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TQPVMQLVITEIDDSVPGVRTLRLAHPEGRALPSYPPGSHVVLQCGDVANAYSLTGDGVSPMRYVVSVLL CPNGSGGSRWIHDEVRIGETIDVSAPRSAFAPVHKARRHLLVAAGIGITPMMSHLYSAKRWGADARLLYI HRAGRGAYLDEVEQLGMPARVCTDRDRFHSELTAALISQPIGTHLYVCGPGTFMDDVIAQARELGWPPSR IHSERFGVDALDAGEPFEVELAGTGQTLTVPSGVSLLEALEKNGQNVPNLCRQGVCGECRIPVARGDILH RDTYLSDDEKQAGDALMACVSRAAGERLELAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4638 | - | - | 100% (313) | vanillate O-demethylase oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_1989 | - | 5e-66 | 41.08% (314) | phenoxybenzoate dioxygenase beta subunit |
| M. smegmatis MC2 155 | MSMEG_4371 | - | 1e-46 | 37.82% (312) | vanillate O-demethylase oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2798c | - | 8e-33 | 31.94% (310) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2623 | - | 3e-97 | 58.53% (299) | ferredoxin |
| M. tuberculosis H37Rv | Rv2776c | - | 8e-33 | 31.94% (310) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2381 | - | 3e-42 | 34.70% (317) | oxidoreductase |
| M. marinum M | MMAR_1933 | - | 1e-31 | 30.82% (305) | oxidoreductase |
| M. avium 104 | MAV_3669 | - | 4e-38 | 35.78% (313) | oxidoreductase |
| M. thermoresistible (build 8) | TH_4289 | - | 7e-42 | 35.71% (294) | PUTATIVE ferredoxin |
| M. ulcerans Agy99 | MUL_2159 | - | 2e-31 | 30.49% (305) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3958 | - | 1e-107 | 60.51% (314) | ferredoxin |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2798c|M.bovis_AF2122/97 --------------------------------------------------
Rv2776c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1933|M.marinum_M ------MAVSESSWTSRPADLYGRSHRDRFATALWGVRTMFGGFARFSRW
MUL_2159|M.ulcerans_Agy99 ------MAVSESSWTSRPADLYGRSHRDRFATALWGVRTMFGGFARFSRW
MAV_3669|M.avium_104 MSIRRAASRAPSIWASRPADLYGRRDHDRFTAVLWGVRAVFEGFASVSRW
MAB_2381|M.abscessus_ATCC_1997 --------------------------------------------------
TH_4289|M.thermoresistible__bu --------------------------------------------------
Mflv_2623|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3958|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4638|M.smegmatis_MC2_155 --------------------------------------------------
Mb2798c|M.bovis_AF2122/97 -------MRRTNPAVVTKRELVAPDVVALTLADPGGGLLPAWSPGGHIDV
Rv2776c|M.tuberculosis_H37Rv -------MRRTNPAVVTKRELVAPDVVALTLADPGGGLLPAWSPGGHIDV
MMAR_1933|M.marinum_M NPSRVTPVGRTHRARVVERELVAPDVVALTLADPDGGLLPSWSPGGHIDV
MUL_2159|M.ulcerans_Agy99 NPSRVTPVGRTHRARVVERELVAPDVVALTLADPDGGLLPSWSPGGHIDV
MAV_3669|M.avium_104 HPARVKPVQRKLTAVVTKREFAAPDVVALTLADPDGGLLPSWTPGAHIDV
MAB_2381|M.abscessus_ATCC_1997 ----MNDTGATLKVAVRQLRWEADGVVSLQLSSACNEPLPAWEPGAHVDL
TH_4289|M.thermoresistible__bu ----MN---MDLELHVAQKRTIADQIVELTLTRPDGGTLPEWTPGAHIDL
