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VRTHTVAAGETLSGLALRFYGEADLYPLIATASGIPDPGVIAVGQRLIFPDFVRHTVVPGETLSDVAARF YADAALAPLIAAASGIAPTTDAEAGQRLVIPDITRYPVVAGDTLSALATRFYGDSAFYPLIAAVNGIPNP NVIEVGRVLLIFAGRSDGFGLRIVDRNESDPRLWYYRFQTAAVGWNPGINVLLPDDYRTSGKTYPVLYLL HGGGDQDFRTFDFLGIRNWTAGKPIIVVMPDGGHAGWYSNPVASFVGPRNWETFHIAQLLPWVEANFRTY AEYDGRAVAGFSMGGFGALKYAAKYYGHFASVSSHSGPASLRRDFGLVVHWANLTSAVLDLGGGTVYGAP LWDQARVSADNPVERIESYRNKRVFLVAGTSPDPLNWFDSVNETQVLAGQREFRERLRAAGIPHEAHEVP GGHIFRPEMFIRDLDGIIARLRPAAAVEV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3437 | - | - | 100% (450) | putative esterase family protein |
| M. smegmatis MC2 155 | MSMEG_3288 | - | 2e-14 | 31.87% (160) | LysM domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_6398 | - | 1e-09 | 27.32% (205) | antigen 85-A |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1319 | - | 0.0 | 85.46% (392) | hypothetical protein Mb1319 |
| M. gilvum PYR-GCK | Mflv_4459 | - | 1e-10 | 28.33% (233) | putative esterase |
| M. tuberculosis H37Rv | Rv1288 | - | 0.0 | 83.89% (447) | hypothetical protein Rv1288 |
| M. leprae Br4923 | MLBr_00097 | fbpA | 3e-08 | 33.33% (132) | antigen 85A, mycolytransferase |
| M. abscessus ATCC 19977 | MAB_4806c | - | 0.0 | 78.30% (447) | hypothetical protein MAB_4806c |
| M. marinum M | MMAR_3773 | - | 6e-10 | 40.62% (96) | hypothetical protein MMAR_3773 |
| M. avium 104 | MAV_0215 | - | 7e-08 | 28.17% (213) | antigen 85-C |
| M. thermoresistible (build 8) | TH_1961 | fbpA | 1e-10 | 30.60% (183) | SECRETED ANTIGEN 85-A FBPA (MYCOLYL TRANSFERASE 85A) |
| M. ulcerans Agy99 | MUL_3720 | - | 3e-09 | 39.58% (96) | hypothetical protein MUL_3720 |
| M. vanbaalenii PYR-1 | Mvan_1902 | - | 2e-10 | 28.33% (233) | putative esterase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4459|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1902|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00097|M.leprae_Br4923 --------------------------------------------------
TH_1961|M.thermoresistible__bu --------------------------------------------------
MAV_0215|M.avium_104 --------------------------------------------------
Mb1319|M.bovis_AF2122/97 MVSTHAVVAGETLSALALRFYGDAELYRLIAAAS----------------
Rv1288|M.tuberculosis_H37Rv MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVGQRLIM
MAB_4806c|M.abscessus_ATCC_199 MVRTHTVVAGDTLWQLALRFYGDAELYRLIATASGISDPGAIGVGRRLVI
MSMEG_3437|M.smegmatis_MC2_155 MVRTHTVAAGETLSGLALRFYGEADLYPLIATASGIPDPGVIAVGQRLIF
MMAR_3773|M.marinum_M --------------------------------------------------
MUL_3720|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4459|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1902|M.vanbaalenii_PYR-1 --------------------------------------------------
MLBr_00097|M.leprae_Br4923 --------------------------------------------------
TH_1961|M.thermoresistible__bu --------------------------------------------------
MAV_0215|M.avium_104 --------------------------------------------------
Mb1319|M.bovis_AF2122/97 -----------------------------------GIADPDVVNVGQRLI
Rv1288|M.tuberculosis_H37Rv PDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLI
MAB_4806c|M.abscessus_ATCC_199 PDVTRYTVVAGDTLSALALRFYGDAELYRLIAAVNGISDPGAIGVGRRLV
MSMEG_3437|M.smegmatis_MC2_155 PDFVRHTVVPGETLSDVAARFYADAALAPLIAAASGIAPTTDAEAGQRLV
MMAR_3773|M.marinum_M --------------------------------------------------
MUL_3720|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4459|M.gilvum_PYR-GCK ---------------MRLLDRIR--GPWA---RRLGIAT------LAALL
Mvan_1902|M.vanbaalenii_PYR-1 ---------------MRLLDRIR--GPWA---RRLGIAA------LAAVL
MLBr_00097|M.leprae_Br4923 ---------------MKFVDRFR--GAVAGMLRRLVVEA------MGVAL
TH_1961|M.thermoresistible__bu ---MNQVKMSGQEKAMNFSAKPRRNGSYRHWFRRLGAVI------AALVL
MAV_0215|M.avium_104 -------------MDMTVVRGVS--ALLRVFCIAVLAAG------LGVAL
Mb1319|M.bovis_AF2122/97 MPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVL
Rv1288|M.tuberculosis_H37Rv MPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVL
MAB_4806c|M.abscessus_ATCC_199 IPDVTRYTVVAGDTLSALALRFYGDAELYRLIAAVNGIADPTALDAGRVL
MSMEG_3437|M.smegmatis_MC2_155 IPDITRYPVVAGDTLSALATRFYGDSAFYPLIAAVNGIPNPNVIEVGRVL
MMAR_3773|M.marinum_M --------------------------------------------------
MUL_3720|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4459|M.gilvum_PYR-GCK LPGVVGLTGGSVTAGAFSRPGLPVEYLMVPSPSMGRD------IKVQFQS
Mvan_1902|M.vanbaalenii_PYR-1 LPGVVGLTGGSATAGAFSRPGLPVEYLMVPSPSMGRD------IKIQFQS
MLBr_00097|M.leprae_Br4923 LSALIGVVG-SAPAEAFSRPGLPVEYLQVPSPSMGRD------IKVQFQN
TH_1961|M.thermoresistible__bu LPALTAVVG------AMPRAQAAPETLMVPSPSMGRD------IPVQFQG
MAV_0215|M.avium_104 QP--AAVTG--------AARAAGYESLMVPSAAMGRD------IPVAFLA
Mb1319|M.bovis_AF2122/97 VIFIGRSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRT
Rv1288|M.tuberculosis_H37Rv VIFIGRSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRT
MAB_4806c|M.abscessus_ATCC_199 LIFRGRSDGFGLTIVDRNEDDPRLWYYRFQTDAIGWNPGVNVLLPDDYRT
MSMEG_3437|M.smegmatis_MC2_155 LIFAGRSDGFGLRIVDRNESDPRLWYYRFQTAAVGWNPGINVLLPDDYRT
MMAR_3773|M.marinum_M -------------------------MPMSDTLTEGQQ-------------
MUL_3720|M.ulcerans_Agy99 ---------------------------MSDTLTEGQQ-------------
: : * :
Mflv_4459|M.gilvum_PYR-GCK GGPNSPALYLLDGLRAQDDFNGWDINTQAFEWYLDSGISVVMPVGGQSSF
Mvan_1902|M.vanbaalenii_PYR-1 GGPNSPALYLLDGLRAQDDFNGWDINTQAFEWYLDSGISVIMPVGGQSSF
MLBr_00097|M.leprae_Br4923 GGANSPALYLLDGLRAQDDFSGWDINTTAFEWYYQSGISVVMPVGGQSSF
TH_1961|M.thermoresistible__bu GGEK--AVYLLDGMRARDDRNGWDIETGAFSWFEGSGLSVVAPVGGMSSF
MAV_0215|M.avium_104 GGPH--AVYLLDAFNAAPDVSNWVTAGNAMNTLGGKGISVVAPAGGAWSM
Mb1319|M.bovis_AF2122/97 SGRTYPVLYLFHGGGTDQDFRTFDFLG-IRDLTAGKPIIIVMPDGGHAGW
Rv1288|M.tuberculosis_H37Rv SGRTYPVLYLFHGGGTDQDFRTFDFLG-IRDLTAGKPIIIVMPDGGHAGW
MAB_4806c|M.abscessus_ATCC_199 SGRTYPVLYMLHGG--AADFRQFDFLG-IRDLTAGRPIIVVMPDGGQAGW
MSMEG_3437|M.smegmatis_MC2_155 SGKTYPVLYLLHGGG-DQDFRTFDFLG-IRNWTAGKPIIVVMPDGGHAGW
MMAR_3773|M.marinum_M ---------LVPGESLVSKNG-------AYTLTLQDDGNLVLASRGTPLW
MUL_3720|M.ulcerans_Agy99 ---------LVPGESLVSKNG-------AYTLTLQDDGNLVLASRGTPLW
:. . . :: . *
Mflv_4459|M.gilvum_PYR-GCK YSNWYKPACGKNGCLTYNWETFLTQELPAWLQANRD--VRPTNNAAVGLS
Mvan_1902|M.vanbaalenii_PYR-1 YSNWYKPACGKSGCLTYNWETFLTQELPGWLQANRD--VKPTGSAAVGLS
MLBr_00097|M.leprae_Br4923 YSDWYSPACGKAGCQTYKWETFLTSELPQYLQSNKQ--IKPTGSAAVGLS
TH_1961|M.thermoresistible__bu YTDWYGPAVGNGRTQTYKWETFLTSELPAWLAENRG--VSPSGNAVVGVS
MAV_0215|M.avium_104 YTNWEQDGSKQ-------WDTFLSSELPDWLAANKG--LAPGGHAAVGAS
Mb1319|M.bovis_AF2122/97 YSNPVSSFVGPR-----NWETFHIAQLLPWIEANFRTYAEYDGRAVAGFS
Rv1288|M.tuberculosis_H37Rv YSNPVSSFVGPR-----NWETFHIAQLLPWIEANFRTYAEYDGRAVAGFS
MAB_4806c|M.abscessus_ATCC_199 YCNPVGSFVGPR-----NWETFHMAQLIPWIEANFRTYAEYDGRAVSGFS
MSMEG_3437|M.smegmatis_MC2_155 YSNPVASFVGPR-----NWETFHIAQLLPWVEANFRTYAEYDGRAVAGFS
MMAR_3773|M.marinum_M ATATNGQQVVRA-------EVQRDGNFVVYTADKPVWHTDTKGKKNVRLV
MUL_3720|M.ulcerans_Agy99 ASATNGQQVVRA-------EVQRDGNFVVYTADKPVWHTDTKGKKNVRLV
:. :: : : .
Mflv_4459|M.gilvum_PYR-GCK MAGGSSLVLAAHHPGQFSYAGSMSGFLNPSEGWWPGLINISMGDAG-GYK
Mvan_1902|M.vanbaalenii_PYR-1 MAGGSSLVLAAHHPGQFVWAGSMSGFLNPSEGWWPGLINISMGDAG-GYK
MLBr_00097|M.leprae_Br4923 MAGLSALTLAIYHPDQFIYVGSMSGLLDPSNAMGPSLIGLAMGDAG-GYK
TH_1961|M.thermoresistible__bu MSGSSALILAAYHPGQFSYAGSLSGYLNLSEDYWPLLIAVAMADAG-GFN
MAV_0215|M.avium_104 QGGYGAMALAAFHPDRFGFAGSLSGFLYPSSTNYNGAILAGLQQYG-GVD
Mb1319|M.bovis_AF2122/97 MGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLG
Rv1288|M.tuberculosis_H37Rv MGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLG
MAB_4806c|M.abscessus_ATCC_199 MGGFGALKYAAKYYGHFASVSSHSGPASLRRDGGLVVHWANLSSAAVELG
MSMEG_3437|M.smegmatis_MC2_155 MGGFGALKYAAKYYGHFASVSSHSGPASLRRDFGLVVHWANLTSAVLDLG
MMAR_3773|M.marinum_M LQDDRNLVLYAADGPAWSTHTETDAPPPPEPTAAAEATASDTAQRVDTTP
MUL_3720|M.ulcerans_Agy99 LQDDRNLVLYAADGPAWSTHTETDAPPPPEPTAAAEATASDTAQRVDTTP
. : : . .. .
Mflv_4459|M.gilvum_PYR-GCK ANDMWGPAETDPAWQYNDPMVQIPNLVANNSRIWVYCGNGTPNE----LG
Mvan_1902|M.vanbaalenii_PYR-1 ANDMWGPAETDPAWQYNDPMVQIPRLVANNSRIWVYCGNGQPNE----LG
MLBr_00097|M.leprae_Br4923 AADMWGPS-TDPAWKRNDPTVNVGTLIANNTRIWMYCGNGKPTE----LG
TH_1961|M.thermoresistible__bu ALDMWGPY-GGPAWQRNDPMLQVGRLVANGTRIWVYTGNGNPTELDAGLG
MAV_0215|M.avium_104 GNGMWGAP-QLGRWKWHDPYVHASLLAQNNTRVWVWS----PTN----MG
Mb1319|M.bovis_AF2122/97 GGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPAN------
Rv1288|M.tuberculosis_H37Rv GGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPAN------
MAB_4806c|M.abscessus_ATCC_199 GATVYGVP-WDEARVSADNPVERIESYRNKRIFTVAGTSPDPVN------
MSMEG_3437|M.smegmatis_MC2_155 GGTVYGAPLWDQARVSADNPVERIESYRNKRVFLVAGTSPDPLN------
MMAR_3773|M.marinum_M EPVAAAVAEPAPPEPAAEPAPRTYTVVSG---------------------
MUL_3720|M.ulcerans_Agy99 EAVAAAVAEPAPPEPAAEPAPRTYTVVSG---------------------
. : . .
Mflv_4459|M.gilvum_PYR-GCK GGDLPATFLEGLTIRTNRTFQDNYLAAGGKNGVFNFPNNGTHNWAYWGRE
Mvan_1902|M.vanbaalenii_PYR-1 GGDLPATFLEGLTIRTNRTFQDNYIAAGGTNGVFNFPNNGTHNWAYWGRE
MLBr_00097|M.leprae_Br4923 GNNLPAKLLEGLVRTSNIKFQDGYNAGGGHNAVFNFPDSGTHSWEYWGEQ
TH_1961|M.thermoresistible__bu DAQIPAQFLEGLTVRTSREFQRAYQRAGGTNAVFNFPASGTHSWGYWGGQ
MAV_0215|M.avium_104 GDDAAMIGQAGAAMGSSREFYQQYRSNGGHNGHFDFPGGGDNGWGSWAGQ
Mb1319|M.bovis_AF2122/97 ---WFDSVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLD
Rv1288|M.tuberculosis_H37Rv ---WFDSVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLD
MAB_4806c|M.abscessus_ATCC_199 ---WFDTVQETQVLAGQREFRGRLSDAGIPHEFREEPGGHVFRPDMFVLD
MSMEG_3437|M.smegmatis_MC2_155 ---WFDSVNETQVLAGQREFRERLRAAGIPHEAHEVPGGHIFRPEMFIRD
MMAR_3773|M.marinum_M --------------DTLWAIAERFYGDGSKYQVIAEASGVANPDLIHPGE
MUL_3720|M.ulcerans_Agy99 --------------DTLWAIAERFYGDGSKYQVIAEASGVANPDLIHPGE
: * . . :
Mflv_4459|M.gilvum_PYR-GCK LQAMKPDLQAHLLG-------
Mvan_1902|M.vanbaalenii_PYR-1 LQAMKPDLQAHLL--------
MLBr_00097|M.leprae_Br4923 LNDMKPDLQQYLGATPGA---
TH_1961|M.thermoresistible__bu LQAMIPDIQRTLGAAPAE---
MAV_0215|M.avium_104 LGAMSGDIVGAIR--------
Mb1319|M.bovis_AF2122/97 LDGIVARLRPASIGAAAERAD
Rv1288|M.tuberculosis_H37Rv LDGIVARLRPASIGAAAERAD
MAB_4806c|M.abscessus_ATCC_199 LDGIIARLRPASASVAV----
MSMEG_3437|M.smegmatis_MC2_155 LDGIIARLRPAAAVEV-----
MMAR_3773|M.marinum_M VLTIP----------------
MUL_3720|M.ulcerans_Agy99 VLTIP----------------
: :