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SRRPDQGACGAPDQVWIDGGTIPVAGEYDVIVVGGGPSGVAAAIAAARRGARTALIERAAFLGGTATGAM VASFMGFYWMDHRVVGGIGFELTQRLEHRGASSGFGRYVLAEASDQSLDVITFPFDPETLKIVLDEMLVE AGVHPYLHAQAISALEEDGVCVGVVYQGVIGRKALRGRTIIDASANGSIAVSAGAAREEARQDPRRRQPM TQVARLVDVDVARFRRLPQPAKQHLARRGLERGVLTQKLLSVLSSPHGDDAIVLMTRVSERDGTDEQQLA LAEIEGRQLVSRLIPFLRAEVPGFENARLGTLASWIGVRETWRVIGDYVITGDDVRVGNSFGDAIALGTG PLDTHHSAGGGLSLAVPERPFQIPYRALLPRNVDGLITTGRCVSATREGMAGLRHMGTVMAMGQAAGTAA ALAAGQGVSPRAISPSAIQEALTRDGAIITAADAVPFTDPETAEQRTSARWSGGTA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1796 | - | - | 100% (477) | membrane protein |
| M. smegmatis MC2 155 | MSMEG_1153 | - | 4e-50 | 32.58% (445) | FAD dependent oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3987 | - | 3e-41 | 28.48% (446) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2732 | sthA | 2e-06 | 52.63% (38) | soluble pyridine nucleotide transhydrogenase |
| M. gilvum PYR-GCK | Mflv_5003 | - | 1e-08 | 43.86% (57) | response regulator receiver modulated FAD-dependent pyridine |
| M. tuberculosis H37Rv | Rv2713 | sthA | 2e-06 | 52.63% (38) | soluble pyridine nucleotide transhydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3032 | - | 2e-06 | 48.00% (50) | soluble pyridine nucleotide transhydrogenase |
| M. marinum M | MMAR_5024 | - | 2e-06 | 53.85% (39) | dehydrogenase |
| M. avium 104 | MAV_0624 | - | 2e-06 | 53.66% (41) | 3-ketosteroid-delta-1-dehydrogenase |
| M. thermoresistible (build 8) | TH_4191 | - | 2e-06 | 48.21% (56) | PUTATIVE 3-ketosteroid-delta4 |
| M. ulcerans Agy99 | MUL_4098 | - | 2e-06 | 53.85% (39) | 3-ketosteroid-delta-1-dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1371 | - | 4e-08 | 42.11% (57) | response regulator receiver modulated FAD-dependent pyridine |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2732|M.bovis_AF2122/97 --------------------------------------------------
Rv2713|M.tuberculosis_H37Rv --------------------------------------------------
MAB_3032|M.abscessus_ATCC_1997 --------------------------------------------MTN---
MMAR_5024|M.marinum_M ---------------------------------------------MFYMT
MUL_4098|M.ulcerans_Agy99 ------------------------------------------------MT
MAV_0624|M.avium_104 ------------------------------------------------MS
Mflv_5003|M.gilvum_PYR-GCK ----------------------------MTGPEHQPRKPVILTVDDDPAV
Mvan_1371|M.vanbaalenii_PYR-1 MPDPPVGSYVHPAARTGFPLDSGGILNAMTGPEHQPRKPVILTVDDDPAV
TH_4191|M.thermoresistible__bu --------------------------------------------------
MSMEG_1796|M.smegmatis_MC2_155 -------------------------------------MSRRPDQGACGAP
Mb2732|M.bovis_AF2122/97 -MR-----------EYDIVVIGSGPGGQKAAIASAKLGKSVAIVERGR--
Rv2713|M.tuberculosis_H37Rv -MR-----------EYDIVVIGSGPGGQKAAIASAKLGKSVAIVERGR--
MAB_3032|M.abscessus_ATCC_1997 GLRPSGSSPTADTPSYDLVVIGSGPGGQKAAIAAAKLGKSVAVVERDN--
MMAR_5024|M.marinum_M ------------SQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAA--
MUL_4098|M.ulcerans_Agy99 ------------SQDYDVVVVGSGGAGMVAALAAAHKGLSTVVIEKAA--
MAV_0624|M.avium_104 ------------AQEYDVVVVGSGGAGMVAALTAAHRGLSTIVIEKAP--
Mflv_5003|M.gilvum_PYR-GCK SRAVARDLRRHYGEKYRIMRAESGPDALETLNELKLRGETVAVFVADYRM
Mvan_1371|M.vanbaalenii_PYR-1 SRAVARDLRRHYGEKFRIVRAESGPDALETLNELKLRGETVAVFVADYRM
TH_4191|M.thermoresistible__bu ---------MPTAQEYDVIIVGFGAAGASAAIEAADRGARVLVLDRGHG-
MSMEG_1796|M.smegmatis_MC2_155 DQVWIDGGTIPVAGEYDVIVVGGGPSGVAAAIAAARRGARTALIERAA--
.: :: * . : * . :.
