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VSGSPDPLDFEALEAAGIANPRERADLIKYLDDLGFTLEEMAEAERRGRLFGLAGDVLQWPGPPIYTLTA AGEQLGLSADDIAHIWALLGLTVAGPDVPTLSQADVDALATWLAVKSVVGEDGAFGLLRVLGAAMARLAE AESTMIRAGTPDIQMTYTNDELATAQAYRAVAEFVPRIGTLIDIVHRHHLTSARTHFEGVTRDASASVVC GIGFADLSSFTVLTQTLTPTELQGLLNEFGAAVADVVHADGGRVVKFIGDAVMWVSSTPQRLAQAAVDLV HHPRAREEGLQVRAGLAYGTALAINGDYFGTPVNLAARLVAAAAPGQVLADAALHDQLPDWPTIPRGKLT LKGFDDPVNAFELQGSADRPDGGQAGPRCGD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3257 | - | - | 100% (381) | adenylate cyclase |
| M. marinum M | MMAR_0157 | cyaA | 8e-23 | 29.79% (376) | adenylate cyclase, CyaA |
| M. marinum M | MMAR_4173 | - | 3e-19 | 28.61% (339) | adenylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2235 | - | 1e-165 | 76.86% (376) | hypothetical protein Mb2235 |
| M. gilvum PYR-GCK | Mflv_2243 | - | 2e-25 | 30.32% (376) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv2212 | - | 1e-165 | 76.86% (376) | hypothetical protein Rv2212 |
| M. leprae Br4923 | MLBr_00201 | - | 7e-09 | 35.29% (136) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_4771 | - | 8e-29 | 29.32% (307) | putative adenylate cyclase |
| M. avium 104 | MAV_1415 | - | 1e-22 | 28.33% (360) | chain A, Myco adenylyl cyclase, holoenzyme, inhibited state |
| M. smegmatis MC2 155 | MSMEG_4279 | - | 1e-126 | 63.20% (356) | adenylate and guanylate cyclase catalytic domain-containing |
| M. thermoresistible (build 8) | TH_1842 | - | 5e-24 | 31.71% (350) | ADENYLYL CYCLASE (ATP PYROPHOSPHATE-LYASE) (ADENYLATE CYCLASE) |
| M. ulcerans Agy99 | MUL_4940 | cyaA | 5e-22 | 29.43% (384) | adenylate cyclase, CyaA |
| M. vanbaalenii PYR-1 | Mvan_4452 | - | 2e-21 | 29.32% (365) | putative adenylate/guanylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2235|M.bovis_AF2122/97 --------------------------------------------------
Rv2212|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3257|M.marinum_M --------------------------------------------------
MSMEG_4279|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2243|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4452|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1842|M.thermoresistible__bu --------------------------------------------------
MAV_1415|M.avium_104 --------------------------------------------------
MUL_4940|M.ulcerans_Agy99 --------------------------------------------------
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00201|M.leprae_Br4923 MATQAAGLPGRIGAFVRWGIRTPWPLFSLSMLQSDIIGALFVLGFLRYGL
Mb2235|M.bovis_AF2122/97 ----------------------------------------MYDSLDFDAL
Rv2212|M.tuberculosis_H37Rv ----------------------------------------MYDSLDFDAL
MMAR_3257|M.marinum_M -------------------------------------MSGSPDPLDFEAL
MSMEG_4279|M.smegmatis_MC2_155 -------------------------------------------MVDFDAL
Mflv_2243|M.gilvum_PYR-GCK -------------------------------------------METSGLL
Mvan_4452|M.vanbaalenii_PYR-1 -------------------------------------MAEDLDLETSELL
TH_1842|M.thermoresistible__bu -------------------------------------MADDVDIEASGLL
MAV_1415|M.avium_104 -----------------------MTSHDGLPALYVDDVHDGDDRDIEDLL
MUL_4940|M.ulcerans_Agy99 -------------------------------------MAADVDIEASGLL
MAB_4771|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00201|M.leprae_Br4923 PPQDRVELQDLPIRNLAISTLSVVVAFSTGFAVNLKLLMPVFRWQRRDNR
Mb2235|M.bovis_AF2122/97 EAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP
Rv2212|M.tuberculosis_H37Rv EAAGIANPRERAGLLTYLDELGFTVEEMVQAERRGRLFGLAGDVLLWSGP
MMAR_3257|M.marinum_M EAAGIANPRERADLIKYLDDLGFTLEEMAEAERRGRLFGLAGDVLQWPGP
MSMEG_4279|M.smegmatis_MC2_155 EAAGIADARRRAGLISYLDRLGFTAEEMVDAERRGRLFGLAGDRLQASGP
Mflv_2243|M.gilvum_PYR-GCK DGLEGAARAERAELIGWLLDRGVAVDEIRG---NPAPMLLASRRVIGDDG
Mvan_4452|M.vanbaalenii_PYR-1 DGLEGDARGERAELIRWLVGRGVGIDQIRG---NPAPMLLASRRVIGDDG
TH_1842|M.thermoresistible__bu DDLTGEAREQRAELIAWLIERGYSIEEIRE---SVSPMLLASRRLIGDDS
MAV_1415|M.avium_104 DGLQGTARTERAELVRWLLAQGITAEEIRT---TNPPLLLATRHLIGDDG
MUL_4940|M.ulcerans_Agy99 DGLEGTARQDRAELIAWLLERGFSFEHIQAS--AAAPVMLPAYRVLGDDG
MAB_4771|M.abscessus_ATCC_1997 ---------------------------MPESDELNAVVDAAVEQVLLGGP
MLBr_00201|M.leprae_Br4923 LAEADPAATELARSRALRMPFYHTIISLVTWGIGGAVFIIASWSAARHSA
: . . .
