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MTIRTVLVVGAAGNAAGHVVTSLAEKEVRVRGFIRDAEKRQQVLRRGASEVAVGDLNRVEDVKAALSDVD AVFYVPPAFIDGEAELGVAFVELARAAGVRRFVFSSVIHPSLGLQNHAAKAPVEAALYDSGMEYAVFQPA LFFQNYAAGWDDILRTGVLAEPWSNETRFSRVDYRDVADAVALALTEDRLVGGTYEVASAGQLDRHDVAE LISRVVGRPIRPRRVDPDQLDGIKPAMKAMFRHYDHAGLVSTDVTLTAVLGRPPRTIEAYFRELARRGYP DGTNTHEKESHDERT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3355 | - | - | 100% (295) | hypothetical protein MSMEG_3355 |
| M. smegmatis MC2 155 | MSMEG_4034 | - | 4e-13 | 28.62% (283) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_5799 | - | 3e-12 | 26.84% (231) | nucleoside-diphosphate-sugar epimerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1635 | - | 2e-13 | 26.46% (223) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3000 | - | 7e-08 | 23.21% (293) | hypothetical protein MAB_3000 |
| M. marinum M | MMAR_4310 | - | 3e-15 | 30.53% (226) | oxidoreductase |
| M. avium 104 | MAV_0162 | - | 3e-11 | 28.16% (277) | hypothetical protein MAV_0162 |
| M. thermoresistible (build 8) | TH_0069 | - | 2e-12 | 27.23% (224) | nucleoside-diphosphate-sugar epimerase |
| M. ulcerans Agy99 | MUL_0982 | - | 4e-05 | 21.93% (228) | hypothetical protein MUL_0982 |
| M. vanbaalenii PYR-1 | Mvan_5113 | - | 6e-09 | 24.66% (223) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1635|M.gilvum_PYR-GCK --------------------------------MPGNDVRCVVTGATGYIG
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------MSTEQVRCLVTGATGYIG
MMAR_4310|M.marinum_M --------------------------------MSAGQVNCLVTGATGYIG
TH_0069|M.thermoresistible__bu --------------------------------MP-DLPRCLVTGATGYIG
MUL_0982|M.ulcerans_Agy99 MCSCGQSRCRFRIGSDRLLPDGPASPRPHRLGSSVETMRILVTGATGYVG
MAB_3000|M.abscessus_ATCC_1997 -------------------------------------MTILVTGATGNVG
MAV_0162|M.avium_104 -------------------------------------MTIVVTGATGNVG
MSMEG_3355|M.smegmatis_MC2_155 ----------------------------------MTIRTVLVVGAAGNAA
:*.**:* .
Mflv_1635|M.gilvum_PYR-GCK GRLVPELLARGLQVRAMARTPSKLDRTEWRDRVEVVRGDLTEADSLTAAF
Mvan_5113|M.vanbaalenii_PYR-1 RRLVPELLDRGHTVRAMARTPAKLDDAAWRDRVEVVRGDLTEPDSLASAF
MMAR_4310|M.marinum_M ARLVPRLLDEGHRVRALARDPGKLADVPWRDRAEVVRGDLGDTDSLEAAF
TH_0069|M.thermoresistible__bu GRLIPRLLDRGHPVQAMARNPEKLAGAPWRDRVDVVQGDLTDGDSLTAAF
MUL_0982|M.ulcerans_Agy99 SRLVTALLADGHEVLAATRNMARLSRLAWFDDVTPVILDATDRASAQAAM
MAB_3000|M.abscessus_ATCC_1997 RPLVDLLVAAGADVRAVTQHPERAS----------FPPQVATVASARAGL
MAV_0162|M.avium_104 RPLVTALLAAGAPVRAVTRRSGPAG----------FPAQVELFDTAADAL
MSMEG_3355|M.smegmatis_MC2_155 GHVVTSLAEKEVRVRGFIRDAEKRQQVLRRGASEVAVGDLNRVEDVKAAL
:: * * . : : .:
Mflv_1635|M.gilvum_PYR-GCK NG---ADVVYYLVHSMGTSRDFVAEERRSAHNVVEAAKKAGVRRIVYLSG
Mvan_5113|M.vanbaalenii_PYR-1 DG---VDVIYYLVHSMGTSRDFVAEEARSARNVVAAAEKAGVRRLVYLGG
MMAR_4310|M.marinum_M AG---MDVVYYLVHSMGSAKHFADEEARAAHNVVLAARRSGVRRVVYLSG
TH_0069|M.thermoresistible__bu AG---VDVVYYLVHSMGSADDFAAEEARSAREVVAAARRTGVRRLVYLGG
MUL_0982|M.ulcerans_Agy99 NAAGQIDVVYYLVHGIGQP-DFRDRDKTAAANLAVAARDTGVRRIVYLGG
MAB_3000|M.abscessus_ATCC_1997 DG---VTAVFLNSRALGED----------LDRFVNQSAREGVTRLVALSA
MAV_0162|M.avium_104 PG---ASAVFLNARALGGQ----------LEDVVARCARGGVTKLVALSA
MSMEG_3355|M.smegmatis_MC2_155 SD---VDAVFYVPPAFIDG------EAELGVAFVELARAAGVRRFVFSSV
.:: .: .. . ** :.* .
Mflv_1635|M.gilvum_PYR-GCK LHPD---RKELSRHLASRVEVGEIL-MQSGIETVVLQAGIVIGSGSASFE
Mvan_5113|M.vanbaalenii_PYR-1 LHPQG--KTDLSRHLASRVEVGDIL-LGSTVETVVLQAGIVVGSGSASFE
MMAR_4310|M.marinum_M LHPE---QSKLSPHLQSRMAVGDAL-IGSGIETIVLQAGVVVGSGSASFE
TH_0069|M.thermoresistible__bu LHPP---GTGLSTHLESRVEVGDIL-LDSGIETVVLQAGIVIGSGSASFE
MUL_0982|M.ulcerans_Agy99 FVPE---CEALSQHLSSRAVVAEALAVDDGAELVWLGAAMIIGAGSTLFE
MAB_3000|M.abscessus_ATCC_1997 INCDDDFSRQPSRFRGDRNKEVEQYAAGSGLQWVSLRPTVFASNFLGMWG
MAV_0162|M.avium_104 INADDDFSRQPSRFRGDRNREVEQLAVGSGLAWVSLRPTVFATNFAGMWS
MSMEG_3355|M.smegmatis_MC2_155 IHPS------LGLQNHAAKAPVEAALYDSGMEYAVFQPALFFQNYAAGWD
: . : . : . :. :
Mflv_1635|M.gilvum_PYR-GCK MVRHLTDRLPVMTTPKWVHNKIQPISISDVLHYLAEAATAEFGE---SRT
Mvan_5113|M.vanbaalenii_PYR-1 MVRHLTDRLPVMTTPKWVHNTIQPIAIADVLYYLAEAATAEVPE---SRT
MMAR_4310|M.marinum_M MIRHLTDRLPVMTTPKWVHNRIQPIAIRDVLHYLVAAATATVPDTARART
TH_0069|M.thermoresistible__bu MIRHLTDRLPVMTTPKWVRNRIQPIAVDDVLHYLAEAATAAVPG---SRA
MUL_0982|M.ulcerans_Agy99 MLRYVGDRFPVLPMPDWMYNPIDPISIRDVLHYLVAAADVDQVP---AGA
MAB_3000|M.abscessus_ATCC_1997 TQLQAGD----VVRGPHAAASAAPIADSDISEVAARALLTDELLG---QR
MAV_0162|M.avium_104 AQLREGD----VVAGPYAAASSAPIVETDIADVAAHALLTDDLVG---QR
MSMEG_3355|M.smegmatis_MC2_155 DILRTGV----LAEPWSNETRFSRVDYRDVADAVALALTEDRLVG---GT
: : *: . *
Mflv_1635|M.gilvum_PYR-GCK WDIGGPDVMEYGDAMQGYADVAGLRRRVMVVLPFLTPTIASWWVGLVTPI
Mvan_5113|M.vanbaalenii_PYR-1 WDIGGPDVMEYGEAMQIYADIAHLRRRVMVVLPFLTPTIASLWVGLVTPI
MMAR_4310|M.marinum_M WDVGGPDVLEYGDMMRVYAEVAGLHRRYLIVLPFLTPTIASLWVGTVTPI
TH_0069|M.thermoresistible__bu WDVGGPDVLEYGEAIQVYAEEAGRRRRVIVPLPWLTPRIASWWVGLVTPL
MUL_0982|M.ulcerans_Agy99 YDICGPDTTSYRELLKTYARIRG-RWHAALPVGRLDTAVASRITAGHPAG
MAB_3000|M.abscessus_ATCC_1997 IPLTGPQAFTNAGLVAVLGDVLGRPLEYQQVSDDLVRQRFGRLG--FPAG
MAV_0162|M.avium_104 IPLTGPQALSNAQLVEVIGTVLGRSLRYREIPAAAVRRRFVGLG--LGAG
MSMEG_3355|M.smegmatis_MC2_155 YEVASAGQLDRHDVAELISRVVGRPIRPRRVDPDQ-----------LDGI
: .. . .
Mflv_1635|M.gilvum_PYR-GCK PSGLARPLVESLECDAICHEHDIDAVIPPPKGGLIGYREAVAKELRSEGG
Mvan_5113|M.vanbaalenii_PYR-1 PSGLARPLVESLECDAVAHEHDIDTVIPPPEGGVTGYRDAVTQALRDDGT
MMAR_4310|M.marinum_M PPGLARPLIESLECDAVMRNSDIDTIIAPPAGGLTNYRRAVELALNRAAH
TH_0069|M.thermoresistible__bu PPGLAPPX---PRCSATCR--------SPPS--------SSAPAWSRSGS
MUL_0982|M.ulcerans_Agy99 PAWSGRRPGGIAGSPDGGIRGRPARQGPRATRRTTEYRRCHYVGAGRPRE
MAB_3000|M.abscessus_ATCC_1997 FADAYLAMQAATVTEPAIVTHDVDRILGRPAETFASWANRFRTRFAPAEF
MAV_0162|M.avium_104 FADAYLAMLAETLDKPALVTHDVEKILGRPAVPFAHWVATHRDLFD-RRN
MSMEG_3355|M.smegmatis_MC2_155 KPAMKAMFRHYDHAGLVSTDVTLTAVLGRPPRTIEAYFRELARRGYPDGT
. .
Mflv_1635|M.gilvum_PYR-GCK SS-AGRRHLLRFSPAASD--------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 AAKGGRRHLLRFSKVVPQ--------------------------------
MMAR_4310|M.marinum_M GLPDATWASLQSEPAEPLPSDPRWAGEIVYTDVRDATTTAAPEAVWKATE
TH_0069|M.thermoresistible__bu GCSSAAS-------------------------------------------
MUL_0982|M.ulcerans_Agy99 RAPVARRRPDRSPPTRIHRSGVGRR-------------------------
MAB_3000|M.abscessus_ATCC_1997 AAQKG---------------------------------------------
MAV_0162|M.avium_104 ERKEGV--------------------------------------------
MSMEG_3355|M.smegmatis_MC2_155 NTHEKESHDERT--------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4310|M.marinum_M RAINSRRWYSLALAPRRRHRAPRWRVAQRTPTTLRLGAGTRVPGPTWLEV
TH_0069|M.thermoresistible__bu --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_3355|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4310|M.marinum_M TLTPRGTAGSTYHQRAIFFPRGIPGRLSWLVLRHLYAAALRALARDVTAA
TH_0069|M.thermoresistible__bu --------------------------------------------------
MUL_0982|M.ulcerans_Agy99 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_3355|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --
Mvan_5113|M.vanbaalenii_PYR-1 --
MMAR_4310|M.marinum_M DR
TH_0069|M.thermoresistible__bu --
MUL_0982|M.ulcerans_Agy99 --
MAB_3000|M.abscessus_ATCC_1997 --
MAV_0162|M.avium_104 --
MSMEG_3355|M.smegmatis_MC2_155 --