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QTIKAAGLFDVDAGEIVRPGLLRVDGDRIVGVGDSGPTGADDNVIDLGEAILLPGLMDMEVNLLMGGRGE KPGLSQVQDDPPTRVLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALAKAIDAGWIDGPRVVPAGH AITPTGGHLDPTMFAAFAPHALELTVEEGIANGIDEIRKAVRYQIKHGAELIKVCCSGGIMSLTGPPGAQ HYSDEELRAIVDEAHRRGMRVAAHTHGADAVKHAVAAGIDCIEHGFLIDDEAIASMVEHGTFLVSTRRLA EGMDVSHAPPELQAKAAQMFPKSRTSILAAHRAGVKIAVGTDAPAIPHGRNADELVTLVEWGLPPVAVLR AATVTAAELINSSDRGRLAEGYLADVIAVPGNPLEDITVTQHVSFVMKGGKVYVHNQN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0903 | - | - | 100% (409) | Xaa-Pro dipeptidase |
| M. avium 104 | MAV_3769 | - | 7e-21 | 28.07% (374) | amidohydrolase 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0076 | - | 4e-35 | 31.62% (389) | hypothetical protein Mb0076 |
| M. gilvum PYR-GCK | Mflv_2437 | - | 0.0 | 81.98% (405) | amidohydrolase |
| M. tuberculosis H37Rv | Rv0074 | - | 4e-35 | 31.62% (389) | hypothetical protein Rv0074 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3236c | - | 2e-26 | 29.44% (377) | amidohydrolase |
| M. marinum M | MMAR_4746 | - | 0.0 | 86.21% (406) | imidazolonepropionase |
| M. smegmatis MC2 155 | MSMEG_4842 | - | 0.0 | 85.32% (402) | amidohydrolase |
| M. thermoresistible (build 8) | TH_2020 | - | 0.0 | 82.31% (407) | amidohydrolase |
| M. ulcerans Agy99 | MUL_0705 | - | 6e-42 | 33.01% (415) | imidazolonepropionase |
| M. vanbaalenii PYR-1 | Mvan_4215 | - | 0.0 | 82.88% (403) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0076|M.bovis_AF2122/97 MGDLSISQVSARPGRIGIRARQMFDGYR-FQRGPVLVVVEDGRISAVDFA
Rv0074|M.tuberculosis_H37Rv MGDLSISQVSARPGRIGIRARQMFDGYR-FQRGPVLVVVEDGRISAVDFA
MAV_0903|M.avium_104 --------------MQTIKAAGLFDVDAGEIVRPGLLRVDGDRIVGVGDS
MMAR_4746|M.marinum_M --------------MLTLKAAGLLDVDAGEILAPAVVRVEGDRIAGVGGD
Mflv_2437|M.gilvum_PYR-GCK ------------MPLTTLKAAGLLDVDAGEIIRPGIVHVDGDRIVSIGGD
Mvan_4215|M.vanbaalenii_PYR-1 --------------MLTLKAAGLLDVVSGEIIRPGVVTVDGDRIVSLGGT
TH_2020|M.thermoresistible__bu --------------VLTLRAAGLLDVDAGEIVRPGLVRIVDDRIVGVGG-
MSMEG_4842|M.smegmatis_MC2_155 --------------MLTLKAAGLVDVDTGELIRPGVVRVEGDRIVGIGG-
MUL_0705|M.ulcerans_Agy99 ----------MEPNELHISNVKVFDSVDGRITGPVDVTVRGPVIASIAPA
MAB_3236c|M.abscessus_ATCC_199 -------------------MRAHLRGRTLPSEEPIDLWVHDGVIS-----
. * : : . *
