_M SER-------------------FLGNLVQGR-FYTTRTLRQYVEEDSRVL
Mflv_2592|M.gilvum_PYR-GCK DYD----DARLDADLPGRAHTSGIARINFDVEHVFVRPMPYQFSAVQELL
Mvan_4034|M.vanbaalenii_PYR-1 DYD----DSTLDADLPGRAATAGLARINFDIESIFVRPLPHQFSALQELL
MSMEG_4670|M.smegmatis_MC2_155 DPD----ADRLDIENPKRARTSGIARINVDIVAFFVAPMAHQADALAKLL
TH_3465|M.thermoresistible__bu AIDPPAAPPWWARYLPSQARRFLLGRA--ELDSVYIRPLGHQAAALRSVL
MAV_3631|M.avium_104 A-----------------------TDEDVDAGARIHRRAARMAVLNVPAL
MUL_3383|M.ulcerans_Agy99 A-----------------------TDEDLDAGARIHRRAAQMALLNAPAL
MAB_3062c|M.abscessus_ATCC_199 PRV---------------------DDDDADSGAKIHQRAAHMALANLDQL
*
Rv2958c|M.tuberculosis_H37Rv NEIAPDVVVGDNRLSLSVS----ARLAGIPYIAIANAYWSPQARRRFPLP
MLBr_00128|M.leprae_Br4923 SEIEPDLVVGDARWSLSVS----ARLASIPYIAIANAYWSSHARRRLPLP
Mb2986c|M.bovis_AF2122/97 DEIAPDLVVGDLRISLSVS----ARLAGIPYIAIANAYWSPYAQRRFPLP
MMAR_1755|M.marinum_M AEVAPDLVVGDLRISLSAS----ARLAGIPYVAIANAYWSPYSRRRFPLP
Mflv_2592|M.gilvum_PYR-GCK AANSFDAVITDAFFLGVIPLLLDPTLARPPIMAYSTTPLFLSSRDTAPAG
Mvan_4034|M.vanbaalenii_PYR-1 VTDRFDAVIADALFLGTLPLLLGDPAKRPPILSYSTTPLFLTSRDTAPAG
MSMEG_4670|M.smegmatis_MC2_155 AQHRFDAVIADYGFFGILPFLLGNRADRPPFLTYSTTPLMLSSRDTAPAG
TH_3465|M.thermoresistible__bu DREPADAVLVDMTFTGAAALLLDDRP-RPPLLVCSVGPLTLSSADTPPFG
MAV_3631|M.avium_104 RDLAPDLVVSDVITAGGG---MAAELLGIPWIELSPHPLYLPSKGLPPIG
MUL_3383|M.ulcerans_Agy99 SDLAPDLVVSDVITACGG---MAAERLGIPWIELNPHPLYRPSKGLPPIG
MAB_3062c|M.abscessus_ATCC_199 RALAPDLIVSDVITACGG---MAGELLGVPWVELNPHPLYLPSKGLPPLG
* :: * * : : *
Rv2958c|M.tuberculosis_H37Rv D--VPWTRFFGVRPVSILYRLYRPLIFALYCLPLNWLRRKHGLSSLGWDL
MLBr_00128|M.leprae_Br4923 D--VLWTRILGVRLVNILFRLYSPLIFAIYCLPLNWVRRKHGLPSLGSNI
Mb2986c|M.bovis_AF2122/97 D--VIWTRLFGVRLVKLLYRLERPLLFALQCMPLNWVRRRHGLSSLGWNL
MMAR_1755|M.marinum_M E--VFWSRLFGVRLVKRAYRLERPLFFALQCMPLNRVRRKHGLPSLGLNL
Mflv_2592|M.gilvum_PYR-GCK PGILPMPGAVGRLRNRLLGLLSRAVLLRPAHRSAERMLRAMGLPDLPVFV
Mvan_4034|M.vanbaalenii_PYR-1 PGIAPMPGMIGRLRNRVLARATQSVLLRPGQRAADRMLEAMGLPELPVFI
MSMEG_4670|M.smegmatis_MC2_155 LGLPPPRHAVERLRNRALETLTHKVLLRASQRAVQEQLHRMNCRPLPVFL
TH_3465|M.thermoresistible__bu MAWQPRPG----VDYRGMTAVAHRVIMAGSRRRFDRALRTAGAGPAPVFL
MAV_3631|M.avium_104 SGLATGTGLRGRLRDATMRALTARSWRAG--------LRQRAAARAEIGL
MUL_3383|M.ulcerans_Agy99 SGLAPGTGIRGRLRDTTMRALTARSWRAG--------LRQRAAVRAEIGL
MAB_3062c|M.abscessus_ATCC_199 SGLAPGVGLRGRLRDGLMRRLTQKSIDQG--------LRQRSQARVEIGL
. :
