For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTNTHPALTSVRLGGLKLDNRFAVAPMTRVSATADGAPTDAMAGYYAEFARGGFGLVITEGTYTDTTHSQ GYLNQPGLATDAHAAGWRPVTDAVHAAGVPIVAQLMHAGALSQGNSHGVETIAPSAVAPRGTMLEEYGGA GTWPTPREMSAADIDAAIAGFVDAAVRARAAGFDGVEIHAANGYLLDQFLTTYTNHRTDEYGGTVAHRIR LAAQISAAVRTAVGADFLVGVRLSQTKVNDFEYRWPGGAQDAEVIFTALAATGIDYLHIASEGRDFIDGA RLDDGRTITALARQVTGLPVIANGGMHDTTQAAGVLDGGHADVLSIGRGALANPDLPQRVSSGAPLERFD HGMLSPMATIVNAAAWTAARHRERVPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2969 | - | - | 100% (377) | NADH:flavin oxidoreductase/NADH oxidase |
| M. smegmatis MC2 155 | MSMEG_3137 | - | 1e-49 | 37.61% (351) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3338 | - | 2e-32 | 32.00% (350) | oxidoreductase, FAD/FMN-binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1208c | fadH | 1e-32 | 34.10% (346) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 1e-47 | 35.94% (345) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv1175c | fadH | 4e-33 | 34.39% (346) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. leprae Br4923 | MLBr_02186 | - | 3e-05 | 28.17% (142) | transcriptional regulator (NifR3/Smm1 family) |
| M. abscessus ATCC 19977 | MAB_2740c | - | 3e-48 | 35.84% (346) | oxidoreductase |
| M. marinum M | MMAR_4276 | fadH | 4e-32 | 32.38% (349) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. avium 104 | MAV_4324 | - | 3e-20 | 31.94% (216) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. thermoresistible (build 8) | TH_3970 | - | 2e-34 | 31.34% (335) | PUTATIVE putative NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 1e-30 | 30.86% (350) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. vanbaalenii PYR-1 | Mvan_5069 | - | 1e-48 | 35.94% (345) | NADH:flavin oxidoreductase/NADH oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1208c|M.bovis_AF2122/97 -------MTNPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRA-RHIDR
Rv1175c|M.tuberculosis_H37Rv -------MTNPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRA-RHIDR
MMAR_4276|M.marinum_M -------MTSPYPNLLSPLDLG-FTTLRNRVVMGSMHTGLEDRP-KDTDR
MUL_1023|M.ulcerans_Agy99 -------MTSPYPNLLFPLDLG-FTTLRNRVVMGSMHTGLEDRP-KDTDR
Mflv_1689|M.gilvum_PYR-GCK ----MTFTLSEQSALLKPIQVG-GTAAGNRLFMAPLTRSRADADGTPSSL
Mvan_5069|M.vanbaalenii_PYR-1 ----MAFTLGAGSALLKPIQVG-GVTAENRIFMAPLTRSRADADGTPSSL
MSMEG_2969|M.smegmatis_MC2_155 --------MTNTHPALTSVRLG-GLKLDNRFAVAPMTRVSATADGAPTDA
MAB_2740c|M.abscessus_ATCC_199 ----MTDVRPDVAPLFEPFAVK-SMTSPNRFAMAPMTRSASPGG-VPGEN
TH_3970|M.thermoresistible__bu MCGRRRDEMVPMTDLSAPLRFAHGPTWRNRLALAPLTNMQSNADGTLHDD
MAV_4324|M.avium_104 --------MPTPPDVFSPAKLG-PITLRNRIIKSATFEAR-TPDALVTDD
MLBr_02186|M.leprae_Br4923 ----MLAPMAGVTNVTFRTLCREFGSTRGNLLRPAPPHLRSPLEQSQVGT
... .
Mb1208c|M.bovis_AF2122/97 LADYFAERARGGVGLIITGGYAPNRTG-WLLPFASELVTSAQARRHRRIN
Rv1175c|M.tuberculosis_H37Rv LADYFAERARGGVGLIITGGYAPNRTG-WLLPFASELVTSAQARRHRRIT
MMAR_4276|M.marinum_M LAEYFAERARGGVGMLITGGYAPNRTG-WLYPFASELVTPAEARRHRRIT
MUL_1023|M.ulcerans_Agy99 LAEYFAERARGGVGMLITGGYAPNRTG-WLYPFASELVTPAEARRHRRIT
Mflv_1689|M.gilvum_PYR-GCK AAQYYAQRASA--GLIISEATAVCEQANGAYLNTPGLYTDRQQDKWSEIA
Mvan_5069|M.vanbaalenii_PYR-1 AAQYYAQRAEA--GLIISEATAVCEQANGAYLNTPGLYTDRQQEAWAEIA
MSMEG_2969|M.smegmatis_MC2_155 MAGYYAEFARGGFGLVITEGTYTDTTHSQGYLNQPGLATDAHAAGWRPVT
MAB_2740c|M.abscessus_ATCC_199 VAAYYRRRAAGGVGLIITEGVFIPHDAAGGQSNVPRLAGADSLAGWSAVT
TH_3970|M.thermoresistible__bu EHHWLVRRAEGGFAMVMTCAAHVSQAG-QAFPGQLGVWHDRHLPGLTRLA
MAV_4324|M.avium_104 LIEYHRLPAAGGVGMTTVAYCAVSPGG--RTEGNGIWMRPEAVPGFRRLT
MLBr_02186|M.leprae_Br4923 ISGLYVCEMVTARALVERNAVTIHMTT----------FAPDESPRSLQLY
.: :
Mb1208c|M.bovis_AF2122/97 RAVHDSGAKILLQILHAGRYAYHP---LAVSASPIKAPITPF--------
Rv1175c|M.tuberculosis_H37Rv RAVHDSGAKILLQILHAGRYAYHP---LAVSASPIKAPITPF--------
MMAR_4276|M.marinum_M GAVHDADAKILLQVLHAGRYAYHP---LSVSASSIKAPINPF--------
MUL_1023|M.ulcerans_Agy99 GAVHDADAKILLQVLHAGRYAYHP---LSVSASSIKAPINPF--------
Mflv_1689|M.gilvum_PYR-GCK SAVHRAGGKMFVQLWHVGRMAHPE---ISGFETVGPSPIAAD-LLTHTPT
Mvan_5069|M.vanbaalenii_PYR-1 SAVHGAGGKMFVQLWHVGRMAHPE---ISGFENVGPSPIAAD-LVTHTPS
MSMEG_2969|M.smegmatis_MC2_155 DAVHAAGVPIVAQLMHAGALSQGN---SHGVETIAPSAVAPRGTMLEEYG
MAB_2740c|M.abscessus_ATCC_199 DAVHGEGSVIAAQLWHQGVERGVDPEFNPGVESVSPSGLAGD--------
TH_3970|M.thermoresistible__bu AGIRAAGAVATVQLHHGGRRAEAR---LTGLPVVAPWDDPDK--------
MAV_4324|M.avium_104 DAIHAEGAAVSAQIGHAGPVANAR---SNKAHALAPVRFFNP--------
MLBr_02186|M.leprae_Br4923 TVDPATTYTAAKMVADEGLADHID------MNFGCPMPKVTR--------
: . *
Mb1208c|M.bovis_AF2122/97 ------RPRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQ
Rv1175c|M.tuberculosis_H37Rv ------RPRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQ
MMAR_4276|M.marinum_M ------RPRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQ
MUL_1023|M.ulcerans_Agy99 ------RSRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQ
Mflv_1689|M.gilvum_PYR-GCK GKKPLPVPRALTTGEIAEIVGQFRAAARRAVDAGMDGVEIHSANGYLLHE
Mvan_5069|M.vanbaalenii_PYR-1 GKKPLPVPRALTAAEIAEIIGLFRAAARRAVDAGMDGVEIHSANGYLLHE
MSMEG_2969|M.smegmatis_MC2_155 GAGTWPTPREMSAADIDAAIAGFVDAAVRARAAGFDGVEIHAANGYLLDQ
MAB_2740c|M.abscessus_ATCC_199 ---ASPRGRALQTGELAPLAGQYAEAARNAKAAGFDAVELHGAHGYLLDQ
TH_3970|M.thermoresistible__bu ------GVTALTTAQVEQVVQDFVDAAVRAEKAGFDGAEIHGAHGYLVAQ
MAV_4324|M.avium_104 --IGMRFAKKATREDIDEVIAAHANAARLAIEAGFDAVEIHLGHNYLASS
MLBr_02186|M.leprae_Br4923 ------RGGGAALPYKRRLFGQIVAAAVRATEGTKIPVTVKFRIG-IDDE
.* * . . : . : .
