For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. smegmatis MC2 155 MSMEG_4501 (-)

annotation: sodium:dicarboxylate symporter
coordinates: 4578798 - 4580165
length: 455

AASATRSPWYSSLFIQLLVAIVAGIVVGWLWPDVGGSLKPLADGFIKLIKMLIAPIIFCTVVLGIAHVGD
LKSVGRIGVKALIYFEAITTFALLFGLVVGNVVKPGAGFNIDAQTLATGAEAVAAKTGDGELPHTVEFLL
NIIPSSVVSAFAENALLQVLFFAVLFGLGLAKFGEHGPPVVLEFIDHLSHIFFTVIGWIMRLAPLGAFGA
MAYIIGQYGIGSLGSYAKLIAACYVAAALFIVILAVVTKVFAGVNLWKFFLYIKDEMFLALGTASTEVVL
PRVMAKLTNAGCSRTTTGLVVPTGYSFNLDGATLYLSICVLFLAQALGVDLSLGEQIMAVLVLMLTSKGM
AGVPGSSFLALSATVAAIGHGAIPVAAVALLLGADRIMDSMRVSVNLLGNCVATLVVAAWEGQLDRERMR
KVLAGEDVPPLDELAEADGSGRGTPVGAQAGSRD*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_4501--100% (455)sodium:dicarboxylate symporter
M. smegmatis MC2 155MSMEG_5302-2e-8741.04% (441) aerobic C4-dicarboxylate transport protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2470dctA2e-7937.05% (448) C4-dicarboxylate-transport transmembrane protein DctA
M. gilvum PYR-GCKMflv_1323-3e-8340.32% (434) sodium:dicarboxylate symporter
M. tuberculosis H37RvRv2443dctA2e-7937.05% (448) C4-dicarboxylate-transport transmembrane protein DctA
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2938-0.085.88% (425) sodium:dicarboxylate symporter
M. marinum MMMAR_3814dctA1e-7536.18% (434) C4-dicarboxylate-transport transmembrane protein DctA
M. avium 104-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_4696-1e-9142.40% (434) sodium:dicarboxylate symporter

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1323|M.gilvum_PYR-GCK          MAATDDDAG--TDTTKKTGKRDRTHWLYILVIVAVVAGIVVGLVAPETAA
Mvan_4696|M.vanbaalenii_PYR-1       -MTTRMDSP--TPPEAPRRKRDRTHWLYIAVIVAVVAGVAVGILAPEVGK
Mb2470|M.bovis_AF2122/97            -MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGK
Rv2443|M.tuberculosis_H37Rv         -MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGK
MMAR_3814|M.marinum_M               -MTTPLDQPPATDPRASKKRPDRTRWLYFAVIGAVILGVIAGLAVPSIGP
MSMEG_4501|M.smegmatis_MC2_155      -------------MAASATRSPWYSSLFIQLLVAIVAGIVVGWLWPDVGG
MAB_2938|M.abscessus_ATCC_1997      -MPTAIEVP-ASEMVRLANKPPWYRSLFVQLLVAIVAGVVIGWLWPGLGA
                                                              *:. :: *:: *:  *   *  . 

Mflv_1323|M.gilvum_PYR-GCK          SLGVLGELFVKLIKMMTVPVIFCTVVLGIGKVRAAASVGKVGGLAIGYFL
Mvan_4696|M.vanbaalenii_PYR-1       SVGVLGTMFVALIKMMIAPVIFCTIVLGIGSVRKAATVGKVGGLAFLYFL
Mb2470|M.bovis_AF2122/97            SLTVLGTVFVNLIKMMIAPVIFCTIVLGIGSVRKAAAVGKVGGLALAYFL
Rv2443|M.tuberculosis_H37Rv         SLTVLGTVFVNLIKMMIAPVIFCTIVLGIGSVRKAAAVGKVGGLALAYFL
MMAR_3814|M.marinum_M               HVAVLGTTFVNLITMMVAPVIFCTIVLGIGSLNRAALLGKVGGLAFLYFL
MSMEG_4501|M.smegmatis_MC2_155      SLKPLADGFIKLIKMLIAPIIFCTVVLGIAHVGDLKSVGRIGVKALIYFE
MAB_2938|M.abscessus_ATCC_1997      DLRPLADGFIKLIKMLIAPIIFCTVVLGIAHVGDLKSVGRIGVKALIYFE
                                     :  *.  *: **.*: .*:****:****. :     :*::*  *: ** 

Mflv_1323|M.gilvum_PYR-GCK          VMSTIALAIGLVVGNLISPGTGLNVP-HDPGKGAELAGEAESAG---GTM
Mvan_4696|M.vanbaalenii_PYR-1       VMSTFALAIGLVVGNLLHPGSGLQVSDTAAGKGAELADKAHEAG---GLL
Mb2470|M.bovis_AF2122/97            TMSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESH---GIA
Rv2443|M.tuberculosis_H37Rv         TMSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESH---GIA
MMAR_3814|M.marinum_M               VMSTAALGIGLFVGNLIGTVRGLHLSVESMGSGVEVADAAPPSG---WMH
MSMEG_4501|M.smegmatis_MC2_155      AITTFALLFGLVVGNVVKPGAGFNIDAQTLATGAEAVAAKTGDGELPHTV
MAB_2938|M.abscessus_ATCC_1997      AVTTFALLFGLLVGNLAKPGAGFHIDAGTLATGADAIAKKTNNGELPHTV
                                    .::: ** :**.***:  .  .:::     ..*.                

Mflv_1323|M.gilvum_PYR-GCK          AFISDIIPSTLFSAVTEGNVLQALFVALLVGFGIQGIGAHG-ESLLRGIE
Mvan_4696|M.vanbaalenii_PYR-1       DFVQGIIPTTMFSSLTEGSVLQALFIALLVGFALQGLGTAG-EPILRGIE
Mb2470|M.bovis_AF2122/97            GFIQQIIPRSLPSALTEGNVLQVLLVALLVGFAVQGLGPAG-ESILRAVE
Rv2443|M.tuberculosis_H37Rv         GFIQQIIPRSLPSALTEGNVLQVLLVALLVGFAVQGLGPAG-ESILRAVE
MMAR_3814|M.marinum_M               GLLDQVIPTSLLSGLTNGNVLQALFVALLVGFAVQGMGAAG-EPILRSVE
MSMEG_4501|M.smegmatis_MC2_155      EFLLNIIPSSVVSAFAENALLQVLFFAVLFGLGLAKFGEHGPPVVLEFID
MAB_2938|M.abscessus_ATCC_1997      EFLLGIIPSSIVSAFAENALLQVLFFAVLFGLALAKFGESGPPVVLEFID
                                     ::  :** :: *..::. :**.*:.*:*.*:.:  :*  *   :*. ::

Mflv_1323|M.gilvum_PYR-GCK          ALQKLVFRILIGVLWLAPIGAFGAIAEVVGDTGFDAVIQLGVLMAAFYIT
Mvan_4696|M.vanbaalenii_PYR-1       HLQKLVFKVLVMILWLAPIGAFGAIANVVGQTGWAAVGQLMALMLGFYLT
Mb2470|M.bovis_AF2122/97            NLQKLVFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMAGFYLT
Rv2443|M.tuberculosis_H37Rv         NLQKLVFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMAGFYLT
MMAR_3814|M.marinum_M               YLQKLVFKVLGMLLWLAPIGAFGWIASIIGATGWGAVANLLILLVGFYLT
MSMEG_4501|M.smegmatis_MC2_155      HLSHIFFTVIGWIMRLAPLGAFGAMAYIIGQYGIGSLGSYAKLIAACYVA
MAB_2938|M.abscessus_ATCC_1997      HLSHIFFTIIGWIMRLAPVGALGAMAYIVGQYGIGSLSSYGKLIAACYAA
                                     *.::.* ::  :: ***:**:* :* ::.  *  :: .   *: . * :

Mflv_1323|M.gilvum_PYR-GCK          CVIFIFGVLGALLWAVARVSIFKLARYLAREYLLIVATSSSESALPRLIA
Mvan_4696|M.vanbaalenii_PYR-1       CAIFVFGVLGALLRVVSGVSIFKLVRYLAREYLLIVSTSSSESALPRLIA
Mb2470|M.bovis_AF2122/97            CVVFVFGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLIT
Rv2443|M.tuberculosis_H37Rv         CVVFVFGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLIT
MMAR_3814|M.marinum_M               CAVFVFGVLGVLLYVVSGVSIFRLVRYLAREYLLIFATSSSEAVLPRLVA
MSMEG_4501|M.smegmatis_MC2_155      AALFIV-ILAVVTKVFAGVNLWKFFLYIKDEMFLALGTASTEVVLPRVMA
MAB_2938|M.abscessus_ATCC_1997      ALLFIG-VLAVIARLFAGVNLWRFVVYIKDELFLALGTASTEVVLPRIMT
                                    . :*:  :*..:   .: :.::::  *:  * :* ..*:*:* .***:::

