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TIVVTGATGNVGRPLVTALLAAGAPVRAVTRRSGPAGFPAQVELFDTAADALPGASAVFLNARALGGQLE DVVARCARGGVTKLVALSAINADDDFSRQPSRFRGDRNREVEQLAVGSGLAWVSLRPTVFATNFAGMWSA QLREGDVVAGPYAAASSAPIVETDIADVAAHALLTDDLVGQRIPLTGPQALSNAQLVEVIGTVLGRSLRY REIPAAAVRRRFVGLGLGAGFADAYLAMLAETLDKPALVTHDVEKILGRPAVPFAHWVATHRDLFDRRNE RKEGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0162 | - | - | 100% (286) | hypothetical protein MAV_0162 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2073c | - | 7e-06 | 28.02% (207) | hypothetical protein Mb2073c |
| M. gilvum PYR-GCK | Mflv_1635 | - | 2e-05 | 23.24% (284) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv2047c | - | 7e-06 | 28.02% (207) | hypothetical protein Rv2047c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3000 | - | 7e-98 | 66.30% (276) | hypothetical protein MAB_3000 |
| M. marinum M | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_5366 | - | 3e-63 | 73.42% (158) | hypothetical protein MSMEG_5366 |
| M. thermoresistible (build 8) | TH_2433 | - | 4e-24 | 32.87% (286) | PUTATIVE putative conserved hypothetical protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_5113 | - | 1e-05 | 22.03% (286) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2073c|M.bovis_AF2122/97 -----MRIAVTGASGVLGRGLTARLLSQGHEVVGIARH--RPD--SWPSS
Rv2047c|M.tuberculosis_H37Rv -----MRIAVTGASGVLGRGLTARLLSQGHEVVGIARH--RPD--SWPSS
MAV_0162|M.avium_104 -----MTIVVTGATGNVGRPLVTALLAAGA-PVRAVTR--RSGPAGFPAQ
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 -----MTILVTGATGNVGRPLVDLLVAAGA-DVRAVTQ--HPERASFPPQ
TH_2433|M.thermoresistible__bu -----MTILVTGATGNIGRRVVDHLIALGATDIRALTT--DPAKAKLPES
Mflv_1635|M.gilvum_PYR-GCK MPGNDVRCVVTGATGYIGGRLVPELLARGLQVRAMARTPSKLDRTEWRDR
Mvan_5113|M.vanbaalenii_PYR-1 MSTEQVRCLVTGATGYIGRRLVPELLDRGHTVRAMARTPAKLDDAAWRDR
Mb2073c|M.bovis_AF2122/97 ADFIAADIRDATAVESAMTGADVVAHCAWVRGRN------------DHIN
Rv2047c|M.tuberculosis_H37Rv ADFIAADIRDATAVESAMTGADVVAHCAWVRGRN------------DHIN
MAV_0162|M.avium_104 VELFDTAADALPGASAVFLNAR-----ALGGQLE------------DVVA
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 VATVASARAGLDGVTAVFLNSR-----ALGEDLD------------RFVN
TH_2433|M.thermoresistible__bu VTAVTGYLGRPETLPAALHGVRRMYLAPLPATLP------------TTLE
Mflv_1635|M.gilvum_PYR-GCK VEVVRGDLTEADSLTAAFNGADVVYYLVHSMGTSRDFVAEERRSAHNVVE
Mvan_5113|M.vanbaalenii_PYR-1 VEVVRGDLTEPDSLASAFDGVDVIYYLVHSMGTSRDFVAEEARSARNVVA
Mb2073c|M.bovis_AF2122/97 IDGTANVLKAMAETG-------TGRIVFTSSGHQPRVEQMLADCGLEWVA
Rv2047c|M.tuberculosis_H37Rv IDGTANVLKAMAETG-------TGRIVFTSSGHQPRVEQMLADCGLEWVA
MAV_0162|M.avium_104 RCARGGVTKLVALSAINADDDFSRQPSRFRGDRNREVEQLAVGSGLAWVS
MSMEG_5366|M.smegmatis_MC2_155 -----------------------------------------MESALQWVS
MAB_3000|M.abscessus_ATCC_1997 QSAREGVTRLVALSAINCDDDFSRQPSRFRGDRNKEVEQYAAGSGLQWVS
TH_2433|M.thermoresistible__bu LAEQAGVEYVVALSG---------------GAHWQQHADTIAAAPLTSTQ
Mflv_1635|M.gilvum_PYR-GCK AAKKAGVRRIVYLSGLHPD----RKELSRHLASRVEVGEILMQSGIETVV
Mvan_5113|M.vanbaalenii_PYR-1 AAEKAGVRRLVYLGGLHPQG---KTDLSRHLASRVEVGDILLGSTVETVV
. : .
Mb2073c|M.bovis_AF2122/97 VRCALIFGRNVDNWVQRLFALP----VLPAGYADRVVQVVHSDDAQRLLV
Rv2047c|M.tuberculosis_H37Rv VRCALIFGRNVDNWVQRLFALP----VLPAGYADRVVQVVHSDDAQRLLV
MAV_0162|M.avium_104 LRPTVFATNFAGMWSAQLREGD----VVAGPYAAASSAPIVETDIADVAA
MSMEG_5366|M.smegmatis_MC2_155 LRPSAFVSNFLGMWAPQLQAGD----VVAGPYATASMAPIAEHDIAAVAA
MAB_3000|M.abscessus_ATCC_1997 LRPTVFASNFLGMWGTQLQAGD----VVRGPHAAASAAPIADSDISEVAA
TH_2433|M.thermoresistible__bu LGPGEFLENFT-LWAEQIKTTR----TVREPYPDVVEAPISMDDIARVAA
Mflv_1635|M.gilvum_PYR-GCK LQAGIVIGSGSASFEMVRHLTDRLPVMTTPKWVHNKIQPISISDVLHYLA
Mvan_5113|M.vanbaalenii_PYR-1 LQAGIVVGSGSASFEMVRHLTDRLPVMTTPKWVHNTIQPIAIADVLYYLA
: . : : * .
Mb2073c|M.bovis_AF2122/97 RALLDTV--IDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSF
Rv2047c|M.tuberculosis_H37Rv RALLDTV--IDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSF
MAV_0162|M.avium_104 HALLTDD--LVGQRIPLTGPQALSNAQLVEVIG---TVLGRSLRYREIPA
MSMEG_5366|M.smegmatis_MC2_155 HALLTDD--LVGQKVPLTGPQALTNADLVDIIG---GVLGRPLRYQEIPA
MAB_3000|M.abscessus_ATCC_1997 RALLTDE--LLGQRIPLTGPQAFTNAGLVAVLG---DVLGRPLEYQQVSD
TH_2433|M.thermoresistible__bu HLLAEPDPSHHGRMYELTGPQALTRARIAEQIG---VGIGVDVTFRRCDR
Mflv_1635|M.gilvum_PYR-GCK EAATAEFG--ESRTWDIGGPDVMEYGDAMQGYADVAGLRRRVMVVLPFLT
Mvan_5113|M.vanbaalenii_PYR-1 EAATAEVP--ESRTWDIGGPDVMEYGEAMQIYADIAHLRRRVMVVLPFLT
. . : .* : . :
Mb2073c|M.bovis_AF2122/97 AELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRT
Rv2047c|M.tuberculosis_H37Rv AELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRT
MAV_0162|M.avium_104 AAVRRRFVG------------------------------------LGLGA
MSMEG_5366|M.smegmatis_MC2_155 VAVRQRFIA------------------------------------LGFPA
MAB_3000|M.abscessus_ATCC_1997 DLVRQRFGR------------------------------------LGFPA
TH_2433|M.thermoresistible__bu AEAERALEP------------------------------------VMG--
Mflv_1635|M.gilvum_PYR-GCK PTIASWWVG-------------------------------------LVTP
Mvan_5113|M.vanbaalenii_PYR-1 PTIASLWVG-------------------------------------LVTP
Mb2073c|M.bovis_AF2122/97 FSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYL
Rv2047c|M.tuberculosis_H37Rv FSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYL
MAV_0162|M.avium_104 GFADAYLAMLAETLDKPALVTHDVEKILGRPAVPFAHWVATHRDLFDRRN
MSMEG_5366|M.smegmatis_MC2_155 AFADAYIQLLAATVDKPALVTHDVEKILGRPATTFAEAVSTHRDLFAKH-
MAB_3000|M.abscessus_ATCC_1997 GFADAYLAMQAATVTEPAIVTHDVDRILGRPAETFASWANRFRTRFAPAE
TH_2433|M.thermoresistible__bu ARARWYLDLLAD--GAPQRANRLVEELTGTPAESVAQWATRHAELFR---
Mflv_1635|M.gilvum_PYR-GCK IPSGLARPLVESLECDAICHEHDIDAVIPPPKGGLIGYREAVAKELRSEG
Mvan_5113|M.vanbaalenii_PYR-1 IPSGLARPLVESLECDAVAHEHDIDTVIPPPEGGVTGYRDAVTQALRDDG
: * :
Mb2073c|M.bovis_AF2122/97 ATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTV
Rv2047c|M.tuberculosis_H37Rv ATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTV
MAV_0162|M.avium_104 ERKEGV--------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 FAAQKG--------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK GSS-AGRRHLLRFSPAASD-------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 TAAKGGRRHLLRFSKVVPQ-------------------------------
Mb2073c|M.bovis_AF2122/97 AVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQR
Rv2047c|M.tuberculosis_H37Rv AVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQR
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 PPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLA
Rv2047c|M.tuberculosis_H37Rv PPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLA
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 FDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGR
Rv2047c|M.tuberculosis_H37Rv FDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGR
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 DTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEA
Rv2047c|M.tuberculosis_H37Rv DTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEA
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 PEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAP
Rv2047c|M.tuberculosis_H37Rv PEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAP
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 QPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRL
Rv2047c|M.tuberculosis_H37Rv QPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRL
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 TEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVF
Rv2047c|M.tuberculosis_H37Rv TEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVF
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 SGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEI
Rv2047c|M.tuberculosis_H37Rv SGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEI
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 LVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGAT
Rv2047c|M.tuberculosis_H37Rv LVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGAT
MAV_0162|M.avium_104 --------------------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb2073c|M.bovis_AF2122/97 RFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR
Rv2047c|M.tuberculosis_H37Rv RFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR
MAV_0162|M.avium_104 --------------------------------------
MSMEG_5366|M.smegmatis_MC2_155 --------------------------------------
MAB_3000|M.abscessus_ATCC_1997 --------------------------------------
TH_2433|M.thermoresistible__bu --------------------------------------
Mflv_1635|M.gilvum_PYR-GCK --------------------------------------
Mvan_5113|M.vanbaalenii_PYR-1 --------------------------------------