Mb2235|M.bovis_AF2122/97 PIYTLATAADELGLSADDVARAWSLLGLT-VAGPDVPTLSQADVDALATW
Rv2212|M.tuberculosis_H37Rv PIYTLATAADELGLSADDVARAWSLLGLT-VAGPDVPTLSQADVDALATW
MMAR_3257|M.marinum_M PIYTLTAAGEQLGLSADDIAHIWALLGLT-VAGPDVPTLSQADVDALATW
MSMEG_4279|M.smegmatis_MC2_155 AIHSLASAADELGLPVAEVERAWAALGLT-VAGVDVPALSAADVEGLRTW
Mflv_2243|M.gilvum_PYR-GCK EYVSARQAADRAGVELELFERIQRAMGLPRVEDPDAEVFLRADAEAAKFT
Mvan_4452|M.vanbaalenii_PYR-1 LYVSARQAAANAGVDLELFERIQRAMGLPRVDDADAQVFLRADAEAAKFT
TH_1842|M.thermoresistible__bu RYVSAAEISRSTGMDLGLLQRMLRALGLPRVDDPDAVVHLRADAEAAARA
MAV_1415|M.avium_104 TYVSTREISETYGIDMALLQRVQRAIGLVRVDDPDAAVHMRADGEAAAFT
MUL_4940|M.ulcerans_Agy99 TLVSAREICAATGIELDVLQRLQRAVSLPRIDDPDEAVLPRADAEAVRHA
MAB_4771|M.abscessus_ATCC_1997 RRYTRSQVSQLSGVPVERARTLWVALGFAAADSDDEVAFTDADVSAIRTF
MLBr_00201|M.leprae_Br4923 PIVALATALGATATAIIGYLQSERVLRPVAVAALRSGVPENVKTPGVTLR
: . : . .. .
Mb2235|M.bovis_AF2122/97 VALKAL-VGEDG-AFGLLRVLGTAMARLAEAES-TMIRAGSPNIQMTHTH
Rv2212|M.tuberculosis_H37Rv VALKAL-VGEDG-AFGLLRVLGTAMARLAEAES-TMIRAGSPNIQMTHTH
MMAR_3257|M.marinum_M LAVKSV-VGEDG-AFGLLRVLGAAMARLAEAES-TMIRAGTPDIQMTYTN
MSMEG_4279|M.smegmatis_MC2_155 SEMRAF-LGDQA-ATGLLRVIGSALARISEAES-SMVRATSPDIMIDVTH
Mflv_2243|M.gilvum_PYR-GCK RDFLDVGIGLDE-LVQITRLLGDGLARAAEAMRYAALAAVIRPAATELET
Mvan_4452|M.vanbaalenii_PYR-1 RDFLDAGIDPDE-LVQITRLLGDGLSRAAEAMRYAALAAVIRPGATELEI
TH_1842|M.thermoresistible__bu QRFIEAGVDPDQ-MVQIAAVLSEGLAKAAELMRSTVVAAVLQPGKTELQI
MAV_1415|M.avium_104 QRFVDVGLDPDQ-VVLVAQVLAEGLSRAAEVMRYSALSAIMRPGATELEI
MUL_4940|M.ulcerans_Agy99 KVFLDIGYDLED-AVAVMRVLVESLGHAAAMMREAALKTLLRPGFSEIEL
MAB_4771|M.abscessus_ATCC_1997 AALGSATAANQQSQIAAARTLGQAMARLAEWQADLLTREVG--GRLAAEG
MLBr_00201|M.leprae_Br4923 LMLTWVPSTGVPVLAIVLAVVADKIALLHAVPEQLFSPILLLALAVLVVG
. : :.