Mflv_1323|M.gilvum_PYR-GCK          KMEHAGVKPATVGIVVPTGYSFNLDGTAIYLTMASLFIADALGDPLSIPE
Mvan_4696|M.vanbaalenii_PYR-1       KMEHLGVDRSTVGVVVPTGYSFNLDGTAIYLTMASLFIAGALGDPLSLGE
Mb2470|M.bovis_AF2122/97            KMKHLGVQSSTVGVVVPTGYSFNLDGTAIYLTMASLFIADAMGHRLTWGE
Rv2443|M.tuberculosis_H37Rv         KMKHLGVQSSTVGVVVPTGYSFNLDGTAIYLTMASLFIADAMGHRLTWGE
MMAR_3814|M.marinum_M               KMKHLGVEPATVGVVVPVGYSFNLDGTALYLTMASLFIADALGRPLAWGE
MSMEG_4501|M.smegmatis_MC2_155      KLTNAGCSRTTTGLVVPTGYSFNLDGATLYLSICVLFLAQALGVDLSLGE
MAB_2938|M.abscessus_ATCC_1997      KLNHAGCSKTTTGLVIPTGYSFNLDGATLYLSICVLFLAQALGVNLTLGE
                                    *: : * . :*.*:*:*.********:::**::. **:* *:*  *:  *

Mflv_1323|M.gilvum_PYR-GCK          QLGLLAFMIIASKGAAGVSGAGLATLAA--GLQSHRPELLDGVGIIVGID
Mvan_4696|M.vanbaalenii_PYR-1       QIGLLVFMIVASKGAAGVTGAGLATLAG--GLQAHRPDLLDGVGLIVGID
Mb2470|M.bovis_AF2122/97            QIALLAFMIIASKGAAGVSGAGLATLAG--GLQAHRPELLDGVGLIVGID
Rv2443|M.tuberculosis_H37Rv         QIALLAFMIIASKGAAGVSGAGLATLAG--GLQAHRPELLDGVGLIVGID
MMAR_3814|M.marinum_M               QISLLVFMIFASKGAAGVSGAGLAALAS--GLQAYRPELLGGVALVAGTD
MSMEG_4501|M.smegmatis_MC2_155      QIMAVLVLMLTSKGMAGVPGSSFLALSATVAAIGHGAIPVAAVALLLGAD
MAB_2938|M.abscessus_ATCC_1997      QITAVLVLMLTSKGMAGVPGSSFLALSATVAAIGHGAIPVAAVALLLGAD
                                    *:  : .::.:*** ***.*:.: :*:.  .  .: .  : .*.:: * *

Mflv_1323|M.gilvum_PYR-GCK          RFMSEARALTNFSGNAVATVLVGSWTDSVDKNRLNEVLDGDRPFDEATML
Mvan_4696|M.vanbaalenii_PYR-1       RFMSEARALTNFSGNAVATLLVGSWTRTIDRDKVNSVLAGDDPFDELTML
Mb2470|M.bovis_AF2122/97            RFMSEARSLTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMV
Rv2443|M.tuberculosis_H37Rv         RFMSEARSLTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMV
MMAR_3814|M.marinum_M               TFMKEARSLTNFSGNAVATILVGWWTKTIDRAKVDAVLHGRDPFDEWTMI
MSMEG_4501|M.smegmatis_MC2_155      RIMDSMRVSVNLLGNCVATLVVAAWEGQLDRERMRKVLAGEDVPPLDELA
MAB_2938|M.abscessus_ATCC_1997      RIMDSMRVSVNLLGNCVATLVVAQWEGQLDKDRMCKVLAGQQVV------
                                     :*.. *  .*: **.***::*. *   :*  :   ** *          

Mflv_1323|M.gilvum_PYR-GCK          DDDDAEDRTTIDRTARSGAPTAG-------------------------
Mvan_4696|M.vanbaalenii_PYR-1       DSDHGS-RAQEPAQEKIPAPV---------------------------
Mb2470|M.bovis_AF2122/97            DPHDEEPPAATPHGGGVPTNPALCDFEQVSLGGLVGRPAGPQRADVDG
Rv2443|M.tuberculosis_H37Rv         DPHDEEPPAATPHGGGVPTNPALCDFEQVSLGGLVGRPAGPQRADVDG
MMAR_3814|M.marinum_M               D-RDDAPPTGVAES----------------------------------
MSMEG_4501|M.smegmatis_MC2_155      EADGSGRGTPVGAQAGSRD-----------------------------
MAB_2938|M.abscessus_ATCC_1997      -------NEPEGESAAAHP-----------------------------