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SASPQWWGPALDDDGRSLRDVLDEFIDAHEPTLTDDVTAVTALVRELAGLGIWTLGTAETAGGGGADRTL TTVAFERLGRAWPALGWAAVQAHTAIDVLAGDDRFADLVTALHVGNAAVAVADAQSLHVRLQRDGAAITG TVDRVDAAAEEPHLLVLFDGGTAALIEPAALTRDPVHRTGLGGALTRSLDIDARAAHVVDGVDVDAARVR LRLGAAAVAAGIAGAAADAAVSYAAERRQFGDTLTAIPTVRKSLMEQTSRAVLILGAVLGAAEDPIQAAA VALHALDGAIDVAADALQSHGGYGYLVEYDAERRLRDAVSLRAAADVRGQATTTARTLVGVGPAGISAKD *
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4113 | - | - | 100% (351) | acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1497 | - | 4e-15 | 28.20% (383) | acyl-CoA dehydrogenase family protein member 8 |
| M. smegmatis MC2 155 | MSMEG_1991 | - | 1e-14 | 25.54% (325) | isovaleryl-CoA dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3593 | fadE32 | 8e-15 | 28.09% (299) | acyl-CoA dehydrogenase FADE32 |
| M. gilvum PYR-GCK | Mflv_5011 | - | 8e-16 | 27.32% (355) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0752c | fadE9 | 9e-15 | 29.19% (322) | acyl-CoA dehydrogenase FADE9 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 9e-11 | 36.75% (117) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3123 | - | 6e-20 | 29.34% (317) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_0455 | fadE3_2 | 7e-16 | 24.72% (356) | acyl-CoA dehydrogenase FadE3_2 |
| M. avium 104 | MAV_1267 | - | 2e-15 | 29.34% (334) | acyl-CoA dehydrogenase domain-containing protein |
| M. thermoresistible (build 8) | TH_3278 | - | 7e-19 | 30.25% (357) | PUTATIVE acyl-CoA dehydrogenase FadE22 |
| M. ulcerans Agy99 | MUL_4024 | fadE3 | 6e-16 | 24.72% (356) | acyl-CoA dehydrogenase FadE3 |
| M. vanbaalenii PYR-1 | Mvan_0221 | - | 2e-14 | 24.52% (367) | butyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1267|M.avium_104 -------------------------------MNLELTDEQVALRDTTRRF
TH_3278|M.thermoresistible__bu -------------------------------MAIALTDDHRELAEVARSF
Mflv_5011|M.gilvum_PYR-GCK ------------------------------MDYFGLDDDDRVIAETAAAF
Rv0752c|M.tuberculosis_H37Rv --------------------------------MFVLNDDERVIVETAAAF
MLBr_00737|M.leprae_Br4923 ---------------------MVGWSGNPLFDLFKLPEEHNELRATIRAL
MMAR_0455|M.marinum_M --------------------------MDNQRADSQLDEDEAMLVATVRAF
MUL_4024|M.ulcerans_Agy99 -------------------------MMNNDSPDSQLDEDEAMLVATVRAF
Mvan_0221|M.vanbaalenii_PYR-1 --------------------------MVEG-----LSSEEAMLVETVRTF
MAB_3123|M.abscessus_ATCC_1997 MSASEDHQTRMSASEDNQTRMSASEDNQAQINEFEFTEEHGDLRSLVRSW
Mb3593|M.bovis_AF2122/97 -----------------------------MTMEFALNEQQRDFAASIDAA
MSMEG_4113|M.smegmatis_MC2_155 ------------------------MSASPQWWGPALDDDGRSLRDVLDEF
: .: :
