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TGTVLKAARWADVEAGVVRAPAVIVVEGNRIQAINPAGEPADSPTVIDLGDVTLLPGLMDMELNLLIGGP GGPEGLPSPMHGVQDDPAYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIEQGWHVGPR IFPAGHAVTPYGGHLDPTVFQRLAPGIMPLSVAEGIANGVDDVRACVRYQIRHGAKLIKVSASGGVMSHS TAPGAQQYSDEEFAAIADEAHRAGVRVAAHAVGDSAIRACIRAGIDCIEHGFLASDETIQMMADHGTFLV STTYLTEAMAIDRIAPELRKKAEVVFPQAQAMLPKAIAAGVRIACGTDAPAIPHGQNAKELRALVSRGMS PMQALRAATMTAAELIEADDELGRLAPGYLADIIAVAGDPSNDIATTLDVRFVMKDGVVHKGAEGGGREG *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4188 | - | - | 100% (421) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_4215 | - | e-130 | 59.95% (407) | amidohydrolase |
| M. vanbaalenii PYR-1 | Mvan_2182 | - | 1e-24 | 29.06% (382) | amidohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0076 | - | 2e-41 | 31.38% (392) | hypothetical protein Mb0076 |
| M. gilvum PYR-GCK | Mflv_2466 | - | 0.0 | 92.48% (412) | amidohydrolase |
| M. tuberculosis H37Rv | Rv0074 | - | 2e-41 | 31.38% (392) | hypothetical protein Rv0074 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3236c | - | 6e-25 | 29.79% (376) | amidohydrolase |
| M. marinum M | MMAR_4746 | - | 1e-131 | 62.25% (408) | imidazolonepropionase |
| M. avium 104 | MAV_0903 | - | 1e-129 | 58.87% (406) | Xaa-Pro dipeptidase |
| M. smegmatis MC2 155 | MSMEG_0297 | - | 0.0 | 85.30% (415) | amidohydrolase |
| M. thermoresistible (build 8) | TH_0262 | - | 0.0 | 86.80% (409) | amidohydrolase |
| M. ulcerans Agy99 | MUL_0705 | - | 2e-40 | 33.25% (418) | imidazolonepropionase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0076|M.bovis_AF2122/97 MGDLSISQVSARPGRIGIRARQMFDGYR-FQRGPVLVVVEDGRISAVDFA
Rv0074|M.tuberculosis_H37Rv MGDLSISQVSARPGRIGIRARQMFDGYR-FQRGPVLVVVEDGRISAVDFA
Mvan_4188|M.vanbaalenii_PYR-1 ------------MTGTVLKAARWADVEAGVVRAPAVIVVEGNRIQAINPA
Mflv_2466|M.gilvum_PYR-GCK ------------MTVTVVKAARWADVEAGVVRSPAVIVVEGNRIRSVDPA
MSMEG_0297|M.smegmatis_MC2_155 ------------MTQTVLRAARWVDVAAGVVRAPAVVVIEGNRITEVNPA
TH_0262|M.thermoresistible__bu -----------VTATTVLRAARWVDVAAGEVCSPAVVVVDGDRISAVNPV
MMAR_4746|M.marinum_M --------------MLTLKAAGLLDVDAGEILAPAVVRVEGDRIAGVGGD
MAV_0903|M.avium_104 --------------MQTIKAAGLFDVDAGEIVRPGLLRVDGDRIVGVGDS
MUL_0705|M.ulcerans_Agy99 ----------MEPNELHISNVKVFDSVDGRITGPVDVTVRGPVIASIAPA
MAB_3236c|M.abscessus_ATCC_199 -----------------------MRAHLRGRTLPSEEPIDLWVHDGVISI
* : :
Mb0076|M.bovis_AF2122/97 GSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG------DPH
Rv0074|M.tuberculosis_H37Rv GSACPDMNLVDLGESTLLPGLVDAHAHLCWDPDGRPEDLAG------DPH
Mvan_4188|M.vanbaalenii_PYR-1 GEPADSPTVIDLGDVTLLPGLMDMELNLLIGGPGGPEGLPSPMHGVQDDP
Mflv_2466|M.gilvum_PYR-GCK AEPPG-AEVLDLGDVTLLPGLMDMELNLLIGGPGGPEGLPSPMHGVQDDP
MSMEG_0297|M.smegmatis_MC2_155 APLPDTAAVIDLGDVTLLPGLMDMELNLLIG---GPEGLPSPMHGVQDDP
TH_0262|M.thermoresistible__bu ESPRDPAVELDLGDVTLLPGLMDMELNLLIGGPGGPSGLPSPMHGVQDDP
MMAR_4746|M.marinum_M ----PEGDVIDLGDQILLPGLMDMEVNLLMGGRGEKPGLS----QVQDDP
MAV_0903|M.avium_104 GPTGADDNVIDLGEAILLPGLMDMEVNLLMGGRGEKPGLS----QVQDDP
MUL_0705|M.ulcerans_Agy99 GAAALSGPAIDGTGKTLLPGLIDAHWHAMFTTIPAALAQVS-------EF
MAB_3236c|M.abscessus_ATCC_199 EPIADADTVFDGG--WLLPGLVDAHCHVGIGP----------------QG
.* *****:* . :
Mb0076|M.bovis_AF2122/97 AVLVGRARRHAAAALRSGITTIRDLGDRDYAA-----LALREEYRQKTTV
Rv0074|M.tuberculosis_H37Rv AVLVGRARRHAAAALRSGITTIRDLGDRDYAA-----LALREEYRQKTTV
Mvan_4188|M.vanbaalenii_PYR-1 AYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIEQGWHV
Mflv_2466|M.gilvum_PYR-GCK AYRTLRGAVNARTTLDAGFTTVRNLGLMVKTGGYLLDVALQRAIEQGWHP
MSMEG_0297|M.smegmatis_MC2_155 AYRTLRGAVNARTTVQAGFTTVRNLGLMVKTGGYLLDVALQRAIDQGWHQ
TH_0262|M.thermoresistible__bu VYRTLRAAVNARTTLRAGFTTVRNLGLMVKTGGYLLDVALQRAIDQGWHD
MMAR_4746|M.marinum_M PTRMLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALGKAIDAGWID
MAV_0903|M.avium_104 PTRVLRAVGNARRTLRAGFTTVRNLGLFVKTGGYLLDVALAKAIDAGWID
MUL_0705|M.ulcerans_Agy99 GYVVARAVVSARETLLRGFTTVRDLGGPVFG--------VKQAIDEGSIP
MAB_3236c|M.abscessus_ATCC_199 PTSLEEAVAQAEAEREVGALLLRDAGSPVDTRGFDEREDLPRIIRAGRHL
.. * * :*: * : .
Mb0076|M.bovis_AF2122/97 G-PELVVSGPPLTRSGGHCWFLG---------------------GVADSV
Rv0074|M.tuberculosis_H37Rv G-PELVVSGPPLTRSGGHCWFLG---------------------GVADSV
Mvan_4188|M.vanbaalenii_PYR-1 G-PRIFPAGHAVTPYGGHLDPTVFQRLAP------GIMPLSVAEGIANGV
Mflv_2466|M.gilvum_PYR-GCK G-PRIYPAGHAVTPYGGHLDPTVFQRLAP------GIMPLSVAEGIANGV
MSMEG_0297|M.smegmatis_MC2_155 G-PRIHPAGHAVTPYGGHLDPTVFQRLAP------GIMPLSVAEGIANGV
TH_0262|M.thermoresistible__bu G-PRIYPAGHAVTPYGGHLDPTVFQRLAP------GIMPLSVAEGIANGV
MMAR_4746|M.marinum_M G-PRIVPAGHAITPTGGHLDPTMFAAFAP------HVLELTIEEGIANGV
MAV_0903|M.avium_104 G-PRVVPAGHAITPTGGHLDPTMFAAFAP------HALELTVEEGIANGI
MUL_0705|M.ulcerans_Agy99 G-PRIYPAGGFISQSGGHGDFRLPNEVPRGVCGHLSYTEIIGAAVIADGE
MAB_3236c|M.abscessus_ATCC_199 AKPKRYIPGLPLD---------------------------------IEDD
. *. .* : :.
Mb0076|M.bovis_AF2122/97 EELVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAA
Rv0074|M.tuberculosis_H37Rv EELVDAVQERAARGADWIKVMATGGFVTTASDPWQPQYGSGQLAAVVAAA
Mvan_4188|M.vanbaalenii_PYR-1 DDVRACVRYQIRHGAKLIKVSASGGVMSHSTAPGAQQYSDEEFAAIADEA
Mflv_2466|M.gilvum_PYR-GCK DDVRACVRYQVRHGAKLIKVSASGGVMSHSTAPGAQQYSDEEFAAIADEA
MSMEG_0297|M.smegmatis_MC2_155 PDVIACVRYQIRHGARLIKVSASGGVMSHSTAPGAQQYGDAELAAIADEA
TH_0262|M.thermoresistible__bu DDVRACVRYQIRHGAKLIKVSASGGVMSHSTAPGAQQFSDEELSAIADEA
MMAR_4746|M.marinum_M DEIRKAVRYQIKHGAQLIKVCCSGGVMSLTGPPGAQHYSDEELRAIVDEA
MAV_0903|M.avium_104 DEIRKAVRYQIKHGAELIKVCCSGGIMSLTGPPGAQHYSDEELRAIVDEA
MUL_0705|M.ulcerans_Agy99 AEVLRGAREMLRRGASQLKLMAGGGVTSAYDPLDVAQFTETEMRAAVEAA
MAB_3236c|M.abscessus_ATCC_199 AQLPEAVALQARWGDGWVKLVG--DWIDRAVGDLAPLWSDKILKQAIDAA
:: . * :*: . : . : *
Mb0076|M.bovis_AF2122/97 EQVGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIV
Rv0074|M.tuberculosis_H37Rv EQVGLPVTAHAHATAGIAAAVAAGVDGIEHCTFLSEGSAAASPDVVEAIV
Mvan_4188|M.vanbaalenii_PYR-1 HRAGVRVAAHAVGDSAIRACIRAGIDCIEHGFLASDETIQMMADHGTFLV
Mflv_2466|M.gilvum_PYR-GCK HRAGVRVAAHAVGDSAIRACIRAGIDCIEHGFLATDETLQMMVDHGTFLV
MSMEG_0297|M.smegmatis_MC2_155 HRAGVKVAAHAVGDTAIQACIRAGIDCIEHGFLATDETIQMMVDHGTFLV
TH_0262|M.thermoresistible__bu HRAGVRVAAHAVGDSAIRACIRAGIDCVEHGFLASDETLQMMADTGTFLV
MMAR_4746|M.marinum_M HRRGLRVAAHTHGADAVKHAVIAGIDCIEHGFLVDDEAIAMMVEHGTFLV
MAV_0903|M.avium_104 HRRGMRVAAHTHGADAVKHAVAAGIDCIEHGFLIDDEAIASMVEHGTFLV
MUL_0705|M.ulcerans_Agy99 ENWGTYVTVHAYTPRAIRAAIAAGVRCVEHGQLIDEPTAALLAEKDIWWC
MAB_3236c|M.abscessus_ATCC_199 HANGARVTAHVFGEDALPGLIHAGIDCIEHGTGLTDDTIALMVEHGTALV
. * *:.*. .: : **: :** : : :
Mb0076|M.bovis_AF2122/97 AQGVWCGMT-----IPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALS
Rv0074|M.tuberculosis_H37Rv AQGVWCGMT-----IPRVYPEMPENLVAVVQDGWRNIRRLIDAGARVALS
Mvan_4188|M.vanbaalenii_PYR-1 STTYLTEA----MAIDRIAPELRKKAEVVFPQAQAMLPKAIAAGVRIACG
Mflv_2466|M.gilvum_PYR-GCK STTYLTEA----MAVDRIAPELRKKAEVVFPQAQAMLPKAIAAGVRIACG
MSMEG_0297|M.smegmatis_MC2_155 STTYLTDA----MAIDRIAPELRKKALDVFPRAKAMLPKAIAAGVRIACG
TH_0262|M.thermoresistible__bu STTYLTEA----MAVDRIAPELRKKAEEVFPRARSMLPKAIAAGVRIACG
MMAR_4746|M.marinum_M STRRLADADA--MDISHAPPELQAKAAEMFPRSRESILAAYQAGVKIAIG
MAV_0903|M.avium_104 STRRLAEG----MDVSHAPPELQAKAAQMFPKSRTSILAAHRAGVKIAVG
MUL_0705|M.ulcerans_Agy99 LQPFLDDE-----DAVAVPPPSVPKFKQMVAGTDTAYQLAIKHGVKIAFG
MAB_3236c|M.abscessus_ATCC_199 PTVINIENFPGIADKAGKYPKYAQHMRDLYAGLHTTFGNAYDAGIPIYAG
* : : * : .
Mb0076|M.bovis_AF2122/97 TDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLG----
Rv0074|M.tuberculosis_H37Rv TDAGVAPGRRHDVLPDDLVYLSRHGFTSTEVLTGATAAAAASCGLG----
Mvan_4188|M.vanbaalenii_PYR-1 TDAPAIPHGQN---AKELRALVSRGMSPMQALRAATMTAAELIEA-----
Mflv_2466|M.gilvum_PYR-GCK TDAPAVPHGQN---AKELCALVSRGMTPMQALRAATITSAELIDA-----
MSMEG_0297|M.smegmatis_MC2_155 TDAPAIPHGQN---AKELCALVERGMTPMQALQAATVVAAELVDA-----
TH_0262|M.thermoresistible__bu TDAPAIPHGEN---ARELCALVDRGMTPMQAIRAATVTSAELIEA-----
MMAR_4746|M.marinum_M TDAPAIPHGRN---ADELVTLVHWGMSPMAVLRAATVTAAELINV-----
MAV_0903|M.avium_104 TDAPAIPHGRN---ADELVTLVEWGLPPVAVLRAATVTAAELINS-----
MUL_0705|M.ulcerans_Agy99 TDTLFDAKLASR--QGAQLAKLTRWFTPAEVLQQATIRNAELLAMSGPRN
MAB_3236c|M.abscessus_ATCC_199 TDAGGSIAHGR--ISDEVAALTRIGMSPTDALGAASWRARSWLGRP----
**: :.. .: *:
Mb0076|M.bovis_AF2122/97 ---HRKGRIAPGYDADLLAVAAGVDHDPAGLCDVK----AVWRSGTQVPL
Rv0074|M.tuberculosis_H37Rv ---HRKGRIAPGYDADLLAVAAGVDHDPAGLCDVK----AVWRSGTQVPL
Mvan_4188|M.vanbaalenii_PYR-1 --DDELGRLAPGYLADIIAVAGDPSNDIATTLDVR----FVMKDGVVHKG
Mflv_2466|M.gilvum_PYR-GCK --EDELGRLAPGYLADIIAVDGDVSADIATTLDVR----FVMKDGVVHKT
MSMEG_0297|M.smegmatis_MC2_155 --SDELGRLAPGYLADVVAVPGDPSTDISAILDVS----FVMKDGAVVKH
TH_0262|M.thermoresistible__bu --GDELGRLAPGYRADIIAVPGDPSRDIAATLDVR----FVMKDGAVYRH
MMAR_4746|M.marinum_M --TDR-GRLAAGQLADIIAVAGNPLDDITVTRNVG----FVMKGGKVYVH
MAV_0903|M.avium_104 --SDR-GRLAEGYLADVIAVPGNPLEDITVTQHVS----FVMKGGKVYVH
MUL_0705|M.ulcerans_Agy99 PYPGRLGVVAEGALADLILVDGDPIADISLIARPDETFTTIIKNGRVVKG
MAB_3236c|M.abscessus_ATCC_199 -------GLEHGAPADLLGYRADPRTGPGVLASPD----LVMLRGQIR--
: * **:: .. . : *
Mb0076|M.bovis_AF2122/97 QASAVGYNTPS-
Rv0074|M.tuberculosis_H37Rv QASAVGYNTPS-
Mvan_4188|M.vanbaalenii_PYR-1 AEGGGREG----
Mflv_2466|M.gilvum_PYR-GCK VDVAQDASTSTV
MSMEG_0297|M.smegmatis_MC2_155 REPSDAAVR---
TH_0262|M.thermoresistible__bu DGVDRRDRG---
MMAR_4746|M.marinum_M QD----------
MAV_0903|M.avium_104 NQN---------
MUL_0705|M.ulcerans_Agy99 AAS---------
MAB_3236c|M.abscessus_ATCC_199 ------------