For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VVDFDALEAAGIADARRRAGLISYLDRLGFTAEEMVDAERRGRLFGLAGDRLQASGPAIHSLASAADELG LPVAEVERAWAALGLTVAGVDVPALSAADVEGLRTWSEMRAFLGDQAATGLLRVIGSALARISEAESSMV RATSPDIMIDVTHDELATAQAYRTAAAYIPRIGALMDAAHRHHLMSTRTYFEHVIRDGSTTGECGVGFAD LSDFTALTQMLTTVELTDLLNEFSSAASDVVHAAGGRVVKFIGDAVMWVATTPHLLARAAVDLVEHPKAR QAHVRVRAGLDFGAVLAINGDYFGNSVNLAARLVQAAEPGQVLVSAALREALGDWPATGPRELKLKGFDH PIPAFALTPRESG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4279 | - | - | 100% (363) | adenylate and guanylate cyclase catalytic domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_5018 | - | 2e-23 | 30.68% (365) | adenylate and guanylate cyclase catalytic domain-containing |
| M. smegmatis MC2 155 | MSMEG_3780 | - | 2e-08 | 30.00% (130) | adenylate and guanylate cyclase catalytic domain-containing |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2235 | - | 1e-133 | 66.57% (356) | hypothetical protein Mb2235 |
| M. gilvum PYR-GCK | Mflv_2243 | - | 2e-24 | 30.62% (356) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv2212 | - | 1e-133 | 66.57% (356) | hypothetical protein Rv2212 |
| M. leprae Br4923 | MLBr_01399 | - | 7e-09 | 28.10% (121) | hypothetical protein MLBr_01399 |
| M. abscessus ATCC 19977 | MAB_4771 | - | 5e-30 | 29.32% (324) | putative adenylate cyclase |
| M. marinum M | MMAR_3257 | - | 1e-126 | 63.20% (356) | adenylate cyclase |
| M. avium 104 | MAV_1415 | - | 4e-19 | 27.27% (352) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. thermoresistible (build 8) | TH_1842 | - | 5e-25 | 30.17% (358) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. ulcerans Agy99 | MUL_4470 | - | 2e-20 | 28.01% (357) | adenylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4452 | - | 1e-20 | 29.19% (322) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2235|M.bovis_AF2122/97 -----------------MYDSLDFDALEAAGIANPRERAGLLTYLDELGF
Rv2212|M.tuberculosis_H37Rv -----------------MYDSLDFDALEAAGIANPRERAGLLTYLDELGF
MMAR_3257|M.marinum_M --------------MSGSPDPLDFEALEAAGIANPRERADLIKYLDDLGF
MSMEG_4279|M.smegmatis_MC2_155 --------------------MVDFDALEAAGIADARRRAGLISYLDRLGF
Mflv_2243|M.gilvum_PYR-GCK --------------------METSGLLDGLEGAARAERAELIGWLLDRGV
Mvan_4452|M.vanbaalenii_PYR-1 --------------MAEDLDLETSELLDGLEGDARGERAELIRWLVGRGV
TH_1842|M.thermoresistible__bu --------------MADDVDIEASGLLDDLTGEAREQRAELIAWLIERGY
MAV_1415|M.avium_104 MTSHDGLPALYVDDVHDGDDRDIEDLLDGLQGTARTERAELVRWLLAQGI
MUL_4470|M.ulcerans_Agy99 MEDS-------VDRAPEPAGQNTDDLLEGLEGAARAERAELIDWLFGQGI
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01399|M.leprae_Br4923 --------------------------------------------------
Mb2235|M.bovis_AF2122/97 TVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAW
Rv2212|M.tuberculosis_H37Rv TVEEMVQAERRGRLFGLAGDVLLWSGPPIYTLATAADELGLSADDVARAW
MMAR_3257|M.marinum_M TLEEMAEAERRGRLFGLAGDVLQWPGPPIYTLTAAGEQLGLSADDIAHIW
MSMEG_4279|M.smegmatis_MC2_155 TAEEMVDAERRGRLFGLAGDRLQASGPAIHSLASAADELGLPVAEVERAW
Mflv_2243|M.gilvum_PYR-GCK AVDEIRGNPAP---MLLASRRVIGDDGEYVSARQAADRAGVELELFERIQ
Mvan_4452|M.vanbaalenii_PYR-1 GIDQIRGNPAP---MLLASRRVIGDDGLYVSARQAAANAGVDLELFERIQ
TH_1842|M.thermoresistible__bu SIEEIRESVSP---MLLASRRLIGDDSRYVSAAEISRSTGMDLGLLQRML
MAV_1415|M.avium_104 TAEEIRTTNPP---LLLATRHLIGDDGTYVSTREISETYGIDMALLQRVQ
MUL_4470|M.ulcerans_Agy99 TAAEIRTTNPP---LLLATRHVIGDDGTYVSSREISETYGIDLDLLQRVQ
MAB_4771|M.abscessus_ATCC_1997 ----MPESDELNAVVDAAVEQVLLGGPRRYTRSQVSQLSGVPVERARTLW
MLBr_01399|M.leprae_Br4923 -------------------------MPPSAKSTYPGQVEGAPHDGTPSAP
. . *
Mb2235|M.bovis_AF2122/97 SLLGLT-VAGPDVPTLSQADVDALA-TWVALKALVGEDG--AFGLLRVLG
Rv2212|M.tuberculosis_H37Rv SLLGLT-VAGPDVPTLSQADVDALA-TWVALKALVGEDG--AFGLLRVLG
MMAR_3257|M.marinum_M ALLGLT-VAGPDVPTLSQADVDALA-TWLAVKSVVGEDG--AFGLLRVLG
MSMEG_4279|M.smegmatis_MC2_155 AALGLT-VAGVDVPALSAADVEGLR-TWSEMRAFLGDQA--ATGLLRVIG
Mflv_2243|M.gilvum_PYR-GCK RAMGLPRVEDPDAEVFLRADAEAAKFTRDFLDVGIGLDE--LVQITRLLG
Mvan_4452|M.vanbaalenii_PYR-1 RAMGLPRVDDADAQVFLRADAEAAKFTRDFLDAGIDPDE--LVQITRLLG
TH_1842|M.thermoresistible__bu RALGLPRVDDPDAVVHLRADAEAAARAQRFIEAGVDPDQ--MVQIAAVLS
MAV_1415|M.avium_104 RAIGLVRVDDPDAAVHMRADGEAAAFTQRFVDVGLDPDQ--VVLVAQVLA
MUL_4470|M.ulcerans_Agy99 RAVGLARVDDPDAVVYMRADGEAAAYTQRFIELGLNPDQ--IVLVVRVLA
MAB_4771|M.abscessus_ATCC_1997 VALGFAAADSDDEVAFTDADVSAIR-TFAALGSATAANQQSQIAAARTLG
MLBr_01399|M.leprae_Br4923 QEPDEDTVTVPAPALIRRSSVSMPNAAQWLHTTNRSPRLVAMVRRARRLL
. . :. . : :
Mb2235|M.bovis_AF2122/97 TAMARLAEAES-TMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGAL
Rv2212|M.tuberculosis_H37Rv TAMARLAEAES-TMIRAGSPNIQMTHTHDELATARAYRAAAEFVPRIGAL
MMAR_3257|M.marinum_M AAMARLAEAES-TMIRAGTPDIQMTYTNDELATAQAYRAVAEFVPRIGTL
MSMEG_4279|M.smegmatis_MC2_155 SALARISEAES-SMVRATSPDIMIDVTHDELATAQAYRTAAAYIPRIGAL
Mflv_2243|M.gilvum_PYR-GCK DGLARAAEAMRYAALAAVIRPAATELETAKASEELVGNVAPLLGPMIQEV
Mvan_4452|M.vanbaalenii_PYR-1 DGLSRAAEAMRYAALAAVIRPGATELEIAQQSEALVAGLAPLLGPMIQEV
TH_1842|M.thermoresistible__bu EGLAKAAELMRSTVVAAVLQPGKTELQIAQDAEALVRRLAPLLGPMIQDL
MAV_1415|M.avium_104 EGLSRAAEVMRYSALSAIMRPGATELEIAKASKALVTQIAPLLGPMIQQM
MUL_4470|M.ulcerans_Agy99 EGLSRAAEVMRYTALEAIMHPGATELDIAKGSKALVSQIAPLLGPMIQEM
MAB_4771|M.abscessus_ATCC_1997 QAMARLAEWQADLLTREVG--GRLAAEGDDASAESSANAATQTIATLTAL
MLBr_01399|M.leprae_Br4923 PGDPDFGDPLSTAGEGGPRAAARAADRLLGDRGAASREVSLSVLQVWQAL
. . .: :
Mb2235|M.bovis_AF2122/97 IDTVHRHHLASARTYFEGVIG--DTSASVTCGIGFADLSSFTALTQALTP
Rv2212|M.tuberculosis_H37Rv IDTVHRHHLASARTYFEGVIG--DTSASVTCGIGFADLSSFTALTQALTP
MMAR_3257|M.marinum_M IDIVHRHHLTSARTHFEGVTR--DASASVVCGIGFADLSSFTVLTQTLTP
MSMEG_4279|M.smegmatis_MC2_155 MDAAHRHHLMSTRTYFEHVIR--DGSTTGECGVGFADLSDFTALTQMLTT
Mflv_2243|M.gilvum_PYR-GCK LLLQLRHAIETEAINATERAEGQHLPGARLVTIGFADLVGFTRLGEALPP
Mvan_4452|M.vanbaalenii_PYR-1 LLLQLRHAIETEAVNATERAEGQHLPGARLVTIGFADLVGFTRLGEAVPP
TH_1842|M.thermoresistible__bu LLLQLRHAMETEAVSVTERAQGVPLPGARLVSIAFADLVGFTRLGEAVPP
MAV_1415|M.avium_104 LFMQLRHMMETEAVNAAERAAGKPLPGARQITVAFADLVGFTRIGEAVSP
MUL_4470|M.ulcerans_Agy99 LFMQLRHMMETEAVNAGERAAGKPLPGAREVSVAFADLVGFTKLGEVVSA
MAB_4771|M.abscessus_ATCC_1997 QNYAWQRHLAAALHRANETGS-----TTRQLLVGFADMVGYTRLSRHLDP
MLBr_01399|M.leprae_Br4923 TEAIARRPVN------------------PEVTLVFTDLVGFSGWSLQAGD
:: : : *:*: .::
Mb2235|M.bovis_AF2122/97 AQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPER----LVRA
Rv2212|M.tuberculosis_H37Rv AQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSSPER----LVRA
MMAR_3257|M.marinum_M TELQGLLNEFGAAVADVVHADGGRVVKFIGDAVMWVSSTPQR----LAQA
MSMEG_4279|M.smegmatis_MC2_155 VELTDLLNEFSSAASDVVHAAGGRVVKFIGDAVMWVATTPHL----LARA
Mflv_2243|M.gilvum_PYR-GCK EDLERLAQRLADLTREIAVAP-VRFIKTIGDEVMLVSPEPAP----LLET
Mvan_4452|M.vanbaalenii_PYR-1 EDLEQLSQRLADMTREFAVAP-VRFIKTIGDEVMLVSPEPAP----LLDT
TH_1842|M.thermoresistible__bu EELEQLAARLADLAREVAEPP-VRFIKTIGDAVMLVSVDPAE----LLAA
MAV_1415|M.avium_104 EELGQLANRLAILARDVTVPP-VRFVKTIGDAVMFVCPEPRP----LLDV
MUL_4470|M.ulcerans_Agy99 EELGQLAGRLADLARELTAPP-VRFIKTIGDAVMLVCPDPAP----LLDT
MAB_4771|M.abscessus_ATCC_1997 DELASLLETFETALTEAITTHGGWVIKNVGDEVMFAAASAAAGARIAVAM
MLBr_01399|M.leprae_Br4923 EATLALLRQVARAVESPLLDAGGHIVKRMGDGIMAVFRDPSVAVQ-AVLA
* . . .:* :** :* . .
Mb2235|M.bovis_AF2122/97 AVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAP
Rv2212|M.tuberculosis_H37Rv AVDLVDHPGARAAELQVRAGLAYGTVLALNGDYFGNPVNLAARLVAAAAP
MMAR_3257|M.marinum_M AVDLVHHPRAREEGLQVRAGLAYGTALAINGDYFGTPVNLAARLVAAAAP
MSMEG_4279|M.smegmatis_MC2_155 AVDLVEHPKARQAHVRVRAGLDFGAVLAINGDYFGNSVNLAARLVQAAEP
Mflv_2243|M.gilvum_PYR-GCK MLRLVEETEGDDDFPRLRAGVATGMAVSRAGDWFGSPVNLAARMTGAARP
Mvan_4452|M.vanbaalenii_PYR-1 LLRLVDETEDDDDFPRLRAGVATGLAVSRAGDWFGSPVNLAARVTGAARP
TH_1842|M.thermoresistible__bu MLELIDGTGADQDFPRVRAGMATGMAVSRAGDWYGSPVNLASRVTGVARP
MAV_1415|M.avium_104 VLKLVEAVDTDNEFPRLRAGVASGTAVSRAGDWFGSPVNVASRVTAVARP
MUL_4470|M.ulcerans_Agy99 VLNLVEVVDTDDAFPRLRAGVACGRAVSRAGDWFGSPVNAASRITGVARP
MAB_4771|M.abscessus_ATCC_1997 NTAITEAAQTIPDMPQIRVGLAYGQVLSRFGDLYGTVVNIAARLTGVARP
MLBr_01399|M.leprae_Br4923 ATEAMKSVEVGGYTPRIRVGIHTGRPQRLAADWLGVDVNIAARVMERATK
. ::*.*: * .* * ** *:*: *
Mb2235|M.bovis_AF2122/97 GQILAAAQLRDMLPDWPA-----------LAHGPLTLKGFDAPVMAFELH
Rv2212|M.tuberculosis_H37Rv GQILAAAQLRDMLPDWPA-----------LAHGPLTLKGFDAPVMAFELH
MMAR_3257|M.marinum_M GQVLADAALHDQLPDWPT-----------IPRGKLTLKGFDDPVNAFELQ
MSMEG_4279|M.smegmatis_MC2_155 GQVLVSAALREALGDWPA-----------TGPRELKLKGFDHPIPAFALT
Mflv_2243|M.gilvum_PYR-GCK GTVLVAEAAREAIGEDDR--------FAWSFAGAKHLKGIKSDVKSFRAR
Mvan_4452|M.vanbaalenii_PYR-1 GSVLVAEATREAIGEDER--------FTWSFAGGKHLKGFKSDVKTFRAR
TH_1842|M.thermoresistible__bu GSVLVAEATREAIGDDER--------FRWSFAGSRRLKGIKGEVKLYRAR
MAV_1415|M.avium_104 GTVLVADSVWDVIGDNGE--------FSGSFAGARRLKGIKNEVKLFRVR
MUL_4470|M.ulcerans_Agy99 GTVLAADSVCDAIRDTAAGAG-----FEWSFAGPRRLKGIKNETKLFRVR
MAB_4771|M.abscessus_ATCC_1997 GTILLDDGAAAALGDDGE--------FSLRHLRGVRVKGFSRLGSHVLRA
MLBr_01399|M.leprae_Br4923 GGIMISGPTLDLIPQSDLKELGIITRRVRKPMFTSKFTGIPPDMVIYRIK
* :: : : ..*:
Mb2235|M.bovis_AF2122/97 DNPRARDADTPSPAASD-
Rv2212|M.tuberculosis_H37Rv DNPRARDADTPSPAASD-
MMAR_3257|M.marinum_M GSADRPDGGQAGPRCGD-
MSMEG_4279|M.smegmatis_MC2_155 ------------PRESG-
Mflv_2243|M.gilvum_PYR-GCK WAPADSH-----------
Mvan_4452|M.vanbaalenii_PYR-1 RTTNL-------------
TH_1842|M.thermoresistible__bu RAE---------------
MAV_1415|M.avium_104 RGG---------------
MUL_4470|M.ulcerans_Agy99 RNLADLAADTATEGR---
MAB_4771|M.abscessus_ATCC_1997 RKR---------------
MLBr_01399|M.leprae_Br4923 ARRELTASDETAQTNSLT