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VLTLKAAGLLDVDAGEILAPAVVRVEGDRIAGVGGDPEGDVIDLGDQILLPGLMDMEVNLLMGGRGEKPG LSQVQDDPPTRMLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIDGPRIVPAGHAIT PTGGHLDPTMFAAFAPHVLELTIEEGIANGVDEIRKAVRYQIKHGAQLIKVCCSGGVMSLTGPPGAQHYS DEELRAIVDEAHRRGLRVAAHTHGADAVKHAVIAGIDCIEHGFLVDDEAIAMMVEHGTFLVSTRRLADAD AMDISHAPPELQAKAAEMFPRSRESILAAYQAGVKIAIGTDAPAIPHGRNADELVTLVHWGMSPMAVLRA ATVTAAELINVTDRGRLAAGQLADIIAVAGNPLDDITVTRNVGFVMKGGKVYVHQD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4746 | - | - | 100% (406) | imidazolonepropionase |
| M. marinum M | MMAR_0954 | - | 4e-40 | 33.16% (395) | imidazolonepropionase |
| M. marinum M | MMAR_1793 | - | 2e-23 | 29.41% (357) | hypothetical protein MMAR_1793 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0076 | - | 5e-32 | 29.82% (389) | hypothetical protein Mb0076 |
| M. gilvum PYR-GCK | Mflv_2437 | - | 0.0 | 81.39% (403) | amidohydrolase |
| M. tuberculosis H37Rv | Rv0074 | - | 5e-32 | 29.82% (389) | hypothetical protein Rv0074 |
| M. leprae Br4923 | MLBr_00533 | pyrC | 9e-05 | 46.81% (47) | dihydroorotase |
| M. abscessus ATCC 19977 | MAB_3236c | - | 1e-26 | 29.75% (363) | amidohydrolase |
| M. avium 104 | MAV_0903 | - | 0.0 | 86.21% (406) | Xaa-Pro dipeptidase |
| M. smegmatis MC2 155 | MSMEG_4842 | - | 0.0 | 86.32% (402) | amidohydrolase |
| M. thermoresistible (build 8) | TH_2020 | - | 0.0 | 81.68% (404) | amidohydrolase |
| M. ulcerans Agy99 | MUL_0705 | - | 2e-40 | 33.16% (395) | imidazolonepropionase |
| M. vanbaalenii PYR-1 | Mvan_4215 | - | 0.0 | 82.60% (408) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0076|M.bovis_AF2122/97 MGDLSISQVSARPGRIGIRARQMFDGYR-FQRGPVLVVVEDGRISAVDFA
Rv0074|M.tuberculosis_H37Rv MGDLSISQVSARPGRIGIRARQMFDGYR-FQRGPVLVVVEDGRISAVDFA
MMAR_4746|M.marinum_M --------------MLTLKAAGLLDVDAGEILAPAVVRVEGDRIAGVGGD
MAV_0903|M.avium_104 --------------MQTIKAAGLFDVDAGEIVRPGLLRVDGDRIVGVGDS
Mflv_2437|M.gilvum_PYR-GCK ------------MPLTTLKAAGLLDVDAGEIIRPGIVHVDGDRIVSIGGD
Mvan_4215|M.vanbaalenii_PYR-1 --------------MLTLKAAGLLDVVSGEIIRPGVVTVDGDRIVSLGGT
TH_2020|M.thermoresistible__bu --------------VLTLRAAGLLDVDAGEIVRPGLVRIVDDRIVGVGG-
MSMEG_4842|M.smegmatis_MC2_155 --------------MLTLKAAGLVDVDTGELIRPGVVRVEGDRIVGIGG-
MUL_0705|M.ulcerans_Agy99 ----------MEPNELHISNVKVFDSVDGRITGPVDVTVRGPVIASIAPA
MAB_3236c|M.abscessus_ATCC_199 -------------------MRAHLRGRTLPSEEPIDLWVHDGVIS-----
MLBr_00533|M.leprae_Br4923 ------------------MSVLLRGVRLYGEGEQVDVLVEGEQIANIGAG
: : . *
Mb0076|M.bovis_AF2122/97 GSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG--DPHAVLV
