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VVSIARYVAAPDGVRLSVTVSGTGPSLVLVHGSLQSGSSWAGVVSELESDFTCFAVDRRGHGASSDAEEH SLQREADDVIAVAAEVGPDAVIVAHSYGAVVVLEAVRRGADVAAVVLYEPPLPISERVASANRDASAALR GRSTVVTREWMAVNRSVESIGEYTRAATPMYLLEGANSPPQFRDPVGYLARRVPGVRVKELVGQDHFAHR EAPAVFAQALRELLLS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0130 | - | - | 100% (226) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3517 | - | 1e-08 | 37.37% (99) | putative hydrolase, alpha/beta fold LipV |
| M. abscessus ATCC 19977 | MAB_4019c | - | 2e-08 | 36.36% (88) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2237c | ephD | 6e-12 | 39.29% (112) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_2937 | - | 3e-11 | 28.17% (252) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv2214c | ephD | 6e-12 | 39.29% (112) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-13 | 40.91% (110) | short chain dehydrogenase |
| M. marinum M | MMAR_2050 | - | 8e-09 | 36.44% (118) | hypothetical protein MMAR_2050 |
| M. avium 104 | MAV_4984 | - | 1e-28 | 34.13% (252) | alpha/beta hydrolase fold-1 |
| M. smegmatis MC2 155 | MSMEG_2984 | - | 9e-13 | 27.35% (245) | putative hydrolase |
| M. thermoresistible (build 8) | TH_0684 | hpx | 8e-13 | 32.80% (186) | POSSIBLE NON-HEME HALOPEROXIDASE HPX |
| M. ulcerans Agy99 | MUL_3299 | - | 5e-09 | 36.44% (118) | hypothetical protein MUL_3299 |
| M. vanbaalenii PYR-1 | Mvan_3576 | - | 6e-14 | 37.58% (149) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2237c|M.bovis_AF2122/97 ---------------------------MPATQQMS----RLVDSPDGVRI
Rv2214c|M.tuberculosis_H37Rv ---------------------------MPATQQMS----RLVDSPDGVRI
MLBr_00862|M.leprae_Br4923 ---------------------------MPATQSIHKVPHQFVESPDGVRL
Mflv_2937|M.gilvum_PYR-GCK ---------------------------MSSQ--------RFVVSRDGVRI
Mvan_3576|M.vanbaalenii_PYR-1 ---------------------------MSTQ--------RFVESSDGVRI
MAB_0130|M.abscessus_ATCC_1997 ----------------------------------MVSIARYVAAPDGVRL
MAV_4984|M.avium_104 --------------------------------------MATVVSPDGTVI
MMAR_2050|M.marinum_M MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
MUL_3299|M.ulcerans_Agy99 MRPTLAAAALAGASGLVGWGGARALARRIERNPDPFPRERLLAEPQGERV
MSMEG_2984|M.smegmatis_MC2_155 ---------------------------------------MILTHAEPLHL
TH_0684|M.thermoresistible__bu ------------------------------VEQMPPGRVVSVTAPDGVRL
: : :
Mb2237c|M.bovis_AF2122/97 AVY--------HEGNPDGPTVVLVHGFPDSHVLWDGVVPLLAER-FRIVR
Rv2214c|M.tuberculosis_H37Rv AVY--------HEGNPDGPTVVLVHGFPDSHVLWDGVVPLLAER-FRIVR
MLBr_00862|M.leprae_Br4923 AIY--------QSGQPEGPAIVLVHGFPDSHVLWDGVVPLLAKR-FRIVR
Mflv_2937|M.gilvum_PYR-GCK AVY--------EEGAADGPTVVLVHGHADTHEAWDAVVALLAAR-FRIVR
Mvan_3576|M.vanbaalenii_PYR-1 AVS--------EQGNPDGPTLVLVHGLRDTHRVWDPVVALLADR-FRIVA
MAB_0130|M.abscessus_ATCC_1997 SVT--------VSG--TGPSLVLVHGSLQSGSSWAGVVSELESD-FTCFA
MAV_4984|M.avium_104 GYE--------SVG--AGPPLLLVHGSTGTRARWRPVTPELARR-YTVHA
MMAR_2050|M.marinum_M AITRPDGTVLHALVAGRGTPVILVHGYCASLTEWNFVWDELLARGLRVIA
MUL_3299|M.ulcerans_Agy99 AITRPDGTVLHALVAGRGTPVILVHGYCASLTEWNFVWDELLARGLRVIA
MSMEG_2984|M.smegmatis_MC2_155 SLETADTRLSAEVRPGHGTPVVIVPGIMADAATWRPVVAHIDLP-NPVVT
TH_0684|M.thermoresistible__bu HAE--------VFGPADAPPIVLAHGITCAIRVWAHQIAELADD-YRVIA
...:::. * * :
Mb2237c|M.bovis_AF2122/97 YDNRGVGRSSVPKPISAYTMAHFADDFDAVIG-ELSPGEPVHVLAHDWGS
Rv2214c|M.tuberculosis_H37Rv YDNRGVGRSSVPKPISAYTMAHFADDFDAVIG-ELSPGEPVHVLAHDWGS
MLBr_00862|M.leprae_Br4923 YDNRGVGQSSVPKPVSAYTMTRFADDFAAVID-ELSPDRPVHVLAHDWGS
Mflv_2937|M.gilvum_PYR-GCK YDTRGAGRSAAPQRTSGFRLERYADDLAAVLD-AVSAEAPVHVLAHDRGS
Mvan_3576|M.vanbaalenii_PYR-1 YDTRGAGNSGAPKQTSAYTVDRFADDFAAVAA-AVGGDTPVHVLAHGWGA
MAB_0130|M.abscessus_ATCC_1997 VDRRGHGAS-SDAEE--HSLQREADDVIAVAA-EVGPD--AVIVAHSYGA
MAV_4984|M.avium_104 MDRRGRGLSTAEAEP--YSLGREAEDVAAVAE-AVGGD--VYVVGHSYGA
MMAR_2050|M.marinum_M FDQRGHGRSTLGAEG--IGSEPMADDLAAVLQ-HFDIRDGVLVGHSMGGF
MUL_3299|M.ulcerans_Agy99 FDQRGHGRSTLGAEG--IGSEPMADDLAAVLQ-HFDLRDGVLVGHSMGGF
MSMEG_2984|M.smegmatis_MC2_155 LNRRGRASSGGLGAD--YSVAVEVDDLRRVVG-ALG---AVHLVGWSYGA
TH_0684|M.thermoresistible__bu FDHRGHGRSSVPRRRWQYSLDHLASDLDAVLDATLDPGERAVIAGHSMGG
: ** . * ..*. * .. . : *
Mb2237c|M.bovis_AF2122/97 VGVWEYLRRP--GASDRVASFTSVSGPSQDHLVNYVYGGLRRPWRPRTFL
Rv2214c|M.tuberculosis_H37Rv VGVWEYLRRP--GASDRVASFTSVSGPSQDHLVNYVYGGLRRPWRPRTFL
MLBr_00862|M.leprae_Br4923 VGVWEYLSRS--GASDRVASFTSVSGPSQDQLVDYILSGLRRPWRPRTFA
Mflv_2937|M.gilvum_PYR-GCK AGVWRYLARP--ESRGRLASFTSVSGPAPEHVARYLRDTLARPQHPARFA
Mvan_3576|M.vanbaalenii_PYR-1 AGVWQYLKRA--DAPERVASLTSVSGPSPEHVAGYVRAALTSPR---RFV
MAB_0130|M.abscessus_ATCC_1997 VVVLEAVRRG--ADVAAVVLYEPPLP-ISERVA------SAN--------
MAV_4984|M.avium_104 LAVLDAAPIT--RAFRRIVLYEPPIPSLGLDVG------SPGGWAR----
MMAR_2050|M.marinum_M VSIRALLDHG--ALAQRLRAVVLFATWAGRVLDGAPQNRLQIP-------
MUL_3299|M.ulcerans_Agy99 VSIRALLDHG--ALAQRLRAVVLFATWAGRVLDGAPQNRLQIP-------
MSMEG_2984|M.smegmatis_MC2_155 LIGLEAALGS--GRIRSVTAYEPVSRPFAPETVAPIRAAVAAG-------
TH_0684|M.thermoresistible__bu IAISSWAERYPERVSERAAAVALINTTTGDLLHNVQLLPVPDRFAAVR--
Mb2237c|M.bovis_AF2122/97 RAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDIPVDQIHHS
Rv2214c|M.tuberculosis_H37Rv RAISQTLRLSYMALFSVPVVAPLLLRVALSSAAVRRNMVGDIPVDQIHHS
MLBr_00862|M.leprae_Br4923 RAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMVDNISTDQIHHS
Mflv_2937|M.gilvum_PYR-GCK GGLGHLAR--------------------LAAAAPR---------------
Mvan_3576|M.vanbaalenii_PYR-1 RGAGQLVR--------------------LAAAAPR---------------
MAB_0130|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4984|M.avium_104 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2984|M.smegmatis_MC2_155 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 ETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQLIVNSQDPYVR
Rv2214c|M.tuberculosis_H37Rv ETLARDAAHSVKTYPANYFRSFSSSRRGRAIPIVDVPVQLIVNSQDPYVR
MLBr_00862|M.leprae_Br4923 ATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQLIVNTMDRYVR
Mflv_2937|M.gilvum_PYR-GCK -------AVTDKTLRANLFPVSSGGD----AHDVDIPVQLIVGSADPYPD
Mvan_3576|M.vanbaalenii_PYR-1 -------AATAKPYRANLRPAAPAG------VPVDVPVQLIVPDHDPHVG
MAB_0130|M.abscessus_ATCC_1997 ---------------RDASAALR-------------GRSTVVTREW----
MAV_4984|M.avium_104 --------ITALSDPRDILEAFYRET----LQLSESAIKDLANREFPYLA
MMAR_2050|M.marinum_M ------------LLERGILQRLLRSR----------TIAVLFGAAQCGAR
MUL_3299|M.ulcerans_Agy99 ------------LLERGILQRLLRSR----------TIAVLFGAAQCGAR
MSMEG_2984|M.smegmatis_MC2_155 --------------DLDRAVALVN-----------TDVSGFSDDYVAGLR
TH_0684|M.thermoresistible__bu -----------VRTASAVIKTVAGMPARLAAVPSRYVVSMMAVGRDADPA
.
Mb2237c|M.bovis_AF2122/97 PYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDFADLADGKQPS
Rv2214c|M.tuberculosis_H37Rv PYGYDQTARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDFADLADGKQPS
MLBr_00862|M.leprae_Br4923 PYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHDLADLVDGKQPS
Mflv_2937|M.gilvum_PYR-GCK PHLFEDRAGRPARLWRRDVKAGHVTPTSHPGILARALTQLVDHLDGAPAA
Mvan_3576|M.vanbaalenii_PYR-1 PHVYDGMSASVSRLWRRDIKTGDLSPGSHPQVLARAVDQLVDHLGGAPAP
MAB_0130|M.abscessus_ATCC_1997 ----------MAVNRSVESIGEYTR-----------AATPMYLLEGANSP
MAV_4984|M.avium_104 GSIRHTAGRELAQTRAYRLTERHAN-----------ITTPVRMLLGTESP
MMAR_2050|M.marinum_M PSPAMISVFLEWFHQHLDRHGPHLPIVRA--FSREDRYPRLAEISVP--A
MUL_3299|M.ulcerans_Agy99 PSPAMISG-IPRVVPSTSRPARTAPTHRAGVLARGSLSTAGRDLGAGGGD
MSMEG_2984|M.smegmatis_MC2_155 RSPAWEVLRPLAQPMGEELAAIDAFEPSFDDYRHLTVPVTLILGALNEGA
TH_0684|M.thermoresistible__bu ITNFVHELFTETPPAARDGWARTLVDAMGPRHIGLHNLTVPTLVIGSDRD
Mb2237c|M.bovis_AF2122/97 RALLRAQVG-RPRGYFGDTLVSVTGAGSGIGRETALAFAREGAEIVISDI
Rv2214c|M.tuberculosis_H37Rv RALLRAQVG-RPRGYFGDTLVSVTGAGSGIGRETALAFAREGAEIVISDI
MLBr_00862|M.leprae_Br4923 RALLRAQVG-RSRDTFGDTLVSVTGAGSGIGRETALALARRGAEVVVSDI
Mflv_2937|M.gilvum_PYR-GCK RELLRAQVG-RPRKAFGDTLVAVTGAASGIGRATALAFAHHGADVVISDV
Mvan_3576|M.vanbaalenii_PYR-1 RELLRAQVG-RARKVFGDTLVSVTGAASGIGRETALAFARAGADVVISDV
MAB_0130|M.abscessus_ATCC_1997 PQFRDPVGY-LARRVPGVRVKELVGQDHFAHREAPAVFAQALRELLLS--
MAV_4984|M.avium_104 AYLRAATAV-LAAKIPGATIVALHGQGHQAIDYDPDQFARAVLEFDSEEV
MMAR_2050|M.marinum_M VVMVGSSDR-TTPPSHSHRLAAGIPG---ARLVT--VPGAGHLLN--WEA
MUL_3299|M.ulcerans_Agy99 GGLLGSHHP-AQPLAPAGRRNPGCPAGHRARRGTPAELGGGRRAGRSRRI
MSMEG_2984|M.smegmatis_MC2_155 APYGTAFVP-FSAALPQARLARLPGQGHLAHVEAPADLADAISRAVRHAE
TH_0684|M.thermoresistible__bu RLLPLVSSRRIAEAAPNLFDFVELPGGHCAILECPDRVNDHLRALAAAAA
Mb2237c|M.bovis_AF2122/97 DEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVSAEHGVPDIVV
Rv2214c|M.tuberculosis_H37Rv DEATVKDTAAEIAARGGIAYPYVLDVSDAEAVEAFAERVSAEHGVPDIVV
MLBr_00862|M.leprae_Br4923 DEAAAKNTAAQIVASGGVAYAYALDVSDAAAVEAFAEQVSAKHGVPDIVV
Mflv_2937|M.gilvum_PYR-GCK NAAGLDETARLVTSAGVHAYPYTVDVADAAAVEAFAEQVCAEHGVPDVVV
Mvan_3576|M.vanbaalenii_PYR-1 DEAGLEQTARLVTAAGAAAHSYTVDVADAAAVEAMAELVCAAHGVPDIVV
MAB_0130|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4984|M.avium_104 DSGGVGAVTA----------------------------------------
MMAR_2050|M.marinum_M VDELAEVVESFAAQR-----------------------------------
MUL_3299|M.ulcerans_Agy99 LCGAAVLMRGHAAGVWR---------------------------------
MSMEG_2984|M.smegmatis_MC2_155 GT------------------------------------------------
TH_0684|M.thermoresistible__bu DARRATS-------------------------------------------
Mb2237c|M.bovis_AF2122/97 NNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQRLVERGTGGHI
Rv2214c|M.tuberculosis_H37Rv NNAGIGQAGRFLDTPAEQFDRVLAVNLGGVVNGCRAFGQRLVERGTGGHI
MLBr_00862|M.leprae_Br4923 NNAGIGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAFGQRLVERGTGGHI
Mflv_2937|M.gilvum_PYR-GCK NNAGVGHAGFFLDTPAEEFDRVLDINFGGVVNGCRSFGKRLADRGVGGHI
Mvan_3576|M.vanbaalenii_PYR-1 NNAGVGHAGFFLDTPAEEFDRVLGINFGGVVNGCRSWGRRLVDRGTGGHI
MAB_0130|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4984|M.avium_104 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2984|M.smegmatis_MC2_155 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 VNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAGVGLTTICPGV
Rv2214c|M.tuberculosis_H37Rv VNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAAGVGLTTICPGV
MLBr_00862|M.leprae_Br4923 VNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELDAVGVGLTTICPGV
Mflv_2937|M.gilvum_PYR-GCK VNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAELDSFGIGLTTICPGF
Mvan_3576|M.vanbaalenii_PYR-1 VNVASMASYTPVNVMNAYCTSKAAVFMFSDCLRAELDSAGIGVTTICPGV
MAB_0130|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4984|M.avium_104 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2984|M.smegmatis_MC2_155 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 IDTNIVATTGFHAPGTDEEKIDGRRGQIDKMFALRSYGPDKVADAIVSAV
Rv2214c|M.tuberculosis_H37Rv IDTNIVATTGFHAPGTDEEKIDGRRGQIDKMFALRSYGPDKVADAIVSAV
MLBr_00862|M.leprae_Br4923 IDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRYGPDKVADTILSAI
Mflv_2937|M.gilvum_PYR-GCK ISTNIVDTTRFSLAQGRDDDVDVLRGRAQKGFSARKYGPEKVADAIVDAV
Mvan_3576|M.vanbaalenii_PYR-1 IGTNIVDTTRFSLPEARRDDAESIRRRARQGFAVRRVGPDKVAKAIVAAV
MAB_0130|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4984|M.avium_104 --------------------------------------------------
MMAR_2050|M.marinum_M --------------------------------------------------
MUL_3299|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2984|M.smegmatis_MC2_155 --------------------------------------------------
TH_0684|M.thermoresistible__bu --------------------------------------------------
Mb2237c|M.bovis_AF2122/97 KKKKPIRPVAPEAYALYGISRVLPQALRSTARLRVI-
Rv2214c|M.tuberculosis_H37Rv KKKKPIRPVAPEAYALYGISRVLPQALRSTARLRVI-
MLBr_00862|M.leprae_Br4923 KKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI-
Mflv_2937|M.gilvum_PYR-GCK RTNKAIRPVAPEARFVYGVAHALPQVLRSTARGGNFV
Mvan_3576|M.vanbaalenii_PYR-1 QKNKPVRPVTTEAYLVYGVAHALPQAMRSAARGGNIM
MAB_0130|M.abscessus_ATCC_1997 -------------------------------------
MAV_4984|M.avium_104 -------------------------------------
MMAR_2050|M.marinum_M -------------------------------------
MUL_3299|M.ulcerans_Agy99 -------------------------------------
MSMEG_2984|M.smegmatis_MC2_155 -------------------------------------
TH_0684|M.thermoresistible__bu -------------------------------------