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VILRGGRVIVGDGHTVLDDATVVVEHGRITTVDTGDAPASRPGDRHVDVSGKTVMPAVVNPHGHVGYMRG STTTAENFSRASVLDYMRRILYAGVATFQSLGTDRDDVEIGLRDQQRSGELADEGPLARFYSAGVGIVAP TPGSPNGGPFFSTESMFEASTPDDARAHVRVLAEKRADIVKFWIDDRHGTKSKLPPEVYRAIVDEAHRLG LKAAAHIYTVDDAKAAVRAGADVLAHLPRTGPDRELIDLMLEHDVAAFTSLSIQRPDGTGWLDDPLVIET VTPQTREYLRTRIESIAPQPLFDTVEAYRRMVDAVHQYVEAGVRIVFSADTGLLTQVPGIAEHRELEAMV DAGVSTAETIHAATGRAAEFLSLDSGSVTEGRRADLLVLDADPLTDIRAVRRIDSLYLDGDLVDRAALRD RFLDF
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4392 | - | - | 100% (425) | organophopsphate acid anhydrase |
| M. smegmatis MC2 155 | MSMEG_6887 | - | 4e-27 | 28.80% (441) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_0297 | - | 2e-15 | 25.78% (446) | amidohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0076 | - | 4e-12 | 25.00% (400) | hypothetical protein Mb0076 |
| M. gilvum PYR-GCK | Mflv_2466 | - | 2e-17 | 25.45% (444) | amidohydrolase |
| M. tuberculosis H37Rv | Rv0074 | - | 4e-12 | 25.00% (400) | hypothetical protein Rv0074 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3236c | - | 3e-08 | 23.32% (373) | amidohydrolase |
| M. marinum M | MMAR_4746 | - | 2e-16 | 25.80% (438) | imidazolonepropionase |
| M. avium 104 | MAV_0903 | - | 7e-15 | 25.48% (416) | Xaa-Pro dipeptidase |
| M. thermoresistible (build 8) | TH_0262 | - | 3e-18 | 26.96% (460) | amidohydrolase |
| M. ulcerans Agy99 | MUL_2041 | - | 2e-14 | 26.04% (361) | hypothetical protein MUL_2041 |
| M. vanbaalenii PYR-1 | Mvan_4188 | - | 3e-18 | 26.13% (444) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2466|M.gilvum_PYR-GCK ----MTVTVVKAARWADVEAGVVRS-------PAVIVVEGNRIRSVDPAA
Mvan_4188|M.vanbaalenii_PYR-1 ----MTGTVLKAARWADVEAGVVRA-------PAVIVVEGNRIQAINPAG
TH_0262|M.thermoresistible__bu ---VTATTVLRAARWVDVAAGEVCS-------PAVVVVDGDRISAVNPVE
MMAR_4746|M.marinum_M ------MLTLKAAGLLDVDAGEILA-------PAVVRVEGDRIAGVGGD-
MAV_0903|M.avium_104 ------MQTIKAAGLFDVDAGEIVR-------PGLLRVDGDRIVGVGDSG
Mb0076|M.bovis_AF2122/97 MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISAVDFAG
Rv0074|M.tuberculosis_H37Rv MGDLSISQVSARPGRIGIRARQMFDGYRFQRGPVLVVVEDGRISAVDFAG
MAB_3236c|M.abscessus_ATCC_199 -------------MRAHLRGRTLPS---------EEPIDLWVHDGVISIE
MUL_2041|M.ulcerans_Agy99 -------------MRLHVRGRGLPD---------ETAVELWIVDGHISAE
MSMEG_4392|M.smegmatis_MC2_155 -------MILRGGRVIVGDGHTVLD-------DATVVVEHGRITTVDTGD
. : ::
Mflv_2466|M.gilvum_PYR-GCK EPP--G-AEVLDLGDVTLLPGLMDMELNLLIGGPGGPEGLPSPMHGVQDD
Mvan_4188|M.vanbaalenii_PYR-1 EPA--DSPTVIDLGDVTLLPGLMDMELNLLIGGPGGPEGLPSPMHGVQDD
TH_0262|M.thermoresistible__bu SPR--DPAVELDLGDVTLLPGLMDMELNLLIGGPGGPSGLPSPMHGVQDD
MMAR_4746|M.marinum_M -----PEGDVIDLGDQILLPGLMDMEVNLLMGGRGEKPGLS----QVQDD
MAV_0903|M.avium_104 PTG--ADDNVIDLGEAILLPGLMDMEVNLLMGGRGEKPGLS----QVQDD
Mb0076|M.bovis_AF2122/97 SAC--PDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG------DP
Rv0074|M.tuberculosis_H37Rv SAC--PDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG------DP
MAB_3236c|M.abscessus_ATCC_199 PIA--DADTVFDGG--WLLPGLVDAHCHVGIGPQG---------------
MUL_2041|M.ulcerans_Agy99 PVS--GADTVFDGG--WILPGLVDAHCHVGLGHQG---------------
MSMEG_4392|M.smegmatis_MC2_155 APASRPGDRHVDVSGKTVMPAVVNPHGHVGYMRGSTTTAEN---------
.* . ::*.::: . :: .
Mflv_2466|M.gilvum_PYR-GCK PAYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIEQGWH
Mvan_4188|M.vanbaalenii_PYR-1 PAYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIEQGWH
TH_0262|M.thermoresistible__bu PVYRTLRAAVNARTTLRAGFTTVRNLGLMVKTGGYLLDVALQRAIDQGWH
MMAR_4746|M.marinum_M PPTRMLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWI
MAV_0903|M.avium_104 PPTRVLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALAKAIDAGWI
Mb0076|M.bovis_AF2122/97 HAVLVGRARRHAAAALRSGITTIRDLG-----DRDYAALALREEYRQKTT
Rv0074|M.tuberculosis_H37Rv HAVLVGRARRHAAAALRSGITTIRDLG-----DRDYAALALREEYRQKTT
MAB_3236c|M.abscessus_ATCC_199 -PTSLEEAVAQAEAEREVGALLLRDAG-----------SPVDTRGFDERE
MUL_2041|M.ulcerans_Agy99 -AIELDQAIAQAEAERDAGALLLRDCG-----------APTDTRPLDDRE
MSMEG_4392|M.smegmatis_MC2_155 --FSRASVLDYMRRILYAGVATFQSLGTDRDDVEIGLRDQQRSGELADEG
* .:. *
Mflv_2466|M.gilvum_PYR-GCK PGPRIYPAGHAVTPYGGHLDPTVFQRLAPGIMPLSVAEGIANGVDDVRAC
Mvan_4188|M.vanbaalenii_PYR-1 VGPRIFPAGHAVTPYGGHLDPTVFQRLAPGIMPLSVAEGIANGVDDVRAC
TH_0262|M.thermoresistible__bu DGPRIYPAGHAVTPYGGHLDPTVFQRLAPGIMPLSVAEGIANGVDDVRAC
MMAR_4746|M.marinum_M DGPRIVPAGHAITPTGGHLDPTMFAAFAPHVLELTIEEGIANGVDEIRKA
MAV_0903|M.avium_104 DGPRVVPAGHAITPTGGHLDPTMFAAFAPHALELTVEEGIANGIDEIRKA
Mb0076|M.bovis_AF2122/97 VGPELVVSGPPLTRSGGHC---------------WFLGGVADSVEELVDA
Rv0074|M.tuberculosis_H37Rv VGPELVVSGPPLTRSGGHC---------------WFLGGVADSVEELVDA
MAB_3236c|M.abscessus_ATCC_199 DLPRIIRAGRHLAKPKRYIP--------------GLPLDIED-DAQLPEA
MUL_2041|M.ulcerans_Agy99 DLPRIIRAGRHLARPKRYIP--------------GFAPELED-ESELPAA
MSMEG_4392|M.smegmatis_MC2_155 PLARFYSAGVGIVAPTPGSP-------NGGPFFSTESMFEASTPDDARAH
... :* :. . :
Mflv_2466|M.gilvum_PYR-GCK VRYQVRHGAKLIKVSASGGVMSHSTAPGAQQYSDEEFAAIADEAHRAGVR
Mvan_4188|M.vanbaalenii_PYR-1 VRYQIRHGAKLIKVSASGGVMSHSTAPGAQQYSDEEFAAIADEAHRAGVR
TH_0262|M.thermoresistible__bu VRYQIRHGAKLIKVSASGGVMSHSTAPGAQQFSDEELSAIADEAHRAGVR
MMAR_4746|M.marinum_M VRYQIKHGAQLIKVCCSGGVMSLTGPPGAQHYSDEELRAIVDEAHRRGLR
MAV_0903|M.avium_104 VRYQIKHGAELIKVCCSGGIMSLTGPPGAQHYSDEELRAIVDEAHRRGMR