Rv0074|M.tuberculosis_H37Rv GSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG--DPHAVLV
MMAR_4746|M.marinum_M ----PEGDVIDLGDQILLPGLMDMEVNLLMGGRGEKPGLSQVQDDPPTRM
MAV_0903|M.avium_104 GPTGADDNVIDLGEAILLPGLMDMEVNLLMGGRGEKPGLSQVQDDPPTRV
Mflv_2437|M.gilvum_PYR-GCK --APPDAEVIDLGDAILMPGLMDMEVNLLMGGRGETPGLSQVQDDPATRV
Mvan_4215|M.vanbaalenii_PYR-1 --PPPDVEVIDLGDSILLPGLMDMEVNLLMGGRGENPGLSQVQDDPATRV
TH_2020|M.thermoresistible__bu ---PEGGHVIDLGDAILLPGLMDMEVNLLMGGRGETPGLSQVQDDPATRV
MSMEG_4842|M.smegmatis_MC2_155 ---PAEGEVIDLGDAILLPGLMDMEVNLLMGGRGENPGLSQVQDDPPTRV
MUL_0705|M.ulcerans_Agy99 GAAALSGPAIDGTGKTLLPGLIDAHWHAMFT---TIPAALAQVSEFGYVV
MAB_3236c|M.abscessus_ATCC_199 -IEPIADADTVFDGGWLLPGLVDAHCHVGIG------------PQGPTSL
MLBr_00533|M.leprae_Br4923 IDIPDTADVIDAIDQVLLPGLVDLHTHLREPGREYAEDIETGSAAAALGG
*:***:* . :
Mb0076|M.bovis_AF2122/97 GRARRHAAAALRSGITTIRDLGDRDYAA-----LALREEYRQKTTVGPEL
Rv0074|M.tuberculosis_H37Rv GRARRHAAAALRSGITTIRDLGDRDYAA-----LALREEYRQKTTVGPEL
MMAR_4746|M.marinum_M LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIDGPRI
MAV_0903|M.avium_104 LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALAKAIDAGWIDGPRV
Mflv_2437|M.gilvum_PYR-GCK LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIAAGWIDGPRV
Mvan_4215|M.vanbaalenii_PYR-1 LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIDGPRV
TH_2020|M.thermoresistible__bu LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIEGPRV
MSMEG_4842|M.smegmatis_MC2_155 LRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWIDGPRV
MUL_0705|M.ulcerans_Agy99 ARAVVSARETLLRGFTTVRDLGGPVFG--------VKQAIDEGSIPGPRI
MAB_3236c|M.abscessus_ATCC_199 EEAVAQAEAEREVGALLLRDAGSPVDTRG-----------FDEREDLPRI
MLBr_00533|M.leprae_Br4923 YTAVFAMPNTTPVADSPVVTDHVWRRGQQ-------VGLVDVHPVGAVTV
* . : :
Mb0076|M.bovis_AF2122/97 VVSGPPLTRSGGHCWFLG---------------------GVADSVEELVD
Rv0074|M.tuberculosis_H37Rv VVSGPPLTRSGGHCWFLG---------------------GVADSVEELVD
MMAR_4746|M.marinum_M VPAGHAITPTGGHLDPTMFAAFAPHVL------ELTIEEGIANGVDEIRK
MAV_0903|M.avium_104 VPAGHAITPTGGHLDPTMFAAFAPHAL------ELTVEEGIANGIDEIRK
Mflv_2437|M.gilvum_PYR-GCK IPAGHAITPTGGHLDPTMFAAFMPGVL------ELTIEEGIANGVDEIRK
Mvan_4215|M.vanbaalenii_PYR-1 IPAGHAITPTGGHLDPTMFAAFMPGVL------ELTVEEGIANGVDEIRK
TH_2020|M.thermoresistible__bu VPAGHAITPTGGHLDPTMFAAFMPGAL------ELTVEEGIANGVDEIRK
MSMEG_4842|M.smegmatis_MC2_155 IPAGHAITPTGGHLDPTMFAAFMPGVL------ELTVEEGIANGVDEIRK
MUL_0705|M.ulcerans_Agy99 YPAGGFISQSGGHGDFRLPNEVPRGVCGHLSYTEIIGAAVIADGEAEVLR
MAB_3236c|M.abscessus_ATCC_199 IRAGRHLAKPKRYIPGLPLD---------------------IEDDAQLPE