Mb2732|M.bovis_AF2122/97 -MLGGVCVNTG---TIP-----------SKTLREAVLYLTGMNQR----E
Rv2713|M.tuberculosis_H37Rv -MLGGVCVNTG---TIP-----------SKTLREAVLYLTGMNQR----E
MAB_3032|M.abscessus_ATCC_1997 -MLGGVCTNTG---TIP-----------SKTLREAVLYLTGMNQR----E
MMAR_5024|M.marinum_M -HYGGSTARSGGGVWIPNNQILKRA-RVSDTTEAARTYLHGIIGDSSVSG
MUL_4098|M.ulcerans_Agy99 -HYGGSTARSGGGVWIPNNQILKRA-RVSDTTEAARTYLHGIIGDSSVSG
MAV_0624|M.avium_104 -HFGGSTARSGGGVWIPNNEVLKRD-GVKDTPEAARTYLHGIIGD----V
Mflv_5003|M.gilvum_PYR-GCK PQMSGIEFLEAAMDIFP---------LARRVLLTAYADTHAAIDAIN--V
Mvan_1371|M.vanbaalenii_PYR-1 PQMSGIEFLEAAMDIFP---------MARRVLLTAYADTHAAIDAIN--V
TH_4191|M.thermoresistible__bu ---GGATAYSGGIVYAGAGTAEQQAGGHADSVENMRAYLAREVGD----A
MSMEG_1796|M.smegmatis_MC2_155 -FLGGTATGAMVASFMG-----------------FYWMDHRVVGG---IG
.*
Mb2732|M.bovis_AF2122/97 LYGASYRVKDRITPADLLARTQHVIGKEVDVVRNQLM-RNRVDLIVGHGR
Rv2713|M.tuberculosis_H37Rv LYGASYRVKDRITPADLLARTQHVIGKEVDVVRNQLM-RNRVDLIVGHGR
MAB_3032|M.abscessus_ATCC_1997 LYGASYRVKANITPEDLLARTEHVIRKEIEVVRAQLQ-RNRIDLISGIGR
MMAR_5024|M.marinum_M VEPERIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDY-YPEAPGGRSGGR
MUL_4098|M.ulcerans_Agy99 VEPERIDTYLERGPEMLSFVLEHTPLKMCWVPGYSDY-YSEAPGGRSGGR
MAV_0624|M.avium_104 VEPERIDTYLERGPEMLSFVLKHTPLKMCWVPRYSDY-YPESPGGRAEGR
Mflv_5003|M.gilvum_PYR-GCK VDLDHYLLKPWDPPQEKLYPVIDALLDAWRSTGDRAIPHTKIIGHPWNAR
Mvan_1371|M.vanbaalenii_PYR-1 VDLDHYLLKPWDPPEEKLYPVIDALVDAWRSTGDRAIPHTKIIGHPWSAR
TH_4191|M.thermoresistible__bu VSPETLTRFCEQSPAMIEWLKAQGVEFRGGPVPPYKTSYPTDEHYLYYSG
MSMEG_1796|M.smegmatis_MC2_155 FELTQRLEHRGASSGFGRYVLAEASDQSLDVITFPFDPETLKIVLDEMLV
. . .