MAV_1267|M.avium_104 LAEKAPIAHHVRRLLDDPTGIEPAVWRGL-ADLGCTGLLVPEQHGGAGMT
TH_3278|M.thermoresistible__bu LTSQQARAAAR-ALLDADDEARPPFWSEL-AGLGWLGLHISEKHGGSGYG
Mflv_5011|M.gilvum_PYR-GCK AEKRLAPHALE---WDETHHFPVDVLREA-AELGMAAIYCGEDAGGSGLR
Rv0752c|M.tuberculosis_H37Rv AGKRLAPHALE---WDAAKHFPVDVLREA-AELGMAAIYCRDDVGGSGLR
MLBr_00737|M.leprae_Br4923 AEKEIAPHAAD---VDQRARFPEEALAAL-NASGFNAIHVPEEYGGQGAD
MMAR_0455|M.marinum_M IDRDVKPSVRE---VEHANTYPQAWIEQM-KRIGIYGLAIGEAYGGSPVS
MUL_4024|M.ulcerans_Agy99 IDRDVRPSVRE---VEHANTYPQAWIEQM-KRIGIYGLAIGEAYGGSPVS
Mvan_0221|M.vanbaalenii_PYR-1 IDREVRPTVRD---VEHANTYPEAWIEKM-KQIGIFGLAIPESEGGAPVS
MAB_3123|M.abscessus_ATCC_1997 CERVWTPKHVR--QIAEAGSVDLDAWRALGSELGVVGLSLPEQHGGGGLG
Mb3593|M.bovis_AF2122/97 LGAADLPGVVR--AWAAGDVAPGRKVWQQLANLGVTALGVAEKFDGLGAS
MSMEG_4113|M.smegmatis_MC2_155 IDAHEPTLTDD--------VTAVTALVRELAGLGIWTLGTAETAGGGGAD
* : : .*
MAV_1267|M.avium_104 MVEAGIVAEELGAALYPGPWLSTAVAAPRALIRLCAGGDTAAGLLRGIAD
TH_3278|M.thermoresistible__bu LPELVVVVEELGRAVAPGPFVPTVVAS--AVLADAGSDEQRDRLLPGLVD
Mflv_5011|M.gilvum_PYR-GCK RIDAVRIFEKLSTADPTVAAFLSIHNMCAWMVDSFGTEEQRKLWVPKLAS
Rv0752c|M.tuberculosis_H37Rv RLDGVRIFEQLAIADPVTAAFLSIHNMCAWMIDSFGTDEQRKDWIPRLAT
MLBr_00737|M.leprae_Br4923 SVAACIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAA
MMAR_0455|M.marinum_M MPCYVQVTQELARGWMSLAGAMGGHTVVAKLLMLFGTDEQKSTYLPAMAT
MUL_4024|M.ulcerans_Agy99 MPCYVQVTQELARGWMSLAGAMGGHTVVAKLLMLFGTDEQKSTYLPAMAT
Mvan_0221|M.vanbaalenii_PYR-1 TRCYVLVTQELARGWMSLAGAMGGHTVVAKLLSLFGTDEQKQRYLPPMAT
MAB_3123|M.abscessus_ATCC_1997 VIELSIVAEELGRALACLPWISSAALGATALVSS-GDDSALAEWVPALAA
Mb3593|M.bovis_AF2122/97 PVDLVVALERLGRWCVPGPVTESIAVAPILLAHDDRAERSHG-----LAS
MSMEG_4113|M.smegmatis_MC2_155 RTLTTVAFERLGRAWPALGWAAVQAHTAIDVLAG---DDRFADLVTALHV
:.:. :
MAV_1267|M.avium_104 GTTHVAVCFLDTP--------PMAATREGE----TTVLHGQARAVPDAAA
TH_3278|M.thermoresistible__bu GSVVAAVGLGG----------DLRVEGPVE----AATASGTAGVVLGAGR
Mflv_5011|M.gilvum_PYR-GCK MDAIASYCLTEPGAGSDASALRTKAVRSGD----EYVLDGVKQFISGAGT
Rv0752c|M.tuberculosis_H37Rv MGVIASYCLTEPGAGSDAGALSTRAVRHGSGKGGDYVLDGVKQFISGAAA
MLBr_00737|M.leprae_Br4923 EGAMASYALSEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGK
MMAR_0455|M.marinum_M GELRATMALTEPGGGSDLQNMSTTAMADGP---DQLLITGAKTWISNARR
MUL_4024|M.ulcerans_Agy99 GELRATMALTEPGGGSDLQNMSTTAMADGP---DQLLITGAKTWISNARR
Mvan_0221|M.vanbaalenii_PYR-1 GELRATMALTEPGGGSDLQAMSTVARRDG----DELVISGAKTWISNARR
MAB_3123|M.abscessus_ATCC_1997 GEKTITLAGGRTR---LADAITVSAESDTD----GWKLTGDTEHVPDGAT
Mb3593|M.bovis_AF2122/97 GELIATVAMPP-----------------------------RVPRAVDADT
MSMEG_4113|M.smegmatis_MC2_155 GNAAVAVADAQS--------LHVRLQRDGA------AITGTVDRVDAAAE
: .
MAV_1267|M.avium_104 ADVLLALAEDAGDT-------ALFGVNTGSAGVAVRPEHHIDPTH--KQS
TH_3278|M.thermoresistible__bu ADLLLLRCGDD-----------VLIVDRTAPGVTVEVPTNLDPTR--RSG
Mflv_5011|M.gilvum_PYR-GCK SDVYIVMARTGSD---GPKGISAFVVPKDTPGLSFGTDEVKMGWNAQPTR
Rv0752c|M.tuberculosis_H37Rv SDVYVVMARTGAE---GPRGVSAFIVEKGTPGLSFGAPEAKMGWHAQPTA
MLBr_00737|M.leprae_Br4923 STWYTVMAVTDPDK--GANGISAFIVHKDDEGFSIGPKEKKLGIKGSPTT
MMAR_0455|M.marinum_M SGLIALLCKTDPHATPRHHGISIVLVE-PGPGLNISADLPKLGYKGVEAC
MUL_4024|M.ulcerans_Agy99 SGLIALLCKTDPHATPRHHGISIVLVE-PGPGLNISADLPKLGYKGVEAC
Mvan_0221|M.vanbaalenii_PYR-1 SGLIALLCKTDPEATPRHSGISVVLVDNPTDGLTVSRDLPKLGYKGVESC
MAB_3123|M.abscessus_ATCC_1997 ADVILVLADTDSGP-------SLFAVDGDAPGVDRHSLATLDMTR--RQA
Mb3593|M.bovis_AF2122/97 AGLVLLAGDGS--------------VTEGTPGDCHRSVDPSRRLYEVAAS
MSMEG_4113|M.smegmatis_MC2_155 EPHLLVLFDGG-------------TAALIEPAALTRDPVHRTGLGGALTR
. .
MAV_1267|M.avium_104 RVTFD--AAPARRLATAS------ADDVAAVVDDVLIAACADALGAARAV
TH_3278|M.thermoresistible__bu RVTLT--GVAVTDVLPGA------AETALALAR---TLFAAEAAGGAVEC
Mflv_5011|M.gilvum_PYR-GCK QVILEGARVPADALLGGPDGEGTGFGIAMKGLNGGRINIAACSLGGAQAA
Rv0752c|M.tuberculosis_H37Rv QVVLDGVRVPAEAMLGGADGEGAGFGIAMSGLNGGRLNIAACSLGGAQAA
MLBr_00737|M.leprae_Br4923 ELYFDKCRIPGDRIIGEP---GTGFKTALATLDHTRPTIGAQAVGIAQGA
MMAR_0455|M.marinum_M ELSFDNYRAPTSAILGGQ--PGQGFSQMMKGLETGRIQVAARALGVASAA
MUL_4024|M.ulcerans_Agy99 ELSFDNYRAPTSAILGGQ--PGQGFSQMMKGLETGRIQVAARALGVASAA
Mvan_0221|M.vanbaalenii_PYR-1 ELTFDGCRVPESAILGGA--AGRGFAQMMKGLETGRIQVASRALGVASAA
MAB_3123|M.abscessus_ATCC_1997 NIHFN---SAPARLIGAQ---GRGAEAVATALDVAATVLAAEQAGIAAHM
Mb3593|M.bovis_AF2122/97 GQAWRAP-----------------KDVVARAYEFGALATAAQLVGAGQAL
MSMEG_4113|M.smegmatis_MC2_155 SLDIDARAAHVVDGVDVD-----------AARVRLRLGAAAVAAGIAGAA
: * .
MAV_1267|M.avium_104 MDLAVEYAKTRTQFGQPIGSFQAVQHLCVDMYETVELARSGVIHALWVSD
TH_3278|M.thermoresistible__bu VETAVEYAKVRRQFGRVIGTFQAVKHHCANMAVAAESAIATVWDAARAAA
Mflv_5011|M.gilvum_PYR-GCK YDKTVSYLADRQAFGGSLLDEPTIRFTLADMATGLETSRALLWRAATALD
Rv0752c|M.tuberculosis_H37Rv FDKAGAYVRDRQAFGGSLLDEPTVRFTLADMATGLQTSRMLLWRAASALD
MLBr_00737|M.leprae_Br4923 LDAAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAE
MMAR_0455|M.marinum_M LDDALAYAQQRHSFGQPIWKHQAIGNYLADMATKLTAARQLTHYAAQRYD
MUL_4024|M.ulcerans_Agy99 LDDALAYAQQRHSFGQPIWKHQAIGNYLADMATKLTAARQLTHYAAQRYD
Mvan_0221|M.vanbaalenii_PYR-1 LADALAYAQDRESFGQPIWKHQAVGHYLADMATKLTAARQLTLYAADRYD
MAB_3123|M.abscessus_ATCC_1997 LDVTTEYAKSRIQFGRIIGSFQAVKHRLADMAAATGNVRGAAYHAAWSHD
Mb3593|M.bovis_AF2122/97 LEAAVNYAKQRTQFGRAIGSYQAIKHKLADVHIAIELACPLVYGAAVSLE
MSMEG_4113|M.smegmatis_MC2_155 ADAAVSYAAERRQFGDTLTAIPTVRKSLMEQTSRAVLILGAVLGAAEDP-
: * * ** : :: : *
MAV_1267|M.avium_104 APDGDERHLAA-LRAKAFAGRLAGVADTAIQVFGGIGYTWEHDAHLYLKR
TH_3278|M.thermoresistible__bu GDPAEFRLMAA-AAAALAFPAYVHNAELNIQVHGGIGYTWEHDAHLHLRR
Mflv_5011|M.gilvum_PYR-GCK NDHPDRVELCA-MAKRYVTDACFEVADQALQLHGGYGYLREYGLEKIVRD
Rv0752c|M.tuberculosis_H37Rv DDDADKVELCA-MAKRYVTDTCFEVADQALQLHGGYGYLREYGLEKIVRD
MLBr_00737|M.leprae_Br4923 RGEPDLGFISA-ASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRD
MMAR_0455|M.marinum_M SGQ-RCDMEAG-MAKLFASETAMEIALNAVRIHGGYGYSTEYDVERYFRD
MUL_4024|M.ulcerans_Agy99 SGQ-RCDMEAG-MAKLFASETAMEIALNAVRIHGGYGYSTEYDVERYFRD
Mvan_0221|M.vanbaalenii_PYR-1 SGA-RADMEAG-MAKLFASEVAMEIALNAVRIHGGYGYSTEYDVERYFRD
MAB_3123|M.abscessus_ATCC_1997 HPSLDDPALATSIAQQVASAGAVEVTAKAIQSHGGIGFTWEHPAHLYYKR
Mb3593|M.bovis_AF2122/97 PRDVSAAKAAA-------SEAALLAARSALQTHGAIGFTCEHDLSLWLLR
MSMEG_4113|M.smegmatis_MC2_155 --------IQAAAVALHALDGAIDVAADALQSHGGYGYLVEYDAERRLRD
: :: .*. *: :.
MAV_1267|M.avium_104 LLGYSAFLGG--PDRYLTEVGARLAKRGSP--------------------
TH_3278|M.thermoresistible__bu ALAVRGVLGGDGPAADVHALTAAGVTRENSLDLPPEAEEMRGRIRADIEE
Mflv_5011|M.gilvum_PYR-GCK LRVHRILEGTNEIMRVVIGRSAASRARAS---------------------
Rv0752c|M.tuberculosis_H37Rv LRVHRILEGTNEIMRLVIGRAEAARFRATV--------------------
MLBr_00737|M.leprae_Br4923 AKITQIYEGTNQIQRVVMSRALLR--------------------------
MMAR_0455|M.marinum_M APLMIVGEGTNEIQRNVIARQLIARGGI----------------------
MUL_4024|M.ulcerans_Agy99 APLMIVGEGTNEIQRNVIARQLIARGGI----------------------
Mvan_0221|M.vanbaalenii_PYR-1 APLMIVGEGTNEIQRNVIAGQLVARGGI----------------------
MAB_3123|M.abscessus_ATCC_1997 AVSNSALFGGRAVHAERIAKEVIDA-------------------------
Mb3593|M.bovis_AF2122/97 VQALHSAWGTPQEHRRRVLEAL----------------------------
MSMEG_4113|M.smegmatis_MC2_155 AVSLRAAADVRGQATTTARTLVGVGPAGISAKD-----------------
.
MAV_1267|M.avium_104 --------------------------------------------------
TH_3278|M.thermoresistible__bu IAALDGNAQRDRLIETGYIMPHWPKPWGRGADAVEQLVIDEEFARAGIER
Mflv_5011|M.gilvum_PYR-GCK --------------------------------------------------
Rv0752c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_0455|M.marinum_M --------------------------------------------------
MUL_4024|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0221|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3123|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_4113|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1267|M.avium_104 --------------------------------------------------
TH_3278|M.thermoresistible__bu PDYSITGWVILTLIQHGTPSQIERFVEKALRQEEIWCQLFSEPDAGSDAA
Mflv_5011|M.gilvum_PYR-GCK --------------------------------------------------
Rv0752c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_0455|M.marinum_M --------------------------------------------------
MUL_4024|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0221|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3123|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_4113|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1267|M.avium_104 --------------------------------------------------
TH_3278|M.thermoresistible__bu AVKTRAIRVDGGWKVTGQKVWTSGAHYCRRGLATVRTDPDAPKHAGITTM
Mflv_5011|M.gilvum_PYR-GCK --------------------------------------------------
Rv0752c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_0455|M.marinum_M --------------------------------------------------
MUL_4024|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0221|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3123|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_4113|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1267|M.avium_104 --------------------------------------------------
TH_3278|M.thermoresistible__bu IIDMHAPGVEVRPLRMITGGAEFNEVFFNDVFVPDEDVVGEPNTGWTVAR
Mflv_5011|M.gilvum_PYR-GCK --------------------------------------------------
Rv0752c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_0455|M.marinum_M --------------------------------------------------
MUL_4024|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0221|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3123|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_4113|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1267|M.avium_104 --------------------------------------------------
TH_3278|M.thermoresistible__bu ATLGNERVSIGGGSGARVFAATSLIPLVQRHADRLAGAEVRVGTFLAEEH
Mflv_5011|M.gilvum_PYR-GCK --------------------------------------------------
Rv0752c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_0455|M.marinum_M --------------------------------------------------
MUL_4024|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0221|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3123|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_4113|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1267|M.avium_104 --------------------------------------------------
TH_3278|M.thermoresistible__bu ALRLLNLRRAVRSIEGAGPGPEGNITKLKLAEHMNERAAIMAGLLGPELA
Mflv_5011|M.gilvum_PYR-GCK --------------------------------------------------
Rv0752c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_0455|M.marinum_M --------------------------------------------------
MUL_4024|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0221|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3123|M.abscessus_ATCC_1997 --------------------------------------------------
Mb3593|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_4113|M.smegmatis_MC2_155 --------------------------------------------------
MAV_1267|M.avium_104 -----------------------------------------------
TH_3278|M.thermoresistible__bu LLDGDTAVAGLMVLGARGMAIAGGTSEVTRNQIAERILGLPRDPLIT
Mflv_5011|M.gilvum_PYR-GCK -----------------------------------------------
Rv0752c|M.tuberculosis_H37Rv -----------------------------------------------
MLBr_00737|M.leprae_Br4923 -----------------------------------------------
MMAR_0455|M.marinum_M -----------------------------------------------
MUL_4024|M.ulcerans_Agy99 -----------------------------------------------
Mvan_0221|M.vanbaalenii_PYR-1 -----------------------------------------------
MAB_3123|M.abscessus_ATCC_1997 -----------------------------------------------
Mb3593|M.bovis_AF2122/97 -----------------------------------------------
MSMEG_4113|M.smegmatis_MC2_155 -----------------------------------------------