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EETSVAGDPGPDAGTSTAPNAAPEPVARRQRILFVGEAATLAHVVRPFVLARSLDPSRYEVHFACDPRFN KLLGPLPFPHHPIHTVPSEEVLLKIAQGRLFYNTRTLRKYIAADRKILNEIAPDVVVGDNRLSLSVSARL AGIPYIAIANAYWSPQARRRFPLPDVPWTRFFGVRPVSILYRLYRPLIFALYCLPLNWLRRKHGLSSLGW DLCRIFTDGDYTLYADVPELVPTYNLPANHRYLGPVLWSPDVKPPTWWHSLPTDRPIIYATLGSSGGKNL LQVVLNALADLPVTVIAATAGRNHLKNVPANAFVADYLPGEAAAARSAVVLCNGGSPTTQQALAAGVPVI GLPSNMDQHLNMEALERAGAGVLLRTERLNTEGVAAAVKQVLSGAEFRQAARRLAEAFGPDFAGFPQHIE SALRLVC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2958c | - | - | 100% (428) | POSSIBLE GLYCOSYL TRANSFERASE |
| M. tuberculosis H37Rv | Rv2962c | - | 0.0 | 77.25% (422) | glycosyl transferase |
| M. tuberculosis H37Rv | Rv2739c | - | 2e-09 | 29.35% (201) | alanine rich transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2986c | - | 0.0 | 77.25% (422) | glycosyl transferase |
| M. gilvum PYR-GCK | Mflv_2592 | - | 3e-21 | 34.34% (198) | glycosyl transferase family protein |
| M. leprae Br4923 | MLBr_00128 | - | 0.0 | 75.06% (417) | putative glycosyl transferase |
| M. abscessus ATCC 19977 | MAB_3062c | - | 3e-09 | 27.81% (187) | hypothetical protein MAB_3062c |
| M. marinum M | MMAR_1755 | - | 1e-173 | 73.09% (405) | glycosyl transferase |
| M. avium 104 | MAV_3631 | - | 1e-08 | 28.71% (202) | hypothetical protein MAV_3631 |
| M. smegmatis MC2 155 | MSMEG_4670 | - | 1e-22 | 36.26% (182) | N-glycosylation |
| M. thermoresistible (build 8) | TH_3465 | - | 2e-15 | 32.78% (180) | PUTATIVE UDP-glucuronosyl/UDP-glucosyltransferase |
| M. ulcerans Agy99 | MUL_3383 | - | 2e-08 | 30.19% (212) | glycosyl transferase |
| M. vanbaalenii PYR-1 | Mvan_4886 | - | 2e-21 | 32.29% (223) | UDP-glucuronosyl/UDP-glucosyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2958c|M.tuberculosis_H37Rv ------------MEETSVAGDPGPDAGTSTAPNAAPEPVARRQRILFVGE
MLBr_00128|M.leprae_Br4923 ---------------------MGKDAGMSTAPDTVPECQSRRMRILFIAE
Mb2986c|M.bovis_AF2122/97 MRVSCVYATASRWGGPPVASEVRGDAAISTTPDAAPGLAARRRRILFVAE
MMAR_1755|M.marinum_M ---------------------------MSIATN-APQP-VRRQRVLFVAE
Mflv_2592|M.gilvum_PYR-GCK ---------------------------------------MNAMPDILITA
