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M. bovis AF2122 / 97 Mb2470 (dctA)

annotation: C4-dicarboxylate-transport transmembrane protein DctA
coordinates: 2708872 - 2710347
length: 491

MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGKSLTVLGTVFVNLIKMMIAPVI
FCTIVLGIGSVRKAAAVGKVGGLALAYFLTMSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAA
ESHGIAGFIQQIIPRSLPSALTEGNVLQVLLVALLVGFAVQGLGPAGESILRAVENLQKLVFKVLVMVLW
LAPIGAFGAIANIVATTGFNAVTNLLLLMAGFYLTCVVFVFGVLGVLLRIVSGLSIFRLLRYLAREYLLI
FATSSSEVVLPRLITKMKHLGVQSSTVGVVVPTGYSFNLDGTAIYLTMASLFIADAMGHRLTWGEQIALL
AFMIIASKGAAGVSGAGLATLAGGLQAHRPELLDGVGLIVGIDRFMSEARSLTNFSGNAVATILVASWTK
TIDLSKADEVLRGRDPFDESTMVDPHDEEPPAATPHGGGVPTNPALCDFEQVSLGGLVGRPAGPQRADVD
G
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2470dctA-100% (491)C4-dicarboxylate-transport transmembrane protein DctA

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_1323-1e-16969.25% (439) sodium:dicarboxylate symporter
M. tuberculosis H37RvRv2443dctA0.0100.00% (491) C4-dicarboxylate-transport transmembrane protein DctA
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_1540-1e-16970.14% (432) sodium:dicarboxylate symporter
M. marinum MMMAR_3814dctA1e-17771.62% (451) C4-dicarboxylate-transport transmembrane protein DctA
M. avium 104-----
M. smegmatis MC2 155MSMEG_5302-0.072.55% (459) aerobic C4-dicarboxylate transport protein
M. thermoresistible (build 8)-----
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_4696-1e-17872.75% (444) sodium:dicarboxylate symporter

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_5302|M.smegmatis_MC2_155      --MSTTLDRQPEPAPPRR-RDRTHWLYIAVIVAVVAGVAVGLLAPEVGKS
Mvan_4696|M.vanbaalenii_PYR-1       --MTTRMDSPTPPEAPRRKRDRTHWLYIAVIVAVVAGVAVGILAPEVGKS
Mflv_1323|M.gilvum_PYR-GCK          -MAATDDDAGTDTTKKTGKRDRTHWLYILVIVAVVAGIVVGLVAPETAAS
MAB_1540|M.abscessus_ATCC_1997      -MTATEPATSESTPPKK-HKDRTHWLYIAVVVAVALGVAVGMLWPGFGRS
Mb2470|M.bovis_AF2122/97            MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGKS
Rv2443|M.tuberculosis_H37Rv         MTAPLDRAPVTDLPANNKGRDRTHWLYLAVIFAVIAGVIVGLTAPSTGKS
MMAR_3814|M.marinum_M               MTTPLDQPPATDPRASKKRPDRTRWLYFAVIGAVILGVIAGLAVPSIGPH
                                       .                ***:***: *: **  *: .*:  *  .  

MSMEG_5302|M.smegmatis_MC2_155      VGVLGTMFVNLIKMMIGPVIFCTIVLGIGSVRKAATVGKVGGLAFTYFLV
Mvan_4696|M.vanbaalenii_PYR-1       VGVLGTMFVALIKMMIAPVIFCTIVLGIGSVRKAATVGKVGGLAFLYFLV
Mflv_1323|M.gilvum_PYR-GCK          LGVLGELFVKLIKMMTVPVIFCTVVLGIGKVRAAASVGKVGGLAIGYFLV
MAB_1540|M.abscessus_ATCC_1997      VGVLGEIFVSLIKMMISPVIFCTIVLGIGSVRKAASVGRVGGLAFVYFLA
Mb2470|M.bovis_AF2122/97            LTVLGTVFVNLIKMMIAPVIFCTIVLGIGSVRKAAAVGKVGGLALAYFLT
Rv2443|M.tuberculosis_H37Rv         LTVLGTVFVNLIKMMIAPVIFCTIVLGIGSVRKAAAVGKVGGLALAYFLT
MMAR_3814|M.marinum_M               VAVLGTTFVNLITMMVAPVIFCTIVLGIGSLNRAALLGKVGGLAFLYFLV
                                    : ***  ** **.**  ******:*****.:. ** :*:*****: ***.