Mb1208c|M.bovis_AF2122/97 FLAPRTNKRTDSWGGTPANRRRFPVEIIRRSRAAVGSDFIICYRLSMADY
Rv1175c|M.tuberculosis_H37Rv FLAPRTNKRTDSWGGTPANRRRFPVEIIRRSRAAVGCDFIICYRLSMADY
MMAR_4276|M.marinum_M FLAPRTNKRTDSWGGTPAKRRRFPVEIVRRTRAAVGPDFIICYRMSMADY
MUL_1023|M.ulcerans_Agy99 FLAPRTNQRTDSWGGTPAKRRRFPVEIVRRTRAAVGPDFIICYRMSMADY
Mflv_1689|M.gilvum_PYR-GCK FLSDVVNQRTDAYGGSPQNRARLAAEVVEAVVAEIGPD-RVGLRISPGNS
Mvan_5069|M.vanbaalenii_PYR-1 FLSDVVNQRTDAYGGSPQNRARFTAEVVEAVAAEIGPE-RVGLRISPGNN
MSMEG_2969|M.smegmatis_MC2_155 FLTTYTNHRTDEYGGTVAHRIRLAAQISAAVRTAVGADFLVGVRLSQTKV
MAB_2740c|M.abscessus_ATCC_199 FLWERTNVRADGYGGSAAQRLRFPVEVVRAVRAAVGPDFPILYRFSQWKQ
TH_3970|M.thermoresistible__bu FLDVRHNHRTDRYGGSPENRFRIVHEIIAGIRAATSPDFQLGLRLSPERY
MAV_4324|M.avium_104 FLSPLINRRNDEFGGSLQNRAKVARGMVMAVRRAVEKEGTPIAVTAKLNM
MLBr_02186|M.leprae_Br4923 HHTHLDAGRIAEAEGAAAVALHARTAAQRYSGTADWAQIAQLKQQVRTIP
. * *: : :
Mb1208c|M.bovis_AF2122/97 VAEGQ-SWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFV
Rv1175c|M.tuberculosis_H37Rv VAEGQ-SWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFV
MMAR_4276|M.marinum_M VEGGQ-SWDEIVALASELETAGATIINSGFGWHEARIPTIVTSVPSGAFV
MUL_1023|M.ulcerans_Agy99 VEGGQ-SWDEIVALATELESAGATIINSGFGWHEARIPTIVTSVPSGAFV
Mflv_1689|M.gilvum_PYR-GCK -AGDMREIDDVSAYEALLCRIASLGIAYLHVLVE----------PSAPAF
Mvan_5069|M.vanbaalenii_PYR-1 -AGDMTEVDQISAYELLLCRIASLNIAYLHVVSE----------PSAPAF
MSMEG_2969|M.smegmatis_MC2_155 NDFEYRWPGGAQDAEVIFTALAATGIDYLHIASEGRDFIDGARLDDGRTI
MAB_2740c|M.abscessus_ATCC_199 ADYTATLADSPAELEGLLAPLVDAGVDVFHPSTRRHYVPAFPELAGADGE
TH_3970|M.thermoresistible__bu GIVLD------EARALAGEVLADGQLDYLDLSLWDAFKEPYEEAHRGRRL
MAV_4324|M.avium_104 ADGVRGGISTEESLTTAKWLESDGGLDAIELTAGSSLVNPMYLFRGDAPL
MLBr_02186|M.leprae_Br4923 VLGNGDIYDASDALAMMAVTGCDGVVIGRGCLGRPWLFAELSAAFTGRPA
:
Mb1208c|M.bovis_AF2122/97 DISS----------AVAEHVTIPVVASNRINMPQAAERILAETQVRLISM
Rv1175c|M.tuberculosis_H37Rv DISS----------AVAEHVTIPVVASNRINMPQAAERILAETQVRLISM
MMAR_4276|M.marinum_M DISN----------AVAEQVSIPVMTSNRINMPQAAEQILADTDVALISM
MUL_1023|M.ulcerans_Agy99 EISN----------AVAEQVSIPVMTSNRINMPQAAEQILADTDVALISM
Mflv_1689|M.gilvum_PYR-GCK AAVR----------TQWEGTLVLNTPRTVETDFATLENLADWGVISAAAV
Mvan_5069|M.vanbaalenii_PYR-1 AAIR----------TQWEGTLVLNTPRAVDTDFAELENLATWGVISAAAV
MSMEG_2969|M.smegmatis_MC2_155 TALA----------RQVTGLPVIAN--GGMHDTTQAAGVLDGGHADVLSI
MAB_2740c|M.abscessus_ATCC_199 LSLAGWT-------KRLTGLPAVAVGSVGLQTEFKPSEVRDIEPAPVEAV
TH_3970|M.thermoresistible__bu IELF----------MDLPRGDTRVGVAGKITDAESARRCLDSG-ADFVLI
MAV_4324|M.avium_104 KEFAGAFKPPLRWGMRMTGKKFLREYPYREAYLLRDAKLFRAELKMPLIL
MLBr_02186|M.leprae_Br4923 PAPP----------TLGEVAEIVRRHGKLLVAHFGEDKGMRDIRKHIAWY
Mb1208c|M.bovis_AF2122/97 ARPMLSDPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRA
Rv1175c|M.tuberculosis_H37Rv ARPMLSDPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRA
MMAR_4276|M.marinum_M ARPMLSDPEWVLKAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRA
MUL_1023|M.ulcerans_Agy99 ARPMLSDPEWVLKAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRA
Mflv_1689|M.gilvum_PYR-GCK GRAFLANPDLIERLKLG---------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 GRAFLANPDLVQRLTSG---------------------------------
MSMEG_2969|M.smegmatis_MC2_155 GRGALANPDLPQRVSSG---------------------------------
MAB_2740c|M.abscessus_ATCC_199 LRQFADN-EFDVIAVGR---------------------------------
TH_3970|M.thermoresistible__bu GKAAIVHHDFARQVLADPAYR-----------------------------
MAV_4324|M.avium_104 LGGITNRETMDLAMAEGFEFVAMAR-------------------------
MLBr_02186|M.leprae_Br4923 LHGFPAGSELRNALALV---------------------------------
Mb1208c|M.bovis_AF2122/97 GRETQLVLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIG
Rv1175c|M.tuberculosis_H37Rv GRETQLVLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIG
MMAR_4276|M.marinum_M GHETLLTLSPTQRARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIG
MUL_1023|M.ulcerans_Agy99 GHETLLTMSPTQRARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIG
Mflv_1689|M.gilvum_PYR-GCK --------AELNEPDVATFYAPGPDGYLDYPTLDEMVTPRSA--------
Mvan_5069|M.vanbaalenii_PYR-1 --------AELNEPDVATFYAPGPAGYIDYPTLDELAEPQSA--------
MSMEG_2969|M.smegmatis_MC2_155 --------APLERFDHGMLSPMATIVNAAAWTAARHRERVPR--------
MAB_2740c|M.abscessus_ATCC_199 --------ALLSDPEWVNKLRSGRQGEFVGFNIGKALSALY---------
TH_3970|M.thermoresistible__bu --------AAPLPVSAEHLAAEAVGPRFVDYLASNWDDFVSTG-------
MAV_4324|M.avium_104 --------ALLAEPDLINRIAADGAAHRVHSACTHCNQCMPTIYSRTHCV
MLBr_02186|M.leprae_Br4923 --------KTLDELDCLLNRLDGAVPFPDAAIGPRGRQGSPAWVALPDSW
.
Mb1208c|M.bovis_AF2122/97 GQFDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEV
Rv1175c|M.tuberculosis_H37Rv GQFDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEV
MMAR_4276|M.marinum_M GQFDLARRIPGKEEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEV
MUL_1023|M.ulcerans_Agy99 GQFDLARRIPGKEEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEV
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 VTGAPDRHTSAAT-------------------------------------
MLBr_02186|M.leprae_Br4923 LTDPDDCTVPIGADIMESGG------------------------------
Mb1208c|M.bovis_AF2122/97 VLATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDV
Rv1175c|M.tuberculosis_H37Rv VLATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDV
MMAR_4276|M.marinum_M VLATGVAPRIPAIPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDV
MUL_1023|M.ulcerans_Agy99 VLATGVAPRIPAIPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDV
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MLBr_02186|M.leprae_Br4923 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 TELLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQR
Rv1175c|M.tuberculosis_H37Rv TELLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQR
MMAR_4276|M.marinum_M TELLITESSPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQR
MUL_1023|M.ulcerans_Agy99 TELLITESSPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQR
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MLBr_02186|M.leprae_Br4923 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 TKGPQGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKR
Rv1175c|M.tuberculosis_H37Rv TKGPQGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKR
MMAR_4276|M.marinum_M TKGPQGKRLGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPER
MUL_1023|M.ulcerans_Agy99 TKGPQGKRLGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPDR
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MLBr_02186|M.leprae_Br4923 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 RRPQLLAVDNVVVCAGQEPVRDLESELRRHGINPHISGGAAVAAELDAKR
Rv1175c|M.tuberculosis_H37Rv RRPQLLAVDNVVVCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKR
MMAR_4276|M.marinum_M QRPQLLAVDSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKR
MUL_1023|M.ulcerans_Agy99 QRPQLLAVDSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKR
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
MLBr_02186|M.leprae_Br4923 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 AIKQGTELAARL
Rv1175c|M.tuberculosis_H37Rv AIKQGTELAARL
MMAR_4276|M.marinum_M AIKQGTELAARL
MUL_1023|M.ulcerans_Agy99 AIKQGTELAARL
Mflv_1689|M.gilvum_PYR-GCK ------------
Mvan_5069|M.vanbaalenii_PYR-1 ------------
MSMEG_2969|M.smegmatis_MC2_155 ------------
MAB_2740c|M.abscessus_ATCC_199 ------------
TH_3970|M.thermoresistible__bu ------------
MAV_4324|M.avium_104 ------------
MLBr_02186|M.leprae_Br4923 ------------