Mflv_2623|M.gilvum_PYR-GCK ----------------------------MTLTHVDGAPLPSFTPGSHIVV
Mvan_3958|M.vanbaalenii_PYR-1 --------MTTLKLTVAAIDDTIAGIRTLTLTHVDEAPLPSFTPGSHLVV
MSMEG_4638|M.smegmatis_MC2_155 ------MTQPVMQLVITEIDDSVPGVRTLRLAHPEGRALPSYPPGSHVVL
: *: ** : **.*: :
Mb2798c|M.bovis_AF2122/97 QLPS--GRRRQYSLCGVPGRRTDYRIAIRRIADGGG----GSIEMHEAFD
Rv2776c|M.tuberculosis_H37Rv QLPS--GRRRQYSLCGVPGRRTDYRIAIRRIADGGG----GSIEMHEAFD
MMAR_1933|M.marinum_M QLPS--GRRRQYSLCGPPGRRTDYRIAVRRIADGGG----GSIEMHAAYQ
MUL_2159|M.ulcerans_Agy99 QLPS--RRRRQYSLCGPPGRRTDYRIAVRRIADGGG----GSIEMHAAYQ
MAV_3669|M.avium_104 LLPS--GRRRQYSLCGPPGHRGEYRIAVRRIADGGG----GSIEMHEAFG
MAB_2381|M.abscessus_ATCC_1997 VLPT--GIERQYSLCGPVDDRSVYQVGVRRERTSRG----GSEYVHAFLR
TH_4289|M.thermoresistible__bu RLG---DLVRQYSLTGLEARPDRWVVSVLREPAGRG----GSQYVHDVLA
Mflv_2623|M.gilvum_PYR-GCK ECEAPGRPTNAYSLTGDGIAPDAYVISVLRRADEITSGPSGSQWIHDELA
Mvan_3958|M.vanbaalenii_PYR-1 ECGARNGPANAYSLTGDGIAPAAYVISVLR-AGTSGEAPSGSRWIHDELA
MSMEG_4638|M.smegmatis_MC2_155 QCGD---VANAYSLTGDGVSPMRYVVSVLLCPNGSG----GSRWIHDEVR
. *** * : :.: ** :*
Mb2798c|M.bovis_AF2122/97 VGDTCEFEGPRNAFHLGLAERDVLFVIGGIGVTPILPMIRAAEQRGIDWR
Rv2776c|M.tuberculosis_H37Rv VGDTCEFEGPRNAFHLGLAERDVLFVIGGIGVTPILPMIRAAEQRGIDWR
MMAR_1933|M.marinum_M PGDILVFEGPRNAFYLGAAEHDMLFVIGGIGVTPILPMVALAHQRGVNWR
MUL_2159|M.ulcerans_Agy99 PGDILVFEGPRNAFYLGAAEHDMLFVIGGIGVTPILPMVALAHQRGVNWR
MAV_3669|M.avium_104 VGDTVEFEGPRNAFYLGTAEHDVLFVIGGIGVTPILPMIRVAAGRGIDWR
MAB_2381|M.abscessus_ATCC_1997 PGQQLRIKGPRNNFGLHR-ADGYLFIAAGIGITPILPMIRQAQDWGADWT
TH_4289|M.thermoresistible__bu EGASIGASLPRNHFPLRSDADNILFIAGGIGITPMLPMISQLEQQARTWN
Mflv_2623|M.gilvum_PYR-GCK VGDTLIARPPRSAFAPVLRARRHLLVAAGIGITPMVSHLRSAKLWGRETR
Mvan_3958|M.vanbaalenii_PYR-1 VGDTVLARPPRSAFAPILRARRHLLVAAGIGITPMVSHLRSARLWGRDAR
MSMEG_4638|M.smegmatis_MC2_155 IGETIDVSAPRSAFAPVHKARRHLLVAAGIGITPMMSHLYSAKRWGADAR
* **. * *:: .***:**::. : .
Mb2798c|M.bovis_AF2122/97 AIYAGRGREYMPFLDEVVAVAPGRVTVWADDEHGRFASVDELLAGAGPTT
Rv2776c|M.tuberculosis_H37Rv AIYAGRGREYMPFLDEVVAVAPGRVTVWADDEHGRFASVDELLAGAGPTT
MMAR_1933|M.marinum_M AMYAGRSREYMPLLDELVAMAPERVSVWADDEHGRFAQVEDLVAGAGPKT
MUL_2159|M.ulcerans_Agy99 AVYAGRSREYMPLLDELVAMAPEGVSVWADDEHGRFAQVEDLVAGAGLKT
MAV_3669|M.avium_104 AIYTGRSREYMPLLDEVVSVDPQRVTVWADDEHGRFPTAAELLAAAGPAT
MAB_2381|M.abscessus_ATCC_1997 LYYGGHTAASMAFLEELRQYGP-RVHLYPADEVG-RIPLRELTTDVRPGL
TH_4289|M.thermoresistible__bu LIYCGRSRTSMAYLDELAKFGD-RVVVRPDDEYG-VPDLAGLIRPTAPDT
Mflv_2623|M.gilvum_PYR-GCK LYYIHRPG-RAAYVDTIRELTDHASIHTERAQFATDVSVALADQPMG--T
Mvan_3958|M.vanbaalenii_PYR-1 LLYIHRPG-RGAYVDTVRSLTDHASIHTLREEFVAELSTALADQPLG--T
MSMEG_4638|M.smegmatis_MC2_155 LLYIHRAG-RGAYLDEVEQLGMPARVCTDRDRFHSELTAALISQPIG--T
* : . :: : .