MLBr_00533|M.leprae_Br4923 GLAGAELTEMGMMAAGAAQVRIFSDDG------NCVHNPLVMRRALEYAT
:* :: :
Mb0076|M.bovis_AF2122/97 AVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGL
Rv0074|M.tuberculosis_H37Rv AVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAAEQVGL
MMAR_4746|M.marinum_M AVRYQIKHGAQLIKVCCSGGVMSLTGPPGAQHYSDEELRAIVDEAHRRGL
MAV_0903|M.avium_104 AVRYQIKHGAELIKVCCSGGIMSLTGPPGAQHYSDEELRAIVDEAHRRGM
Mflv_2437|M.gilvum_PYR-GCK AVRYQIKHGAELIKVCCSGGVMSLTGEAGAQHYSDEELRVIVDEAHRRGL
Mvan_4215|M.vanbaalenii_PYR-1 AVRYQIKHGAQLIKVCCSGGVMSLTGEAGAQHYSDEELRVIVDEAHRRGL
TH_2020|M.thermoresistible__bu AVRYQIKHGAQVIKVCCSGGVMSLTGEAGAQHYSDEELRAIVDEAHRRGL
MSMEG_4842|M.smegmatis_MC2_155 AVRYQIKHGAQLIKVCCSGGVMSLTGEAGAQHYSDEELRVIVDEAHRRGL
MUL_0705|M.ulcerans_Agy99 GAREMLRRGASQLKLMAGGGVTSAYDPLDVAQFTETEMRAAVEAAENWGT
MAB_3236c|M.abscessus_ATCC_199 AVALQARWGDGWVKLVG--DWIDRAVGDLAPLWSDKILKQAIDAAHANGA
MLBr_00533|M.leprae_Br4923 GLGVLIAQHAEEPRLTVG--AVAHEGPTAARLGLSGWPRAAEESIVARDA
. :: . .
Mb0076|M.bovis_AF2122/97 PVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVW
Rv0074|M.tuberculosis_H37Rv PVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIVAQGVW
MMAR_4746|M.marinum_M RVAAHTHGADAVKHAVIAGIDCIEHGFLVDDEAIAMMVEHGTFLVSTRRL
MAV_0903|M.avium_104 RVAAHTHGADAVKHAVAAGIDCIEHGFLIDDEAIASMVEHGTFLVSTRRL
Mflv_2437|M.gilvum_PYR-GCK RVAAHTHGAEAVKHAIDCGIDCIEHGFLMDDEAIQMLVDNDRFLVSTRRL
Mvan_4215|M.vanbaalenii_PYR-1 RVAAHTHGAEAVKHAVECGIDCIEHGFLMDDEAIQMLVDNDRFLVSTRRL
TH_2020|M.thermoresistible__bu KVAAHTHGAEAVKHAIECGIDCIEHGFLMDDEAIKMLVDNDRFLVSTRRL
MSMEG_4842|M.smegmatis_MC2_155 RVAAHTHGAEAVKHAIDCGIDCIEHGFLMDDEAIEMMVAHDRFLVSTRRL
MUL_0705|M.ulcerans_Agy99 YVTVHAYTPRAIRAAIAAGVRCVEHGQLIDEPTAALLAEKDIWWCLQPFL
MAB_3236c|M.abscessus_ATCC_199 RVTAHVFGEDALPGLIHAGIDCIEHGTGLTDDTIALMVEHGTALVPTVIN
MLBr_00533|M.leprae_Br4923 LLARDAGARVHICHASTAGTVEILKWAKEQGISITAEVTPHHLLLDDSRL
:: .. : .* : : :
Mb0076|M.bovis_AF2122/97 CGMT-----------IPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVAL
Rv0074|M.tuberculosis_H37Rv CGMT-----------IPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVAL
MMAR_4746|M.marinum_M ADADA--------MDISHAPPELQAKAAEMFPRSRESILAAYQAGVKIAI
MAV_0903|M.avium_104 AEG----------MDVSHAPPELQAKAAQMFPKSRTSILAAHRAGVKIAV
Mflv_2437|M.gilvum_PYR-GCK AEY----------MDVSKAPKELQAKAAEMFPKARTSIKAAYEAGVKIAV
Mvan_4215|M.vanbaalenii_PYR-1 AEY----------MDVSKAPPELQAKAAEMFPKARTSIKAAYEAGVKIAV
TH_2020|M.thermoresistible__bu AEY----------MDVSKAPPELQAKAAEMFPRARTSIKAAFEAGAKIAV
MSMEG_4842|M.smegmatis_MC2_155 AEY----------MDVSKAPPELQAKAAEMFPKARTSIKAAYEAGVKIAI
