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QWNRAITMTEAVPRNLSDLLRRSASAHPDSVFAFPDQRYTYAEMDVRVGDFVRMLRRAGVQAGDHVGLWM PASLDMIAAIVACARAGAVTVAINDRFRIDELSYVIAHSDLAAVITIAPTQHSDRPAELLSAIPGLAEAP GPDLALTATPRLRRIIVLADDGYSPPARAFTHQSAVGLPTTHPRERTSRHGVEEEEPAPGGEVAYLMYTS GTSASPKACMIAHVAVVAQGTSLAFDRYLLDETSVFWCPLPLFHTAGLATLTACITAGASFVHAGVFDPA QSLRAMVEERVTHAIPCFETIWMRILDHPDFAVADLSSLRVLMNTGGEDLLRKLQARVPHAIQLANYGIT EGSGHVAMTTVADPLDVRVCTGGKPLPGMEARIVDLDTREPVAPNVLGEIQFRGESRFLGYYRDEEANAA CIDAEGWFTSGDLGVLDEAGRLTFKGRIKDMLKVGGENVSALEVESYLLRHPAVAVVAVVGAPDAYYGEV PVAYIQLTREHKLTEADVIDFCLDRIATYKVPRYVRFVDEWPMSGTKIRKVELRERIRTELTAGGITQAP RLQSRRARSVVQHSSE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4019 | - | - | 100% (577) | AMP-dependent synthetase and ligase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 2e-64 | 32.35% (541) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 2e-52 | 29.61% (537) | feruloyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 2e-66 | 33.71% (525) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4867 | - | 2e-68 | 34.27% (534) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 2e-66 | 33.71% (525) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01051 | xclC | 1e-34 | 32.10% (377) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 3e-66 | 32.08% (558) | AMP-binding domain protein |
| M. marinum M | MMAR_3852 | fadD35 | 2e-62 | 33.33% (522) | fatty-acid-CoA ligase FadD35 |
| M. avium 104 | MAV_0600 | fadD | 2e-61 | 33.09% (547) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 4e-64 | 33.99% (556) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 1e-58 | 33.03% (548) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1563 | - | 2e-68 | 34.12% (551) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2533c|M.bovis_AF2122/97 MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVA
Rv2505c|M.tuberculosis_H37Rv MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVA
MMAR_3852|M.marinum_M MATTAAADQNQLSYDRGPIAPALLEMTIGANLAATASQCESRDALVDVRS
Mflv_4867|M.gilvum_PYR-GCK ---------MTGSYDAGPTDVAILEETIGANFARIARTHPGRDALVDVAG
Mvan_1563|M.vanbaalenii_PYR-1 ---------MSQSYDAGPTDTAILEETIGANFERIAATYPDHEALVDVTG
MAB_4377c|M.abscessus_ATCC_199 ----------MKAYDAGATLSPIIEETIGENFERIARAHPDVGALVDVSG
MSMEG_4019|M.smegmatis_MC2_155 -----------MQWNRAITMTEAVPRNLSDLLRRSASAHPDS---VFAFP
MAV_0600|M.avium_104 --------------------MTTDPRTVPAALDRLARRLPDHDALIT---
MUL_4126|M.ulcerans_Agy99 --------------------MTSDPRTVPTALDRLVRRLPNHDALVT---
TH_2068|M.thermoresistible__bu ------------------------MRTIPAVLDRAAERLPDHDALVTAAT
MLBr_01051|M.leprae_Br4923 --------------------------MLLASLNPSVVTATDIADAVCVDG
: : . :
Mb2533c|M.bovis_AF2122/97 ----RRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQY
Rv2505c|M.tuberculosis_H37Rv ----RRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQY
MMAR_3852|M.marinum_M ----GRRWSYAQLLTDVRQLATGLVRAGIGRGDRVGIWAPNRWEWVLVQY
Mflv_4867|M.gilvum_PYR-GCK ----GRRWTYAELDAEIDTVARGLMAIGVERGDRVGIWAPNCPEWVIVQY
Mvan_1563|M.vanbaalenii_PYR-1 ----GRRWTYAELDREIDTVAKGLMSLGTESGDRVGIWAPNCPEWTIVQY
MAB_4377c|M.abscessus_ATCC_199 ----DRRWTYRELDAEINRVARGLMSLGVAAGDRVGIWAPNCAEWVLVQY
MSMEG_4019|M.smegmatis_MC2_155 ----DQRYTYAEMDVRVGDFVRMLRRAGVQAGDHVGLWMPASLDMIAAIV
MAV_0600|M.avium_104 ---EDRSFTAAALRDEVHRAAAALIELGVRAGDRVAIWSPNTWHWVVACL
MUL_4126|M.ulcerans_Agy99 ---DERSFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTWHWVVACL
TH_2068|M.thermoresistible__bu GGAEARRFSYAELRAEVRRAAAAMIAAGIAPGDRVALWAPNTWHWVVACL
MLBr_01051|M.leprae_Br4923 ----------VVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAIT
: . . *.: . .
Mb2533c|M.bovis_AF2122/97 ATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAE
Rv2505c|M.tuberculosis_H37Rv ATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAE
MMAR_3852|M.marinum_M ATAEIGAVLVTINPAYQARELEYALRQSGVAMVIAASGFKGSDYAAILAE
Mflv_4867|M.gilvum_PYR-GCK ATAKIGAILVNINPAYRTHELRYVLEQSGVATLISATQFKTSDYVAMVDE
Mvan_1563|M.vanbaalenii_PYR-1 ATAKIGAILVNINPAYRTHELSYVLEQSGVSTLISATRFKTSDYVAMVDE
MAB_4377c|M.abscessus_ATCC_199 ATAKIGAILVNINPAYRTHELAYALNQSGVRTLICAKAFKSSDYVAMASQ
MSMEG_4019|M.smegmatis_MC2_155 ACARAGAVTVAINDRFRIDELSYVIAHSDLAAVITIAPTQHSDRPAELLS
MAV_0600|M.avium_104 AIHHAGAAMVPLNTRYTAAEAGDILARVGAPVLFGMGRFLGHDRLADLDR
MUL_4126|M.ulcerans_Agy99 AIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAMGHFLGSDRVAGLDR
TH_2068|M.thermoresistible__bu ATHYAGAVMVPLNTRYTASEAADVLARTGAPLLVAAGEFLGADKTADLDR
MLBr_01051|M.leprae_Br4923 GCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADS--------
. *. * : * : .
Mb2533c|M.bovis_AF2122/97 VGP-------------RCPDLADVILLESD----RWDALAG----AEPDL
Rv2505c|M.tuberculosis_H37Rv VGP-------------RCPDLADVILLESD----RWDALAG----AEPDL
MMAR_3852|M.marinum_M VAP-------------GCPELHDVAFLDGD----GWAKLAG----SGADL
Mflv_4867|M.gilvum_PYR-GCK VRP-------------DVPALQRVLFIGTA----DWDTLRAAG--SGVDD
Mvan_1563|M.vanbaalenii_PYR-1 VRP-------------DVPALQRVLFIGTD----DWDRLRSRA--DVIDD
MAB_4377c|M.abscessus_ATCC_199 VMP-------------DAPGLRDVVFIGTS----DWTELVAGA--ERVTE
MSMEG_4019|M.smegmatis_MC2_155 AIPGLAEAPGPDLALTATPRLRRIIVLADD----GYSPPARAF--THQSA
MAV_0600|M.avium_104 AALP------------ALRHIVRIPIETDDPVPGSWDEFIAHG----TDL
MUL_4126|M.ulcerans_Agy99 KALP------------ALRHIVRIPIEEPD---GTWDEFIETG----TDT
TH_2068|M.thermoresistible__bu DALP------------ALRRIVRIPVDKPD---GTWDEFIAGGSMSGAAL
MLBr_01051|M.leprae_Br4923 ----------------APDGLPHIPVQLDAR-------------------
: : .
Mb2533c|M.bovis_AF2122/97 PALQQTAARLDGS-------------DPVNIQYTSGTTAYPKGVTLSHRN
Rv2505c|M.tuberculosis_H37Rv PALQQTAARLDGS-------------DPVNIQYTSGTTAYPKGVTLSHRN
MMAR_3852|M.marinum_M VALQEIATTLSAD-------------DPINIQYTSGTTGFPKGVTLSHRN
Mflv_4867|M.gilvum_PYR-GCK ADLRRRSGALSNR-------------DPINIQYTSGTTGFPKGATLSHRN
Mvan_1563|M.vanbaalenii_PYR-1 ALLRERSASLSHH-------------DPVNIQYTSGTTGFPKGATLSHRN
MAB_4377c|M.abscessus_ATCC_199 TALRARMSQLSNT-------------DPINIQYTSGTTGYPKGATLSHRN
MSMEG_4019|M.smegmatis_MC2_155 VGLPTTHPRERTSRHGVEEEEPAPGGEVAYLMYTSGTSASPKACMIAHVA
MAV_0600|M.avium_104 GAVAERAAAVTSD-------------DVSDILFTSGTTGRSKGVLCAHRQ
MUL_4126|M.ulcerans_Agy99 GAVTARAAAVSPD-------------DVSDILFTSGTTGRSKGVLCAHRQ
TH_2068|M.thermoresistible__bu AEVDARAAAVRPD-------------DVSDILFTSGTTGRSKGALCAHRQ
MLBr_01051|M.leprae_Br4923 --SWNRYPEPSPD-------------ATAMVIYTSGTTGPPKGVLLSRRA
: :****:. .*. ::
Mb2533c|M.bovis_AF2122/97 ILNNG-YLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIP
Rv2505c|M.tuberculosis_H37Rv ILNNG-YLVGELLGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIP
MMAR_3852|M.marinum_M ILNNG-YLVGELLEYTAEDRICIPVPFYHCFGMVMGNLAATSHGACMVIP
Mflv_4867|M.gilvum_PYR-GCK ILNNG-FFVTEQIRLQPGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVIP
Mvan_1563|M.vanbaalenii_PYR-1 ILNNG-FFVTEQIRLGPGDRLCIPVPFYHCFGMVMGNLGCTTHGATMVIP
MAB_4377c|M.abscessus_ATCC_199 VLNNG-FFVAESIQLQAGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVMP
MSMEG_4019|M.smegmatis_MC2_155 VVAQGTSLAFDRYLLDETSVFWCPLPLFHTAGLAT--LTACITAGASFVH
MAV_0600|M.avium_104 SLSAS-ASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQTG-ATLIP
MUL_4126|M.ulcerans_Agy99 SLSAS-ASWAANGKITADDRHLCINPFFHNFGYKAGILACLQTG-ATLFP
TH_2068|M.thermoresistible__bu SLDAS-AAWAECGRLSSDDRYLCINPFFHNFGYKAGILACIQTG-ATLYP
MLBr_01051|M.leprae_Br4923 IAVDL-DALAQAWQWTADDVLVHGLPLFHVHGLVLGLLGSLRIG-NRFVH
. *::* * * . . .
Mb2533c|M.bovis_AF2122/97 APGFDPAATLRAVQDERCT-SLYGVPTMFIAELGLPDFTDYELGSLRTGI
Rv2505c|M.tuberculosis_H37Rv APGFDPAATLRAVQDERCT-SLYGVPTMFIAELGLPDFTDYELGSLRTGI
MMAR_3852|M.marinum_M APGFDPAATLRAVQAERCT-SLYGVPTMFIAELGLADFATYDLSSLRTGI
Mflv_4867|M.gilvum_PYR-GCK APAFDPGLTLRAIETERCT-AVYGVPTMFIAMQNHPDFAERDLSTLRTGI
Mvan_1563|M.vanbaalenii_PYR-1 APGFDPGQTLKTIETERCT-AVYGVPTMFIAMQNHADFAERDLSSLRTGI
MAB_4377c|M.abscessus_ATCC_199 APGFDPGRTLEAIERERCV-GVYGVPTMFIAMLADPGFAHRDLSTLRTGI
MSMEG_4019|M.smegmatis_MC2_155 AGVFDPAQSLRAMVEERVTHAIPCFETIWMRILDHPDFAVADLSSLRVLM
MAV_0600|M.avium_104 HLTFDPLRALQAIEQHRIT-VLPGPPTIYQTLLDHPARRDYDLSSLRFAV
MUL_4126|M.ulcerans_Agy99 HLTFDPLRTLQAIERHRIT-VLPGPPTIYQTLLDHPARDDYDLSSLRFAV
TH_2068|M.thermoresistible__bu QLTFDPEQAMRAVAEHRIT-VLPGPPTIYQTILDHPKRGEYDLSSLRFAV
MLBr_01051|M.leprae_Br4923 TGKPTPTAYAQACSEAGGS-LYFGVPTVWSRLVADEAVAR-ALRPARLLV
* .: *:: * . * :
Mb2533c|M.bovis_AF2122/97 MAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVG
Rv2505c|M.tuberculosis_H37Rv MAGAACPVEVMRKVISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVG
MMAR_3852|M.marinum_M MAGSTCPVEVMRKVIDQMHMAGISICYGMTETSPVATQTRSNDSLQRRVT
Mflv_4867|M.gilvum_PYR-GCK MAGAVCPVEVMKRCVEEMHLTEMSIAYGMTETSPVSCQTLIDDDLERRTS
Mvan_1563|M.vanbaalenii_PYR-1 MAGAVCPVEVMKRCVEEMNMSEISIAYGMTETSPVSCQTLIDDDLERRTS
MAB_4377c|M.abscessus_ATCC_199 MAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETSPVSCQTLFDDDLDRRTA
MSMEG_4019|M.smegmatis_MC2_155 NTGGE---DLLRKLQARVPHAIQLANYGITEGSGHVAMTTVADPLDVRVC
MAV_0600|M.avium_104 TGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDDAVTVAT
MUL_4126|M.ulcerans_Agy99 TGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVAT
TH_2068|M.thermoresistible__bu TGAAVVPVVLIERMQSELDIDIVLTAYGLTEASGFGTMCRPEDDAVTVAT
MLBr_01051|M.leprae_Br4923 SGSASLPVPVFDRLAHLTGHRPIER-YGSTES--LITLSTLAD-GERRAG
.. :. : ** ** * .
Mb2533c|M.bovis_AF2122/97 TVGRVGPHLEIKVVDPATG-ETVPRGVVGEFCTRGYSVMAGYWNDPQKTA
Rv2505c|M.tuberculosis_H37Rv TVGRVGPHLEIKVVDPATG-ETVPRGVVGEFCTRGYSVMAGYWNDPQKTA
MMAR_3852|M.marinum_M TVGRVGPHLEIKVVDPATG-RIVPRGTAGEFCTRGYSVMSGYWKAPERTA
Mflv_4867|M.gilvum_PYR-GCK TIGRVHPHVEIKIVDPETG-EIVERGTPGEFCTRGYSVMLGYWREDEKTA
Mvan_1563|M.vanbaalenii_PYR-1 SIGRVHPHVEIKIVDPDTG-HVVERGTPGEFCTRGYSVMLGYWRDEEKTA
MAB_4377c|M.abscessus_ATCC_199 TVGRAHPHIEIKIVDPNSG-ETVQRGQSGELCTRGYSVMLGYWNDEAHTR
MSMEG_4019|M.smegmatis_MC2_155 TGGKPLPGMEARIVDLDTR-EPVAPNVLGEIQFRGESRFLGYYRDEEANA
MAV_0600|M.avium_104 TCGRPFADFELRID------------DSGEVLLRGPNVMLGYLDDPDATA
MUL_4126|M.ulcerans_Agy99 TCGRPFADFELRIGP-----------DTGEVLLRGPNVMLGYLDDPRATA
TH_2068|M.thermoresistible__bu TCGRPIAGFELRIDNP-------AEDGTGEVLLRGPNVMLGYLDDPEATA
MLBr_01051|M.leprae_Br4923 WVGLPLAGVQTRLVDESGGPVPYDGETVGRLQVRSPTMFGGYLNRPEATA
* . .: :: *.. *. . : ** .
Mb2533c|M.bovis_AF2122/97 EVIDADGWMHTGDLAEMDPSGYVRIAGR-IKDLVVRGGENISPREIEELL
Rv2505c|M.tuberculosis_H37Rv EVIDADGWMHTGDLAEMDPSGYVRIAGR-IKDLVVRGGENISPREIEELL
MMAR_3852|M.marinum_M EVIDPEGWMHTGDLALMDECGYVQITGR-IKDIVVRGGENISPREIEEFL
Mflv_4867|M.gilvum_PYR-GCK QAIDADGWMHTGDLAVMRPDGYCNIVGR-IKDVVIRGGENIYPREIEEFL
Mvan_1563|M.vanbaalenii_PYR-1 QAVDADGWMHTGDLAVMRPDGYCNIVGR-IKDVVIRGGENIYPREVEEFL
MAB_4377c|M.abscessus_ATCC_199 EVLDTDGWMHTGDLAVMRDDGYCTIIGR-LKDMVIRGGENIYPREIEEFL
MSMEG_4019|M.smegmatis_MC2_155 ACIDAEGWFTSGDLGVLDEAGRLTFKGR-IKDMLKVGGENVSALEVESYL
MAV_0600|M.avium_104 AAIDADGWLHTGDIGVLDEAGNLRITDR-LKDMYICGGFNVYPAEVEQVL
MUL_4126|M.ulcerans_Agy99 AAIDADGWLHTGDIGVLDEAGNLRITDR-LKDMYICGGFNVYPAEVEQVL
TH_2068|M.thermoresistible__bu AAIDADGWLHTGDVGKVDERGNLTITDR-LKDMYICGGFNVYPAEVEQVL
MLBr_01051|M.leprae_Br4923 EAFDEDGWYRTGDVAVVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMAL
.* :** :**:. : * : .* *: ** .: . *:* *
Mb2533c|M.bovis_AF2122/97 HTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIA
Rv2505c|M.tuberculosis_H37Rv HTHPDIVDGHVIGVPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIA
MMAR_3852|M.marinum_M HSHPDIVDAHVVGVPDERMGEELMAVVKLRAGAPELTTGLLREYCAGQIA
Mflv_4867|M.gilvum_PYR-GCK YTHPDVEDAHVIGVPDDRYGEEVCAWIRMRPGRTALDAAAVREFATDKLA
Mvan_1563|M.vanbaalenii_PYR-1 YTHPDIEDAQVVGVPDARYGEEICAWIRMRPGRRALDAAAVREFAAGKLA
MAB_4377c|M.abscessus_ATCC_199 LTHPDIEDVHVVGVPDEKYGEELCAWVRMRPDRVVIDAVAIRAFASGRLA
MSMEG_4019|M.smegmatis_MC2_155 LRHPAVAVVAVVGAPDAYYGEVPVAYIQLTR-EHKLTEADVIDFCLDRIA
MAV_0600|M.avium_104 ARMEGVADAAVIGVPDERLGEVGRAFVVPRP-GAQLDEQSVIAYTRDHLA
MUL_4126|M.ulcerans_Agy99 ARLDGVADVAVIGIPDHRLGEVGRAFIVARP-GFNLDEKSVIDYTREHLA
TH_2068|M.thermoresistible__bu ARLDGVAEAAVIGVPDQRLGEVGKAFVVRRP-GATLDEQAVIAYCKQHLA
MLBr_01051|M.leprae_Br4923 LGHPDVREVAVVGLPDEDLGQRIVAFVVGAE---ALDADELINYVAQQLS
: *:* ** *: * : : : : :::
Mb2533c|M.bovis_AF2122/97 RFKIPRYLWIVDEFPMTVTGKVRKVEMRQQALEYLRGQQ-----------
Rv2505c|M.tuberculosis_H37Rv RFKIPRYLWIVDEFPMTVTGKVRKVEMRQQALEYLRGQQ-----------
MMAR_3852|M.marinum_M KFKIPRYLRLVDEFPMTVTGKVRKVEMRQQAIEYLRGQH-----------
Mflv_4867|M.gilvum_PYR-GCK HYKIPRYVHVVDEFPMTVTGKIRKVEMREVSARLLGL-------------
Mvan_1563|M.vanbaalenii_PYR-1 HYKIPRYVHVVDEFPMTVTGKIRKVEMREVSAGLFAD-------------
MAB_4377c|M.abscessus_ATCC_199 HYKIPRYVHVVESFPMTVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ----
MSMEG_4019|M.smegmatis_MC2_155 TYKVPRYVRFVDEWPMSGT-KIRKVELRERIRTELTAGGITQAPRLQSRR
MAV_0600|M.avium_104 NFKAPRSVRFVDALPRNSGGKVVKPQLRELD-------------------
MUL_4126|M.ulcerans_Agy99 NFKAPRSVRFVDTLPRNAGGKVVKPQLRELA-------------------
TH_2068|M.thermoresistible__bu NFKVPRSVEFLDALPRNPGGKVVKPLLRERA-------------------
MLBr_01051|M.leprae_Br4923 IHKRPREVRFVDALPRNAMGKVLKKQLLFEG-------------------
.* ** : .:: * . *: * :
Mb2533c|M.bovis_AF2122/97 ----------
Rv2505c|M.tuberculosis_H37Rv ----------
MMAR_3852|M.marinum_M ----------
Mflv_4867|M.gilvum_PYR-GCK ----------
Mvan_1563|M.vanbaalenii_PYR-1 ----------
MAB_4377c|M.abscessus_ATCC_199 ----------
MSMEG_4019|M.smegmatis_MC2_155 ARSVVQHSSE
MAV_0600|M.avium_104 ----------
MUL_4126|M.ulcerans_Agy99 ----------
TH_2068|M.thermoresistible__bu ----------
MLBr_01051|M.leprae_Br4923 ----------