Mb2732|M.bovis_AF2122/97 FIDPHTILVEDQARR-------------EKTTVTGDYIIIATGTRPARPS
Rv2713|M.tuberculosis_H37Rv FIDPHTILVEDQARR-------------EKTTVTGDYIIIATGTRPARPS
MAB_3032|M.abscessus_ATCC_1997 FADEHTVVVEEPSRG-------------ERTTLHADYVVIATGTNPARPD
MMAR_5024|M.marinum_M SIEPKPFDARKLGADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGV
MUL_4098|M.ulcerans_Agy99 SIEPKPFDARKLGADMAELEPAYGKIPLNVVVMQQDYVRLNQLKRHPRGV
MAV_0624|M.avium_104 SIEPKPFNARKLGPDEAGLEPAYGKVPLNVVVMQQDYVRLNQLKRHPRGV
Mflv_5003|M.gilvum_PYR-GCK SSEVREFLARNRLYYTWFRSDEPKGAALLEAAGQDGMTLPVIITEQGETL
Mvan_1371|M.vanbaalenii_PYR-1 SSEVREFLARNRLYYTWFRSDEPRGAQLLEAAGEDGMTLPVVITEQGETL
TH_4191|M.thermoresistible__bu NETAFPYSEHAHPAPRG--------HRALAPGMRSGRVLFERLRDSALSK
MSMEG_1796|M.smegmatis_MC2_155 EAGVHPYLHAQ-----------------AISALEEDGVCVGVVYQGVIGR
.
Mb2732|M.bovis_AF2122/97 -GVEFDEERVLDSDGILDLKSLPSSMVVVGAGVIGIEYASMFAALGTKVT
Rv2713|M.tuberculosis_H37Rv -GVEFDEERVLDSDGILDLKSLPSSMVVVGAGVIGIEYASMFAALGTKVT
MAB_3032|M.abscessus_ATCC_1997 -GVAFDEKRVLDSDGILNLRFIPGSMVVVGAGVIGIEYASMFAALGTKVT
MMAR_5024|M.marinum_M -LRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTALT
MUL_4098|M.ulcerans_Agy99 -LRSMKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRKGVPVQLNTALT
MAV_0624|M.avium_104 -LRSLKVGARTMWAKATGKNLVGMGRALIGPLRIGLQRAGVPVVLNTALT
Mflv_5003|M.gilvum_PYR-GCK -VDPTDAELGSTLGLTTTPSGDFYDLVVIGGGPAGLAAAVYGASEGLRTV
Mvan_1371|M.vanbaalenii_PYR-1 -VDPTDSELAATLGLTTTPSDDFYDLVVIGGGPAGLAAAVYGASEGLKTV
TH_4191|M.thermoresistible__bu GVEFVPLAHVHSLIQADDGRVTGVRYTVLDPGHRHARRHRLITRATGKLG
MSMEG_1796|M.smegmatis_MC2_155 -----KALRGRTIIDASANGSIAVSAGAAREEARQDPRRRQPMTQVARLV
Mb2732|M.bovis_AF2122/97 VVEKRD-----------NMLDFCDPEVVEALK---------FHLRDLAVT
Rv2713|M.tuberculosis_H37Rv VVEKRD-----------NMLDFCDPEVVEALK---------FHLRDLAVT
MAB_3032|M.abscessus_ATCC_1997 VVEKRD-----------TMLDFCDPEVVEALR---------FHLRDLAVT
MMAR_5024|M.marinum_M DLYLEDGMVRGIYVRSTDAQESEEPQLIRARKGVILACGGFDHNEQMRVK
MUL_4098|M.ulcerans_Agy99 DLYLEDGVVRGIYVRSTDAHESEEPQLIRARKGVILACGGFDHNEQMRVK
MAV_0624|M.avium_104 DLYLEDGVVRGVYVRDSQAAESAEPRLIRARRGVILASGGFEHNEQMRVK
Mflv_5003|M.gilvum_PYR-GCK LIERTATGG----QAGQSSRIENYLGFPDGLSGAQLAERARRQAEKFEAE
Mvan_1371|M.vanbaalenii_PYR-1 LIERTATGG----QAGQSSRIENYLGFPDGLSGAQLAERARRQAEKFEAE
TH_4191|M.thermoresistible__bu TWMPGVVSG---AVRYAERLRAEASVETETRAGAVILAAGGFINNRGWVR
MSMEG_1796|M.smegmatis_MC2_155 DVDVAR-------------------------------------FRRLPQP
.