MSMEG_4670|M.smegmatis_MC2_155 ------------------------------------------MADILIAS
TH_3465|M.thermoresistible__bu ------------------VGGYGLTRTRLLGRRLSSGSEDEFLARYLLAA
Mvan_4886|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3631|M.avium_104 -------------------------------------------MRVAVVA
MUL_3383|M.ulcerans_Agy99 -------------------------------------------MRVAVVA
MAB_3062c|M.abscessus_ATCC_199 -------------------------------------------MRVAVVA
Rv2958c|M.tuberculosis_H37Rv AATLAHVVRPFVLARSLDPSRYEVHFACDPRFNKLLGPLPFPHHPIHTVP
MLBr_00128|M.leprae_Br4923 AVTLSTVVRPFAVARLLDPSRYEVHFACDPRYNNLLGPLPFPHHPIHTVP
Mb2986c|M.bovis_AF2122/97 AVTLAHVVRPFALAQSLDPSRYEVHFACDPRYNQLLGPLPFRHHAIHTIP
MMAR_1755|M.marinum_M ATTLAHVVRPFVVALSLDPSRYEVHFACDPRFNKLLGPIPFPHHPIYTIP
Mflv_2592|M.gilvum_PYR-GCK CPPVGHIGPLLNVAHGLVAHGHRVTVLTSARHADKIRAVGADPRPLPYGA
MSMEG_4670|M.smegmatis_MC2_155 HSPIGHIGPLLNVAYGLVGRGDRVTVLTSAQHTDAIRASGAAPVALPDAG
TH_3465|M.thermoresistible__bu TPLSGHVAPLVQIGATLRSRGHTVTVLTTTEFADAVTRAGLRFTALPAGT
Mvan_4886|M.vanbaalenii_PYR-1 -------MPMVNVGIGLQALGHDICVLTGAEFSDAVHAAGLQMIPLPDSV
MAV_3631|M.avium_104 GPDPGHSFPAIALCRRFADAGDTPTLFTGAEWLDTARGAGVDAVELDGLA
MUL_3383|M.ulcerans_Agy99 GPDPGHSFPAIALCRRFLAAGDIPTLLTGVEWLDTARAAGVDAIELAGLV
MAB_3062c|M.abscessus_ATCC_199 GPDPGHAFPALALCLKFAAAGDDPVLLTGTRWLDQARAAGVESVELLGLQ
. : : . . . :
Rv2958c|M.tuberculosis_H37Rv SEE-------------------VLLKIAQGRLFYNTRTLRKYIAADRKIL
MLBr_00128|M.leprae_Br4923 SEW-------------------VLTRIAQGRLFYTTRTLRKYVEEDSKLL
Mb2986c|M.bovis_AF2122/97 SER-------------------FFGNLTQGR-FYAMRTLRKYVEADLRVL
MMAR_1755|M.marinum_M SER-------------------FLGNLVQGR-FYTTRTLRQYVEEDSRVL
Mflv_2592|M.gilvum_PYR-GCK DYD----DARLDADLPGRAHTSGIARINFDVEHVFVRPMPYQFSAVQELL
MSMEG_4670|M.smegmatis_MC2_155 DPD----ADRLDIENPKRARTSGIARINVDIVAFFVAPMAHQADALAKLL
TH_3465|M.thermoresistible__bu AIDPPAAPPWWARYLPSQARRFLLGRA--ELDSVYIRPLGHQAAALRSVL
Mvan_4886|M.vanbaalenii_PYR-1 RIDPPAAAPALLRKLPVAVRRFWLGRA--ELASVFAEPLAAEAQSLRAVL
MAV_3631|M.avium_104 A-----------------------TDEDVDAGARIHRRAARMAVLNVPAL
MUL_3383|M.ulcerans_Agy99 A-----------------------TDEDLDAGARIHRRAAQMALLNAPAL
MAB_3062c|M.abscessus_ATCC_199 PRV---------------------DDDDADSGAKIHQRAAHMALANLDQL
*
