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VPQNTLHTAGFPFAHRIAGFSALPADALTERGKVTPMGEAHDTQARRTVFGHPMGLVNLFGVELWERFSF YGMLTILGYYLYYTATDGGLGLPQSTATGIVGAYGGLVYLSTVLGGWIADRVLGMERTVFYGGVVVMCGH IALAVLPGLAGVGIGLVLVALGSGALKANASSLLGTLYDKDDPRCDGGFTLFYLGVNLGAFVGPLVTGIL QTRIGFHYGFGAAAIGMALGLVQYVVYRRNLGTHGRIVPNPLPSSSFGKVAAFATALVIAAVALFVSGVV TLANLSQATTVVIALASVAYFAVFLTSSKVSTLERTRVRAFIPLFVANAVFWSLFQQIFTVLAVYSDERM NWSVFGWTAPSNWIGSIEPVWIIVLSPVFAWLWTRLGDRAPTTPRKFSYAVIGMGVAFLLFLPMAGTTGR AVPALVVAAILALFAISELTISPIGLSVTTKLAPEAFRAQMMALYFFSLGLGTAMSGVLAGYYDPAHEFA YFGILGLVAIVVGIVVFAVSPRITRLMEGVH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3533 | - | - | 100% (521) | di-/tripeptide transporter |
| M. smegmatis MC2 155 | MSMEG_2619 | - | 9e-05 | 29.46% (258) | efflux protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2871c | efpA | 6e-05 | 23.30% (382) | integral membrane efflux protein EfpA |
| M. gilvum PYR-GCK | Mflv_2746 | - | 0.0 | 78.79% (481) | amino acid/peptide transporter |
| M. tuberculosis H37Rv | Rv2846c | efpA | 6e-05 | 23.30% (382) | integral membrane efflux protein EfpA |
| M. leprae Br4923 | MLBr_01562 | - | 4e-07 | 24.54% (383) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_1338 | - | 5e-07 | 31.90% (163) | putative membrane efflux protein |
| M. marinum M | MMAR_2515 | - | 5e-05 | 25.77% (194) | integral membrane drug efflux protein |
| M. avium 104 | MAV_2368 | - | 2e-06 | 21.24% (499) | transporter, major facilitator family protein |
| M. thermoresistible (build 8) | TH_2729 | - | 9e-06 | 21.95% (442) | PUTATIVE putative drug resistance transporter, EmrB/QacA |
| M. ulcerans Agy99 | MUL_2115 | efpA | 8e-05 | 22.75% (400) | integral membrane efflux protein EfpA |
| M. vanbaalenii PYR-1 | Mvan_3792 | - | 0.0 | 79.83% (476) | amino acid/peptide transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2871c|M.bovis_AF2122/97 ------MTALNDTERAVRNWRAGRPHRPAPMRPPRSEETASERPSRYYPT
Rv2846c|M.tuberculosis_H37Rv ------MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPT
MUL_2115|M.ulcerans_Agy99 ------MTALNDTERAVHNWTSGRQERPTSARATRETETASERASRYYPT
MLBr_01562|M.leprae_Br4923 ------MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSK-YPT
MAV_2368|M.avium_104 --------------------------------MTMSVAPT---------T
Mflv_2746|M.gilvum_PYR-GCK -------------------------------------MVTHQRDSTRTLF
Mvan_3792|M.vanbaalenii_PYR-1 -------------------------------------MTIREQGDRRTFF
MSMEG_3533|M.smegmatis_MC2_155 MPQNTLHTAGFPFAHRIAGFSALPADALTERGKVTPMGEAHDTQARRTVF
TH_2729|M.thermoresistible__bu --------------------------------------------------
MMAR_2515|M.marinum_M ---------------------------------------MPDTGQQGSSD
MAB_1338|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2871c|M.bovis_AF2122/97 WLPSR-----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAG
Rv2846c|M.tuberculosis_H37Rv WLPSR-----SFIAAVIAIGGMQLLATMDSTVAIVALPKIQNELSLSDAG
MUL_2115|M.ulcerans_Agy99 WLPSR-----RFIAAVIAIGGMQLLATMDSTVAIVALPKIQDELSLSDAG
MLBr_01562|M.leprae_Br4923 LLPSGRFPSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAG
MAV_2368|M.avium_104 RLWSR-----QFVAVIVAIGGMQLMVAMDGPVAVFALPKIQNEMGLSDAA
Mflv_2746|M.gilvum_PYR-GCK GHPIG----LTNLFGVELWERFSFYGMLTILGYYLYYSVAEGGLGLPQAT
Mvan_3792|M.vanbaalenii_PYR-1 GHPVG----LTNLFGVELWERFSFYGMLTILGYYLYYSVTDGGLGLPQST
MSMEG_3533|M.smegmatis_MC2_155 GHPMG----LVNLFGVELWERFSFYGMLTILGYYLYYTATDGGLGLPQST
TH_2729|M.thermoresistible__bu --------------VLVALILTMALVAMDTTILATAVPQVVGDLGGFDQV
MMAR_2515|M.marinum_M QLDAR----LLKIAGVCVLG--SMMAIVDTTVVTVAQRTFVSTFDSPQAI
MAB_1338|M.abscessus_ATCC_1997 ---------------------------MTDLANDEQLTVRHDRRITPTPV
: .
