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M. smegmatis MC2 155 MSMEG_4009 (-)

annotation: vanillate O-demethylase oxidoreductase
coordinates: 4083529 - 4083852
length: 107

VITSPRSSRRPSPSPRQMVESFEIELRRSGRVVTVPSDRTALSAVRDVLPTAEFDCLRGECGACVAKVLE
GIPDHRDTVLSERARQAGKRIILCVSRSATPRLVLDL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_4009--100% (107)vanillate O-demethylase oxidoreductase
M. smegmatis MC2 155MSMEG_4152-3e-1946.51% (86) phenoxybenzoate dioxygenase beta subunit
M. smegmatis MC2 155MSMEG_4371-2e-1746.59% (88) vanillate O-demethylase oxidoreductase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2798c-4e-1436.89% (103) oxidoreductase
M. gilvum PYR-GCKMflv_3426-6e-1038.46% (91) ferredoxin
M. tuberculosis H37RvRv2776c-4e-1436.89% (103) oxidoreductase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2381-5e-1841.84% (98) oxidoreductase
M. marinum MMMAR_1933-3e-1640.78% (103) oxidoreductase
M. avium 104MAV_4119-8e-1438.83% (103) oxidoreductase
M. thermoresistible (build 8)TH_4289-2e-1847.13% (87) PUTATIVE ferredoxin
M. ulcerans Agy99MUL_2159-2e-1640.78% (103) oxidoreductase
M. vanbaalenii PYR-1Mvan_3180-3e-1039.08% (87) ferredoxin

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_4009|M.smegmatis_MC2_155      --------------------------------------------------
TH_4289|M.thermoresistible__bu      --------------------------------------------------
MAB_2381|M.abscessus_ATCC_1997      -------------------------------------------------M
Mb2798c|M.bovis_AF2122/97           --------------------------------------------------
Rv2776c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_1933|M.marinum_M               MAVSESSWTSRPADLYGRSHRDRFA-TALWGVRTMFGGFARFSRWNPSRV
MUL_2159|M.ulcerans_Agy99           MAVSESSWTSRPADLYGRSHRDRFA-TALWGVRTMFGGFARFSRWNPSRV
MAV_4119|M.avium_104                MTMAQAIWESIPADLYGRRKRDRMY-TALYGVGALFGGLASASRWTPARV
Mflv_3426|M.gilvum_PYR-GCK          ------------MGVLGRLRYDVTIGLADAALHGMFATSAAMRRIRPP--
Mvan_3180|M.vanbaalenii_PYR-1       MTRLFSQFRQTPPSPSGRLRHDVMLGIAETAIAGMFAASAAVRRVRMP--
                                                                                      

MSMEG_4009|M.smegmatis_MC2_155      --------------------------------------------------
TH_4289|M.thermoresistible__bu      --MNMDLELHVAQKRTIAD--QIVELTLTRPDGGTLPEWTPGAHIDLRLG
MAB_2381|M.abscessus_ATCC_1997      NDTGATLKVAVRQLRWEAD--GVVSLQLSSACNEPLPAWEPGAHVDLVLP
Mb2798c|M.bovis_AF2122/97           --MRRTNPAVVTKRELVAP--DVVALTLADPGGGLLPAWSPGGHIDVQLP
Rv2776c|M.tuberculosis_H37Rv        --MRRTNPAVVTKRELVAP--DVVALTLADPGGGLLPAWSPGGHIDVQLP
MMAR_1933|M.marinum_M               TPVGRTHRARVVERELVAP--DVVALTLADPDGGLLPSWSPGGHIDVQLP
MUL_2159|M.ulcerans_Agy99           TPVGRTHRARVVERELVAP--DVVALTLADPDGGLLPSWSPGGHIDVQLP
MAV_4119|M.avium_104                VPVRRTTTAVVTQREELAP--DVVAFTLADPHGGLLPSWTPGAHIDVRLP
Mflv_3426|M.gilvum_PYR-GCK          DGVPETFPLTVTSRRVVARDQDVVELTLS---GDDLPRWHPGAHLDLHLP
Mvan_3180|M.vanbaalenii_PYR-1       AAGPDTIPLTVTGRRVVAHDQDVVELTLA---GDRLPRWFPGAHLDVHLP
                                                                                      

MSMEG_4009|M.smegmatis_MC2_155      --------------------------------------------------
TH_4289|M.thermoresistible__bu      D-LVRQYSLTGLEARPDRWVVSVLREPAGRGGSQYVHDVLAEGASIGASL
MAB_2381|M.abscessus_ATCC_1997      TGIERQYSLCGPVDDRSVYQVGVRRERTSRGGSEYVHAFLRPGQQLRIKG
Mb2798c|M.bovis_AF2122/97           SGRRRQYSLCGVPGRRTDYRIAIRRIADGGGGSIEMHEAFDVGDTCEFEG
Rv2776c|M.tuberculosis_H37Rv        SGRRRQYSLCGVPGRRTDYRIAIRRIADGGGGSIEMHEAFDVGDTCEFEG
MMAR_1933|M.marinum_M               SGRRRQYSLCGPPGRRTDYRIAVRRIADGGGGSIEMHAAYQPGDILVFEG
MUL_2159|M.ulcerans_Agy99           SRRRRQYSLCGPPGRRTDYRIAVRRIADGGGGSIEMHAAYQPGDILVFEG
MAV_4119|M.avium_104                SGRRRQYSLCGPPGRRTDYRIAVRRIEDGGGGSIEMHDTFRVGDALEFEG
Mflv_3426|M.gilvum_PYR-GCK          SGRIRQYSLCGEP-TAGHYRVAVRRIPDGGGGSVEVHDALPVGSTVRTHG
Mvan_3180|M.vanbaalenii_PYR-1       SGRVRQYSLCGDP-DSAEYRIAVRRIPDGGGGSVEVHDALEIGSTVHTHG
                                                                                      

MSMEG_4009|M.smegmatis_MC2_155      ----------------------------------------------MITS
TH_4289|M.thermoresistible__bu      PRNHFPLRSD-----ADNILFIAGGIGITPMLPMISQLEQQARTWNLIYC
MAB_2381|M.abscessus_ATCC_1997      PRNNFGLHR------ADGYLFIAAGIGITPILPMIRQAQDWGADWTLYYG
Mb2798c|M.bovis_AF2122/97           PRNAFHLGLA-----ERDVLFVIGGIGVTPILPMIRAAEQRGIDWRAIYA
Rv2776c|M.tuberculosis_H37Rv        PRNAFHLGLA-----ERDVLFVIGGIGVTPILPMIRAAEQRGIDWRAIYA
MMAR_1933|M.marinum_M               PRNAFYLGAA-----EHDMLFVIGGIGVTPILPMVALAHQRGVNWRAMYA
MUL_2159|M.ulcerans_Agy99           PRNAFYLGAA-----EHDMLFVIGGIGVTPILPMVALAHQRGVNWRAVYA
MAV_4119|M.avium_104                PRNAFYLVTD-----ERDVLFVIGGIGVTPILPMIQTAQQHGINWRAVYA
Mflv_3426|M.gilvum_PYR-GCK          PRNAFPLAVPGYGSPARRFRFIAGGIGITPILPMLALARSLGVDWSMVYT
Mvan_3180|M.vanbaalenii_PYR-1       PRNAFPLTVPGYGSPARRFRFIAGGIGITPILPMLGLARRLGVDWSMVYT
                                                                                      

MSMEG_4009|M.smegmatis_MC2_155      PRSSR----------------------------------RPSP-------
TH_4289|M.thermoresistible__bu      GRSRTSMAYLDELAKFG-DRVVVRPDDEYG-VPDLAGLIRPTAPDTVVYS
MAB_2381|M.abscessus_ATCC_1997      GHTAASMAFLEELRQYG-PRVHLYPADEVG-RIPLRELTTDVRPGLQIYA
Mb2798c|M.bovis_AF2122/97           GRGREYMPFLDEVVAVAPGRVTVWADDEHGRFASVDELLAGAGPTTAVYV
Rv2776c|M.tuberculosis_H37Rv        GRGREYMPFLDEVVAVAPGRVTVWADDEHGRFASVDELLAGAGPTTAVYV
MMAR_1933|M.marinum_M               GRSREYMPLLDELVAMAPERVSVWADDEHGRFAQVEDLVAGAGPKTAVYV
MUL_2159|M.ulcerans_Agy99           GRSREYMPLLDELVAMAPEGVSVWADDEHGRFAQVEDLVAGAGLKTAVYV
MAV_4119|M.avium_104                GRSRDYMPLLDEVVAVAPERVSVWADDERGRIPTAADLLAEAGPATAVYV
Mflv_3426|M.gilvum_PYR-GCK          GRSADALPFVDEVAAFG-SPVEIRTDDRRG-LPTAAELLGDCPADTSVYA
Mvan_3180|M.vanbaalenii_PYR-1       GRSVDSLPFVDEVTAFG-AAVDIRTDDRHG-LPAAAELLGDCADGTAVYA
                                     :                                                

