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TQTVLRAARWVDVAAGVVRAPAVVVIEGNRITEVNPAAPLPDTAAVIDLGDVTLLPGLMDMELNLLIGGP EGLPSPMHGVQDDPAYRTLRGAVNARTTVQAGFTTVRNLGLMVKTGGYLLDVALQRAIDQGWHQGPRIHP AGHAVTPYGGHLDPTVFQRLAPGIMPLSVAEGIANGVPDVIACVRYQIRHGARLIKVSASGGVMSHSTAP GAQQYGDAELAAIADEAHRAGVKVAAHAVGDTAIQACIRAGIDCIEHGFLATDETIQMMVDHGTFLVSTT YLTDAMAIDRIAPELRKKALDVFPRAKAMLPKAIAAGVRIACGTDAPAIPHGQNAKELCALVERGMTPMQ ALQAATVVAAELVDASDELGRLAPGYLADVVAVPGDPSTDISAILDVSFVMKDGAVVKHREPSDAAVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0297 | - | - | 100% (419) | amidohydrolase |
| M. smegmatis MC2 155 | MSMEG_4842 | - | e-124 | 57.53% (405) | amidohydrolase |
| M. smegmatis MC2 155 | MSMEG_2431 | - | 5e-22 | 31.98% (344) | amidohydrolase 3 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0076 | - | 9e-40 | 30.33% (399) | hypothetical protein Mb0076 |
| M. gilvum PYR-GCK | Mflv_2466 | - | 0.0 | 85.19% (412) | amidohydrolase |
| M. tuberculosis H37Rv | Rv0074 | - | 1e-39 | 30.33% (399) | hypothetical protein Rv0074 |
| M. leprae Br4923 | MLBr_00533 | pyrC | 2e-06 | 23.91% (389) | dihydroorotase |
| M. abscessus ATCC 19977 | MAB_3236c | - | 2e-25 | 30.40% (375) | amidohydrolase |
| M. marinum M | MMAR_4746 | - | 1e-127 | 59.90% (409) | imidazolonepropionase |
| M. avium 104 | MAV_0903 | - | 1e-127 | 57.49% (407) | Xaa-Pro dipeptidase |
| M. thermoresistible (build 8) | TH_0262 | - | 0.0 | 83.66% (410) | amidohydrolase |
| M. ulcerans Agy99 | MUL_0705 | - | 2e-41 | 32.85% (417) | imidazolonepropionase |
| M. vanbaalenii PYR-1 | Mvan_4188 | - | 0.0 | 85.30% (415) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0076|M.bovis_AF2122/97 MGDLSISQVSARPGRIGIRARQMFDGYR-FQRGPVLVVVEDGRISAVDFA
Rv0074|M.tuberculosis_H37Rv MGDLSISQVSARPGRIGIRARQMFDGYR-FQRGPVLVVVEDGRISAVDFA
Mflv_2466|M.gilvum_PYR-GCK ------------MTVTVVKAARWADVEAGVVRSPAVIVVEGNRIRSVDPA
Mvan_4188|M.vanbaalenii_PYR-1 ------------MTGTVLKAARWADVEAGVVRAPAVIVVEGNRIQAINPA
MSMEG_0297|M.smegmatis_MC2_155 ------------MTQTVLRAARWVDVAAGVVRAPAVVVIEGNRITEVNPA
TH_0262|M.thermoresistible__bu -----------VTATTVLRAARWVDVAAGEVCSPAVVVVDGDRISAVNPV
MMAR_4746|M.marinum_M --------------MLTLKAAGLLDVDAGEILAPAVVRVEGDRIAGVGGD
MAV_0903|M.avium_104 --------------MQTIKAAGLFDVDAGEIVRPGLLRVDGDRIVGVGDS
MUL_0705|M.ulcerans_Agy99 ----------MEPNELHISNVKVFDSVDGRITGPVDVTVRGPVIASIAPA
MAB_3236c|M.abscessus_ATCC_199 -----------------------MRAHLRGRTLPSEEPIDLWVHDGVISI
MLBr_00533|M.leprae_Br4923 ------------------MSVLLRGVRLYGEGEQVDVLVEGEQIANIGAG
: :
Mb0076|M.bovis_AF2122/97 GSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG------DPH
Rv0074|M.tuberculosis_H37Rv GSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG------DPH
Mflv_2466|M.gilvum_PYR-GCK AEPPG-AEVLDLGDVTLLPGLMDMELNLLIGGPGGPEGLPSPMHGVQDDP
Mvan_4188|M.vanbaalenii_PYR-1 GEPADSPTVIDLGDVTLLPGLMDMELNLLIGGPGGPEGLPSPMHGVQDDP
MSMEG_0297|M.smegmatis_MC2_155 APLPDTAAVIDLGDVTLLPGLMDMELNLLIG---GPEGLPSPMHGVQDDP
TH_0262|M.thermoresistible__bu ESPRDPAVELDLGDVTLLPGLMDMELNLLIGGPGGPSGLPSPMHGVQDDP
MMAR_4746|M.marinum_M ----PEGDVIDLGDQILLPGLMDMEVNLLMGGRGEKPGLS----QVQDDP
MAV_0903|M.avium_104 GPTGADDNVIDLGEAILLPGLMDMEVNLLMGGRGEKPGLS----QVQDDP
MUL_0705|M.ulcerans_Agy99 GAAALSGPAIDGTGKTLLPGLIDAHWHAMFTTIPAALAQVS-------EF
MAB_3236c|M.abscessus_ATCC_199 EPIADADTVFDGG--WLLPGLVDAHCHVGIGP----------------QG
MLBr_00533|M.leprae_Br4923 IDIPDTADVIDAIDQVLLPGLVDLHTHLREPGR---------------EY
.* *****:* . :
Mb0076|M.bovis_AF2122/97 AVLVGRARRHAAAALRSGITTIRDLGDRDYAA-----LALREEYRQKTTV
Rv0074|M.tuberculosis_H37Rv AVLVGRARRHAAAALRSGITTIRDLGDRDYAA-----LALREEYRQKTTV
Mflv_2466|M.gilvum_PYR-GCK AYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIEQGWHP
Mvan_4188|M.vanbaalenii_PYR-1 AYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIEQGWHV
MSMEG_0297|M.smegmatis_MC2_155 AYRTLRGAVNARTTVQAGFTTVRNLGLMVKTGGYLLDVALQRAIDQGWHQ
TH_0262|M.thermoresistible__bu VYRTLRAAVNARTTLRAGFTTVRNLGLMVKTGGYLLDVALQRAIDQGWHD
MMAR_4746|M.marinum_M PTRMLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWID
MAV_0903|M.avium_104 PTRVLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALAKAIDAGWID
MUL_0705|M.ulcerans_Agy99 GYVVARAVVSARETLLRGFTTVRDLGGPVFG--------VKQAIDEGSIP
MAB_3236c|M.abscessus_ATCC_199 PTSLEEAVAQAEAEREVGALLLRDAGSPVDTRGFDEREDLPRIIRAGRHL
MLBr_00533|M.leprae_Br4923 AEDIETGSAAAALGGYTAVFAMPNTTPVADSP-----VVTDHVWRRGQQV
. * . : : .
Mb0076|M.bovis_AF2122/97 G-PELVVSGPPLTRSGGHCWFLG---------------------GVADSV
Rv0074|M.tuberculosis_H37Rv G-PELVVSGPPLTRSGGHCWFLG---------------------GVADSV
Mflv_2466|M.gilvum_PYR-GCK G-PRIYPAGHAVTPYGGHLDPTVFQRLAP------GIMPLSVAEGIANGV
Mvan_4188|M.vanbaalenii_PYR-1 G-PRIFPAGHAVTPYGGHLDPTVFQRLAP------GIMPLSVAEGIANGV
MSMEG_0297|M.smegmatis_MC2_155 G-PRIHPAGHAVTPYGGHLDPTVFQRLAP------GIMPLSVAEGIANGV
TH_0262|M.thermoresistible__bu G-PRIYPAGHAVTPYGGHLDPTVFQRLAP------GIMPLSVAEGIANGV
MMAR_4746|M.marinum_M G-PRIVPAGHAITPTGGHLDPTMFAAFAP------HVLELTIEEGIANGV
MAV_0903|M.avium_104 G-PRVVPAGHAITPTGGHLDPTMFAAFAP------HALELTVEEGIANGI
MUL_0705|M.ulcerans_Agy99 G-PRIYPAGGFISQSGGHGDFRLPNEVPRGVCGHLSYTEIIGAAVIADGE
MAB_3236c|M.abscessus_ATCC_199 AKPKRYIPGLPLD---------------------------------IEDD
MLBr_00533|M.leprae_Br4923 GLVDVHPVGAVTVGLAGAELTEMGMMAAG----AAQVRIFSDDGNCVHNP
. * ..
Mb0076|M.bovis_AF2122/97 EELVDAVQERAARGADWIKVMATG----GFVTTASDPWQPQYGSGQLAAV
Rv0074|M.tuberculosis_H37Rv EELVDAVQERAARGADWIKVMATG----GFVTTASDPWQPQYGSGQLAAV
Mflv_2466|M.gilvum_PYR-GCK DDVRACVRYQVRHGAKLIKVSASG----GVMSHSTAPGAQQYSDEEFAAI
Mvan_4188|M.vanbaalenii_PYR-1 DDVRACVRYQIRHGAKLIKVSASG----GVMSHSTAPGAQQYSDEEFAAI
MSMEG_0297|M.smegmatis_MC2_155 PDVIACVRYQIRHGARLIKVSASG----GVMSHSTAPGAQQYGDAELAAI
TH_0262|M.thermoresistible__bu DDVRACVRYQIRHGAKLIKVSASG----GVMSHSTAPGAQQFSDEELSAI
MMAR_4746|M.marinum_M DEIRKAVRYQIKHGAQLIKVCCSG----GVMSLTGPPGAQHYSDEELRAI
MAV_0903|M.avium_104 DEIRKAVRYQIKHGAELIKVCCSG----GIMSLTGPPGAQHYSDEELRAI
MUL_0705|M.ulcerans_Agy99 AEVLRGAREMLRRGASQLKLMAGG----GVTSAYDPLDVAQFTETEMRAA
MAB_3236c|M.abscessus_ATCC_199 AQLPEAVALQARWGDGWVKLVG------DWIDRAVGDLAPLWSDKILKQA
MLBr_00533|M.leprae_Br4923 LVMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPTAARLGLSGWPRAA
: * : . .
Mb0076|M.bovis_AF2122/97 VAAAEQVGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVV
Rv0074|M.tuberculosis_H37Rv VAAAEQVGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVV
Mflv_2466|M.gilvum_PYR-GCK ADEAHRAGVRVAAHAVGDSAIRACIRAGIDCIEHGFLATDETLQMMVDHG
Mvan_4188|M.vanbaalenii_PYR-1 ADEAHRAGVRVAAHAVGDSAIRACIRAGIDCIEHGFLASDETIQMMADHG
MSMEG_0297|M.smegmatis_MC2_155 ADEAHRAGVKVAAHAVGDTAIQACIRAGIDCIEHGFLATDETIQMMVDHG
TH_0262|M.thermoresistible__bu ADEAHRAGVRVAAHAVGDSAIRACIRAGIDCVEHGFLASDETLQMMADTG
MMAR_4746|M.marinum_M VDEAHRRGLRVAAHTHGADAVKHAVIAGIDCIEHGFLVDDEAIAMMVEHG
MAV_0903|M.avium_104 VDEAHRRGMRVAAHTHGADAVKHAVAAGIDCIEHGFLIDDEAIASMVEHG
MUL_0705|M.ulcerans_Agy99 VEAAENWGTYVTVHAYTPRAIRAAIAAGVRCVEHGQLIDEPTAALLAEKD
MAB_3236c|M.abscessus_ATCC_199 IDAAHANGARVTAHVFGEDALPGLIHAGIDCIEHGTGLTDDTIALMVEHG
MLBr_00533|M.leprae_Br4923 EESIVARDALLARDAGARVHICHASTAGTVEILKWAKEQGISITAEVTPH
. :: .. : ** : : :
Mb0076|M.bovis_AF2122/97 EAIVAQGVWCGMT-----IPRVYPEMPENLVAVVQ----------DGWRN
Rv0074|M.tuberculosis_H37Rv EAIVAQGVWCGMT-----IPRVYPEMPENLVAVVQ----------DGWRN
Mflv_2466|M.gilvum_PYR-GCK TFLVSTTYLTEA----MAVDRIAPELRKKAEVVFP----------QAQAM
Mvan_4188|M.vanbaalenii_PYR-1 TFLVSTTYLTEA----MAIDRIAPELRKKAEVVFP----------QAQAM
MSMEG_0297|M.smegmatis_MC2_155 TFLVSTTYLTDA----MAIDRIAPELRKKALDVFP----------RAKAM
TH_0262|M.thermoresistible__bu TFLVSTTYLTEA----MAVDRIAPELRKKAEEVFP----------RARSM
MMAR_4746|M.marinum_M TFLVSTRRLADADA--MDISHAPPELQAKAAEMFP----------RSRES
MAV_0903|M.avium_104 TFLVSTRRLAEG----MDVSHAPPELQAKAAQMFP----------KSRTS
MUL_0705|M.ulcerans_Agy99 IWWCLQPFLDDE-----DAVAVPPPSVPKFKQMVA----------GTDTA
MAB_3236c|M.abscessus_ATCC_199 TALVPTVINIENFPGIADKAGKYPKYAQHMRDLYA----------GLHTT
MLBr_00533|M.leprae_Br4923 HLLLDDSRLASYDG----VNRVNPPLRETADAVALRQALADGIIDCVTTD
* :
Mb0076|M.bovis_AF2122/97 IRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGAT
Rv0074|M.tuberculosis_H37Rv IRRLIDAGARVALSTDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGAT
Mflv_2466|M.gilvum_PYR-GCK LPKAIAAGVRIACGTDAPAVPHGQN---AKELCALVSRGMTPMQALRAAT
Mvan_4188|M.vanbaalenii_PYR-1 LPKAIAAGVRIACGTDAPAIPHGQN---AKELRALVSRGMSPMQALRAAT
MSMEG_0297|M.smegmatis_MC2_155 LPKAIAAGVRIACGTDAPAIPHGQN---AKELCALVERGMTPMQALQAAT
TH_0262|M.thermoresistible__bu LPKAIAAGVRIACGTDAPAIPHGEN---ARELCALVDRGMTPMQAIRAAT
MMAR_4746|M.marinum_M ILAAYQAGVKIAIGTDAPAIPHGRN---ADELVTLVHWGMSPMAVLRAAT
MAV_0903|M.avium_104 ILAAHRAGVKIAVGTDAPAIPHGRN---ADELVTLVEWGLPPVAVLRAAT
MUL_0705|M.ulcerans_Agy99 YQLAIKHGVKIAFGTDTLFDAKLASR--QGAQLAKLTRWFTPAEVLQQAT
MAB_3236c|M.abscessus_ATCC_199 FGNAYDAGIPIYAGTDAGGSIAHGR--ISDEVAALTRIGMSPTDALGAAS
MLBr_00533|M.leprae_Br4923 HAPHADHEKCVEFSAARPGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMS
: .: :. . :
Mb0076|M.bovis_AF2122/97 AAAAASCGLG-------HRKGRIAPGYDADLLAVA--------AGVDHDP
Rv0074|M.tuberculosis_H37Rv AAAAASCGLG-------HRKGRIAPGYDADLLAVA--------AGVDHDP
Mflv_2466|M.gilvum_PYR-GCK ITSAELIDA-------EDELGRLAPGYLADIIAVD--------GDVSADI
Mvan_4188|M.vanbaalenii_PYR-1 MTAAELIEA-------DDELGRLAPGYLADIIAVA--------GDPSNDI
MSMEG_0297|M.smegmatis_MC2_155 VVAAELVDA-------SDELGRLAPGYLADVVAVP--------GDPSTDI
TH_0262|M.thermoresistible__bu VTSAELIEA-------GDELGRLAPGYRADIIAVP--------GDPSRDI
MMAR_4746|M.marinum_M VTAAELINV-------TDR-GRLAAGQLADIIAVA--------GNPLDDI
MAV_0903|M.avium_104 VTAAELINS-------SDR-GRLAEGYLADVIAVP--------GNPLEDI
MUL_0705|M.ulcerans_Agy99 IRNAELLAMSGPRNPYPGRLGVVAEGALADLILVD--------GDPIADI
MAB_3236c|M.abscessus_ATCC_199 WRARSWLGRP-----------GLEHGAPADLLGYR--------ADPRTGP
MLBr_00533|M.leprae_Br4923 ENPARIAGLP-------DHGRPLEVGEPANLTVVDPDVTWTVTGDGLASR
: * *:: .. .
Mb0076|M.bovis_AF2122/97 AGLCDVK----AVWRSGTQVPLQASAVGYNTPS-
Rv0074|M.tuberculosis_H37Rv AGLCDVK----AVWRSGTQVPLQASAVGYNTPS-
Mflv_2466|M.gilvum_PYR-GCK ATTLDVR----FVMKDGVVHKTVDVAQDASTSTV
Mvan_4188|M.vanbaalenii_PYR-1 ATTLDVR----FVMKDGVVHKGAEGGGREG----
MSMEG_0297|M.smegmatis_MC2_155 SAILDVS----FVMKDGAVVKHREPSDAAVR---
TH_0262|M.thermoresistible__bu AATLDVR----FVMKDGAVYRHDGVDRRDRG---
MMAR_4746|M.marinum_M TVTRNVG----FVMKGGKVYVHQD----------
MAV_0903|M.avium_104 TVTQHVS----FVMKGGKVYVHNQN---------
MUL_0705|M.ulcerans_Agy99 SLIARPDETFTTIIKNGRVVKGAAS---------
MAB_3236c|M.abscessus_ATCC_199 GVLASPD----LVMLRGQIR--------------
MLBr_00533|M.leprae_Br4923 SANTPYEAMTLPATVTATLLRGKVTARGQKSPV-
.