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ALASSSDAHKAIGRAVLRPRQQVEETIKAAILSGELRSGEMLPPEAELARQFNVSRTTLREALRSLVSQH LITKIPGARGGNVVRAVDYRALSSVMTEAVDNLLALGGIGFDEVADVRQFLEVPSVRLAAKHRSSAELAT LADIVQRQKEASVDDPDIPELDRQFHTLIAQASGNRVLASLVSALHQATEPVHYLNLSPEVGRETVRQHA AILRSVQHQDADAAEKAIVEHLTYLSRHIQAHRAN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4121 | - | - | 100% (246) | GntR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2605 | - | 4e-27 | 32.44% (225) | transcriptional regulator, GntR family protein |
| M. smegmatis MC2 155 | MSMEG_0895 | - | 1e-19 | 30.94% (223) | GntR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3086c | - | 1e-08 | 24.68% (231) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2114 | - | 3e-19 | 30.53% (226) | GntR domain-containing protein |
| M. tuberculosis H37Rv | Rv3060c | - | 1e-08 | 24.68% (231) | GntR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4644c | - | 3e-13 | 31.90% (163) | GntR family transcriptional regulator |
| M. marinum M | MMAR_3975 | - | 1e-16 | 27.97% (236) | FadR family transcriptional regulator |
| M. avium 104 | MAV_2560 | - | 6e-23 | 33.03% (218) | regulatory protein GntR, HTH |
| M. thermoresistible (build 8) | TH_2873 | - | 2e-21 | 32.11% (218) | PUTATIVE regulatory protein GntR, HTH |
| M. ulcerans Agy99 | MUL_3832 | - | 6e-17 | 28.81% (236) | FadR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0294 | - | 4e-21 | 33.33% (234) | GntR domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2560|M.avium_104 ----------------MEVTSLREPKMADRVATVLRRMFIRGEITEGTML
TH_2873|M.thermoresistible__bu ------------VEDDMEVTSLREPKMADRVATVLRRMFIRGEIPEGTML
Mflv_2114|M.gilvum_PYR-GCK MARSTPLAPMIGPDAVASRTAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
MMAR_3975|M.marinum_M -----MTALGIGPD---PRRRLSAPRIAEIVADELRRQIIDGELADGDLL
MUL_3832|M.ulcerans_Agy99 -----MTALGIGPD---PRRRLSAPRIAEIVADELRRQIIDGELADGDLL
Mb3086c|M.bovis_AF2122/97 --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
Rv3060c|M.tuberculosis_H37Rv --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
Mvan_0294|M.vanbaalenii_PYR-1 --------MNAPGGEAIPPLIRRPQSVSVALAAHFERLIATGEISPGTRL
MAB_4644c|M.abscessus_ATCC_199 -----------------MHPRLSSQSLAEQVANILAAQIGDGRWSTGAKL
MSMEG_4121|M.smegmatis_MC2_155 -------MALASSSDAHKAIGRAVLRPRQQVEETIKAAILSGELRSGEML
: : . * *
MAV_2560|M.avium_104 PPESELMERFGVSRPTLREAFRVLESESLIQVQRGVRGGARVTRPRRETL
TH_2873|M.thermoresistible__bu PPESELMERFGVSRPTLREAFRVLESESLIVVQRGVRGGARVTRPRRETL
Mflv_2114|M.gilvum_PYR-GCK PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
MMAR_3975|M.marinum_M PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKTSA
MUL_3832|M.ulcerans_Agy99 PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKASA
Mb3086c|M.bovis_AF2122/97 GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
Rv3060c|M.tuberculosis_H37Rv GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
Mvan_0294|M.vanbaalenii_PYR-1 PSERELAASMSVSRSSLREAMHELESKRLVSRTRGR--GTIVLAP---TA
MAB_4644c|M.abscessus_ATCC_199 PGEVALCEEFGVSRATVREAIRDLKTKGLVSTRQGAGVFVTSDRP-----
MSMEG_4121|M.smegmatis_MC2_155 PPEAELARQFNVSRTTLREALRSLVSQHLITKIPGARGGNVVRAVDYRAL
: * : ** :***.: : . : *
MAV_2560|M.avium_104 ARYAGLILE----YEGVTVKDVYDARVTLEVPMVEQLAK--DRNPKVIAE
TH_2873|M.thermoresistible__bu ARYAGLILE----YEGVTVKDVYEARVALEVPMVVQLAK--DRNPAVIAE
Mflv_2114|M.gilvum_PYR-GCK ARPAGLLLE----LSGATIADLLTAKSAIEPMAARLLAE--SGSAAAFDE
MMAR_3975|M.marinum_M AYMLGLLLQ----SESVAVSDLGAALQELEPACAALAAQRPDRADTLVPE
MUL_3832|M.ulcerans_Agy99 AYMLGLLLQ----SESVAVSDLGAALQELEPACAALAAQRPDRADTLVPE
Mb3086c|M.bovis_AF2122/97 TRAVVIYLE----YLGTTIGDLLGARLVLEPLAASLAAEHIDEPG-----
Rv3060c|M.tuberculosis_H37Rv TRAVVIYLE----YLGTTIGDLLGARLVLEPLAASLAAEHIDEPG-----
Mvan_0294|M.vanbaalenii_PYR-1 SVDELLAIA----GGGTEQEHAAELRSVIEPSIAELAAHRATSAN--VLQ
MAB_4644c|M.abscessus_ATCC_199 --LGQWDRV----LAAAEIDAVVEIRRLLEVQAAGLAAERRNRSDVAAIR
MSMEG_4121|M.smegmatis_MC2_155 SSVMTEAVDNLLALGGIGFDEVADVRQFLEVPSVRLAAK--HRSSAELAT
. :* . *.
MAV_2560|M.avium_104 LEQIVERESQLNPGSEAVDQLT-DFHAAIARLSGNSTLQIVSDMLHHIIE
TH_2873|M.thermoresistible__bu LERIVEAESKLEPGAETVSQLT-DFHGAIARLSGNKTLQIVTDMLHHVIE
Mflv_2114|M.gilvum_PYR-GCK LEQLLEELVADSHQSPRLAEATGAFHLRVVQLSGNATLSIVAGMLHEITV
MMAR_3975|M.marinum_M LKRVNEAMSEHLDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWT
MUL_3832|M.ulcerans_Agy99 LKRVNEAMSEHLDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWT
Mb3086c|M.bovis_AF2122/97 IERLRAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTK
Rv3060c|M.tuberculosis_H37Rv IERLRAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTK
Mvan_0294|M.vanbaalenii_PYR-1 LRDVLDKSHENLLQAESL-RLDIEFHLLLAQAAQNPLLTALQTLASEWTG
MAB_4644c|M.abscessus_ATCC_199 RALVARAKAESAGDDIEYVDADLEFHRAVVAAVHNPLLDELFDSFSVRMR
MSMEG_4121|M.smegmatis_MC2_155 LADIVQRQKEASVDDPDIPELDRQFHTLIAQASGNRVLASLVSALHQATE
: *: :. * : .
MAV_2560|M.avium_104 KANRSLQPTKGTR----AEQAVRRSAKTHRMVLDMIKEGDAEKAGELWKR
TH_2873|M.thermoresistible__bu KANRSLQPTEGTR----AEQAVKKSTKTHRMVLDYIKAGDAEKAGELWQK
Mflv_2114|M.gilvum_PYR-GCK RHTAFVFNERRPV----SKADYETLLRSYRRLLQFLRSRDADGAEAHWRR
MMAR_3975|M.marinum_M SHEQQWADESAARGTYPSLTKRRAVLNTHIKLTETIAEGDVDRARRIAGR
MUL_3832|M.ulcerans_Agy99 SHEQQWADESAARGTYPSLAKRRAVLNAHIKLTETIAEGDVDRARRIAGR
Mb3086c|M.bovis_AF2122/97 RYVQKSGTQSAGE----AVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSER
Rv3060c|M.tuberculosis_H37Rv RYVQKSGTQSAGE----AVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSER
Mvan_0294|M.vanbaalenii_PYR-1 EVRKHSHSTRHGR---------CASVRGHQEIFDAVRTHDGLAARQAMED
MAB_4644c|M.abscessus_ATCC_199 EAMLALLAGSAER---------PHDQEHHQWLFDAIVDGSTRRAVELATD
MSMEG_4121|M.smegmatis_MC2_155 PVHYLNLSPEVGR----------ETVRQHAAILRSVQHQDADAAEKAIVE
. : : : . *
MAV_2560|M.avium_104 HLQKAEEFVLTGAELSTVVDLLE---------------------------
TH_2873|M.thermoresistible__bu HLQKAGEYLLSGTEMSTVVDLLE---------------------------
Mflv_2114|M.gilvum_PYR-GCK HLDKTRELLLAGLESVPVRDVMG---------------------------
MMAR_3975|M.marinum_M HLADTQTYVLSGRAEQRIYALSPQALSRPRDMRRP---------------
MUL_3832|M.ulcerans_Agy99 HLADTQTYVLSGRAEQRIYALSPQALSRPRDMRRP---------------
Mb3086c|M.bovis_AF2122/97 HVEAVAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAA
Rv3060c|M.tuberculosis_H37Rv HVEAVAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAA
Mvan_0294|M.vanbaalenii_PYR-1 HLRDVSELVAKATRS-----------------------------------
MAB_4644c|M.abscessus_ATCC_199 QLQHVRMR------------------------------------------
MSMEG_4121|M.smegmatis_MC2_155 HLTYLSRHIQAHRAN-----------------------------------
::
MAV_2560|M.avium_104 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 TIGDDIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMR
Rv3060c|M.tuberculosis_H37Rv TIGDDIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMR
Mvan_0294|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4121|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2560|M.avium_104 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 RGPGGGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKV
Rv3060c|M.tuberculosis_H37Rv RGPGGGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKV
Mvan_0294|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4121|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2560|M.avium_104 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 VKRRSEPEVASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTM
Rv3060c|M.tuberculosis_H37Rv VKRRSEPEVASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTM
Mvan_0294|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4121|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2560|M.avium_104 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 LDLFLLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSL
Rv3060c|M.tuberculosis_H37Rv LDLFLLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSL
Mvan_0294|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_4121|M.smegmatis_MC2_155 --------------------------------------------------
MAV_2560|M.avium_104 -----------------
TH_2873|M.thermoresistible__bu -----------------
Mflv_2114|M.gilvum_PYR-GCK -----------------
MMAR_3975|M.marinum_M -----------------
MUL_3832|M.ulcerans_Agy99 -----------------
Mb3086c|M.bovis_AF2122/97 ARCRTRRHLDAAASWWL
Rv3060c|M.tuberculosis_H37Rv ARCRTRRHLDAAASWWL
Mvan_0294|M.vanbaalenii_PYR-1 -----------------
MAB_4644c|M.abscessus_ATCC_199 -----------------
MSMEG_4121|M.smegmatis_MC2_155 -----------------