Mb0076|M.bovis_AF2122/97 GSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG--DPHAVLV
Rv0074|M.tuberculosis_H37Rv GSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG--DPHAVLV
MAV_0903|M.avium_104 GPTGADDNVIDLGEAILLPGLMDMEVNLLMGGRGEKPGLSQVQDDPPTRV
MMAR_4746|M.marinum_M ----PEGDVIDLGDQILLPGLMDMEVNLLMGGRGEKPGLSQVQDDPPTRM
Mflv_2437|M.gilvum_PYR-GCK --APPDAEVIDLGDAILMPGLMDMEVNLLMGGRGETPGLSQVQDDPATRV
Mvan_4215|M.vanbaalenii_PYR-1 --PPPDVEVIDLGDSILLPGLMDMEVNLLMGGRGENPGLSQVQDDPATRV
TH_2020|M.thermoresistible__bu ---PEGGHVIDLGDAILLPGLMDMEVNLLMGGRGETPGLSQVQDDPATRV
MSMEG_4842|M.smegmatis_MC2_155 ---PAEGEVIDLGDAILLPGLMDMEVNLLMGGRGENPGLSQVQDDPPTRV
MUL_0705|M.ulcerans_Agy99 GAAALSGPAIDGTGKTLLPGLIDAHWHAMFT---TIPAALAQVSEFGYVV
MAB_3236c|M.abscessus_ATCC_199 -IEPIADADTVFDGGWLLPGLVDAHCHVGIG------------PQGPTSL
*:***:* . : :
Mb0076|M.bovis_AF2122/97 GRARRHAAAALRSGITTIRDLGDRDYAA-----LALREEYRQKTTVGPEL
Rv0074|M.tuberculosis_H37Rv GRARRHAAAALRSGITTIRDLGDRDYAA-----LALREEYRQKTTVGPEL
MAV_0903|M.avium_104 LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALAKAIDAGWIDGPRV
MMAR_4746|M.marinum_M LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIDGPRI
Mflv_2437|M.gilvum_PYR-GCK LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIAAGWIDGPRV
Mvan_4215|M.vanbaalenii_PYR-1 LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIDGPRV
TH_2020|M.thermoresistible__bu LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIEGPRV
MSMEG_4842|M.smegmatis_MC2_155 LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIDGPRV
MUL_0705|M.ulcerans_Agy99 ARAVVSARETLLRGFTTVRDLGGPVFG--------VKQAIDEGSIPGPRI
MAB_3236c|M.abscessus_ATCC_199 EEAVAQAEAEREVGALLLRDAGSPVDTR----------GFDER-EDLPRI
.* * * :*: * *.:
Mb0076|M.bovis_AF2122/97 VVSGPPLTRSGGHCWFLG---------------------GVADSVEELVD
Rv0074|M.tuberculosis_H37Rv VVSGPPLTRSGGHCWFLG---------------------GVADSVEELVD
MAV_0903|M.avium_104 VPAGHAITPTGGHLDPTMFAAFAPHAL------ELTVEEGIANGIDEIRK
MMAR_4746|M.marinum_M VPAGHAITPTGGHLDPTMFAAFAPHVL------ELTIEEGIANGVDEIRK
Mflv_2437|M.gilvum_PYR-GCK IPAGHAITPTGGHLDPTMFAAFMPGVL------ELTIEEGIANGVDEIRK
Mvan_4215|M.vanbaalenii_PYR-1 IPAGHAITPTGGHLDPTMFAAFMPGVL------ELTVEEGIANGVDEIRK
TH_2020|M.thermoresistible__bu VPAGHAITPTGGHLDPTMFAAFMPGAL------ELTVEEGIANGVDEIRK
MSMEG_4842|M.smegmatis_MC2_155 IPAGHAITPTGGHLDPTMFAAFMPGVL------ELTVEEGIANGVDEIRK
