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LGRIDVHQHIVPPAWHSAMEAMIGAGTPWPQPPHWSASAALTFMDDAEIDTGILSVTAPGVVLDGFTTTD AQSLAIAVNDQTAEVVKDRPDRFGFFASLPLPDVDGAITEAVRAFDELSADGVVLQSNVRGRYLGDPSFE PLWAELNERSAVVHIHPNQPPLPALAGTPFPLADFIFDTTRSALDMALRGVPRRYPRMRVILSHGGGFLP YAAHRFAALAPEQVDANLTPTDLIADLQWFYMDTALASSPTSWPALRAFAAPGHVVYGSDWPFAPPHVSA YFDSHLEEVSSQGELDEASWGAAQRLFPRLAARVSTI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4043 | - | - | 100% (317) | amidohydrolase 2 |
| M. smegmatis MC2 155 | MSMEG_6813 | - | 2e-63 | 42.36% (314) | amidohydrolase 2 |
| M. smegmatis MC2 155 | MSMEG_5364 | - | 1e-21 | 30.23% (258) | amidohydrolase 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2325c | - | 5e-06 | 25.73% (171) | antibiotic-resistance protein |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2303c | - | 5e-06 | 25.73% (171) | antibiotic-resistance protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0299 | - | 4e-28 | 32.59% (316) | putative amidohydrolase (aminocarboxymuconate-semialdehyde |
| M. marinum M | MMAR_1500 | - | 1e-64 | 41.35% (312) | hypothetical protein MMAR_1500 |
| M. avium 104 | MAV_2515 | - | 3e-68 | 44.73% (313) | amidohydrolase 2 |
| M. thermoresistible (build 8) | TH_1451 | - | 4e-06 | 24.67% (300) | amidohydrolase family protein |
| M. ulcerans Agy99 | MUL_2437 | - | 8e-65 | 41.67% (312) | hypothetical protein MUL_2437 |
| M. vanbaalenii PYR-1 | Mvan_0424 | - | 1e-06 | 22.49% (289) | amidohydrolase 2 |
CLUSTAL 2.0.9 multiple sequence alignment
TH_1451|M.thermoresistible__bu --------------------------------------------------
Mvan_0424|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2325c|M.bovis_AF2122/97 -----------------------------------------------MTA
Rv2303c|M.tuberculosis_H37Rv -----------------------------------------------MTA
MMAR_1500|M.marinum_M --------------------------------------------------
MUL_2437|M.ulcerans_Agy99 MGTRLEPHRGRRIHLGADDLPGNQHLGPYSRGTAHHRQVGPVQDGGAFVA
MAV_2515|M.avium_104 --------------------------------------------------
MSMEG_4043|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0299|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1451|M.thermoresistible__bu ------VRELWRGLG-LPGLIDVHTHFMPKRVMD--KVWRYFDSAGPLVG
Mvan_0424|M.vanbaalenii_PYR-1 MDEPESARRIWQALE-LPGIVDVHTHFMPKNVMD--KVWRYFDDAGPLVG
Mb2325c|M.bovis_AF2122/97 PEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKTTISAEQFG
Rv2303c|M.tuberculosis_H37Rv PEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKTTISAEQFG
MMAR_1500|M.marinum_M -----------------MWRIDTHHHMIPPDYRRALRNAGVDGAGGRALP
MUL_2437|M.ulcerans_Agy99 AARGQRGAALRPGKEFAIWRIDTHHHMIPPDYRRALRNAGVDGAGGRALP
MAV_2515|M.avium_104 -----------------MLRIDTHHHLIPPDYRKALQQKGIDEAGGRALP
MSMEG_4043|M.smegmatis_MC2_155 -----------------MGRIDVHQHIVPPAWHSAMEAMIGAGTPWPQPP
MAB_0299|M.abscessus_ATCC_1997 ---------------MTSVRIDIHAHLWSDEYLSLLDGYGRPATDVHRGL
:* . .