Rv2958c|M.tuberculosis_H37Rv NEIAPDVVVGDNRLSLSVS----ARLAGIPYIAIANAYWSPQARRRFPLP
MLBr_00128|M.leprae_Br4923 SEIEPDLVVGDARWSLSVS----ARLASIPYIAIANAYWSSHARRRLPLP
Mb2986c|M.bovis_AF2122/97 DEIAPDLVVGDLRISLSVS----ARLAGIPYIAIANAYWSPYAQRRFPLP
MMAR_1755|M.marinum_M AEVAPDLVVGDLRISLSAS----ARLAGIPYVAIANAYWSPYSRRRFPLP
Mflv_2592|M.gilvum_PYR-GCK AANSFDAVITDAFFLGVIPLLLDPTLARPPIMAYSTTPLFLSSRDTAPAG
MSMEG_4670|M.smegmatis_MC2_155 AQHRFDAVIADYGFFGILPFLLGNRADRPPFLTYSTTPLMLSSRDTAPAG
TH_3465|M.thermoresistible__bu DREPADAVLVDMTFTGAAALLLDDRP-RPPLLVCSVGPLTLSSADTPPFG
Mvan_4886|M.vanbaalenii_PYR-1 RNGSVDAIVADVAFTGVLPVLLQDSP-RPPVVVCGVGPLTISSRDTPPFG
MAV_3631|M.avium_104 RDLAPDLVVSDVITAGGG---MAAELLGIPWIELSPHPLYLPSKGLPPIG
MUL_3383|M.ulcerans_Agy99 SDLAPDLVVSDVITACGG---MAAERLGIPWIELNPHPLYRPSKGLPPIG
MAB_3062c|M.abscessus_ATCC_199 RALAPDLIVSDVITACGG---MAGELLGVPWVELNPHPLYLPSKGLPPLG
* :: * * : : *
Rv2958c|M.tuberculosis_H37Rv DVPWTRFFG--VRPVSILYRLYRPLIFALYCLPLNWLRRKHGLSSLGWDL
MLBr_00128|M.leprae_Br4923 DVLWTRILG--VRLVNILFRLYSPLIFAIYCLPLNWVRRKHGLPSLGSNI
Mb2986c|M.bovis_AF2122/97 DVIWTRLFG--VRLVKLLYRLERPLLFALQCMPLNWVRRRHGLSSLGWNL
MMAR_1755|M.marinum_M EVFWSRLFG--VRLVKRAYRLERPLFFALQCMPLNRVRRKHGLPSLGLNL
Mflv_2592|M.gilvum_PYR-GCK PGILPMPGAVGRLRNRLLGLLSRAVLLRPAHRSAERMLRAMGLPDLPVFV
MSMEG_4670|M.smegmatis_MC2_155 LGLPPPRHAVERLRNRALETLTHKVLLRASQRAVQEQLHRMNCRPLPVFL
TH_3465|M.thermoresistible__bu MAWQPRPG----VDYRGMTAVAHRVIMAGSRRRFDRALRTAGAGPAPVFL
Mvan_4886|M.vanbaalenii_PYR-1 VAWQPERG----LDYRRMTTAAHRVIMRSSQRRFNHALRQAGSDACPLFV
MAV_3631|M.avium_104 SGLATGTG--------LRGRLRDATMRALTARSWRAGLRQRAAARAEIGL
MUL_3383|M.ulcerans_Agy99 SGLAPGTG--------IRGRLRDTTMRALTARSWRAGLRQRAAVRAEIGL
MAB_3062c|M.abscessus_ATCC_199 SGLAPGVG--------LRGRLRDGLMRRLTQKSIDQGLRQRSQARVEIGL
. : : :
Rv2958c|M.tuberculosis_H37Rv CRIFTDGDYTLYADVPELVP-TYNLPANHRYLGPVLWSPDV--KPPTWWH
MLBr_00128|M.leprae_Br4923 GCIYTDGDYTLYADVPELVP-TYDLPANHQYLGPVLWSPAG--ELPRWWD
Mb2986c|M.bovis_AF2122/97 CRIFTDGDHTLYADVPELMP-TYDLPANHEYLGPVLWSPAG--KPPTWWD
MMAR_1755|M.marinum_M CRIFTDGDQTLYADIPELQP-TYNRPDNHQYLGPVLWSPSG--ETPDWWD
Mflv_2592|M.gilvum_PYR-GCK LECAILADRVIVPTVPDFEYPRRDLPAHVRFVGAVSPLPGDDFIAPAWWG
MSMEG_4670|M.smegmatis_MC2_155 FDGAVLSERVIAPTVPQFDYHRSDLPKNVRYVGAVHPMPNQGFRRPMWWR
TH_3465|M.thermoresistible__bu SDWPALADRLIQLGVPGFEYHRGDLPSTVDFAGPVLPTGLDGVTLPAWWD
Mvan_4886|M.vanbaalenii_PYR-1 SDWPRLADGLLQLSVQALEYPRGDLPATVEFVGPVLPAGPEDFDPPHWWG
MAV_3631|M.avium_104 PARDPGPLRRLIATLPALEVPRPDWPDEAVLVGPLHFEPTDRVLD-----
MUL_3383|M.ulcerans_Agy99 AEHDPGPLRRLIATLPALEVPRPDWPAEAIVVGPLHFEPTDQLLK-----
MAB_3062c|M.abscessus_ATCC_199 PARDPGPMRRLIATLPALEVPRPDWPAEAVVVGPLHWEPTDVVLQ-----
: : : : * *.:
Rv2958c|M.tuberculosis_H37Rv SLPTDRPIIYATLG---SSGGKNLLQVVLNALADLPVTVIAATAGRNHLK
MLBr_00128|M.leprae_Br4923 SLPTDRPIVYATLG---TSGGKNLLQVVLDALADLPVTVIAATAGRSELQ
Mb2986c|M.bovis_AF2122/97 SLPTDRPIVYATLG---TSGGRNLLQLVLNALAELPVTVIAATAGRSDLK
MMAR_1755|M.marinum_M SLPADRPIVYATLG---TSGGRNLLQVVLNGLADLPVTVIAATADRSDLD
Mflv_2592|M.gilvum_PYR-GCK ELYRGRPVVHVTQGTVDNADLTRLIEPTIEALAG-EDVTVVVSTGGRPVS
MSMEG_4670|M.smegmatis_MC2_155 LLDGDRPVVHVTQGTVDNTDLTRLLEPTLEALAD-EDVVVIASTGGRDLD
TH_3465|M.thermoresistible__bu DIRSAATVVHVTQGTFDNTDLDQLVVPTLEALTDRPDVLVVATTGGRPGQ
Mvan_4886|M.vanbaalenii_PYR-1 DVMNAGAVVHVTQGTFDNADLDQLIAPTLEALGDRADLLVVATTGGRQGQ
MAV_3631|M.avium_104 -IPAGSGPVVVVAPSTAQTGARGLAEVALSCLTPGETLPAGARLVVSRLA
MUL_3383|M.ulcerans_Agy99 -VPAGSGPVLVIAPSTALSGTAGLAEVALESLIPGGTLSSGSRLVVSRLG
MAB_3062c|M.abscessus_ATCC_199 -PPSGSGPVVVIAPSTAFTGAEGMTELAVQALES-----AGARVVISALE
: . :. : .:. *
Rv2958c|M.tuberculosis_H37Rv N----VPANAFVADYLPGEAAAARSAVVLCNGGSPTTQQALAAGVPVIGL
MLBr_00128|M.leprae_Br4923 N----VPANAFVADYLPGEAAAARSAVVICNGGSLTTQQAFVAGVPVVGI
Mb2986c|M.bovis_AF2122/97 T----VPANAFVADYLPGEAAAARSAVVVCNGGSLTTQQALVAGVPVIGV
MMAR_1755|M.marinum_M D----IPANAYVADYLPGEAAAARSDVVICNGGSLTTQQALVAGVPVLGI
Mflv_2592|M.gilvum_PYR-GCK QIRTPLPANTFVAEFLPHDVLLPLVDVLVTNGGYGAVQRALAEGVPLVVA
MSMEG_4670|M.smegmatis_MC2_155 VLRTPVPANTYVAKYIPHDLLMPKVDVLVTNGGYGTVQRALSCGVPLVVA
TH_3465|M.thermoresistible__bu RSGFRVPGNARVTGWLPYRMLMPHVDVMITNGGYGGVQYALSHGVPLIVA
Mvan_4886|M.vanbaalenii_PYR-1 RIHGRIPANARIADWIPYSALLPHVDVMITNGGYGGVQHALAHGVPLVVA
MAV_3631|M.avium_104 GPELAAPP-WAVVGLGSQAELLRHADVVVCGGGHGMVAKTLLAGVPLVAV
MUL_3383|M.ulcerans_Agy99 GDDLVTPS-WAAVGLGSQAELLTHADVVICGGGHGMVSKTLLAGVPLVVV
MAB_3062c|M.abscessus_ATCC_199 PPSSGLPS-WAIAGLARQDLLLSGADLAVCGGGHGFLSKALLAGVPTVVV
* . : : .** :: *** :
Rv2958c|M.tuberculosis_H37Rv PSNMDQHLNMEALERAGAGVLLRTERLNTEGVAAAVKQVLSGAEFRQAAR
MLBr_00128|M.leprae_Br4923 AGNLDQHLNMEAVEAAGAGILLRSERLKVRRVADAVNRVLGQSEYRQAAQ
Mb2986c|M.bovis_AF2122/97 AGNLDQHLNMEAVERAGAGVLLRTERLKSQRVAGAVMQVISRSEYRQAAA
MMAR_1755|M.marinum_M ASNLDQHLNMQAIEAAGAGLLLRTERLKARSVSAAVCQLLDRPGYRQSAE
Mflv_2592|M.gilvum_PYR-GCK GDTEDKPEVAARVEYFGVGVNLRTGTPAPQDLRDAVNAVLSDAGYRTRAG
MSMEG_4670|M.smegmatis_MC2_155 GKTEDKPEVAARVAWSGAGIDLRTGTPTPAAIRDAVREVLTDKRYLSRAR
TH_3465|M.thermoresistible__bu GETSDKAEIAARVEFCGAGIDLGTATPTVRALRAGFDRIRDQDRYRTAAR
Mvan_4886|M.vanbaalenii_PYR-1 GETSDKAEVAARVDYSGVGIDLKTATPTPEAIRAAVDHVRRDGRYRSAAE
MAV_3631|M.avium_104 PGGGDQWEIANRVVRQGSARLIRPLS--ADALVAAVNEVLSSPGYRAAAQ
MUL_3383|M.ulcerans_Agy99 PGGGDQWEIANRVVRQGSARLIRPLG--ADALAAAVNEVLSSPGYREAAQ
MAB_3062c|M.abscessus_ATCC_199 PGGGDQWELANRVVRQGSAELVRPLS--RDSLASAIGRVLGEPRYREAAR
*: : * . : . : .. : : *
Rv2958c|M.tuberculosis_H37Rv RLAEAFGPDFAGFPQHIESALRLVC-------------------------
MLBr_00128|M.leprae_Br4923 RLAEVLERHVAGLPQHMENVLHTVSQNPPPTSLARQNETTT---------
Mb2986c|M.bovis_AF2122/97 RLADAFGRDRVGFPQHVENALRLMPENRPRTWLAS---------------
MMAR_1755|M.marinum_M ELAEVFGRELARFPQHVESALRRVSEGAVAKSAAG---------------
Mflv_2592|M.gilvum_PYR-GCK RLQAAYAS-RDSVTAIAALLDEVIPEQAAAR-------------------
MSMEG_4670|M.smegmatis_MC2_155 TLEAAFAQ-RDGVAEIIALVDEVIAERRAEVGGELACEVTHEQR------
TH_3465|M.thermoresistible__bu RLAREIRS-AAPLDSIAATLERIVAADALNRSARTGSAGAPDPDSTDDRP
Mvan_4886|M.vanbaalenii_PYR-1 RLRSAIEA-STPVDAIANAIKRLCNA------------------------
MAV_3631|M.avium_104 RAAAGIAD-VADPVRVCREALAG---------------------------
MUL_3383|M.ulcerans_Agy99 RAAASIAD-VADPVQVCHEALALAG-------------------------
MAB_3062c|M.abscessus_ATCC_199 RAAAGAIA-VEDPVRVCQDVLAALR-------------------------
Rv2958c|M.tuberculosis_H37Rv ----------
MLBr_00128|M.leprae_Br4923 ----------
Mb2986c|M.bovis_AF2122/97 ----------
MMAR_1755|M.marinum_M ----------
Mflv_2592|M.gilvum_PYR-GCK ----------
MSMEG_4670|M.smegmatis_MC2_155 ----------
TH_3465|M.thermoresistible__bu APRPARPRVH
Mvan_4886|M.vanbaalenii_PYR-1 ----------
MAV_3631|M.avium_104 ----------
MUL_3383|M.ulcerans_Agy99 ----------
MAB_3062c|M.abscessus_ATCC_199 ----------