MUL_0705|M.ulcerans_Agy99 YPAGGFISQSGGHGDFRLPNEVPRGVCGHLSYTEIIGAAVIADGEAEVLR
MAB_3236c|M.abscessus_ATCC_199 IRAGRHLAKPKRYIPGLPLD---------------------IEDDAQLPE
:* :: . : :. ::
Mb0076|M.bovis_AF2122/97 AVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGL
Rv0074|M.tuberculosis_H37Rv AVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGL
MAV_0903|M.avium_104 AVRYQIKHGAELIKVCCSGGIMSLTGPPGAQHYSDEELRAIVDEAHRRGM
MMAR_4746|M.marinum_M AVRYQIKHGAQLIKVCCSGGVMSLTGPPGAQHYSDEELRAIVDEAHRRGL
Mflv_2437|M.gilvum_PYR-GCK AVRYQIKHGAELIKVCCSGGVMSLTGEAGAQHYSDEELRVIVDEAHRRGL
Mvan_4215|M.vanbaalenii_PYR-1 AVRYQIKHGAQLIKVCCSGGVMSLTGEAGAQHYSDEELRVIVDEAHRRGL
TH_2020|M.thermoresistible__bu AVRYQIKHGAQVIKVCCSGGVMSLTGEAGAQHYSDEELRAIVDEAHRRGL
MSMEG_4842|M.smegmatis_MC2_155 AVRYQIKHGAQLIKVCCSGGVMSLTGEAGAQHYSDEELRVIVDEAHRRGL
MUL_0705|M.ulcerans_Agy99 GAREMLRRGASQLKLMAGGGVTSAYDPLDVAQFTETEMRAAVEAAENWGT
MAB_3236c|M.abscessus_ATCC_199 AVALQARWGDGWVKLVG--DWIDRAVGDLAPLWSDKILKQAIDAAHANGA
.. * :*: . : . : : *. *
Mb0076|M.bovis_AF2122/97 PVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVW
Rv0074|M.tuberculosis_H37Rv PVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVW
MAV_0903|M.avium_104 RVAAHTHGADAVKHAVAAGIDCIEHGFLIDDEAIASMVEHGTFLVSTRRL
MMAR_4746|M.marinum_M RVAAHTHGADAVKHAVIAGIDCIEHGFLVDDEAIAMMVEHGTFLVSTRRL
Mflv_2437|M.gilvum_PYR-GCK RVAAHTHGAEAVKHAIDCGIDCIEHGFLMDDEAIQMLVDNDRFLVSTRRL
Mvan_4215|M.vanbaalenii_PYR-1 RVAAHTHGAEAVKHAVECGIDCIEHGFLMDDEAIQMLVDNDRFLVSTRRL
TH_2020|M.thermoresistible__bu KVAAHTHGAEAVKHAIECGIDCIEHGFLMDDEAIKMLVDNDRFLVSTRRL
MSMEG_4842|M.smegmatis_MC2_155 RVAAHTHGAEAVKHAIDCGIDCIEHGFLMDDEAIEMMVAHDRFLVSTRRL
MUL_0705|M.ulcerans_Agy99 YVTVHAYTPRAIRAAIAAGVRCVEHGQLIDEPTAALLAEKDIWWCLQPFL
MAB_3236c|M.abscessus_ATCC_199 RVTAHVFGEDALPGLIHAGIDCIEHGTGLTDDTIALMVEHGTALVPTVIN
*:.*.. .: : .*: :** : : :
Mb0076|M.bovis_AF2122/97 CGMT-----IPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALSTDAGV
Rv0074|M.tuberculosis_H37Rv CGMT-----IPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALSTDAGV
MAV_0903|M.avium_104 AEG----MDVSHAPPELQAKAAQMFPKSRTSILAAHRAGVKIAVGTDAP-
MMAR_4746|M.marinum_M ADADA--MDISHAPPELQAKAAEMFPRSRESILAAYQAGVKIAIGTDAP-
Mflv_2437|M.gilvum_PYR-GCK AEY----MDVSKAPKELQAKAAEMFPKARTSIKAAYEAGVKIAVGTDAP-
Mvan_4215|M.vanbaalenii_PYR-1 AEY----MDVSKAPPELQAKAAEMFPKARTSIKAAYEAGVKIAVGTDAP-
