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SRETSSDGGAAGIDVAPHDGTVRLHALLTQSGLQVEALTPIGDGDRPIRYVYPTELADPSQYLSGGELIL SVGVPVVQEPDDVIRRYVATLSDRGVTALMVGLGDLFDEPPAALVQACLDRDLPLLTLPPDVPFRRIVDW AEAHRAAEREAGKREGDLGSILRWFVAGTLGVGPVENALAERGLAGAPVAVCAFNSDAHTAVHDLVDKHG GAVALLDDDRIVSLCAHTENFRAELAASPLSCGVAIAPDAAAMVYAIPEALEALHEATRWRRAVHIDEIA TLDGLLAAVPKVRLVPFVHRLIAPLVEHDKVNNSYLVSSLEAFLAPRNDINAAATQLYVHVNTLRNRLAK IAELTGANPLDESDRVNFRIALWAARNMGMREQGGEAAKPSGVAGDLATPGPGPGPNAVRHNGIRQTSGT RRSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4370 | - | - | 100% (425) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_1068 | - | 1e-18 | 36.20% (163) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_6688 | - | 6e-14 | 36.97% (165) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 4e-08 | 27.11% (273) | hypothetical protein Mb2266 |
| M. gilvum PYR-GCK | Mflv_0801 | - | 4e-17 | 38.33% (120) | transcriptional regulator, CdaR |
| M. tuberculosis H37Rv | Rv2242 | - | 4e-08 | 27.11% (273) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01652 | - | 1e-06 | 25.73% (171) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_4202c | - | 2e-14 | 38.71% (124) | putative regulatory protein |
| M. marinum M | MMAR_3335 | - | 3e-08 | 27.95% (161) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_2195 | - | 9e-08 | 28.57% (182) | hypothetical protein MAV_2195 |
| M. thermoresistible (build 8) | TH_1338 | - | 3e-08 | 27.27% (187) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1307 | - | 2e-08 | 27.95% (161) | hypothetical protein MUL_1307 |
| M. vanbaalenii PYR-1 | Mvan_0042 | - | 2e-18 | 40.83% (120) | purine catabolism PurC domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3335|M.marinum_M --MNDNQFS-AIARLGSARSPLELLETVPDSLLRRLKQYSGRLATEAVS-
MUL_1307|M.ulcerans_Agy99 --MNNNQFS-AIARLGSARSPLELLETVPDSLLRRLKQYSGRLATEAVS-
Mb2266|M.bovis_AF2122/97 --MNDNQLA-PVARP---RSPLELLDTVPDSLLRRLKQYSGRLATEAVS-
Rv2242|M.tuberculosis_H37Rv --MNDNQLA-PVARP---RSPLELLDTVPDSLLRRLKQYSGRLATEAVS-
MLBr_01652|M.leprae_Br4923 --MNHNHFV-PAPPR---RLPLELLDTVPDSLLRRLKQYSGRLATEAVT-
MAV_2195|M.avium_104 --MNDNPFAGPFAKHP--RSPLETLDTVPESVLRRLKQYSGRLATEAVS-
TH_1338|M.thermoresistible__bu --VPDNRFV----PP---QSTLEVLESVPESVLRRLKQYSGRLATEAVH-
Mflv_0801|M.gilvum_PYR-GCK --MSEDRAESAAPTLRDLLEAAQLSLSGPDPADRNLDREVSWVHTTEMRD
Mvan_0042|M.vanbaalenii_PYR-1 --MSEVHAEPAAPTLRDLATAG-LGLSVPDGTAQELDRPVSWVHTTEMRD
MSMEG_4370|M.smegmatis_MC2_155 MSRETSS-----------DGGAAGIDVAPHDGTVRLHALLTQSG------
MAB_4202c|M.abscessus_ATCC_199 ---MRWVLDQPELKLTLKSGAAGVGREINLALTTELADPAQWLSGGELVL
.*
MMAR_3335|M.marinum_M -------------------AMQERLPFFADLEASQRASVALVVQTAVVNF
MUL_1307|M.ulcerans_Agy99 -------------------AMQERLPFFADLEASQRASVALVVQTAVVNF
Mb2266|M.bovis_AF2122/97 -------------------AMQERLPFFADLEASQRASVALVVQTAVVNF
Rv2242|M.tuberculosis_H37Rv -------------------AMQERLPFFADLEASQRASVALVVQTAVVNF
MLBr_01652|M.leprae_Br4923 -------------------AMQERLPFFADLEASQRASVTLVVQTAVVNF
MAV_2195|M.avium_104 -------------------VMQDRLPFFADLEASQRASVSLVVQTAVVNF
TH_1338|M.thermoresistible__bu -------------------TMEERLPFFADLEASQRASVHLVVQTAVVNF
Mflv_0801|M.gilvum_PYR-GCK PSRYLRGGELVCTVGISLHSAEDCSTFVDALAGAGAAGVCFGVGDGHDDV
Mvan_0042|M.vanbaalenii_PYR-1 PSRYLRGGELVCTVGISLHTDQDCATFVDALSRARAAGVCFGVGDEHDAV
MSMEG_4370|M.smegmatis_MC2_155 -------------------LQVEALTPIGDGDRPIRYVYPTELADPSQYL
MAB_4202c|M.abscessus_ATCC_199 TTGIG-----------LPKSSRDRRRYLRSLDENNVAALGFGTGLTFDEV
: . .
MMAR_3335|M.marinum_M AEWMQNPR------SDVSYTAQAFELVPQDLTRRIALRHTVDMVRVT---
MUL_1307|M.ulcerans_Agy99 AEWMQNPR------SDVSYTAQAFELVPQDLTRRIALRHTVDMVRVT---
Mb2266|M.bovis_AF2122/97 VEWMHDPH------SDVGYTAQAFELVPQDLTRRIALRQTVDMVRVT---
Rv2242|M.tuberculosis_H37Rv VEWMHDPH------SDVGYTAQAFELVPQDLTRRIALRQTVDMVRVT---
MLBr_01652|M.leprae_Br4923 VQWMQNPH------SDVSYTAQAFELVPQDLARRIALRHTVDMVRVT---
MAV_2195|M.avium_104 AEWMQDPK------SNVRHTAQAFELVPQDLARRIALRHSVEMVRVT---
TH_1338|M.thermoresistible__bu VEWMRDPR------SNVTYTMQAFEVVPQDLTRRIALRQTVEMVRTT---
Mflv_0801|M.gilvum_PYR-GCK PAALLDACRRAGLPVLVAPPSVPFSVISR-FVAESRLGTEIAVARAT---
Mvan_0042|M.vanbaalenii_PYR-1 PEALLAQCRLHGLPLLVAPPSVPFSVVSR-FVAEYWLGSEIAVARAT---
MSMEG_4370|M.smegmatis_MC2_155 SGGELILS------VGVPVVQEPDDVIRR-YVATLSDRGVTALMVGL---
MAB_4202c|M.abscessus_ATCC_199 PPELVSTADELGMPLLEIPLRTPFAAVVKAVSTRIAELEYDAVLRASRAQ
. : : :
MMAR_3335|M.marinum_M ------------MEFFEEVVPLLAR-----------SEEQLTALTVGILK
MUL_1307|M.ulcerans_Agy99 ------------MEFFEEVVPLLAR-----------SEEQLTALTVGILK
Mb2266|M.bovis_AF2122/97 ------------MEFFEEVVPLLAR-----------SEEQLTALTVGILK
Rv2242|M.tuberculosis_H37Rv ------------MEFFEEVVPLLAR-----------SEEQLTALTVGILK
MLBr_01652|M.leprae_Br4923 ------------MEFFEEVVPLLAR-----------SEEQLTALTVGILK
MAV_2195|M.avium_104 ------------MEFFEEVVPLLAR-----------SEEQLTALTVGVLK
TH_1338|M.thermoresistible__bu ------------MEFFEQVVPLLAR-----------SEEQVTALTAGILR
Mflv_0801|M.gilvum_PYR-GCK ------------NALVPELLLSLRR-----------HDSPRRLLDAAGQV
Mvan_0042|M.vanbaalenii_PYR-1 ------------NALVPELLSSLRR-----------HDSPRQLLDSAGQL
MSMEG_4370|M.smegmatis_MC2_155 ------------GDLFDEPPAALVQ-----------ACLDR---DLPLLT
MAB_4202c|M.abscessus_ATCC_199 PRITRAIVNGGVQAVTAELGRSLRASVVVLDPGGTVVASHPRNLDVATVN
. : *
MMAR_3335|M.marinum_M YSRDLAFTAASAYADAAEARGTWDSRMEAS---------VVDAVVRGDTG
MUL_1307|M.ulcerans_Agy99 YSRDLAFTAASAYADAAEARGTWDSRMEAS---------VVDAVVRGDTG
Mb2266|M.bovis_AF2122/97 YSRDLAFTAATAYADAAEARGTWDSRMEAS---------VVDAVVRGDTG
Rv2242|M.tuberculosis_H37Rv YSRDLAFTAATAYADAAEARGTWDSRMEAS---------VVDAVVRGDTG
MLBr_01652|M.leprae_Br4923 YSRDLAFTAATAYADAAEARGTWDSRMEAS---------VVDAVVRGDTG
MAV_2195|M.avium_104 YSRDLAFTAATAYADAAEARGTWDSRMEAS---------VVDAVVRGDTG
TH_1338|M.thermoresistible__bu YSRDLAFAAATAYADAAEARGAWDTRMEAN---------VVDAVVRGAVG
Mflv_0801|M.gilvum_PYR-GCK LGCYFLLEPEGA-AKGDEAAVTVPVPGLGA---------LVWMGRGDRPE
Mvan_0042|M.vanbaalenii_PYR-1 LGCYFLLEPEGG-ADSDDDAVTVPVPGLGT---------LVWVGRGDHPE
MSMEG_4370|M.smegmatis_MC2_155 LPPDVPFRRIVDWAEAHRAAEREAGKREG---------------------
MAB_4202c|M.abscessus_ATCC_199 LVRGALSPGASAGVQQLDPGITVSQQAIGVGGTSYGVLAVVSKTPLTFVD
.. .
MMAR_3335|M.marinum_M PELLSRAAALNWDTTAPATVVVGTPASARDGS--DG------SERAIQDV
MUL_1307|M.ulcerans_Agy99 PELLSRAAALNWDTTAPATVVVGTPASARDGS--DG------SERAIQDV
Mb2266|M.bovis_AF2122/97 PELLSRAAALNWDTTAPATVLVGTPAPGPNGSNSDGD-----SERASQDV
Rv2242|M.tuberculosis_H37Rv PELLSRAAALNWDTTAPATVLVGTPAPGPNGSNSDGD-----SERASQDV
MLBr_01652|M.leprae_Br4923 PELLSRAAALNWDTTAPATVVVGTPTPNHDGPNGQVS-----SERASQEV
MAV_2195|M.avium_104 PELLSRAAALNWDTTAPATVVVGTPAPGRDGSTGPGD-----SERASQHV
TH_1338|M.thermoresistible__bu PELQSQAAALNWDATAPATVVVGLPRPD--------R-----LEVVSQDV
Mflv_0801|M.gilvum_PYR-GCK PALLDLIARFVRAAQGERDIEAALTRERVGQLLSLVERRMLLPDALSQLV
Mvan_0042|M.vanbaalenii_PYR-1 PALLDLIARFVRAAQGERDIEAALARERVGQLLSLVERRMLLPDALSQLL
MSMEG_4370|M.smegmatis_MC2_155 -DLGSILRWFVAGTLGVGPVENALAERGLAGAPVAVCAFN--SDAHTAVH
MAB_4202c|M.abscessus_ATCC_199 QVLLGHTNSLLALDFDKPSRLQEAQRRLNGQALGLLLGDERNLGPVWAQL
* . :
MMAR_3335|M.marinum_M RDAAAQHGRAALTDVHG-------------------------------TW
MUL_1307|M.ulcerans_Agy99 RDAAAQHGRAALTDVHG-------------------------------TW
Mb2266|M.bovis_AF2122/97 RDTAARHGRAALTDVHG-------------------------------TW
Rv2242|M.tuberculosis_H37Rv RDTAARHGRAALTDVHG-------------------------------TW
MLBr_01652|M.leprae_Br4923 REIAARHGRAALTDVHG-------------------------------TW
MAV_2195|M.avium_104 RDIAAQHGRAALTDVHG-------------------------------TW
TH_1338|M.thermoresistible__bu HHVANRHGRTALSDVHG-------------------------------TW
Mflv_0801|M.gilvum_PYR-GCK QWPGF-AGEIACSAWPAGAGALLS-----------------------ISF
Mvan_0042|M.vanbaalenii_PYR-1 EWPGFSAGEIACSAWPAGAGALVS-----------------------MAF
MSMEG_4370|M.smegmatis_MC2_155 DLVDKHGGAVALLDDDR---------------------------------
MAB_4202c|M.abscessus_ATCC_199 GQAADARGRIRVLVVDAESQTALVRVLPAVTRDMESAGYPVFAHTGERQL
*
MMAR_3335|M.marinum_M LVAIVSGHLSPTDKVFKDLLEAFSDGPVVIGPTAPMLTAAYHSASEAISG
MUL_1307|M.ulcerans_Agy99 LVAIVSGHLSPTDKVFKDLLEAFSDGPVVIGPTAPMLTAAYHSASEAISG
Mb2266|M.bovis_AF2122/97 LVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSASEAISG
Rv2242|M.tuberculosis_H37Rv LVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSASEAISG
MLBr_01652|M.leprae_Br4923 LVAIISGQLAPTDKFFSDLLHAFSDGPVVIGPTAPMLTAAYHSASEAVSG
MAV_2195|M.avium_104 LVAIVSGQLSPTDKFLGDLLEAFSDGPVVVGPTAPMLTAAYHSASEAISG
TH_1338|M.thermoresistible__bu LVTIVSGALSPTDRFLTDLLDVFADGPVVLGPTAPTLSAAYRSATEAIAG
Mflv_0801|M.gilvum_PYR-GCK PGALIGDAPDLCMMLTAGAVEMPDDLALPTGHSAPVTLADLGSAIAQARI
Mvan_0042|M.vanbaalenii_PYR-1 PDALIGDAPDLCLMLTVGALEVTDDLALPTGHSAPVPLTDIGSAIAQARI
MSMEG_4370|M.smegmatis_MC2_155 ----IVSLCAHTENFRAELAASPLSCGVAIAPDAAAMVYAIPEALEALHE
MAB_4202c|M.abscessus_ATCC_199 TVVLPGAETADFARRLFGDVDARIKKGLRAGLSGAHPVGRLADAVQNARL
. : . .. .*
MMAR_3335|M.marinum_M MNAVAGWRG---APRPVLARELLPERALMGDASAIVALHTDVMRPLAD-A
MUL_1307|M.ulcerans_Agy99 MNAVAGWRG---ASRPVLARELLPERALMGDASAIVALHTDVMRPLAD-A
Mb2266|M.bovis_AF2122/97 MNAVAGWRG---APRPVLARELLPERALMGDASAIVALHTDVMRPLAD-A
Rv2242|M.tuberculosis_H37Rv MNAVAGWRG---APRPVLARELLPERALMGDASAIVALHTDVMRPLAD-A
MLBr_01652|M.leprae_Br4923 MNAVAGWSG---APRPVQARELLPERALMGDASAIVALHTDVMLPLAD-A
MAV_2195|M.avium_104 MNAVGGWRG---APRPVLARELLPERALMGDASAIVALHTDVMGPLAD-A
TH_1338|M.thermoresistible__bu MNAVAGWSG---APRPVPARELLPERALLGDQTAIAALESEVMRPLAD-A
Mflv_0801|M.gilvum_PYR-GCK ALTLAEHRGGRVGPDQLSTLESLLEQLPLAQLAPFRQLLIDPLTELDTSR
Mvan_0042|M.vanbaalenii_PYR-1 ALTLAEHRGGRVGPDQLSTLESLLEQLPLAQLAPFKQLLIAPLAELDSQR
MSMEG_4370|M.smegmatis_MC2_155 ATRWRRAVH----IDEIATLDGLLAAVPKVRLVPFVHRLIAPLVEHDKVN
MAB_4202c|M.abscessus_ATCC_199 AASVAERGGTPLEFTSLAGSALLSFGASREVLVAVANATLEPIVEHDAVH
: * .. :
MMAR_3335|M.marinum_M GPTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDFTGRDPTQP
MUL_1307|M.ulcerans_Agy99 GPTLIETLDAYLDCGGAIEACARKLFVHPNTIRYRLKRITDFTGRDPTQP
Mb2266|M.bovis_AF2122/97 GPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQP
Rv2242|M.tuberculosis_H37Rv GPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQP
MLBr_01652|M.leprae_Br4923 GPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGHDPTLP
MAV_2195|M.avium_104 GPTLIETLDAFLDSGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPMQP
TH_1338|M.thermoresistible__bu GPTLTETLDAFLESGGAIEACARRLFVHPNTVRYRLRRIAEITGRDPAVP
Mflv_0801|M.gilvum_PYR-GCK GTQHVRTLRTFVACNGSLSETAKELFLHTNTVRHRLGRIQEITGRDPLQH
Mvan_0042|M.vanbaalenii_PYR-1 GTQHVRTLRVFLACNGSLSETAKELFLHTNTVRHRLSRIQEITGRDPLQH
MSMEG_4370|M.smegmatis_MC2_155 NSYLVSSLEAFLAPRNDINAAATQLYVHVNTLRNRLAKIAELTGANPLDE
MAB_4202c|M.abscessus_ATCC_199 GSELMTSLRAYLEANGHWESAATVVGVHRHTLRKRIETVQSLLACDLDIA
.. :* .:: . . * : :* :*:* *: : .: . :
MMAR_3335|M.marinum_M RDAYVLRVAATVGQ-LNYPTPPSGAANNTITPVPLPVRRGTEGP------
MUL_1307|M.ulcerans_Agy99 RDAYVLRVAATVGQ-LNYPTPPSGAANNTITPVPLPVRRGTEGP------
Mb2266|M.bovis_AF2122/97 RDAYVLRVAATVGQ-LNYPTPH----------------------------
Rv2242|M.tuberculosis_H37Rv RDAYVLRVAATVGQ-LNYPTPH----------------------------
MLBr_01652|M.leprae_Br4923 RDAYVLRVAATVGK-LNYPTHH----------------------------
MAV_2195|M.avium_104 RDAYVLRVAATVGQ-LNYPTHPPSAAGAAMPAVPLPVNGAARGQSGG---
TH_1338|M.thermoresistible__bu RDAYVLRVAVSVSR-LTRQSYQSSTVNPDLGSTAGWRGQAAGGHRAM---
Mflv_0801|M.gilvum_PYR-GCK NDLTTFVIGMWAAD-RGE--------------------------------
Mvan_0042|M.vanbaalenii_PYR-1 NDLTAFVIGLWAAD-RAERPAGL---------------------------
MSMEG_4370|M.smegmatis_MC2_155 SDRVNFRIALWAARNMGMREQGGEAAKPSGVAGDLATPGPGPGPNAVRHN
MAB_4202c|M.abscessus_ATCC_199 RVRAELLLAMLTGTPGTGN-------------------------------
: :. ..
MMAR_3335|M.marinum_M ------------
MUL_1307|M.ulcerans_Agy99 ------------
Mb2266|M.bovis_AF2122/97 ------------
Rv2242|M.tuberculosis_H37Rv ------------
MLBr_01652|M.leprae_Br4923 ------------
MAV_2195|M.avium_104 ------------
TH_1338|M.thermoresistible__bu ------------
Mflv_0801|M.gilvum_PYR-GCK ------------
Mvan_0042|M.vanbaalenii_PYR-1 ------------
MSMEG_4370|M.smegmatis_MC2_155 GIRQTSGTRRSR
MAB_4202c|M.abscessus_ATCC_199 ------------