MUL_0705|M.ulcerans_Agy99 DDE-----------DAVAVPPPSVPKFKQMVAGTDTAYQLAIKHGVKIAF
MAB_3236c|M.abscessus_ATCC_199 IENFPG------IADKAGKYPKYAQHMRDLYAGLHTTFGNAYDAGIPIYA
MLBr_00533|M.leprae_Br4923 ASYDGVNRVNPPLRETADAVALRQALADGIIDCVTTDHAPHADHEKCVEF
: :
Mb0076|M.bovis_AF2122/97 STDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLGHR-
Rv0074|M.tuberculosis_H37Rv STDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLGHR-
MMAR_4746|M.marinum_M GTDAP---AIPHGRNADELVTLVHWGMSPMAVLRAATVTAAELINVTD--
MAV_0903|M.avium_104 GTDAP---AIPHGRNADELVTLVEWGLPPVAVLRAATVTAAELINSSD--
Mflv_2437|M.gilvum_PYR-GCK GTDAP---AIPHGKNADELVTLVDWGMPEAAVLRAATVVAADLINRSDS-
Mvan_4215|M.vanbaalenii_PYR-1 GTDAP---AIPHGKNADELVTLVDWGMPPAAVLRAATVVAADLINRSDS-
TH_2020|M.thermoresistible__bu GTDAP---AIPHGRNAEELVTLVQWGLPPAAVLRAATVTAADLIGRSD--
MSMEG_4842|M.smegmatis_MC2_155 GTDAP---AIPHGRNADELVTLVQWGLPPAAVLKAATVTAAELINVTD--
MUL_0705|M.ulcerans_Agy99 GTDTLFD-AKLASRQGAQLAKLTRW-FTPAEVLQQATIRNAELLAMSGPR
MAB_3236c|M.abscessus_ATCC_199 GTDAG--GSIAHGRISDEVAALTRIGMSPTDALGAASWRARSWLGRPG--
MLBr_00533|M.leprae_Br4923 SAARPGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMSENPARIAGLPDHG
.: . . : :. . :
Mb0076|M.bovis_AF2122/97 ------KGRIAPGYDADLLAVA--------AGVDHDPAGLCDVK----AV
Rv0074|M.tuberculosis_H37Rv ------KGRIAPGYDADLLAVA--------AGVDHDPAGLCDVK----AV
MMAR_4746|M.marinum_M ------RGRLAAGQLADIIAVA--------GNPLDDITVTRNVG----FV
MAV_0903|M.avium_104 ------RGRLAEGYLADVIAVP--------GNPLEDITVTQHVS----FV
Mflv_2437|M.gilvum_PYR-GCK ------LGRLAEGYIADIIAVP--------GDPLADIRVTQAVN----FV
Mvan_4215|M.vanbaalenii_PYR-1 ------LGRIAEGYLADIIAVP--------GDPLADIGVTKNVT----FV
TH_2020|M.thermoresistible__bu ------LGRIAEGCLADIVAVP--------GDPLADIGVTREVN----FV
MSMEG_4842|M.smegmatis_MC2_155 ------RGRLAEGLLADIIAVP--------GNPLEDISVTQNVD----FV
MUL_0705|M.ulcerans_Agy99 NPYPGRLGVVAEGALADLILVD--------GDPIADISLIARPDETFTTI
MAB_3236c|M.abscessus_ATCC_199 ---------LEHGAPADLLGYR--------ADPRTGPGVLASPD----LV
MLBr_00533|M.leprae_Br4923 -------RPLEVGEPANLTVVDPDVTWTVTGDGLASRSANTPYEAMTLPA
: * *:: .. .
Mb0076|M.bovis_AF2122/97 WRSGTQVPLQASAVGYNTPS
Rv0074|M.tuberculosis_H37Rv WRSGTQVPLQASAVGYNTPS
MMAR_4746|M.marinum_M MKGGKVYVHQD---------
MAV_0903|M.avium_104 MKGGKVYVHNQN--------
Mflv_2437|M.gilvum_PYR-GCK MKDGKVFKNDVTH-------
Mvan_4215|M.vanbaalenii_PYR-1 MKGGKVYKNEHATDTN----
TH_2020|M.thermoresistible__bu MKGGEVFRHDAN--------
MSMEG_4842|M.smegmatis_MC2_155 MKGGKVFRNDKAN-------
MUL_0705|M.ulcerans_Agy99 IKNGRVVKGAAS--------
MAB_3236c|M.abscessus_ATCC_199 MLRGQIR-------------
MLBr_00533|M.leprae_Br4923 TVTATLLRGKVTARGQKSPV
.