Mb2732|M.bovis_AF2122/97 FRFGEEVTAVDVGSAG-TVTTLASGKQIPAETVMYSAGRQGQTDHLD---
Rv2713|M.tuberculosis_H37Rv FRFGEEVTAVDVGSAG-TVTTLASGKQIPAETVMYSAGRQGQTDHLD---
MAB_3032|M.abscessus_ATCC_1997 FRFGEEVTTVEVNDTG-TMTTLASGKQIPADTVMYSAGRQGQTDQLD---
MMAR_5024|M.marinum_M YQRAPITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRP
MUL_4098|M.ulcerans_Agy99 YQRAPITTDWTVGAKANTGDGIVAAEKLGAALDLMEDAWWGPTVPLVGRP
MAV_0624|M.avium_104 YQRAPITTEWTVGAKANTGDGILAAEKLGAALELMEDAWWGPTVPLVGAP
Mflv_5003|M.gilvum_PYR-GCK LITAAEVTRLEVDGNA-RTVHLSDGRTIGTRAVILAMGVEYRQLPADG--
Mvan_1371|M.vanbaalenii_PYR-1 LITAAEVVRLEVDGNA-RTVHLSDGRTIGTRAVILAMGVEYRQLPAEG--
TH_4191|M.thermoresistible__bu QYAPQFLKISPLGTVGDDGTGIRLGLDAGGKTDKMGNVTAWRFLSPPS--
MSMEG_1796|M.smegmatis_MC2_155 AKQHLARRGLERGVLTQKLLSVLSSPHGDDAIVLMTRVSERDGTDEQQ--
. : .
Mb2732|M.bovis_AF2122/97 -------LHNAGLEVQGRGRIFVDDRFQTKVDHIYAVGDVIG--------
Rv2713|M.tuberculosis_H37Rv -------LHNAGLEVQGRGRIFVDDRFQTKVDHIYAVGDVIG--------
MAB_3032|M.abscessus_ATCC_1997 -------LPKAGLEADRRGRIWVDANFQTKVDHIYAVGDVIG--------
MMAR_5024|M.marinum_M WFALSERNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGEN
MUL_4098|M.ulcerans_Agy99 WFALSERNSPGSIIVNMSGQRFMNESMPYVEACHHMYGGQYGQGPGPGEN
MAV_0624|M.avium_104 WFALSERNSPGSIIVNMSGKRFMNESMPYVEACHHMYGGEYGQGPGPGEN
Mflv_5003|M.gilvum_PYR-GCK ------CADLTGAGVYYGATASVAADCDDDEVYVIGGANSAGQAAMHLAR
Mvan_1371|M.vanbaalenii_PYR-1 ------CADLTGAGVYYGATASVAADCDDDEVYVIGGANSAGQAAMFLSR
TH_4191|M.thermoresistible__bu -------AFLEGLTVGADGRRIANEDLYGATHGDVLMREFGGTG------
MSMEG_1796|M.smegmatis_MC2_155 ----LALAEIEGRQLVSRLIPFLRAEVPGFENARLGTLASWIG-------
.
Mb2732|M.bovis_AF2122/97 FPALAATSMEQGRLAAYHAFGE----PTDGITELQPIGIYSIPEVSYVGA
Rv2713|M.tuberculosis_H37Rv FPALAATSMEQGRLAAYHAFGE----PTDGITELQPIGIYSIPEVSYVGA
MAB_3032|M.abscessus_ATCC_1997 FPALAATSMDQGRLAAYHAFGE----PSKGMTDLQPIGIYSIPEVSYVGA
MMAR_5024|M.marinum_M IPAWLVFDQRYRDRYIFAGLQPGQRIPRKWLDSGVIVMADTLEELAAKAG
MUL_4098|M.ulcerans_Agy99 IPAWLVFDQRYRDRYIFAGLQPGQRIPRKWLDSGVIVMADTLEELAAKAG
MAV_0624|M.avium_104 IPAWLVFDQQYRDRYIFAGLQPGQRIPRKWLESGVIIQAETLEELASKAG
Mflv_5003|M.gilvum_PYR-GCK TAKTVTIVSRRTLEDSMSHYLIQQIRAQDNIRELPHTVVHAVKGDGHLEG
Mvan_1371|M.vanbaalenii_PYR-1 TAKSVTIVSRRTLEDSMSHYLIQQIRAQDNITEMPNTVVHAVKGDGHLEG
TH_4191|M.thermoresistible__bu WAIYDAATWRKIRTQITDQTQVFQRLQVWYLLTIGHKKAATIADLARKNG
MSMEG_1796|M.smegmatis_MC2_155 ----VRETWRVIGDYVITGDDVRVGNSFGDAIALGTGPLDTHHSAGGGLS
: . .
Mb2732|M.bovis_AF2122/97 TEVELTKSSIPYEVGVAR---YRELARGQIAGDSYGMLKLLVSTEDLKLL
Rv2713|M.tuberculosis_H37Rv TEVELTKSSIPYEVGVAR---YRELARGQIAGDSYGMLKLLVSTEDLKLL
MAB_3032|M.abscessus_ATCC_1997 TEVELTKNAIPYEVGVSR---YRELARGQIAGDSYGMLKLLVSTEDLRLL
MMAR_5024|M.marinum_M LPVDELTSTVSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPNLGEI
MUL_4098|M.ulcerans_Agy99 LPVDELTSTVSRFNGFARSGVDEDYHRGESAYDRYYGDPTNKPNPNLGEI
MAV_0624|M.avium_104 LPVDEFLATVQRFNGFARTGIDEDYHRGESAYDRYYGDPTNKPNPNLGEI
Mflv_5003|M.gilvum_PYR-GCK ICLENTQTGQRDEVTCGR----MFIFIGAEPRTEWLDGVVVRDDHGFIPA
Mvan_1371|M.vanbaalenii_PYR-1 VCLENTRTGEREEFRCGR----MFIFIGAEPRTEWLDGVVVRDDHGFILA
TH_4191|M.thermoresistible__bu IDAAGLQQTVDEYNRGISSGAGDPGHKHPSLCPPLERGPFYSIN--ISAD
MSMEG_1796|M.smegmatis_MC2_155 LAVPERPFQIPYRALLPRN-VDGLITTGRCVSATREGMAGLRHMGTVMAM
.
Mb2732|M.bovis_AF2122/97 GVHIFGTSATEMVHIG-----------QAVMGCGGSVEYLVDA-VFNYPT
Rv2713|M.tuberculosis_H37Rv GVHIFGTSATEMVHIG-----------QAVMGCGGSVEYLVDA-VFNYPT
MAB_3032|M.abscessus_ATCC_1997 GIHIFGSDATDLVHIG-----------QAVMGCGGTVEYLVDA-VFNYPT
MMAR_5024|M.marinum_M NHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPV
MUL_4098|M.ulcerans_Agy99 NHAPYYAAKMVPGDLGTKGGIRTDVNGRALRDDGSIIDGLYAAGNVSAPV
MAV_0624|M.avium_104 SHPPYYAAKMVPGDLGTKGGIRTDIHGRALRDDGSIIEGLYAAGNVSAPV
Mflv_5003|M.gilvum_PYR-GCK GPDLRDVSGWTLDRPP--------------HHLESSVPGVFVAGDVRADS
Mvan_1371|M.vanbaalenii_PYR-1 GPDLRDVSGWTLDRPP--------------HHLESSVPGVFVAGDVRAES
TH_4191|M.thermoresistible__bu ASLFYPIPGLTLGGLVVD-----EDSGAVVHRDGGVIPGLYAAGRNAVGV
MSMEG_1796|M.smegmatis_MC2_155 GQAAGTAAALAAGQGVS----------PRAISPSAIQEALTRDGAIITAA
. :
Mb2732|M.bovis_AF2122/97 FSEAYKN---AALDVMNKMRALNQFRR-----
Rv2713|M.tuberculosis_H37Rv FSEAYKN---AALDVMNKMRALNQFRR-----
MAB_3032|M.abscessus_ATCC_1997 FSEAYKV---AALDVMNKIRALNQFKA-----
MMAR_5024|M.marinum_M MGHTYPGPG-GTIGPAMTFGYLAALHIAGDR-
MUL_4098|M.ulcerans_Agy99 MGHTYPGPG-GTIGPAMTFGYLAALHIAGDR-
MAV_0624|M.avium_104 MGHTYPGPG-GTIGPAMTFGYLAALHIAGEN-
Mflv_5003|M.gilvum_PYR-GCK AKRVAAAVGEGSMAVMLVHRYLAET-------
Mvan_1371|M.vanbaalenii_PYR-1 AKRVAAAVGEGSMAVMLVHRYLAET-------
TH_4191|M.thermoresistible__bu CSNSYVSG--LSISDCVFSGRRAGAHAAGGTR
MSMEG_1796|M.smegmatis_MC2_155 DAVPFTDP--ETAEQRTSARWSGGTA------
: