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ILTHAEPLHLSLETADTRLSAEVRPGHGTPVVIVPGIMADAATWRPVVAHIDLPNPVVTLNRRGRASSGG LGADYSVAVEVDDLRRVVGALGAVHLVGWSYGALIGLEAALGSGRIRSVTAYEPVSRPFAPETVAPIRAA VAAGDLDRAVALVNTDVSGFSDDYVAGLRRSPAWEVLRPLAQPMGEELAAIDAFEPSFDDYRHLTVPVTL ILGALNEGAAPYGTAFVPFSAALPQARLARLPGQGHLAHVEAPADLADAISRAVRHAEGT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2984 | - | - | 100% (271) | putative hydrolase |
| M. smegmatis MC2 155 | MSMEG_6085 | - | 2e-06 | 26.72% (247) | hydrolase, alpha/beta hydrolase fold family protein |
| M. smegmatis MC2 155 | MSMEG_2681 | - | 1e-05 | 25.00% (212) | proline imino-peptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3622c | - | 3e-08 | 28.93% (242) | putative hydrolase |
| M. gilvum PYR-GCK | Mflv_4502 | - | 8e-07 | 25.60% (293) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3591c | - | 3e-08 | 28.93% (242) | hydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0130 | - | 9e-13 | 27.35% (245) | putative hydrolase |
| M. marinum M | MMAR_2050 | - | 2e-07 | 27.17% (254) | hypothetical protein MMAR_2050 |
| M. avium 104 | MAV_4984 | - | 1e-16 | 28.99% (238) | alpha/beta hydrolase fold-1 |
| M. thermoresistible (build 8) | TH_2963 | - | 2e-07 | 27.98% (218) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_3358 | - | 2e-06 | 22.10% (267) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_2912 | - | 4e-08 | 25.86% (263) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3358|M.ulcerans_Agy99 -------------------------------MTERKRNLRPVREVTAPSL
Mvan_2912|M.vanbaalenii_PYR-1 ---------------------------------------------MHDDV
Mb3622c|M.bovis_AF2122/97 --------------------------------------------------
Rv3591c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0130|M.abscessus_ATCC_1997 --------------------------------------------MVSIAR
MAV_4984|M.avium_104 ------------------------------------------------MA
MSMEG_2984|M.smegmatis_MC2_155 ---------------------------------------MILTHAEPLHL
Mflv_4502|M.gilvum_PYR-GCK ------------------------MARSSSTRSRRAGSGPAVELPRGRVV
MMAR_2050|M.marinum_M MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
TH_2963|M.thermoresistible__bu ---------------------------------------------MPRFS
MUL_3358|M.ulcerans_Agy99 QFRTIHGYKRAFRIAG--SGPAILLIHGIGDNSTTWTGIHAKLAQR-FTV
Mvan_2912|M.vanbaalenii_PYR-1 KYLDLHGDRVAYREAG--QGPAVLLIHGMGGSSLTWKALLPHLATR-YRV
Mb3622c|M.bovis_AF2122/97 --MPRMPANLLTHRGG--RGEPLVLVHGLMGRGSTWARQLPWLTLL-GAV
Rv3591c|M.tuberculosis_H37Rv --MPRMPANLLTHRGG--RGEPLVLVHGLMGRGSTWARQLPWLTLL-GAV
MAB_0130|M.abscessus_ATCC_1997 YVAAPDGVRLSVTVSG--TGPSLVLVHGSLQSGSSWAGVVSELESD-FTC
MAV_4984|M.avium_104 TVVSPDGTVIGYESVG--AGPPLLLVHGSTGTRARWRPVTPELARR-YTV
MSMEG_2984|M.smegmatis_MC2_155 SLETADTRLSAEVRPG--HGTPVVIVPGIMADAATWRPVVAHIDLP-NPV
Mflv_4502|M.gilvum_PYR-GCK DVRSRDGVRLHAEVFGPEDGYPIVLAHGITCAIPVWAHQIADLSRD-HRV
MMAR_2050|M.marinum_M AITRPDGTVLHALVAG--RGTPVILVHGYCASLTEWNFVWDELLARGLRV
TH_2963|M.thermoresistible__bu RAGTTIDYTDTGAPAGRLEAPTILFGHGLLFSGWQFNLQIYALRRY-YRC
* . .::: * : :
MUL_3358|M.ulcerans_Agy99 IAPDL-LGHGRSDKPRAD--YSIAAYANGMRDLLSVLDIER--VTIIGHS
Mvan_2912|M.vanbaalenii_PYR-1 IAPDL-LGHGQSDKPRGD--YSLGAFAVWLRDLLDLLGIAR--VTLVGHS
Mb3622c|M.bovis_AF2122/97 YTYDAPWHRGRDVADPHP--ISTERFVADLGDAVSALGAP---TRMVGHS
Rv3591c|M.tuberculosis_H37Rv YTYDAPWHRGRDVADPHP--ISTERFVADLGDAVSALGAP---TRMVGHS
MAB_0130|M.abscessus_ATCC_1997 FAVDR-RGHGAS-SDAEE--HSLQREADDVIAVAAEVGPD---AVIVAHS
MAV_4984|M.avium_104 HAMDR-RGRGLSTAEAEP--YSLGREAEDVAAVAEAVGGD---VYVVGHS
MSMEG_2984|M.smegmatis_MC2_155 VTLNR-RGRASSGGLGAD--YSVAVEVDDLRRVVGALGAV----HLVGWS
Mflv_4502|M.gilvum_PYR-GCK IAYDH-RGHGRSGVPPRRGGYSLDYLASDLDAVLEATMAPGERAVIAGHS
MMAR_2050|M.marinum_M IAFDQ-RGHGRSTLGAEG--IGSEPMADDLAAVLQHFDIRDG--VLVGHS
TH_2963|M.thermoresistible__bu LAIDW-RGQGASSGAARP--YDMDTLTEDAAHLVRSLGVAP--AHYVGLS
: : :. . . . . *
MUL_3358|M.ulcerans_Agy99 LGGGVAMQFAYQFPQ----LVDRLILVGAGG-------VTKDVNVVFRLA
Mvan_2912|M.vanbaalenii_PYR-1 LGGGVAMQFVHQHPD----YCERLVLISSGG-------LGPELGRSLRLL
Mb3622c|M.bovis_AF2122/97 MGALHSWCLAAERPE----LVSALVVED----------MAPDFRGRTTGP
Rv3591c|M.tuberculosis_H37Rv MGALHSWCLAAERPE----LVSALVVED----------MAPDFRGRTTGP
MAB_0130|M.abscessus_ATCC_1997 YGAVVVLEAVRRGAD----VAAVVLYEP----------PLP-ISERVASA
MAV_4984|M.avium_104 YGALAVLDAAPITRA----FRRIVLYEP----------PIPSLGLDVGSP
MSMEG_2984|M.smegmatis_MC2_155 YGALIGLEAALGSGR----IRSVTAYEP----------VSRPFAPETVAP
Mflv_4502|M.gilvum_PYR-GCK MGGIAISSWSERLPHRVAERADGVALINTTTGDLLRNVNLLPVPARFADA
MMAR_2050|M.marinum_M MGGFVSIRALLDHGALAQRLRAVVLFATWAG-----RVLDGAPQNRLQIP
TH_2963|M.thermoresistible__bu MGGFVGIRLAARHPEL---VRSLVLMNTSAG------PEDPAKADRYRTM
*.
MUL_3358|M.ulcerans_Agy99 SLPMGAEALALLRLPMVLPTVQLAGKVLGMALGSTALG-QDLPNVLRILD
Mvan_2912|M.vanbaalenii_PYR-1 STPG----IELLLPVAAAPSVVAVGERVRSWLGARGLASPEVGETWNAYA
Mb3622c|M.bovis_AF2122/97 WEP------WLRALPVEFDSAEQVFAEFGPVAGRYFLDAFDRTATGWRLH
Rv3591c|M.tuberculosis_H37Rv WEP------WLRALPVEFDSAEQVFAEFGPVAGRYFLDAFDRTATGWRLH
MAB_0130|M.abscessus_ATCC_1997 N----------------RDASAALR---------GRSTVVTREW------
MAV_4984|M.avium_104 GGWA-----RITALSDPRDILEAFYRETLQLSESAIKDLANREFPYLAGS
MSMEG_2984|M.smegmatis_MC2_155 IRAA-------VAAGDLDRAVALVNTDVSGFSDDYVAGLRRSPAWEVLRP
Mflv_4502|M.gilvum_PYR-GCK RVRAAGGVIRTFGGTSMVRVADLPSRRFVSMIAVGRDADPAIADFVFELF
MMAR_2050|M.marinum_M LLERG-------ILQRLLRSRTIAVLFGAAQCGARPSPAMISVFLEWFHQ
TH_2963|M.thermoresistible__bu ARIYR------FTGIGPLRRAVLPLMFGPAFLADPDSEDVIDEWERRLRR
MUL_3358|M.ulcerans_Agy99 DLPEPTASSAFTRTLRAVVDWRGQIVTMLDRCYLTQAIPVQIIWGSRDA-
Mvan_2912|M.vanbaalenii_PYR-1 SLSDPQTRTAFLRTLRSVVDAQGQAVSALNRLHFTLGLPTLLIWGDQDR-
Mb3622c|M.bovis_AF2122/97 GRTARWIEIAAEWGTRDYWAQWRAVR------------SPALLIEAGDG-
Rv3591c|M.tuberculosis_H37Rv GRTARWIEIAAEWGTRDYWAQWRAVR------------SPALLIEAGDG-
MAB_0130|M.abscessus_ATCC_1997 --------MAVNRSVESIGEYTRAAT------------PMYLLEGANSP-
MAV_4984|M.avium_104 IRHTAGRELAQTRAYRLTERHANITT------------PVRMLLGTESP-
MSMEG_2984|M.smegmatis_MC2_155 LAQPMGEELAAIDAFEPSFDDYRHLT-----------VPVTLILGALNEG
Mflv_4502|M.gilvum_PYR-GCK HRTPPAGRGGWARVLVDHLGPRHIGLDN-------LTVPALVIGSTHDR-
MMAR_2050|M.marinum_M HLDRHGPHLPIVRAFSREDRYPRLAEIS---------VPAVVMVGSSDR-
TH_2963|M.thermoresistible__bu YPRSSVRDAVLAVANRAGVEDELAAID----------VPTLVIGGAQDA-
. :: .
MUL_3358|M.ulcerans_Agy99 -VVPVRHAEMAHAAMPGSKLEVFEGSGHFPFHDDPARFIDIVLRFIDSTQ
Mvan_2912|M.vanbaalenii_PYR-1 -LIPPAHGEAAHAALPGSRLVILPAVGHFPQVEAPLAVADTLDDFIANSS
Mb3622c|M.bovis_AF2122/97 -VTPPGQMRAMAERDYPTAYLRVPDAGHLVHDEAPQVYRRAVESFLAGLT
Rv3591c|M.tuberculosis_H37Rv -VTPPGQMRAMAERDYPTAYLRVPDAGHLVHDEAPQVYRRAVESFLAGLT
MAB_0130|M.abscessus_ATCC_1997 -PQFRDPVGYLARRVPGVRVKELVGQDHFAHREAPAVFAQALRELLLS--
MAV_4984|M.avium_104 -AYLRAATAVLAAKIPGATIVALHGQGHQAIDYDPDQFARAVLEFDSEEV
MSMEG_2984|M.smegmatis_MC2_155 AAPYGTAFVPFSAALPQARLARLPGQGHLAHVEAPADLADAISRAVRHAE
Mflv_4502|M.gilvum_PYR-GCK -LLPVSSARHIASAAPNLARFVELAGGHCAILERPEEVNQQLRWLVDSVS
MMAR_2050|M.marinum_M -TTPPSHSHRLAAGIPGARLVTVPGAGHLLNWEAVDELAEVVESFAAQR-
TH_2963|M.thermoresistible__bu -ATPPAHAQALAAGIRGARLEIIDDCGHSSPLERPDVVTELLRGFLLEHT
.* :
MUL_3358|M.ulcerans_Agy99 PPEYDQAALRELLRTGGGERTVSDPADTRVAVLSAMGSDERSAT
Mvan_2912|M.vanbaalenii_PYR-1 P--------------WHGPPRHADHAEAD---------------
Mb3622c|M.bovis_AF2122/97 P-------------------------------------------
Rv3591c|M.tuberculosis_H37Rv P-------------------------------------------
MAB_0130|M.abscessus_ATCC_1997 --------------------------------------------
MAV_4984|M.avium_104 DSGGVGAVTA----------------------------------
MSMEG_2984|M.smegmatis_MC2_155 GT------------------------------------------
Mflv_4502|M.gilvum_PYR-GCK RSTRASAATGDQARASEATGDQARASAATGDQARASSR------
MMAR_2050|M.marinum_M --------------------------------------------
TH_2963|M.thermoresistible__bu --------------------------------------------