Rv2958c|M.tuberculosis_H37Rv CRIFTDGDYTLYADVPELVP-TYNLPANHRYLGPVLWSPDVKPPT--WWH
MLBr_00128|M.leprae_Br4923 GCIYTDGDYTLYADVPELVP-TYDLPANHQYLGPVLWSPAGELPR--WWD
Mb2986c|M.bovis_AF2122/97 CRIFTDGDHTLYADVPELMP-TYDLPANHEYLGPVLWSPAGKPPT--WWD
MMAR_1755|M.marinum_M CRIFTDGDQTLYADIPELQP-TYNRPDNHQYLGPVLWSPSGETPD--WWD
Mflv_2592|M.gilvum_PYR-GCK LECAILADRVIVPTVPDFEYPRRDLPAHVRFVGAVSPLPGDDFIAPAWWG
Mvan_4034|M.vanbaalenii_PYR-1 LDSAVLADRVIVPTVPEFEYRRSDLPSHVRFVGPVSPLPGSDFVAPPWWG
MSMEG_4670|M.smegmatis_MC2_155 FDGAVLSERVIAPTVPQFDYHRSDLPKNVRYVGAVHPMPNQGFRRPMWWR
TH_3465|M.thermoresistible__bu SDWPALADRLIQLGVPGFEYHRGDLPSTVDFAGPVLPTGLDGVTLPAWWD
MAV_3631|M.avium_104 PARDPGPLRRLIATLPALEVPRPDWPDEAVLVGPLHFEPTDRVLD-----
MUL_3383|M.ulcerans_Agy99 AEHDPGPLRRLIATLPALEVPRPDWPAEAIVVGPLHFEPTDQLLK-----
MAB_3062c|M.abscessus_ATCC_199 PARDPGPMRRLIATLPALEVPRPDWPAEAVVVGPLHWEPTDVVLQ-----
: :* : : * *.:
Rv2958c|M.tuberculosis_H37Rv SLPTDRPIIYATLG---SSGGKNLLQVVLNALADLPVTVIAATAGRNHLK
MLBr_00128|M.leprae_Br4923 SLPTDRPIVYATLG---TSGGKNLLQVVLDALADLPVTVIAATAGRSELQ
Mb2986c|M.bovis_AF2122/97 SLPTDRPIVYATLG---TSGGRNLLQLVLNALAELPVTVIAATAGRSDLK
MMAR_1755|M.marinum_M SLPADRPIVYATLG---TSGGRNLLQVVLNGLADLPVTVIAATADRSDLD
Mflv_2592|M.gilvum_PYR-GCK ELYRGRPVVHVTQGTVDNADLTRLIEPTIEALAG-EDVTVVVSTGGRPVS
Mvan_4034|M.vanbaalenii_PYR-1 ELNAGRPVVHVTQGTIDNADLTRLIEPTIEALAD-EDVTVVATTGGRPIS
MSMEG_4670|M.smegmatis_MC2_155 LLDGDRPVVHVTQGTVDNTDLTRLLEPTLEALAD-EDVVVIASTGGRDLD
TH_3465|M.thermoresistible__bu DIRSAATVVHVTQGTFDNTDLDQLVVPTLEALTDRPDVLVVATTGGRPGQ
MAV_3631|M.avium_104 -IPAGSGPVVVVAPSTAQTGARGLAEVALSCLTPGETLPAGARLVVSRLA
MUL_3383|M.ulcerans_Agy99 -VPAGSGPVLVIAPSTALSGTAGLAEVALESLIPGGTLSSGSRLVVSRLG
MAB_3062c|M.abscessus_ATCC_199 -PPSGSGPVVVIAPSTAFTGAEGMTELAVQALES-----AGARVVISALE
: . :. : .:. *
Rv2958c|M.tuberculosis_H37Rv N----VPANAFVADYLPGEAAAARSAVVLCNGGSPTTQQALAAGVPVIGL
MLBr_00128|M.leprae_Br4923 N----VPANAFVADYLPGEAAAARSAVVICNGGSLTTQQAFVAGVPVVGI
Mb2986c|M.bovis_AF2122/97 T----VPANAFVADYLPGEAAAARSAVVVCNGGSLTTQQALVAGVPVIGV
MMAR_1755|M.marinum_M D----IPANAYVADYLPGEAAAARSDVVICNGGSLTTQQALVAGVPVLGI
Mflv_2592|M.gilvum_PYR-GCK QIRTPLPANTFVAEFLPHDVLLPLVDVLVTNGGYGAVQRALAEGVPLVVA
Mvan_4034|M.vanbaalenii_PYR-1 QIRIPLPANTFVAKYVPHDVLLPMVDVMVTNGGYGAVQRALSDGVPVVVA
MSMEG_4670|M.smegmatis_MC2_155 VLRTPVPANTYVAKYIPHDLLMPKVDVLVTNGGYGTVQRALSCGVPLVVA
TH_3465|M.thermoresistible__bu RSGFRVPGNARVTGWLPYRMLMPHVDVMITNGGYGGVQYALSHGVPLIVA