Mb2235|M.bovis_AF2122/97 DELATARAYRAAAEFVPRIGALIDTVHR----------------------
Rv2212|M.tuberculosis_H37Rv DELATARAYRAAAEFVPRIGALIDTVHR----------------------
MMAR_3257|M.marinum_M DELATAQAYRAVAEFVPRIGTLIDIVHR----------------------
MSMEG_4279|M.smegmatis_MC2_155 DELATAQAYRTAAAYIPRIGALMDAAHR----------------------
Mflv_2243|M.gilvum_PYR-GCK AKASEELVGNVAPLLGPMIQEVLLLQLR----------------------
Mvan_4452|M.vanbaalenii_PYR-1 AQQSEALVAGLAPLLGPMIQEVLLLQLR----------------------
TH_1842|M.thermoresistible__bu AQDAEALVRRLAPLLGPMIQDLLLLQLR----------------------
MAV_1415|M.avium_104 AKASKALVTQIAPLLGPMIQQMLFMQLR----------------------
MUL_4940|M.ulcerans_Agy99 AEASEQLAQAAIPLLPPMMDDLMRLELR----------------------
MAB_4771|M.abscessus_ATCC_1997 DDASAESSANAATQTIATLTALQNYAWQ----------------------
MLBr_00201|M.leprae_Br4923 LVSTWLVAMSIADPLRQLRWALSEVQRGNYNAHMQIYDASELGLLQAGFN
: :
Mb2235|M.bovis_AF2122/97 -----------------HHLASARTYFEGVIGD--TSASVTCGIGFADLS
Rv2212|M.tuberculosis_H37Rv -----------------HHLASARTYFEGVIGD--TSASVTCGIGFADLS
MMAR_3257|M.marinum_M -----------------HHLTSARTHFEGVTRD--ASASVVCGIGFADLS
MSMEG_4279|M.smegmatis_MC2_155 -----------------HHLMSTRTYFEHVIRD--GSTTGECGVGFADLS
Mflv_2243|M.gilvum_PYR-GCK -----------------HAIETEAINATERAEGQHLPGARLVTIGFADLV
Mvan_4452|M.vanbaalenii_PYR-1 -----------------HAIETEAVNATERAEGQHLPGARLVTIGFADLV
TH_1842|M.thermoresistible__bu -----------------HAMETEAVSVTERAQGVPLPGARLVSIAFADLV
MAV_1415|M.avium_104 -----------------HMMETEAVNAAERAAGKPLPGARQITVAFADLV
MUL_4940|M.ulcerans_Agy99 -----------------HSVETEAVNAAERAAG-TLPGARPVTVAFADMA
MAB_4771|M.abscessus_ATCC_1997 -----------------RHLAAALHRANETGST-----TRQLLVGFADMV
MLBr_00201|M.leprae_Br4923 DMVRELSERQRLRDLFGRYVGEDVARRALEHGTELGGQERDVAVLFVDLI
: : : *.*:
Mb2235|M.bovis_AF2122/97 SFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSS
Rv2212|M.tuberculosis_H37Rv SFTALTQALTPAQLQDLLTEFDAAVTDVVHADGGRLVKFIGDAVMWVSSS
MMAR_3257|M.marinum_M SFTVLTQTLTPTELQGLLNEFGAAVADVVHADGGRVVKFIGDAVMWVSST
MSMEG_4279|M.smegmatis_MC2_155 DFTALTQMLTTVELTDLLNEFSSAASDVVHAAGGRVVKFIGDAVMWVATT
Mflv_2243|M.gilvum_PYR-GCK GFTRLGEALPPEDLERLAQRLADLTREIAVAP-VRFIKTIGDEVMLVSPE
Mvan_4452|M.vanbaalenii_PYR-1 GFTRLGEAVPPEDLEQLSQRLADMTREFAVAP-VRFIKTIGDEVMLVSPE
TH_1842|M.thermoresistible__bu GFTRLGEAVPPEELEQLAARLADLAREVAEPP-VRFIKTIGDAVMLVSVD
MAV_1415|M.avium_104 GFTRIGEAVSPEELGQLANRLAILARDVTVPP-VRFVKTIGDAVMFVCPE
MUL_4940|M.ulcerans_Agy99 GFTRLGEVMPAEDLERVAARLADLAHDAATMP-VRFVKSIGDAVMLVCPE
MAB_4771|M.abscessus_ATCC_1997 GYTRLSRHLDPDELASLLETFETALTEAITTHGGWVIKNVGDEVMFAAAS
MLBr_00201|M.leprae_Br4923 GSTQLAETKPPTKVVHLLNEFFRVVVDTVGRHGGFVNKFQGDAALAIFGA
. * : . . .: : : : . * ** .:
Mb2235|M.bovis_AF2122/97 PER-------LVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNG-----
Rv2212|M.tuberculosis_H37Rv PER-------LVRAAVDLVDHPGARAAELQVRAGLAYGTVLALNG-----
MMAR_3257|M.marinum_M PQR-------LAQAAVDLVHHPRAREEGLQVRAGLAYGTALAING-----
MSMEG_4279|M.smegmatis_MC2_155 PHL-------LARAAVDLVEHPKARQAHVRVRAGLDFGAVLAING-----
Mflv_2243|M.gilvum_PYR-GCK PAP-------LLETMLRLVEETEGDDDFPRLRAGVATGMAVSRAG-----
Mvan_4452|M.vanbaalenii_PYR-1 PAP-------LLDTLLRLVDETEDDDDFPRLRAGVATGLAVSRAG-----
TH_1842|M.thermoresistible__bu PAE-------LLAAMLELIDGTGADQDFPRVRAGMATGMAVSRAG-----
MAV_1415|M.avium_104 PRP-------LLDVVLKLVEAVDTDNEFPRLRAGVASGTAVSRAG-----
MUL_4940|M.ulcerans_Agy99 PAP-------LLRAALDLAAAAANN--LPPLRIGVASGAAVTRAG-----
MAB_4771|M.abscessus_ATCC_1997 AAAG---ARIAVAMNTAITEAAQTIPDMPQIRVGLAYGQVLSRFG-----
MLBr_00201|M.leprae_Br4923 PIEHPDSAGAALSAARELHDELLPVLGSAEFGIGVSAGRAIAGHIGAQAR
. : . *: * .::
Mb2235|M.bovis_AF2122/97 ---DYFGNPVNLAARLVAAAA--PGQILAAAQLRDMLP---DWPALAHGP
Rv2212|M.tuberculosis_H37Rv ---DYFGNPVNLAARLVAAAA--PGQILAAAQLRDMLP---DWPALAHGP
MMAR_3257|M.marinum_M ---DYFGTPVNLAARLVAAAA--PGQVLADAALHDQLP---DWPTIPRGK
MSMEG_4279|M.smegmatis_MC2_155 ---DYFGNSVNLAARLVQAAE--PGQVLVSAALREALG---DWPATGPRE
Mflv_2243|M.gilvum_PYR-GCK ---DWFGSPVNLAARMTGAAR--PGTVLVAEAAREAIGEDDRFAWSFAGA
Mvan_4452|M.vanbaalenii_PYR-1 ---DWFGSPVNLAARVTGAAR--PGSVLVAEATREAIGEDERFTWSFAGG
TH_1842|M.thermoresistible__bu ---DWYGSPVNLASRVTGVAR--PGSVLVAEATREAIGDDERFRWSFAGS
MAV_1415|M.avium_104 ---DWFGSPVNVASRVTAVAR--PGTVLVADSVWDVIGDNGEFSGSFAGA
MUL_4940|M.ulcerans_Agy99 ---DWFGSPVNLASRVTSIAY--PGTVVVAESTRDAVGNAGDFEWFSIGA
MAB_4771|M.abscessus_ATCC_1997 ---DLYGTVVNIAARLTGVAR--PGTILLDDGAAAALGDDGEFSLRHLRG
MLBr_00201|M.leprae_Br4923 FEYTVIGDPVNEAARLTELAKLEDGHVLASAIAVSGALDAEALCWNVGEI
* ** *:*:. * * ::
Mb2235|M.bovis_AF2122/97 LTLKGFDAPVMAFELHDNPRARDADTPSPAASD
Rv2212|M.tuberculosis_H37Rv LTLKGFDAPVMAFELHDNPRARDADTPSPAASD
MMAR_3257|M.marinum_M LTLKGFDDPVNAFELQGSADRPDGGQAGPRCGD
MSMEG_4279|M.smegmatis_MC2_155 LKLKGFDHPIPAFALT------------PRESG
Mflv_2243|M.gilvum_PYR-GCK KHLKGIKSDVKSFRARWAPADSH----------
Mvan_4452|M.vanbaalenii_PYR-1 KHLKGFKSDVKTFRARRTTNL------------
TH_1842|M.thermoresistible__bu RRLKGIKGEVKLYRARRAE--------------
MAV_1415|M.avium_104 RRLKGIKNEVKLFRVRRGG--------------
MUL_4940|M.ulcerans_Agy99 QRIRGMRAEVKLFRVEPARPAGRG---------
MAB_4771|M.abscessus_ATCC_1997 VRVKGFSRLGSHVLRARKR--------------
MLBr_00201|M.leprae_Br4923 VELRGRTAPTQLARPLNLAVPEQITSEVTG---
::*