TH_1451|M.thermoresistible__bu REWPISYRLA--ETERVEV---LRGFGVTRFTSLVYPHKP--DMAAWLNQ
Mvan_0424|M.vanbaalenii_PYR-1 RPWPITYRSD--ENARLHT---LRSFGVLAFTSLIYAHKP--DMAAWLNQ
Mb2325c|M.bovis_AF2122/97 -AYAESLRRT--DDQILDS---LDDAGITRSLITGFDERSTCGVTFVHNA
Rv2303c|M.tuberculosis_H37Rv -AYAESLRRT--DDQILDS---LDDAGITRSLITGFDERSTCGVTFVHNA
MMAR_1500|M.marinum_M -DWSPAGSLQ--AMAELTVGAAILSVSAPATAFLP-QASDAAALARDIND
MUL_2437|M.ulcerans_Agy99 -DWSPAGSLQ--AMAELTVGAAILSVSAPATAFLP-QASDAAALARDIND
MAV_2515|M.avium_104 -DWSPEASLQ--TMAELDVGTAILSVSTPGTTFLS-EPADAAALARDLND
MSMEG_4043|M.smegmatis_MC2_155 -HWSASAALT--FMDDAEIDTGILSVTAPGVVLDGFTTTDAQSLAIAVND
MAB_0299|M.abscessus_ATCC_1997 GAGATRDDLDGRFELMDEAGVDLQILTATPASPHFEDQAAAVASARFIND
. : : *
TH_1451|M.thermoresistible__bu WAAEFARTTPDCLATAT----FYPEPGVAEYVTRAIDDGVRVFKVHVQVG
Mvan_0424|M.vanbaalenii_PYR-1 WAAGFAADTPDCMATAT----FYPEPGAAGYVSAAIESGTRVFKAHVQVG
Mb2325c|M.bovis_AF2122/97 SVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRPFMI
Rv2303c|M.tuberculosis_H37Rv SVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRPFMI
MMAR_1500|M.marinum_M YAADIVAGRPTQFGFFATVPMPHLDQSVAETVRALDDLKADGVVLLANHA
MUL_2437|M.ulcerans_Agy99 YAADVVAGRPAQFGFFATVPMPHLDQSVAETVRALDDLKADGVVLLANHA
MAV_2515|M.avium_104 YTAELAAAQPDRFGFFATVPMPHVDAAVAETVRALDELSADGVVLLANNA
MSMEG_4043|M.smegmatis_MC2_155 QTAEVVKDRPDRFGFFASLPLPDVDGAITEAVRAFDELSADGVVLQSNVR
MAB_0299|M.abscessus_ATCC_1997 EYAKLSSEYPGRFGALASLPLPHVPAALEELARAIDELGMYGASITTSVL
* . * : : . :
TH_1451|M.thermoresistible__bu GYDPTDPLLDDVWGVIEDAGVPVVIHCG---SGPAPGE------------
Mvan_0424|M.vanbaalenii_PYR-1 DYDPTDPLLDDVWGLIEDAGTPVVIHCG---SGPAPGR------------
Mb2325c|M.bovis_AF2122/97 GRPASDPAYFPCYAKCVELGVPVSIHTS---ADWTRTR------------
Rv2303c|M.tuberculosis_H37Rv GRPASDPAYFPCYAKCVELGVPVSIHTS---ADWTRTR------------
MMAR_1500|M.marinum_M GVYLGEDGQDDLFTALNSRAAVVFVHPA---ELPGPAVPGVAPWAGDFLL
MUL_2437|M.ulcerans_Agy99 GVYLGEDGQDDLFTALNSRAAVVFVHPA---ELPGPAVPGVAPWAGDFLL
MAV_2515|M.avium_104 GVYVGQDGQDALFDALNHRSAVVFIHPA---ELPGPTVPGVAPFAADFLL
MSMEG_4043|M.smegmatis_MC2_155 GRYLGDPSFEPLWAELNERSAVVHIHPN---QPPLPALAGTPFPLADFIF
MAB_0299|M.abscessus_ATCC_1997 GRSIADPIFDPLYAELNRRRAVLFVHPAGCGAESSLITDHSLTWSIGAPI
. : : . : :*
TH_1451|M.thermoresistible__bu -FTG---PEPVRSLLGRHPRLRLIIAHMG--MPEYVDFIDLAE----RFD
Mvan_0424|M.vanbaalenii_PYR-1 -YTG---PAPIRAVLAEHPRLRLVIAHMG--GPEYSEFLDLCR----DFE
Mb2325c|M.bovis_AF2122/97 -LSDLGHPRHIDDVACRFPELTILMSHGG--YPWVLQACLIAW----KHP
Rv2303c|M.tuberculosis_H37Rv -LSDLGHPRHIDDVACRFPELTILMSHGG--YPWVLQACLIAW----KHP
MMAR_1500|M.marinum_M DTTRAAHLLVRNGIRQRYPDIKFVLSHAGGFVPYASHRLALAI--TADTG
MUL_2437|M.ulcerans_Agy99 DTTRAAHLLVRNGIRQRYPDINFVLSHAGGFVPYASHRLALVI--TADTG
MAV_2515|M.avium_104 DTTRSAYLLVRNGIRNRYPNIRFLLSHAGGFVPYASHRMAMAI--MADTG
MSMEG_4043|M.smegmatis_MC2_155 DTTRSALDMALRGVPRRYPRMRVILSHGGGFLPYAAHRFAALAPEQVDAN
MAB_0299|M.abscessus_ATCC_1997 EDTVAIMHLIVAGVPSRYPDMKIVTCHLGGALPMVLERAHRQVT-EWEAT
: : ..* : .: .* * * .
TH_1451|M.thermoresistible__bu GVRLDTTMAFTD-FAEKVMPFPADQYPRLAGLG--ERIVFGSDFPNIPYP
Mvan_0424|M.vanbaalenii_PYR-1 QLHLDTTMAFTG-FTEKNMPFPAGEYGRLRDMG--DRILFGSDFPNIPYG
Mb2325c|M.bovis_AF2122/97 NVYLELAAHRPKYFASPGAGWEPLMRFGQTTIR--NKIVYGTGGFLINRP
Rv2303c|M.tuberculosis_H37Rv NVYLELAAHRPKYFASPGAGWEPLMRFGQTTIR--NKIVYGTGGFLINRP
MMAR_1500|M.marinum_M RSPADVLEEFSSFYFDTALSSSAAALPTLIAFAKPGHITFGSDWPFAPTA
MUL_2437|M.ulcerans_Agy99 RSPADVLEEFSSFYFDTALSSSAAALPTLIAFAKPGHITFGSDWPFAPTA
MAV_2515|M.avium_104 RSFADVLDDFSSFYFDTALSSSAAALPSLLAFARPGHITFGSDWPFAPVA
MSMEG_4043|M.smegmatis_MC2_155 LTPTDLIADLQWFYMDTALASSPTSWPALRAFAAPGHVVYGSDWPFAPPH
MAB_0299|M.abscessus_ATCC_1997 QCPEAPRDAARRLWYDTVGHDHTPALRAAVASLGVDRLIFGSDFPYQAGP
: . . :: :*:.
TH_1451|M.thermoresistible__bu YPHALQVLTELPG----IDDDWLCNVLYRNAAELFRV-------------
Mvan_0424|M.vanbaalenii_PYR-1 YTHAMSVLTELPC----VDDTWLRNVFHDNAVRLFGATGSCPGLPSAEPH
Mb2325c|M.bovis_AF2122/97 YLQLCDEMRALP-----VPREVLEDWLWRNATRVLRLDT-----------
Rv2303c|M.tuberculosis_H37Rv YLQLCDEMRALP-----VPREVLEDWLWRNATRVLRLDT-----------
MMAR_1500|M.marinum_M AGKLFAAGLETYP---ALDAAARGAIDRGSALSLFPRFGVAAPPPQPSAA
MUL_2437|M.ulcerans_Agy99 AGKLFAAGLETYP---ALDAAARGAIDRGSALSLFPRFGVAAPPPQPSAA
MAV_2515|M.avium_104 VGKLFAAGLETYP---ALDTSTRGAIEHTNALALFPRLGTPPHPIPQSPA
MSMEG_4043|M.smegmatis_MC2_155 VSAYFDSHLEEVSSQGELDEASWGAAQR-----LFPRLAARVSTI-----
MAB_0299|M.abscessus_ATCC_1997 RYVSSATYIEEG-----LSAEDASAILDHNGAELLGLTGV----------
: ::
TH_1451|M.thermoresistible__bu -----------------------
Mvan_0424|M.vanbaalenii_PYR-1 RVRKAAP----------------
Mb2325c|M.bovis_AF2122/97 -----------------------
Rv2303c|M.tuberculosis_H37Rv -----------------------
MMAR_1500|M.marinum_M QRIRHTLSRTAMRGVARLMNSGG
MUL_2437|M.ulcerans_Agy99 QRIRHTLSRTAMRGVARLMNSGG
MAV_2515|M.avium_104 QRIRHSLSRGAMRVVARMTSTS-
MSMEG_4043|M.smegmatis_MC2_155 -----------------------
MAB_0299|M.abscessus_ATCC_1997 -----------------------