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VTDLANDEQLTVRHDRRITPTPVSAWNRMRYWVIAHAVDDFYQGLVPAAIPFFVLERHYSYAAASGLALA ATLGSALPQPLLGLIADRWRLLWMAPAGLAAAGIGAGLAGLVPGYWLVWTMLLVSGLGVAAFHPAAGRDA RRDAGDSATAMSLFAAGGSVGFFLAPALVTPALVSAGLGATAWFIPPAVIMGFVLWRYQLRQGSANSVDR QLTGNDRWGAFSILVAVEVVRSAVYFGMNTFIALYLIDHLDVSAAVGGVGLAMFLGGGVIGTLLGGRISD RLGMIATIRVGSIVAIPAFVALRICPQPWIALALAAVVGITVNIPFAVLVKLGQDYLPTRPGTAAGVTLG LAVSIGGFFVPLLGVLADHHGPQAVLTTLCVAPILAIVLAFLLPHPERE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1338 | - | - | 100% (399) | putative membrane efflux protein |
| M. abscessus ATCC 19977 | MAB_3449c | - | 1e-10 | 22.13% (375) | putative transporter |
| M. abscessus ATCC 19977 | MAB_1429 | - | 3e-08 | 24.75% (404) | major facilitator superfamily permease |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1288c | - | 8e-07 | 23.36% (381) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_3420 | - | 1e-10 | 27.35% (351) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1258c | - | 8e-07 | 23.36% (381) | integral membrane transport protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2515 | - | 3e-06 | 26.49% (268) | integral membrane drug efflux protein |
| M. avium 104 | MAV_3974 | - | 4e-11 | 24.76% (319) | permease of the major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3671 | - | 4e-13 | 35.03% (177) | integral membrane protein |
| M. thermoresistible (build 8) | TH_3240 | - | 6e-12 | 29.23% (349) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0911 | - | 7e-05 | 23.28% (305) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_3174 | - | 4e-10 | 28.77% (358) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1288c|M.bovis_AF2122/97 ---------------------MRNSNRGPAFLILFATLMAAAGDGVSIVA
Rv1258c|M.tuberculosis_H37Rv ---------------------MRNSNRGPAFLILFATLMAAAGDGVSIVA
Mflv_3420|M.gilvum_PYR-GCK MDAILHRPRAARDLKGAWVGSHLMASDARIRRARAASAALFLTNGALFAN
Mvan_3174|M.vanbaalenii_PYR-1 -----------------MAPEPLGSGEARNRRARIAVAALFLTNGALFAN
MSMEG_3671|M.smegmatis_MC2_155 -----------------MVTEQR--DPVTTRRARVAVAALFLTNGAIFAN
TH_3240|M.thermoresistible__bu -----------------MASGRVESRTRQHQRARRAVAVLFLTNGALFAN
MAB_1338|M.abscessus_ATCC_1997 -----MTDLANDEQLTVRHDRRITPTPVSAWNRMRYWVIAHAVDDFYQGL
MAV_3974|M.avium_104 ------------------------------------------MVALGYGV
MUL_0911|M.ulcerans_Agy99 -------------------MRIQPVFRDHPILALAVICLSVFVISVDATI
MMAR_2515|M.marinum_M -------------MPDTGQQGSSDQLDARLLKIAGVCVLGSMMAIVDTTV
Mb1288c|M.bovis_AF2122/97 FPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVAD
Rv1258c|M.tuberculosis_H37Rv FPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVAD
Mflv_3420|M.gilvum_PYR-GCK LLPRFPEIKSDLAMSNAGYGAAVAAFSAGALLAGPAAGALIRR-FQSARV
Mvan_3174|M.vanbaalenii_PYR-1 LLPRYPEIKADLAMSNAAYGAAVASFSAGALLAGPTAAALIRR-FQSSRV
MSMEG_3671|M.smegmatis_MC2_155 LLPRYPEIKTDLQLSNATYGAAVAAFSAGALIAGLTAGALIRR-FRSSRV
TH_3240|M.thermoresistible__bu LLPRYPEIKTDLALSNTGYGVTIAAFSAGALTAGLTAAMLIRR-FRSARV
MAB_1338|M.abscessus_ATCC_1997 VPAAIPFFVLERHYSYAAASGLALAATLGSALPQPLLGLIADR-WRLLWM
MAV_3974|M.avium_104 ISPALPTFARSFGVSIKAVTFLVTVFSLSRLCFAPISGLLTER-LGERRI
MUL_0911|M.ulcerans_Agy99 VNVALPTLSRELGADTAQLQWIVDAYTLVMSGLLLSAGSLSDR-YGRRGW
MMAR_2515|M.marinum_M VTVAQRTFVSTFDSPQAIVAWTMTGYTLALAAVIPLAGWVADR-FGTKRP
. . *
Mb1288c|M.bovis_AF2122/97 ALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLP
Rv1258c|M.tuberculosis_H37Rv ALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLP
Mflv_3420|M.gilvum_PYR-GCK AVVTTVALASLIVTAAVAPTPLVFAATLLFAGASDAITDVAQNVNALRVQ
Mvan_3174|M.vanbaalenii_PYR-1 ALATTVALAVLIVVAGLAGTPLLFAVALFAAGACDAVTDVAQNVNGLRLQ
MSMEG_3671|M.smegmatis_MC2_155 GVTLTVALAVFVFAAGLAPTPILFAGALFLAGACDSIVDVAQNAHGLRVQ
TH_3240|M.thermoresistible__bu AVVGTLVLAAAVLAAGLAGTAPVLGAALFVAGAADAVTDVAQNAHGLRVQ
MAB_1338|M.abscessus_ATCC_1997 APAGLAAAGIGAGLAGLVPGYWLVWTMLLVSGLGVAAFHPAAGRDARRDA
MAV_3974|M.avium_104 YIGGLLIVAVSTAACAFSQAYWQLMLCRVFSGVGSTMFYVSALGLMIHIS
MUL_0911|M.ulcerans_Agy99 LSAGLILFALTSALAAQVNSADTLVAARAAMGVGAAVIFPTTLGLITNIF
MMAR_2515|M.marinum_M FIASLLAFSAGSLLCALAPNISALIAFRVIQGLGGGMLMPLVLTMLTREA
. . . .
Mb1288c|M.bovis_AF2122/97 EAAARAGWSLDRINGAYEAILNLAFIVGPAIG------------------
Rv1258c|M.tuberculosis_H37Rv EAAARAGWSLDRINGAYEAILNLAFIVGPAIG------------------
Mflv_3420|M.gilvum_PYR-GCK RNYGRS------IINSLHAIWAAGAITGGLMG------------------
Mvan_3174|M.vanbaalenii_PYR-1 RNYGRS------IINSLHAVWAVGAIVGGLMG------------------
MSMEG_3671|M.smegmatis_MC2_155 REYGRS------IINSLHAVWAIGAVLGGLTG------------------
TH_3240|M.thermoresistible__bu RAYGRS------IINSFHAVWSVGALFGGLMG------------------
MAB_1338|M.abscessus_ATCC_1997 GDSATA-------MSLFAAGGSVGFFLAPALV------------------
MAV_3974|M.avium_104 PADARG-----RIAGLFTTSFMVGAVGGPAVG------------------
MUL_0911|M.ulcerans_Agy99 TDPVPR----AKAIGLWTAMVGVGVAVGPITGGWLLEHFSWGSIFLVNVP
MMAR_2515|M.marinum_M GPARLG-----RVLAVLGIPMLLGPVFGPVLGGWLIDRFGWEWIFWINLP
. .
Mb1288c|M.bovis_AF2122/97 ---------GLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHT
Rv1258c|M.tuberculosis_H37Rv ---------GLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHT
Mflv_3420|M.gilvum_PYR-GCK ---------AGAIALG-VPRAIHLVVAAVLFCAIVCAAYPYLLKGPDHDD
Mvan_3174|M.vanbaalenii_PYR-1 ---------AGAIALQ-IPRPIHLAAAAVLFCGVVLAAYPSLLHGPDHDD
MSMEG_3671|M.smegmatis_MC2_155 ---------AATIAMH-IPRGVHLAAIAVVFSIVALAAFRFLLPGDDHDD
TH_3240|M.thermoresistible__bu ---------GTAVALN-IPRSVHLAVAAVLFSVVVLVGYRFLLPGEDHDD
MAB_1338|M.abscessus_ATCC_1997 ---------TPALVSAGLGATAWFIPPAVIMGFVLWRYQLRQGSANSVDR
MAV_3974|M.avium_104 ---------GLAAGWG---LTAPFVVYGVAMLGVALVLFLGLRNSALAAP
MUL_0911|M.ulcerans_Agy99 IAVAAMAGAILFVPTSRDPAAPRVDVPGLMLSAVGITALVYTIIEAPNWG
MMAR_2515|M.marinum_M IGLITVGLAAVVFPKDRPEPSESFDVIGMLLLSPGLATFLYGVSALPASG
. .. :
Mb1288c|M.bovis_AF2122/97 SRPQGLVSGIAEGLRFVW-----------NLRVLRTLGMIDLTVTALYLP
Rv1258c|M.tuberculosis_H37Rv SRPQGLVSGIAEGLRFVW-----------NLRVLRTLGMIDLTVTALYLP
Mflv_3420|M.gilvum_PYR-GCK HPSARDGGTARVGPMVYL-----------TLLALVALAMAGATVEDAGSS
Mvan_3174|M.vanbaalenii_PYR-1 HPSTRNTDGSGVRAVVLL-----------TLLALVGIAVAGATVEDAGSS
MSMEG_3671|M.smegmatis_MC2_155 HPAAHAPAGLRAGPRTYL-----------ILLALVVIAIAGATVEDAGSS
TH_3240|M.thermoresistible__bu RAHGVRNPGPRSGLRVYA-----------ILAALVGIAVAGAVIEDAGST
MAB_1338|M.abscessus_ATCC_1997 QLTGNDRWG--------------------AFSILVAVEVVRSAVYFGMNT
MAV_3974|M.avium_104 PPPTRSTVTMREALRVRA-----------YQSALLSNFATGWSAFGLRMA
MUL_0911|M.ulcerans_Agy99 WTSTRASGGFIAAAIVLVG--FALWERRSSHPMLDVSVFANRRFSGGSLA
MMAR_2515|M.marinum_M TIADRHVWLPAAVGLVLIGGFVLHALYRADHPLIDLRLFDNRVVTLANVA
: .
Mb1288c|M.bovis_AF2122/97 MESVLFPKY-----------FTDHQQPVQLGWALMAIAGGGLVGALGYAV
Rv1258c|M.tuberculosis_H37Rv MESVLFPKY-----------FTDHQQPVQLGWALMAIAGGGLVGALGYAV
Mflv_3420|M.gilvum_PYR-GCK WATLYLRDE-----------LGAPGAVAAFGY--VALVGFLFVGRLIGDR
Mvan_3174|M.vanbaalenii_PYR-1 WATLYLRDS-----------LGAPGAVAVMGY--IALVGFMFIGRMTGDR
MSMEG_3671|M.smegmatis_MC2_155 WATLYLRDT-----------LHTPPAVAAFGY--IALVGFMFIGRMIGDR
TH_3240|M.thermoresistible__bu WAILYLRDN-----------LTAPPAVAVSGY--LALAGGMLIGRMTGDR
MAB_1338|M.abscessus_ATCC_1997 FIALYLIDH-----------LDVSAAVGGVGL--AMFLGGGVIGTLLGGR
MAV_3974|M.avium_104 LVPLFVSDV-----------MGR--GIGTIGVVLAAFAGGNALAVVPSGY
MUL_0911|M.ulcerans_Agy99 VTAGFLTLFGFIFVITQYFQFIKDYTALQTGVRLLPVAFSIALAAILGPR
MMAR_2515|M.marinum_M MFLFAASFFGAGLLFPSYFQELLGQTPMQAGMSMVPRGLGAMVTMPIAGA
* :
Mb1288c|M.bovis_AF2122/97 LAIRVPRRVTMSTAVLTLGLASMVIAFLPPLP-------VIMVLCAVVGL
Rv1258c|M.tuberculosis_H37Rv LAIRVPRRVTMSTAVLTLGLASMVIAFLPPLP-------VIMVLCAVVGL
Mflv_3420|M.gilvum_PYR-GCK LVDRYGDRAVARAGGMITAVGMGIALAFPTVP-------GTIVGFAAAGL
Mvan_3174|M.vanbaalenii_PYR-1 LVDRFGERAVARSGGLITAAGMGAALAFPSVP-------GTIAGFAAAGL
MSMEG_3671|M.smegmatis_MC2_155 LVDRFGETAVVRAGGLIAAVGMGAALAFPSTA-------GSIAGFAAAGF
TH_3240|M.thermoresistible__bu LVDRFGERAVVRTGALLIAAGMGGALAVPTVP-------GTIGGFAAAGL
MAB_1338|M.abscessus_ATCC_1997 ISDRLGMIATIRVGSIVAIPAFVALRICPQPW-------IALALAAVVGI
MAV_3974|M.avium_104 LSDRMGRRTLLIVGLVTSGAATVWLGFVASLP-------VFLVAAGVVGV
MUL_0911|M.ulcerans_Agy99 LVERVGTTAVVAAGLAVFAAALAWASTADATTPYTQITLQMLLLGGGLGL
MMAR_2515|M.marinum_M LMDKRGAGKILMVGVGLIAAGMGLFAIGVSLN--AAYLPTLVTGLTIMGL
: : . . : *.
Mb1288c|M.bovis_AF2122/97 VYGPIQPIYN----------YVIQTRAAQHLRG------------RVVGV
Rv1258c|M.tuberculosis_H37Rv VYGPIQPIYN----------YVIQTRAAQHLRG------------RVVGV
Mflv_3420|M.gilvum_PYR-GCK GVATVIPAA---------------MRTADELPG------------LRPGT
Mvan_3174|M.vanbaalenii_PYR-1 GVATVIPAA---------------MRAADELPG------------LRAGT
MSMEG_3671|M.smegmatis_MC2_155 GVATLIPAA---------------MHAADQLPG------------LRPGT
TH_3240|M.thermoresistible__bu GVATLIPAA---------------MHGADQLPG------------IRAGT
MAB_1338|M.abscessus_ATCC_1997 TVNIPFAVLV----------KLG-QDYLPTRPG------------TAAGV
MAV_3974|M.avium_104 VTGIYMSPL---------------QAAVADILGNE----------ARAGL
MUL_0911|M.ulcerans_Agy99 TTAPATEAIMGSLPADRAGVGSAVNDTTRELGGTLGVAIAGSVFASVYSG
MMAR_2515|M.marinum_M GMGATMMPLS----------AVAVQTLTPHQIARG-------STLINVNQ
. .
Mb1288c|M.bovis_AF2122/97 MTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALR
Rv1258c|M.tuberculosis_H37Rv MTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALR
Mflv_3420|M.gilvum_PYR-GCK GLTMLTWLMRIGFLGAPLIVGVVADAVSLRAGLLSVPIAGIAIIALAAAL
Mvan_3174|M.vanbaalenii_PYR-1 GLTVLTWLMRVGFLGAPLIVGVVADATSLRAGLLTVPVAGAALVVLAGVL
MSMEG_3671|M.smegmatis_MC2_155 GLTAVTWLMRVGFFGAPLLVGVVADAAGLRAGLLVVPAAGVLAIVLAGAL
TH_3240|M.thermoresistible__bu GLMAVTWLMRVGFLASPPVVGAIADATSLRVGLLGVPLAGLVAAVLAGVL
MAB_1338|M.abscessus_ATCC_1997 TLGLAVSIG--GFFVP--LLGVLADHHGPQAVLTTLCVAPILAIVLAFLL
MAV_3974|M.avium_104 PVATVQMMSDLGAIVGSMAVGWAAEQIGYGWGFFISGVVLLIAAVGWVMA
MUL_0911|M.ulcerans_Agy99 QLGSASALATLPSDVRSAMKGSMAVAHKVIDQLPAGPAAGVRDAVNHAFL
MMAR_2515|M.marinum_M QVAASIGTALMSVILTSQFNRSANISAAHRIDSLRADAARSGVPVDQSLM
.
Mb1288c|M.bovis_AF2122/97 ELDLAPQADIDRPVGSAQ--------------------------------
Rv1258c|M.tuberculosis_H37Rv ELDLAPQADIDRPVGSAQ--------------------------------
Mflv_3420|M.gilvum_PYR-GCK LTARRRR-------------------------------------------
Mvan_3174|M.vanbaalenii_PYR-1 GSRCRG--------------------------------------------
MSMEG_3671|M.smegmatis_MC2_155 RPHRVSVGDAGQLDREHT--------------------------------
TH_3240|M.thermoresistible__bu SGRRRTPRW-----------------------------------------
MAB_1338|M.abscessus_ATCC_1997 PHPERE--------------------------------------------
MAV_3974|M.avium_104 PETRTATELEADLMAASRTSSRCEQQL-----------------------
MUL_0911|M.ulcerans_Agy99 DGLQVATLVCAGIALAAAIVVGWLLPARAGQPTPAQTEPALAQV------
MMAR_2515|M.marinum_M PERASTPDFPLVLMHDLSHAYAVVFVVAVGLVALMFVPVAFLPKKPPAVR
Mb1288c|M.bovis_AF2122/97 -----------------
Rv1258c|M.tuberculosis_H37Rv -----------------
Mflv_3420|M.gilvum_PYR-GCK -----------------
Mvan_3174|M.vanbaalenii_PYR-1 -----------------
MSMEG_3671|M.smegmatis_MC2_155 -----------------
TH_3240|M.thermoresistible__bu -----------------
MAB_1338|M.abscessus_ATCC_1997 -----------------
MAV_3974|M.avium_104 -----------------
MUL_0911|M.ulcerans_Agy99 -----------------
MMAR_2515|M.marinum_M RNPPPQPAEHSDTEVNR