TH_2020|M.thermoresistible__bu AEY----MDVSKAPPELQAKAAEMFPRARTSIKAAFEAGAKIAVGTDAP-
MSMEG_4842|M.smegmatis_MC2_155 AEY----MDVSKAPPELQAKAAEMFPKARTSIKAAYEAGVKIAIGTDAP-
MUL_0705|M.ulcerans_Agy99 DDE-----DAVAVPPPSVPKFKQMVAGTDTAYQLAIKHGVKIAFGTDTLF
MAB_3236c|M.abscessus_ATCC_199 IENFPGIADKAGKYPKYAQHMRDLYAGLHTTFGNAYDAGIPIYAGTDAG-
: : * : .**:
Mb0076|M.bovis_AF2122/97 APGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLGHR-------
Rv0074|M.tuberculosis_H37Rv APGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLGHR-------
MAV_0903|M.avium_104 --AIPHGRNADELVTLVEWGLPPVAVLRAATVTAAELINSSD--------
MMAR_4746|M.marinum_M --AIPHGRNADELVTLVHWGMSPMAVLRAATVTAAELINVTD--------
Mflv_2437|M.gilvum_PYR-GCK --AIPHGKNADELVTLVDWGMPEAAVLRAATVVAADLINRSDS-------
Mvan_4215|M.vanbaalenii_PYR-1 --AIPHGKNADELVTLVDWGMPPAAVLRAATVVAADLINRSDS-------
TH_2020|M.thermoresistible__bu --AIPHGRNAEELVTLVQWGLPPAAVLRAATVTAADLIGRSD--------
MSMEG_4842|M.smegmatis_MC2_155 --AIPHGRNADELVTLVQWGLPPAAVLKAATVTAAELINVTD--------
MUL_0705|M.ulcerans_Agy99 D-AKLASRQGAQLAKLTRW-FTPAEVLQQATIRNAELLAMSGPRNPYPGR
MAB_3236c|M.abscessus_ATCC_199 -GSIAHGRISDEVAALTRIGMSPTDALGAASWRARSWLGRPG--------
. . ::. * :. .* *:
Mb0076|M.bovis_AF2122/97 KGRIAPGYDADLLAVAAGVDHDPAGLCDVK----AVWRSGTQVPLQASAV
Rv0074|M.tuberculosis_H37Rv KGRIAPGYDADLLAVAAGVDHDPAGLCDVK----AVWRSGTQVPLQASAV
MAV_0903|M.avium_104 RGRLAEGYLADVIAVPGNPLEDITVTQHVS----FVMKGGKVYVHNQN--
MMAR_4746|M.marinum_M RGRLAAGQLADIIAVAGNPLDDITVTRNVG----FVMKGGKVYVHQD---
Mflv_2437|M.gilvum_PYR-GCK LGRLAEGYIADIIAVPGDPLADIRVTQAVN----FVMKDGKVFKNDVTH-
Mvan_4215|M.vanbaalenii_PYR-1 LGRIAEGYLADIIAVPGDPLADIGVTKNVT----FVMKGGKVYKNEHATD
TH_2020|M.thermoresistible__bu LGRIAEGCLADIVAVPGDPLADIGVTREVN----FVMKGGEVFRHDAN--
MSMEG_4842|M.smegmatis_MC2_155 RGRLAEGLLADIIAVPGNPLEDISVTQNVD----FVMKGGKVFRNDKAN-
MUL_0705|M.ulcerans_Agy99 LGVVAEGALADLILVDGDPIADISLIARPDETFTTIIKNGRVVKGAAS--
MAB_3236c|M.abscessus_ATCC_199 ---LEHGAPADLLGYRADPRTGPGVLASPD----LVMLRGQIR-------
: * **:: .. . : *
Mb0076|M.bovis_AF2122/97 GYNTPS
Rv0074|M.tuberculosis_H37Rv GYNTPS
MAV_0903|M.avium_104 ------
MMAR_4746|M.marinum_M ------
Mflv_2437|M.gilvum_PYR-GCK ------
Mvan_4215|M.vanbaalenii_PYR-1 TN----
TH_2020|M.thermoresistible__bu ------
MSMEG_4842|M.smegmatis_MC2_155 ------
MUL_0705|M.ulcerans_Agy99 ------
MAB_3236c|M.abscessus_ATCC_199 ------