Mb0076|M.bovis_AF2122/97 VQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGLP
Rv0074|M.tuberculosis_H37Rv VQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGLP
MAB_3236c|M.abscessus_ATCC_199 VALQARWGDGWVKLVG--DWIDRAVGDLAPLWSDKILKQAIDAAHANGAR
MUL_2041|M.ulcerans_Agy99 VAAQARRGDGWIKLVG--DWIDRQIGDLAPLWSDEVLKAAIDAAHANGAR
MSMEG_4392|M.smegmatis_MC2_155 VRVLAEKRADIVKFWIDDRHGTKSKLP------PEVYRAIVDEAHRLGLK
* :*. *. *
Mflv_2466|M.gilvum_PYR-GCK VAAHAVGDSAIRACIRAGIDCIEHG--FLATDETLQMMVDHGTFLVSTTY
Mvan_4188|M.vanbaalenii_PYR-1 VAAHAVGDSAIRACIRAGIDCIEHG--FLASDETIQMMADHGTFLVSTTY
TH_0262|M.thermoresistible__bu VAAHAVGDSAIRACIRAGIDCVEHG--FLASDETLQMMADTGTFLVSTTY
MMAR_4746|M.marinum_M VAAHTHGADAVKHAVIAGIDCIEHG--FLVDDEAIAMMVEHGTFLVSTRR
MAV_0903|M.avium_104 VAAHTHGADAVKHAVAAGIDCIEHG--FLIDDEAIASMVEHGTFLVSTRR
Mb0076|M.bovis_AF2122/97 VTAHAHATAGIAAAVAAGVDGIEHC--TFLSEGSAAASPDVVEAIVAQG-
Rv0074|M.tuberculosis_H37Rv VTAHAHATAGIAAAVAAGVDGIEHC--TFLSEGSAAASPDVVEAIVAQG-
MAB_3236c|M.abscessus_ATCC_199 VTAHVFGEDALPGLIHAGIDCIEHG--TGLTDDTIALMVEHGTALVPTVI
MUL_2041|M.ulcerans_Agy99 VTAHVFGEDALPGLINAGIDCIEHG--TGLTDDTISLMRDHGTALVPTLI
MSMEG_4392|M.smegmatis_MC2_155 AAAHIYTVDDAKAAVRAGADVLAHLPRTGPDRELIDLMLEHDVAAFTSLS
.:** : ** * : * : ..
Mflv_2466|M.gilvum_PYR-GCK LTEA------------------------MAVDRIAPELRKKAEVVFPQAQ
Mvan_4188|M.vanbaalenii_PYR-1 LTEA------------------------MAIDRIAPELRKKAEVVFPQAQ
TH_0262|M.thermoresistible__bu LTEA------------------------MAVDRIAPELRKKAEEVFPRAR
MMAR_4746|M.marinum_M LADADA----------------------MDISHAPPELQAKAAEMFPRSR
MAV_0903|M.avium_104 LAEG------------------------MDVSHAPPELQAKAAQMFPKSR
Mb0076|M.bovis_AF2122/97 VWCG------------------------MTIPRVYPEMPENLVAVVQDGW
Rv0074|M.tuberculosis_H37Rv VWCG------------------------MTIPRVYPEMPENLVAVVQDGW
MAB_3236c|M.abscessus_ATCC_199 NIENFPG--------------------IADKAGKYPKYAQHMRDLYAGLH
MUL_2041|M.ulcerans_Agy99 NVENFPG--------------------IADSAVRYPTYAAHMRDLYASTY
MSMEG_4392|M.smegmatis_MC2_155 IQRPDGTGWLDDPLVIETVTPQTREYLRTRIESIAPQPLFDTVEAYRRMV
* .
Mflv_2466|M.gilvum_PYR-GCK AMLPKAIAAGVRIACGTDAPAVP---HGQNAKELCALVSRGMTPMQALRA
Mvan_4188|M.vanbaalenii_PYR-1 AMLPKAIAAGVRIACGTDAPAIP---HGQNAKELRALVSRGMSPMQALRA
TH_0262|M.thermoresistible__bu SMLPKAIAAGVRIACGTDAPAIP---HGENARELCALVDRGMTPMQAIRA
MMAR_4746|M.marinum_M ESILAAYQAGVKIAIGTDAPAIP---HGRNADELVTLVHWGMSPMAVLRA
MAV_0903|M.avium_104 TSILAAHRAGVKIAVGTDAPAIP---HGRNADELVTLVEWGLPPVAVLRA
Mb0076|M.bovis_AF2122/97 RNIRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTG
Rv0074|M.tuberculosis_H37Rv RNIRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTG
MAB_3236c|M.abscessus_ATCC_199 TTFGNAYDAGIPIYAGTDAGGSIA--HGRISDEVAALTRIGMSPTDALGA
MUL_2041|M.ulcerans_Agy99 PRVAAAREAGIAIYAGTDAGGTIQ--HGRIADEVEALKKIGMSATEALGA
MSMEG_4392|M.smegmatis_MC2_155 DAVHQYVEAGVRIVFSADTGLLTQVPGIAEHRELEAMVDAGVSTAETIHA
. ** : .:*: :: : *... .: .
Mflv_2466|M.gilvum_PYR-GCK ATITSAELIDAEDELGRLAPGYLADIIAVDGDVSADIATTLDVRFVMKDG
Mvan_4188|M.vanbaalenii_PYR-1 ATMTAAELIEADDELGRLAPGYLADIIAVAGDPSNDIATTLDVRFVMKDG
TH_0262|M.thermoresistible__bu ATVTSAELIEAGDELGRLAPGYRADIIAVPGDPSRDIAATLDVRFVMKDG
MMAR_4746|M.marinum_M ATVTAAELINVTDR-GRLAAGQLADIIAVAGNPLDDITVTRNVGFVMKGG
MAV_0903|M.avium_104 ATVTAAELINSSDR-GRLAEGYLADVIAVPGNPLEDITVTQHVSFVMKGG
Mb0076|M.bovis_AF2122/97 ATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVWRSG
Rv0074|M.tuberculosis_H37Rv ATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDVKAVWRSG
MAB_3236c|M.abscessus_ATCC_199 ASWRARSWLG----RPGLEHGAPADLLGYRADPRTGPGVLASPDLVMLRG
MUL_2041|M.ulcerans_Agy99 ACWEARRWLG----RPTVEHGASADLVCFSEDPRRGAAILNRPDLVILRG
MSMEG_4392|M.smegmatis_MC2_155 ATGRAAEFLSLDS--GSVTEGRRADLLVLDADPLTDIRAVRRIDSLYLDG
* : : * **:: . . : *
Mflv_2466|M.gilvum_PYR-GCK VVHKTVDVAQDASTSTV
Mvan_4188|M.vanbaalenii_PYR-1 VVHKGAEGGGREG----
TH_0262|M.thermoresistible__bu AVYRHDGVDRRDRG---
MMAR_4746|M.marinum_M KVYVHQD----------
MAV_0903|M.avium_104 KVYVHNQN---------
Mb0076|M.bovis_AF2122/97 TQVPLQASAVGYNTPS-
Rv0074|M.tuberculosis_H37Rv TQVPLQASAVGYNTPS-
MAB_3236c|M.abscessus_ATCC_199 QIR--------------
MUL_2041|M.ulcerans_Agy99 RTYRPNQLGHR------
MSMEG_4392|M.smegmatis_MC2_155 DLVDRAALRDRFLDF--