MAV_3631|M.avium_104 GPELAAPP-WAVVGLGSQAELLRHADVVVCGGGHGMVAKTLLAGVPLVAV
MUL_3383|M.ulcerans_Agy99 GDDLVTPS-WAAVGLGSQAELLTHADVVICGGGHGMVSKTLLAGVPLVVV
MAB_3062c|M.abscessus_ATCC_199 PPSSGLPS-WAIAGLARQDLLLSGADLAVCGGGHGFLSKALLAGVPTVVV
* . : : .** :: *** :
Rv2958c|M.tuberculosis_H37Rv PSNMDQHLNMEALERAGAGVLLRTERLNTEGVAAAVKQVLSGAEFRQAAR
MLBr_00128|M.leprae_Br4923 AGNLDQHLNMEAVEAAGAGILLRSERLKVRRVADAVNRVLGQSEYRQAAQ
Mb2986c|M.bovis_AF2122/97 AGNLDQHLNMEAVERAGAGVLLRTERLKSQRVAGAVMQVISRSEYRQAAA
MMAR_1755|M.marinum_M ASNLDQHLNMQAIEAAGAGLLLRTERLKARSVSAAVCQLLDRPGYRQSAE
Mflv_2592|M.gilvum_PYR-GCK GDTEDKPEVAARVEYFGVGVNLRTGTPAPQDLRDAVNAVLSDAGYRTRAG
Mvan_4034|M.vanbaalenii_PYR-1 GHTEDKPEVAARVRHFGVGIDLRTGTPTPTQVRRAVRKVLHEPGFRTKAG
MSMEG_4670|M.smegmatis_MC2_155 GKTEDKPEVAARVAWSGAGIDLRTGTPTPAAIRDAVREVLTDKRYLSRAR
TH_3465|M.thermoresistible__bu GETSDKAEIAARVEFCGAGIDLGTATPTVRALRAGFDRIRDQDRYRTAAR
MAV_3631|M.avium_104 PGGGDQWEIANRVVRQGSARLIRP--LSADALVAAVNEVLSSPGYRAAAQ
MUL_3383|M.ulcerans_Agy99 PGGGDQWEIANRVVRQGSARLIRP--LGADALAAAVNEVLSSPGYREAAQ
MAB_3062c|M.abscessus_ATCC_199 PGGGDQWELANRVVRQGSAELVRP--LSRDSLASAIGRVLGEPRYREAAR
*: : * . : . : .. : : *
Rv2958c|M.tuberculosis_H37Rv RLAEAFGP--DFAGFPQHIESALRLVC-----------------------
MLBr_00128|M.leprae_Br4923 RLAEVLER--HVAGLPQHMENVLHTVSQNPPPTSLARQNETTT-------
Mb2986c|M.bovis_AF2122/97 RLADAFGR--DRVGFPQHVENALRLMPENRPRTWLAS-------------
MMAR_1755|M.marinum_M ELAEVFGR--ELARFPQHVESALRRVSEGAVAKSAAG-------------
Mflv_2592|M.gilvum_PYR-GCK RLQAAYASRDSVTAIAALLDEVIPEQAAAR--------------------
Mvan_4034|M.vanbaalenii_PYR-1 WLRSAYAAYDSVAEIAKLVDEAVAQRTQPLQSA-----------------
MSMEG_4670|M.smegmatis_MC2_155 TLEAAFAQRDGVAEIIALVDEVIAERRAEVGGELACEVTHEQR-------
TH_3465|M.thermoresistible__bu RLAREIRSAAPLDSIAATLERIVAADALNRSARTGSAGAPDPDSTDDRPA
MAV_3631|M.avium_104 RAAAGIAD---VADPVRVCREALAG-------------------------
MUL_3383|M.ulcerans_Agy99 RAAASIAD---VADPVQVCHEALALAG-----------------------
MAB_3062c|M.abscessus_ATCC_199 RAAAGAIA---VEDPVRVCQDVLAALR-----------------------
:
Rv2958c|M.tuberculosis_H37Rv ---------
MLBr_00128|M.leprae_Br4923 ---------
Mb2986c|M.bovis_AF2122/97 ---------
MMAR_1755|M.marinum_M ---------
Mflv_2592|M.gilvum_PYR-GCK ---------
Mvan_4034|M.vanbaalenii_PYR-1 ---------
MSMEG_4670|M.smegmatis_MC2_155 ---------
TH_3465|M.thermoresistible__bu PRPARPRVH
MAV_3631|M.avium_104 ---------
MUL_3383|M.ulcerans_Agy99 ---------
MAB_3062c|M.abscessus_ATCC_199 ---------