Mb2871c|M.bovis_AF2122/97 RSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTISSVLCAVA
Rv2846c|M.tuberculosis_H37Rv RSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTISSVLCAVA
MUL_2115|M.ulcerans_Agy99 RSWVITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTISSVLCAVA
MLBr_01562|M.leprae_Br4923 RSWGITAYVLTFGGLMLLGGRLGDTIGRKR-TFIVGVALFTISSVLCAVA
MAV_2368|M.avium_104 RSWVITAYMLTFGGLMLLGGRLGDTIGRKRAAFLVGVALFTFASGLCGIA
Mflv_2746|M.gilvum_PYR-GCK ATGIVGAYGGLVYLSTVLGGWIADRVLGMERTVFYGGVVVMLGHIALAVL
Mvan_3792|M.vanbaalenii_PYR-1 ATGIVGAYGGLVYLSTVLGGWIADRLLGMERTVFYGGVVVMLGHIALAIL
MSMEG_3533|M.smegmatis_MC2_155 ATGIVGAYGGLVYLSTVLGGWIADRVLGMERTVFYGGVVVMCGHIALAVL
TH_2729|M.thermoresistible__bu G-WVFSGYLLAQTVTIPIYGKLADLYGRRP-ILIFGVVAFLIGSALSAAS
MMAR_2515|M.marinum_M VAWTMTGYTLALAAVIPLAGWVADRFGTKR-PFIASLLAFSAGSLLCALA
MAB_1338|M.abscessus_ATCC_1997 SAWNRMRYWVIAHAVD---------------DFYQGLVPAAIPFFVLERH
* . .
Mb2871c|M.bovis_AF2122/97 WDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPAR-NAATAVFAAMT
Rv2846c|M.tuberculosis_H37Rv WDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPAR-NAATAVFAAMT
MUL_2115|M.ulcerans_Agy99 WDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPTR-NAATAVFAAMT
MLBr_01562|M.leprae_Br4923 WDEVTLVIARLLQGIGSAIASPTGLALVATTFSKGSAR-NTATAVFAAMT
MAV_2368|M.avium_104 WAGGTLIAARLLHGAAAAIIAPTNLALIATTFPRGSAR-NAATAVFGAMT
Mflv_2746|M.gilvum_PYR-GCK PGLAGVGAGLVLVALGSGALKANASSLLGTLYAKGDPRADGGFTLFYLGI
Mvan_3792|M.vanbaalenii_PYR-1 PGLTGVGVGLVLVALGSGALKANASSLLGTLYDKGDARADGGFTLFYLGI
MSMEG_3533|M.smegmatis_MC2_155 PGLAGVGIGLVLVALGSGALKANASSLLGTLYDKDDPRCDGGFTLFYLGV
TH_2729|M.thermoresistible__bu WNMATLAIFRAIQGLGAGAISATVQTVAGDLYTVAERG--RIQGYLASVW
MMAR_2515|M.marinum_M PNISALIAFRVIQGLGGGMLMPLVLTMLTR--EAGPARLGRVLAVLGIPM
MAB_1338|M.abscessus_ATCC_1997 YSYAAASGLALAATLGSALPQPLLGLIADRWRLLWMAP------AGLAAA
... . :
Mb2871c|M.bovis_AF2122/97 AIGSVMG-LVVGGALTEVSWRWAF---LVNVPIGLVMIYLAR-TALRETN
Rv2846c|M.tuberculosis_H37Rv AIGSVMG-LVVGGALTEVSWRWAF---LVNVPIGLVMIYLAR-TALRETN
MUL_2115|M.ulcerans_Agy99 AVGSVMG-LVVGGALTEVSWRLAF---MVNVPIGLVMIYLAR-TALRETN
MLBr_01562|M.leprae_Br4923 AIGSVMG-LVVGGALTEVSWRLAF---LVNVPIGLVMIYLAR-TALHETH
MAV_2368|M.avium_104 GLGGVLG-LVVGGALTDVSWRLAF---LVNVPIGLAVIYLVL-ITRQETQ