MSMEG_5302|M.smegmatis_MC2_155      MSTFALAIGLVVGNVLHPGTGMHLTESAAGKGAELAETAHEAGGLMDFVQ
Mvan_4696|M.vanbaalenii_PYR-1       MSTFALAIGLVVGNLLHPGSGLQVSDTAAGKGAELADKAHEAGGLLDFVQ
Mflv_1323|M.gilvum_PYR-GCK          MSTIALAIGLVVGNLISPGTGLNVP-HDPGKGAELAGEAESAGGTMAFIS
MAB_1540|M.abscessus_ATCC_1997      MSTVALAIGLVVGNLLAPGTGLHLSGSNQGAGAKYVDQAHAAGGTWHFIK
Mb2470|M.bovis_AF2122/97            MSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESHGIAGFIQ
Rv2443|M.tuberculosis_H37Rv         MSSVALGIGLIVGNLLSPGRDLHLRPGAVGSGAALAGQAAESHGIAGFIQ
MMAR_3814|M.marinum_M               MSTAALGIGLFVGNLIGTVRGLHLSVESMGSGVEVADAAPPSGWMHGLLD
                                    **: **.***.***:: .  .:::     * *.  .  *  :     ::.

MSMEG_5302|M.smegmatis_MC2_155      GIIPETLFSALTAGSVLQALFVALLVGFALQAMGSAGEPVLRGIVHLQKL
Mvan_4696|M.vanbaalenii_PYR-1       GIIPTTMFSSLTEGSVLQALFIALLVGFALQGLGTAGEPILRGIEHLQKL
Mflv_1323|M.gilvum_PYR-GCK          DIIPSTLFSAVTEGNVLQALFVALLVGFGIQGIGAHGESLLRGIEALQKL
MAB_1540|M.abscessus_ATCC_1997      SIVPETMFSALTSGSVLQTLFIALLVGFAVQALGGTGESIVRGVGMLQKL
Mb2470|M.bovis_AF2122/97            QIIPRSLPSALTEGNVLQVLLVALLVGFAVQGLGPAGESILRAVENLQKL
Rv2443|M.tuberculosis_H37Rv         QIIPRSLPSALTEGNVLQVLLVALLVGFAVQGLGPAGESILRAVENLQKL
MMAR_3814|M.marinum_M               QVIPTSLLSGLTNGNVLQALFVALLVGFAVQGMGAAGEPILRSVEYLQKL
                                     ::* :: *.:* *.***.*::******.:*.:*  **.::*.:  ****

MSMEG_5302|M.smegmatis_MC2_155      VFKVLAMILWLAPIGAFGAIANVVGQTGWTAVTQLLALMFGFYVTCFVFV
Mvan_4696|M.vanbaalenii_PYR-1       VFKVLVMILWLAPIGAFGAIANVVGQTGWAAVGQLMALMLGFYLTCAIFV
Mflv_1323|M.gilvum_PYR-GCK          VFRILIGVLWLAPIGAFGAIAEVVGDTGFDAVIQLGVLMAAFYITCVIFI
MAB_1540|M.abscessus_ATCC_1997      VFKVLIMVLWLAPIGAFGAIANVVGQTGWDAVKELGTLMLGFYVTCAIFI
Mb2470|M.bovis_AF2122/97            VFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMAGFYLTCVVFV
Rv2443|M.tuberculosis_H37Rv         VFKVLVMVLWLAPIGAFGAIANIVATTGFNAVTNLLLLMAGFYLTCVVFV
MMAR_3814|M.marinum_M               VFKVLGMLLWLAPIGAFGWIASIIGATGWGAVANLLILLVGFYLTCAVFV
                                    **::*  :********** **.::. **: ** :*  *: .**:** :*:

MSMEG_5302|M.smegmatis_MC2_155      FGVLGVLMRAVAGVSIFKLVRYLAREYLLIVSTSSSESALPRLIAKMEHL
Mvan_4696|M.vanbaalenii_PYR-1       FGVLGALLRVVSGVSIFKLVRYLAREYLLIVSTSSSESALPRLIAKMEHL
Mflv_1323|M.gilvum_PYR-GCK          FGVLGALLWAVARVSIFKLARYLAREYLLIVATSSSESALPRLIAKMEHA
MAB_1540|M.abscessus_ATCC_1997      FGVLGTLLWAVSRVSIFRLVRYLAREYLLIVSTSSSESALPRLIAKMAHL
Mb2470|M.bovis_AF2122/97            FGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLITKMKHL
Rv2443|M.tuberculosis_H37Rv         FGVLGVLLRIVSGLSIFRLLRYLAREYLLIFATSSSEVVLPRLITKMKHL
MMAR_3814|M.marinum_M               FGVLGVLLYVVSGVSIFRLVRYLAREYLLIFATSSSEAVLPRLVAKMKHL
                                    *****.*:  *: :***:* **********.:***** .****::** * 

MSMEG_5302|M.smegmatis_MC2_155      GVDRSTVGVVVPTGYSFNLDGTAIYLTMASLFIAGALGDPLSVTEQIGLL
Mvan_4696|M.vanbaalenii_PYR-1       GVDRSTVGVVVPTGYSFNLDGTAIYLTMASLFIAGALGDPLSLGEQIGLL
Mflv_1323|M.gilvum_PYR-GCK          GVKPATVGIVVPTGYSFNLDGTAIYLTMASLFIADALGDPLSIPEQLGLL
MAB_1540|M.abscessus_ATCC_1997      GVDKSTVGIVVPTGYSFNLDGTAIYLTMASLFVADAMGAPLSVGEQISLL
Mb2470|M.bovis_AF2122/97            GVQSSTVGVVVPTGYSFNLDGTAIYLTMASLFIADAMGHRLTWGEQIALL
Rv2443|M.tuberculosis_H37Rv         GVQSSTVGVVVPTGYSFNLDGTAIYLTMASLFIADAMGHRLTWGEQIALL
MMAR_3814|M.marinum_M               GVEPATVGVVVPVGYSFNLDGTALYLTMASLFIADALGRPLAWGEQISLL
                                    **. :***:***.**********:********:*.*:*  *:  **:.**

MSMEG_5302|M.smegmatis_MC2_155      VFMIVASKGAAGVTGAGLATLAGGLQAHRPDLLDGVGLIVGIDRFMSEAR
Mvan_4696|M.vanbaalenii_PYR-1       VFMIVASKGAAGVTGAGLATLAGGLQAHRPDLLDGVGLIVGIDRFMSEAR
Mflv_1323|M.gilvum_PYR-GCK          AFMIIASKGAAGVSGAGLATLAAGLQSHRPELLDGVGIIVGIDRFMSEAR
MAB_1540|M.abscessus_ATCC_1997      AFMMIASKGAAGVTGAGMATLAAGLQSHRPDLVDGVGMIVGIDRFMSEAR
Mb2470|M.bovis_AF2122/97            AFMIIASKGAAGVSGAGLATLAGGLQAHRPELLDGVGLIVGIDRFMSEAR
Rv2443|M.tuberculosis_H37Rv         AFMIIASKGAAGVSGAGLATLAGGLQAHRPELLDGVGLIVGIDRFMSEAR
MMAR_3814|M.marinum_M               VFMIFASKGAAGVSGAGLAALASGLQAYRPELLGGVALVAGTDTFMKEAR
                                    .**:.********:***:*:**.***::**:*:.**.::.* * **.***

MSMEG_5302|M.smegmatis_MC2_155      AVTNFSGNAVATILVGSWTHTIDKDKVDAVLGGDDPFDELTMVD-DHQTA
Mvan_4696|M.vanbaalenii_PYR-1       ALTNFSGNAVATLLVGSWTRTIDRDKVNSVLAGDDPFDELTMLDSDHGSR
Mflv_1323|M.gilvum_PYR-GCK          ALTNFSGNAVATVLVGSWTDSVDKNRLNEVLDGDRPFDEATMLDDDDAED
MAB_1540|M.abscessus_ATCC_1997      ALTNFSGNAVATLLIATWTKTMDRDRVKTVLSGADPFDETTMLDDHAGEA
Mb2470|M.bovis_AF2122/97            SLTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMVDPHDEEP
Rv2443|M.tuberculosis_H37Rv         SLTNFSGNAVATILVASWTKTIDLSKADEVLRGRDPFDESTMVDPHDEEP
MMAR_3814|M.marinum_M               SLTNFSGNAVATILVGWWTKTIDRAKVDAVLHGRDPFDEWTMID-RDDAP
                                    ::**********:*:. ** ::*  : . ** *  **** **:*      

MSMEG_5302|M.smegmatis_MC2_155      APEKEPAATPA------------------------------
Mvan_4696|M.vanbaalenii_PYR-1       AQEPAQEKIPAPV----------------------------
Mflv_1323|M.gilvum_PYR-GCK          RTTIDRTARSGAPTAG-------------------------
MAB_1540|M.abscessus_ATCC_1997      --VVDKVVS--------------------------------
Mb2470|M.bovis_AF2122/97            PAATPHGGGVPTNPALCDFEQVSLGGLVGRPAGPQRADVDG
Rv2443|M.tuberculosis_H37Rv         PAATPHGGGVPTNPALCDFEQVSLGGLVGRPAGPQRADVDG
MMAR_3814|M.marinum_M               PTGVAES----------------------------------