Mb2798c|M.bovis_AF2122/97 AVYVCGPPGMLEAVRVARNQHA--DAPLHYERFSPPPVVDG--VPFELEL
Rv2776c|M.tuberculosis_H37Rv AVYVCGPPGMLEAVRVARNQHA--DAPLHYERFSPPPVVDG--VPFELEL
MMAR_1933|M.marinum_M AVYVCGPPPMLEAVRAARAEYP--CAPLHYERFSPPPVVDG--VPFELEL
MUL_2159|M.ulcerans_Agy99 AVYVCGPPPMLEAVRAARAEYP--CAPLHYERFSPPPVVDG--VPFELEL
MAV_3669|M.avium_104 AVYVCGPSAMLEAVWIARNEHA--GAPLHYERFSPAPVVDG--VPFELEL
MAB_2381|M.abscessus_ATCC_1997 QIYACGPTELISDLTAAVSHWP--ADTLHVERFKPIPCAPAEDKPVDVTC
TH_4289|M.thermoresistible__bu VVYSCGPEGMLSTLETVCADPAH-SRTLVLERFVPKEYDTEGDTAFEVEF
Mflv_2623|M.gilvum_PYR-GCK HLYVCGPAGFIEFVSATAAALGWPASRIHIEHFGSEALDPG--EPFSVRV
Mvan_3958|M.vanbaalenii_PYR-1 HLYVCGPASFIDFVAATATELGWPASRIHFEHFGAGALDPG--EPFTVRV
MSMEG_4638|M.smegmatis_MC2_155 HLYVCGPGTFMDDVIAQARELGWPPSRIHSERFGVDALDAG--EPFEVEL
:* *** ::. : : *:* .. :
Mb2798c|M.bovis_AF2122/97 ARSRRVLRVPANRSALDVMLDWDPTTAYSCQQGFCGTCKVRVLAGQVDRR
Rv2776c|M.tuberculosis_H37Rv ARSRRVLRVPANRSALDVMLDWDPTTAYSCQQGFCGTCKVRVLAGQVDRR
MMAR_1933|M.marinum_M ARTGEVLSIPANRTALDVMLDRDPTTAYSCQQGFCGTCKVKVLAGQVDHR
MUL_2159|M.ulcerans_Agy99 ARTGEVLSIPANRTALDVMLDRDPTTAYSCQQGFCGTCKVKVLAGQVDHR
MAV_3669|M.avium_104 ARSRQVLAVPANRTALDVMLDRDATTPYSCRQGFCGTCRVKVLAGQVDHR
MAB_2381|M.abscessus_ATCC_1997 AASRQTIAVPPGQSILAAVEQAGIQVSASCRAGVCGSCETAVLEGVPDHR
TH_4289|M.thermoresistible__bu AQSGVTVTVPADRSILEVAEEAGIDILSSCSEGTCGTCESPVLEGIPEHR
Mflv_2623|M.gilvum_PYR-GCK RSTGEEFPVEPGVSLLEALERRGFDIPNLCRRGVCGECRIPVSGSVITHR
Mvan_3958|M.vanbaalenii_PYR-1 PSTADEFTVEAGVSLLEALESRGFAIPNLCRRGVCGECRVPVSGGAITHR
MSMEG_4638|M.smegmatis_MC2_155 AGTGQTLTVPSGVSLLEALEKNGQNVPNLCRQGVCGECRIPVARGDILHR
: . : .. : * . . * * ** *. * . :*
Mb2798c|M.bovis_AF2122/97 GRIIEGDN-----EMLVCVSRA-VSGRVVIDA
Rv2776c|M.tuberculosis_H37Rv GRIIEGDN-----EMLVCVSRA-VSGRVVIDA
MMAR_1933|M.marinum_M GRAAQGDD-----EMLVCVSRG-HSARVVIDA
MUL_2159|M.ulcerans_Agy99 GRAAQGDD-----EMLVCVSRG-HSARVVIDA
MAV_3669|M.avium_104 GRTDPGQD-----GMLVCVSRA-DGGRLVIDA
MAB_2381|M.abscessus_ATCC_1997 DDILSEEDRAAGDRMYICVSRA-LTPRLVLDL
TH_4289|M.thermoresistible__bu DSVLTKEERASNATMMPCVSRC-RTPRLVLDL
Mflv_2623|M.gilvum_PYR-GCK DLYLTEDDKVAGDSLMACVSRADGSQTLEVAL
Mvan_3958|M.vanbaalenii_PYR-1 DLYLSDDEKRAGNSMMACVSRA-ASQSLELKL
MSMEG_4638|M.smegmatis_MC2_155 DTYLSDDEKQAGDALMACVSRA-AGERLELAL
. :: : **** : :