Mflv_2746|M.gilvum_PYR-GCK NLGAFIGPLITGLLQTRVGFHYGFGAAAIGMALGLLQYVAFR-RNLGEHG
Mvan_3792|M.vanbaalenii_PYR-1 NLGAFIGPLITGLLQTRIGFHYGFGAAAIGMALGLIQYVVFR-RNLGEHG
MSMEG_3533|M.smegmatis_MC2_155 NLGAFVGPLVTGILQTRIGFHYGFGAAAIGMALGLVQYVVYR-RNLGTHG
TH_2729|M.thermoresistible__bu GISAVIAPALGGFFAQYLTWRWIF---LVNIPIGVFALYLIA-RDLHEDV
MMAR_2515|M.marinum_M LLGPVFGPVLGGWLIDRFGWEWIF---WINLPIGLITVGLAA-VVFPKDR
MAB_1338|M.abscessus_ATCC_1997 GIGAGLAGLVPGYWLVWTMLLVSG--------LGVAAFHPAAGRDARRDA
:. .. : * :*:
Mb2871c|M.bovis_AF2122/97 KER---MKLDATGAILATLACTAAVFAFSIG-PEKGWMSGITIGSGLVAL
Rv2846c|M.tuberculosis_H37Rv KER---MKLDATGAILATLACTAAVFAFSIG-PEKGWMSGITIGSGLVAL
MUL_2115|M.ulcerans_Agy99 RER---MKLDAAGAILATLACTAAVFAFSMG-PEKGWLSITTIGSGAVAF
MLBr_01562|M.leprae_Br4923 KER---MKLDAAGAILATLACTAAVFAFSMG-PEKGWISLTTIGSGLVAL
MAV_2368|M.avium_104 TER---IKLDVTGAVLATVTGTAAVFGISMG-PEAGWRSPITIGSGVVAL
Mflv_2746|M.gilvum_PYR-GCK REVPNPLPRGAIGKTASVFAVVVLVVAAAVA-LRLVTLENLSQVTTGVIV
Mvan_3792|M.vanbaalenii_PYR-1 RQVPNPLPRSAIGKTAGVFVAVIVVIAAAVA-LKLVTLANLSQVTTGVII
MSMEG_3533|M.smegmatis_MC2_155 RIVPNPLPSSSFGKVAAFATALVIAAVALFV-SGVVTLANLSQATTVVIA
TH_2729|M.thermoresistible__bu VRR--PHRIDYLGAGLVLVSAGLFILGLLSGGVHWSWTSPTSVVVFTGAA
MMAR_2515|M.marinum_M PEP--SESFDVIGMLLLSPGLATFLYGVSALPASGTIADRHVWLPAAVGL
MAB_1338|M.abscessus_ATCC_1997 GDSATAMSLFAAGGSVGFFLAPALVTPALVS-------AGLGATAWFIPP
*
Mb2871c|M.bovis_AF2122/97 AAAVAFVIVERT-AENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCI
Rv2846c|M.tuberculosis_H37Rv AAAVAFVIVERT-AENPVVPFHLFRDRNRLVTFSAILLAGGVMFSLTVCI
MUL_2115|M.ulcerans_Agy99 AAALGFVLVERT-AENPVVPFDLFHDRNRLVTFIAIFLAGGVMFSLTVCI
MLBr_01562|M.leprae_Br4923 VAAIAFAVVERT-AENPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSI
MAV_2368|M.avium_104 AAFVAFVVVERT-AENPIVPFNLFLDRNRLAAFAAMFLAGGVFFTLTVLV
Mflv_2746|M.gilvum_PYR-GCK IASVAYFVVLFR-SPKVTA-----PERIRVRAFIPLFVANAVFWSLFQQI
Mvan_3792|M.vanbaalenii_PYR-1 VASIGYFLIMLG-SDKVSG-----PERVRLRAFIPLFVANAVFWSLFQQI
MSMEG_3533|M.smegmatis_MC2_155 LASVAYFAVFLT-SSKVST-----LERTRVRAFIPLFVANAVFWSLFQQI
TH_2729|M.thermoresistible__bu LAGVALLVVESR-AAEPVLPLSMLTRRLTAPSFAATATAGMIVIGLSVYL
MMAR_2515|M.marinum_M VLIGGFVLHALYRADHPLIDLRLFDNRVVTLANVAMFLFAASFFGAGLLF
MAB_1338|M.abscessus_ATCC_1997 AVIMGFVLWRYQLRQGSANSVDRQLTGNDRWGAFSILVAVEVVRSAVYFG
. . .