MSMEG_4009|M.smegmatis_MC2_155      -SPRQMVES-------------------------------FEIELRRSGR
TH_4289|M.thermoresistible__bu      CGPEGMLSTLETVCADPAHSRTLVLERFVPKEYDTEGDTAFEVEFAQSGV
MAB_2381|M.abscessus_ATCC_1997      CGPTELISDLTAAVSHWP-ADTLHVERFKPIPCAPAEDKPVDVTCAASRQ
Mb2798c|M.bovis_AF2122/97           CGPPGMLEAVRVARNQHA-DAPLHYERFSPPP--VVDGVPFELELARSRR
Rv2776c|M.tuberculosis_H37Rv        CGPPGMLEAVRVARNQHA-DAPLHYERFSPPP--VVDGVPFELELARSRR
MMAR_1933|M.marinum_M               CGPPPMLEAVRAARAEYP-CAPLHYERFSPPP--VVDGVPFELELARTGE
MUL_2159|M.ulcerans_Agy99           CGPPPMLEAVRAARAEYP-CAPLHYERFSPPP--VVDGVPFELELARTGE
MAV_4119|M.avium_104                CGPTAMLEAVRTARDEHA-DAPLHYERFGPPP--VVDGVPFELELARSRR
Mflv_3426|M.gilvum_PYR-GCK          CGPAPMLTAVRDALVGRD-DVELHFERFAAPP--VVDGRPFR--VAAAGV
Mvan_3180|M.vanbaalenii_PYR-1       CGPAPMLTAVRAALVGRD-DVELHFERFAAPP--VTDGRPFQATVASTGQ
                                     .*  ::                                 .      :  

MSMEG_4009|M.smegmatis_MC2_155      VVTVPSDRTALSAVRDVLPTAEFDCLRGECGACVAKVLEGIPDHRDTVLS
TH_4289|M.thermoresistible__bu      TVTVPADRSILEVAEEAGIDILSSCSEGTCGTCESPVLEGIPEHRDSVLT
MAB_2381|M.abscessus_ATCC_1997      TIAVPPGQSILAAVEQAGIQVSASCRAGVCGSCETAVLEGVPDHRDDILS
Mb2798c|M.bovis_AF2122/97           VLRVPANRSALDVMLDWDPTTAYSCQQGFCGTCKVRVLAGQVDRRGRIIE
Rv2776c|M.tuberculosis_H37Rv        VLRVPANRSALDVMLDWDPTTAYSCQQGFCGTCKVRVLAGQVDRRGRIIE
MMAR_1933|M.marinum_M               VLSIPANRTALDVMLDRDPTTAYSCQQGFCGTCKVKVLAGQVDHRGRAAQ
MUL_2159|M.ulcerans_Agy99           VLSIPANRTALDVMLDRDPTTAYSCQQGFCGTCKVKVLAGQVDHRGRAAQ
MAV_4119|M.avium_104                VLTVPGNRSALDVMLDRDPATPYSCQQGFCGTCKVKVLAGQVDRRGRTVE
Mflv_3426|M.gilvum_PYR-GCK          TVDVGVDETLLAALGRAGVTTPYSCRQGFCGTCRTRVLSGEVDHRDTLLT
Mvan_3180|M.vanbaalenii_PYR-1       QVDVGADETLLAALRRAGVDASYSCQQGFCGTCRTRVLAGSVEHRDTLLT
                                     : :  ..: * .          .*  * **:*   ** *  ::*.    

MSMEG_4009|M.smegmatis_MC2_155      ERARQAGKRIILCVSRSATPR-LVLDL
TH_4289|M.thermoresistible__bu      KEERASNATMMPCVSRCRTPR-LVLDL
MAB_2381|M.abscessus_ATCC_1997      EEDRAAGDRMYICVSRALTPR-LVLDL
Mb2798c|M.bovis_AF2122/97           GDN-----EMLVCVSRAVSGR-VVIDA
Rv2776c|M.tuberculosis_H37Rv        GDN-----EMLVCVSRAVSGR-VVIDA
MMAR_1933|M.marinum_M               GDD-----EMLVCVSRGHSAR-VVIDA
MUL_2159|M.ulcerans_Agy99           GDD-----EMLVCVSRGHSAR-VVIDA
MAV_4119|M.avium_104                GDD-----EMLVCVSRAKNDR-LVIDA
Mflv_3426|M.gilvum_PYR-GCK          DAERAA-GLMLPCVSRAAEGTVLALDL
Mvan_3180|M.vanbaalenii_PYR-1       GPERAA-GLMLTCVSRAGDGSGLTLDL
                                             :  ****      :.:*