Mb2871c|M.bovis_AF2122/97 GLYVQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGG
Rv2846c|M.tuberculosis_H37Rv GLYVQDILGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGG
MUL_2115|M.ulcerans_Agy99 GLYVQDVLGYSALRAGVGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGG
MLBr_01562|M.leprae_Br4923 GLYIQDILGYSALRAGIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGG
MAV_2368|M.avium_104 GLYVQTMMGYSPLRAGVAFIPFGLAMAIGVGVASKLVTWFPPRVVVIASG
Mflv_2746|M.gilvum_PYR-GCK ---FTVLAVYSDERMNWSIFGWTAPSNWIGSIEPIWIIALSP-LFALMWT
Mvan_3792|M.vanbaalenii_PYR-1 ---FTVLAVYSDERMNWSIFGWTAPSNWIGSIEPIWIIVLSP-LFALMWT
MSMEG_3533|M.smegmatis_MC2_155 ---FTVLAVYSDERMNWSVFGWTAPSNWIGSIEPVWIIVLSP-VFAWLWT
TH_2729|M.thermoresistible__bu PNWGQTVLGLSPVAAGFVLAIMSITWPISSGFSARLYLRIGFRDTALVGA
MMAR_2515|M.marinum_M PSYFQELLGQTPMQAGMSMVPRGLGAMVTMPIAGALMDKRGAGKILMVGV
MAB_1338|M.abscessus_ATCC_1997 MNTFIALYLIDHLDVSAAVGGVGLAMFLGGGVIGTLLGGRISDRLGMIAT
: . . .
Mb2871c|M.bovis_AF2122/97 YLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGV
Rv2846c|M.tuberculosis_H37Rv YLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLTLSAIAGV
MUL_2115|M.ulcerans_Agy99 YLLVCAMIYGWAFMQRGVPYFPNLVAPIVIGGIGIGMAVVPLTLAAIAGV
MLBr_01562|M.leprae_Br4923 WLLMVAMLYGWAFMNRGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGV
MAV_2368|M.avium_104 GLILGATLYGSTFN-RGMPYFPNLVVPLIVCAIGIGAVFVTLTLSVIASV
Mflv_2746|M.gilvum_PYR-GCK RLGKRAPTTPRKFAYGVIGMGVAFLCFVPLAGVS---AVPALVVLAILGV
Mvan_3792|M.vanbaalenii_PYR-1 RLGKRAPTTPRKFAYGVIGMGLAFLCFVPLAGIT---AVPALLVMAVLGV
MSMEG_3533|M.smegmatis_MC2_155 RLGDRAPTTPRKFSYAVIGMGVAFLLFLPMAGTTG-RAVPALVVAAILAL
TH_2729|M.thermoresistible__bu SCAVAAGTG--LVLLGPAPPVWQPVVYTALMGAGMGLLFSPLIVGLQNTV
MMAR_2515|M.marinum_M GLIAAGMGLFAIGVSLNAAYLPTLVTGLTIMGLGMGATMMPLSAVAVQTL
MAB_1338|M.abscessus_ATCC_1997 IRVGSIVAIPAFVALRICPQPWIALALAAVVGITVNIPFAVLVKLGQDYL
: : . . * :
Mb2871c|M.bovis_AF2122/97 GFDQIG---PVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKF
Rv2846c|M.tuberculosis_H37Rv GFDQIG---PVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKF
MUL_2115|M.ulcerans_Agy99 GFDRIG---PVSALTLMLQSLGGPLVLAGIQAVITSRTLYLGGTTGPVKF
MLBr_01562|M.leprae_Br4923 GFDRIG---PVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKF
MAV_2368|M.avium_104 DVDRIG---PTSAIAVMLQTLGGPLVLVVVQVAITSHALRLGGTLGPVKS
Mflv_2746|M.gilvum_PYR-GCK FAVSEL---LLSPIGLSVTTKLAPQAFRAQMMALYFFSVGLG------TS
Mvan_3792|M.vanbaalenii_PYR-1 FAVSEL---LLSPIGLSVTTKLAPEAFRAQMMALYFFSVGLG------TS
MSMEG_3533|M.smegmatis_MC2_155 FAISEL---TISPIGLSVTTKLAPEAFRAQMMALYFFSLGLG------TA
TH_2729|M.thermoresistible__bu GWDQRG---TVTG-GLMFSRFLGQSIGAAGFGAVANAVLRRY--------
MMAR_2515|M.marinum_M TPHQIARGSTLINVNQQVAASIGTALMSVILTSQFNRSANISAAHRIDSL
MAB_1338|M.abscessus_ATCC_1997 PTRPGT----AAGVTLGLAVSIGGFFVPLLGVLA----------------
. .
Mb2871c|M.bovis_AF2122/97 MNDVQLA------------------------ALDHAYTYGLLWVAGAAII
Rv2846c|M.tuberculosis_H37Rv MNDVQLA------------------------ALDHAYTYGLLWVAGAAII
MUL_2115|M.ulcerans_Agy99 MNDAQLH------------------------ALDHGYTYGLLWVAGAAVI
MLBr_01562|M.leprae_Br4923 MNDAQLR------------------------ALDHGYTYGLLWVAGAVVI
MAV_2368|M.avium_104 MNAAQLH------------------------ALDRGYTYGLLWLAGVVAL
Mflv_2746|M.gilvum_PYR-GCK MSGVLAG------------------------YYDTSREAAYFGVLGAIAV
Mvan_3792|M.vanbaalenii_PYR-1 MSGVLAR------------------------YYDPSREVAYFGILGGVAV
MSMEG_3533|M.smegmatis_MC2_155 MSGVLAG------------------------YYDPAHEFAYFGILGLVAI
TH_2729|M.thermoresistible__bu --EPDTS------------------------AAAMGAASHAVFVGLLVAA
MMAR_2515|M.marinum_M RADAARSGVPVDQSLMPERASTPDFPLVLMHDLSHAYAVVFVVAVGLVAL
MAB_1338|M.abscessus_ATCC_1997 ---------------------------------DHHGPQAVLTTLCVAPI
.
Mb2871c|M.bovis_AF2122/97 VGGMALFIGYTPQQVAHAQEVKEAIDAGEL---
Rv2846c|M.tuberculosis_H37Rv VGGMALFIGYTPQQVAHAQEVKEAIDAGEL---
MUL_2115|M.ulcerans_Agy99 VGGAAVFIGYTPEQVAHAQEVKEAIDAGEL---
MLBr_01562|M.leprae_Br4923 VGVAALFIGYTPEQVAYAQEVKEAVDAGEL---
MAV_2368|M.avium_104 LGGVTLLIGYTAAQVARAQEVKKAVDAGEL---
Mflv_2746|M.gilvum_PYR-GCK VAGVVVFA-ISPWISRQMEGVH-----------
Mvan_3792|M.vanbaalenii_PYR-1 AAGVIVFA-IAPWISRQMEGVH-----------
MSMEG_3533|M.smegmatis_MC2_155 VVGIVVFA-VSPRITRLMEGVH-----------
TH_2729|M.thermoresistible__bu VATVVLLLTVPRRFPTHHVAVVD----------
MMAR_2515|M.marinum_M MFVPVAFLPKKPPAVRRNPPPQPAEHSDTEVNR
MAB_1338|M.abscessus_ATCC_1997 LAIVLAFLLPHPERE------------------
: