For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTDSLDTSLDTLFTPLSVGTMRIPNRFAMAPMTRRASPGGVPGADVAEYYARRAAGGVGLIITEGVRLAD PVAAWPHSIPTLAGADAVAGWRAVTDAVHAHGSVIAAQLWHQGAERDDSDGLQPVSPSGVNSVGAAHGRA LRGDELPGLAAQYAEAARNAVEAGFDAVELHGAHGYLLDEFLWDRTNQRTDGYGGSVAARTRFPVEVVAA VRAAVGPDFPIIYRFSQWKANAYDARIAEDPAQLEAILGRLVTAGVDVLHPSTRRHYLPAFPGSDLSLAG WTRKITGIPVIGVGSVGLATEFRPGRRDGDIIAAAPVEKVVEQFTAGEFDIVAVGRALLAEPAWVNRLRD NSLDGFAGYHAETALARLY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3137 | - | - | 100% (369) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2969 | - | 1e-49 | 37.61% (351) | NADH:flavin oxidoreductase/NADH oxidase |
| M. smegmatis MC2 155 | MSMEG_2889 | - | 1e-31 | 31.48% (359) | NADH:flavin oxidoreductase/NADH oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1208c | fadH | 5e-29 | 29.06% (351) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 6e-38 | 34.86% (350) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv1175c | fadH | 2e-29 | 29.34% (351) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2740c | - | 1e-129 | 64.13% (368) | oxidoreductase |
| M. marinum M | MMAR_4276 | fadH | 7e-32 | 29.46% (353) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. avium 104 | MAV_4324 | - | 7e-27 | 28.37% (363) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. thermoresistible (build 8) | TH_2463 | - | 3e-34 | 32.05% (365) | PUTATIVE NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 1e-31 | 29.46% (353) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. vanbaalenii PYR-1 | Mvan_5069 | - | 9e-37 | 34.67% (349) | NADH:flavin oxidoreductase/NADH oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4276|M.marinum_M ----MTSPYPNLLSPLDLGFTTLRNRVVMGSMHT-GLEDRPKDTDRLAEY
MUL_1023|M.ulcerans_Agy99 ----MTSPYPNLLFPLDLGFTTLRNRVVMGSMHT-GLEDRPKDTDRLAEY
Mb1208c|M.bovis_AF2122/97 ----MTNPYPNLLSPLDLGFTTLRNRVVMGSMHT-GLEDRARHIDRLADY
Rv1175c|M.tuberculosis_H37Rv ----MTNPYPNLLSPLDLGFTTLRNRVVMGSMHT-GLEDRARHIDRLADY
MAV_4324|M.avium_104 -----MPTPPDVFSPAKLGPITLRNRIIKSATFE-ARTPDALVTDDLIEY
TH_2463|M.thermoresistible__bu ----VTHTSLDPFAPAQLGPVRLRNRVIKAATSE-GRSPDGLVTDDLVEF
MSMEG_3137|M.smegmatis_MC2_155 MTDSLDTSLDTLFTPLSVGTMRIPNRFAMAPMTR-RASPGGVPGADVAEY
MAB_2740c|M.abscessus_ATCC_199 MTD-VRPDVAPLFEPFAVKSMTSPNRFAMAPMTR-SASPGGVPGENVAAY
Mflv_1689|M.gilvum_PYR-GCK -MTFTLSEQSALLKPIQVGGTAAGNRLFMAPLTRSRADADGTPSSLAAQY
Mvan_5069|M.vanbaalenii_PYR-1 -MAFTLGAGSALLKPIQVGGVTAENRIFMAPLTRSRADADGTPSSLAAQY
: * : **. .. :
MMAR_4276|M.marinum_M FAERARGGVGMLITGGYAPNRTGWLYPFAS-ELVTPAEARRHRRITGAVH
MUL_1023|M.ulcerans_Agy99 FAERARGGVGMLITGGYAPNRTGWLYPFAS-ELVTPAEARRHRRITGAVH
Mb1208c|M.bovis_AF2122/97 FAERARGGVGLIITGGYAPNRTGWLLPFAS-ELVTSAQARRHRRINRAVH
Rv1175c|M.tuberculosis_H37Rv FAERARGGVGLIITGGYAPNRTGWLLPFAS-ELVTSAQARRHRRITRAVH
MAV_4324|M.avium_104 HRLPAAGGVGMTTVA-YCAVSPGGRTEGNG-IWMRPEAVPGFRRLTDAIH
TH_2463|M.thermoresistible__bu HRRFARGGVAMTTVA-YCCVSPEAASAPGQ-IVMADRALPGLRRLTDAVH
MSMEG_3137|M.smegmatis_MC2_155 YARRAAGGVGLIITEGVRLADPVAAWPHSIPTLAGADAVAGWRAVTDAVH
MAB_2740c|M.abscessus_ATCC_199 YRRRAAGGVGLIITEGVFIPHDAAGGQSNVPRLAGADSLAGWSAVTDAVH
Mflv_1689|M.gilvum_PYR-GCK YAQRAS--AGLIISEATAVCEQANGAYLNTPGLYTDRQQDKWSEIASAVH
Mvan_5069|M.vanbaalenii_PYR-1 YAQRAE--AGLIISEATAVCEQANGAYLNTPGLYTDRQQEAWAEIASAVH
. * ..: : *:*
MMAR_4276|M.marinum_M DADAKILLQVLHAGRYAYHP--------LSVSASSIKAPINPFRP-----
MUL_1023|M.ulcerans_Agy99 DADAKILLQVLHAGRYAYHP--------LSVSASSIKAPINPFRS-----
Mb1208c|M.bovis_AF2122/97 DSGAKILLQILHAGRYAYHP--------LAVSASPIKAPITPFRP-----
Rv1175c|M.tuberculosis_H37Rv DSGAKILLQILHAGRYAYHP--------LAVSASPIKAPITPFRP-----
MAV_4324|M.avium_104 AEGAAVSAQIGHAGPVANAR----SNKAHALAPVRFFNPIGMRFA-----
TH_2463|M.thermoresistible__bu EAGAAVSAQLGHAGVVAPKK----LTGVTAVAPSRFINPTSLAYC-----
MSMEG_3137|M.smegmatis_MC2_155 AHGSVIAAQLWHQGAER----DDS-DGLQPVSPSGVNSVGAAHG------
MAB_2740c|M.abscessus_ATCC_199 GEGSVIAAQLWHQGVERGVDPEFN-PGVESVSPSGLAGDASPRG------
Mflv_1689|M.gilvum_PYR-GCK RAGGKMFVQLWHVGRMAH---PEI-SGFETVGPSPIAADLLTHTPTGKKP
Mvan_5069|M.vanbaalenii_PYR-1 GAGGKMFVQLWHVGRMAH---PEI-SGFENVGPSPIAADLVTHTPSGKKP
.. : *: * * :.. .
MMAR_4276|M.marinum_M ----RKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAP
MUL_1023|M.ulcerans_Agy99 ----RKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAP
Mb1208c|M.bovis_AF2122/97 ----RALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFLAP
Rv1175c|M.tuberculosis_H37Rv ----RALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFLAP
MAV_4324|M.avium_104 ----KKATREDIDEVIAAHANAARLAIEAGFDAVEIHLGHNYLASSFLSP
TH_2463|M.thermoresistible__bu ----REITRDEIEAVIDQFGEAARIAAEAGFDAVELHFGHLYLPSSFLSP
MSMEG_3137|M.smegmatis_MC2_155 ----RALRGDELPGLAAQYAEAARNAVEAGFDAVELHGAHGYLLDEFLWD
MAB_2740c|M.abscessus_ATCC_199 ----RALQTGELAPLAGQYAEAARNAKAAGFDAVELHGAHGYLLDQFLWE
Mflv_1689|M.gilvum_PYR-GCK LPVPRALTTGEIAEIVGQFRAAARRAVDAGMDGVEIHSANGYLLHEFLSD
Mvan_5069|M.vanbaalenii_PYR-1 LPVPRALTAAEIAEIIGLFRAAARRAVDAGMDGVEIHSANGYLLHEFLSD
: : . .*: * ** *.**: .. ** .**
MMAR_4276|M.marinum_M RTNKRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFIICYRMSMADYV
MUL_1023|M.ulcerans_Agy99 RTNQRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFIICYRMSMADYV
Mb1208c|M.bovis_AF2122/97 RTNKRTDSWGGTPANRRRFPVEIIRRSR---AAVGSDFIICYRLSMADYV
Rv1175c|M.tuberculosis_H37Rv RTNKRTDSWGGTPANRRRFPVEIIRRSR---AAVGCDFIICYRLSMADYV
MAV_4324|M.avium_104 LINRRNDEFGGSLQNRAKVARGMVMAVRRAVEKEGTPIAVTAKLNMADGV
TH_2463|M.thermoresistible__bu LINRRTDEYGGDIDNRSRFVRRIARRVR---EVVGDRIAVIAKLNMDDGL
MSMEG_3137|M.smegmatis_MC2_155 RTNQRTDGYGGSVAARTRFPVEVVAAVR---AAVGPDFPIIYRFSQWKAN
MAB_2740c|M.abscessus_ATCC_199 RTNVRADGYGGSAAQRLRFPVEVVRAVR---AAVGPDFPILYRFSQWKQA
Mflv_1689|M.gilvum_PYR-GCK VVNQRTDAYGGSPQNRARLAAEVVEAVV---AEIGPDR-VGLRISPGNSA
Mvan_5069|M.vanbaalenii_PYR-1 VVNQRTDAYGGSPQNRARFTAEVVEAVA---AEIGPER-VGLRISPGNNA
* * * :** * :. : * : ::. .
MMAR_4276|M.marinum_M EGGQSWDEIVALASELETAGATIINSGFGWHEARIPTIVTSVPSGAFVDI
MUL_1023|M.ulcerans_Agy99 EGGQSWDEIVALATELESAGATIINSGFGWHEARIPTIVTSVPSGAFVEI
Mb1208c|M.bovis_AF2122/97 AEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDI
Rv1175c|M.tuberculosis_H37Rv AEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDI
MAV_4324|M.avium_104 RGGISTEESLTTAKWLESDGG---------LDAIELTAGSSLVNPMYLFR
TH_2463|M.thermoresistible__bu PGGIWIDEALRTAQLLDADAT---------LDALELTQGSSVFKPMYLFR
MSMEG_3137|M.smegmatis_MC2_155 AYDARIAEDPAQLEAILGRLVT-------------AGVDVLHPSTRRHYL
MAB_2740c|M.abscessus_ATCC_199 DYTATLADSPAELEGLLAPLVD-------------AGVDVFHPSTRRHYV
Mflv_1689|M.gilvum_PYR-GCK G-DMREIDDVSAYEALLCRIAS-------------LGIAYLHVLVE----
Mvan_5069|M.vanbaalenii_PYR-1 G-DMTEVDQISAYELLLCRIAS-------------LNIAYLHVVSE----
: :
MMAR_4276|M.marinum_M SNAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVL
MUL_1023|M.ulcerans_Agy99 SNAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVL
Mb1208c|M.bovis_AF2122/97 SSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVL
Rv1175c|M.tuberculosis_H37Rv SSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVL
MAV_4324|M.avium_104 GDAPLKEFAGAFKPPLRWGMRMTGKKFLREYPYREAYLLR----------
TH_2463|M.thermoresistible__bu GDVPVREFAEVMPAMMRPGVRLMGKRFMGSYPYEDLYMLP----------
MSMEG_3137|M.smegmatis_MC2_155 PAFP---GSD--LSLAGWTRKITGIPVIGVGSVGLATEFR----------
MAB_2740c|M.abscessus_ATCC_199 PAFPELAGADGELSLAGWTKRLTGLPAVAVGSVGLQTEFK----------
Mflv_1689|M.gilvum_PYR-GCK PSAP---------AFAAVRTQWEGTLVLNT-PRTVETDFA----------
Mvan_5069|M.vanbaalenii_PYR-1 PSAP---------AFAAIRTQWEGTLVLNT-PRAVDTDFA----------
. . :
MMAR_4276|M.marinum_M KAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTLSPTQ
MUL_1023|M.ulcerans_Agy99 KAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTMSPTQ
Mb1208c|M.bovis_AF2122/97 KAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTR
Rv1175c|M.tuberculosis_H37Rv KAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTR
MAV_4324|M.avium_104 -----------------------------DAKLFRAELKMP-LILLG---
TH_2463|M.thermoresistible__bu -----------------------------AARQFVPVMRHTKLILLG---
MSMEG_3137|M.smegmatis_MC2_155 -----------------------------------PGRRDGDIIAAAP--
MAB_2740c|M.abscessus_ATCC_199 -----------------------------------PSEVRD--IEPAP--
Mflv_1689|M.gilvum_PYR-GCK -----------------------------------TLENLADWGVISA--
Mvan_5069|M.vanbaalenii_PYR-1 -----------------------------------ELENLATWGVISA--
.
MMAR_4276|M.marinum_M RARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGK
MUL_1023|M.ulcerans_Agy99 RARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGK
Mb1208c|M.bovis_AF2122/97 RARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGK
Rv1175c|M.tuberculosis_H37Rv RARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGK
MAV_4324|M.avium_104 -----GITNRETMDLAMAEGFEFVAMARALLAEPDLINRIAADGAAHRVH
TH_2463|M.thermoresistible__bu -----GITNRDHLETGLREGFDFLAMGRALLREPDLVNKMIADGS---VR
MSMEG_3137|M.smegmatis_MC2_155 --------VEKVVEQFTAGEFDIVAVGRALLAEPAWVNRLRDNSLDGFAG
MAB_2740c|M.abscessus_ATCC_199 --------VEAVLRQFADNEFDVIAVGRALLSDPEWVNKLRSGRQGEFVG
Mflv_1689|M.gilvum_PYR-GCK --------AAVGRAFLANPDLIERLKLGAELNEPDVATFYAPGP-DGYLD
Mvan_5069|M.vanbaalenii_PYR-1 --------AAVGRAFLANPDLVQRLTSGAELNEPDVATFYAPGP-AGYID
: :
MMAR_4276|M.marinum_M EEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAPRIPA
MUL_1023|M.ulcerans_Agy99 EEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAPRIPA
Mb1208c|M.bovis_AF2122/97 EEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAPRIPA
Rv1175c|M.tuberculosis_H37Rv EEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAPRIPA
MAV_4324|M.avium_104 SACTHCNQCMPTIYSRT---------------------------------
TH_2463|M.thermoresistible__bu SRCNHNNKCMVTVFGRT---------------------------------
MSMEG_3137|M.smegmatis_MC2_155 YHAETALARLY---------------------------------------
MAB_2740c|M.abscessus_ATCC_199 FNIGKALSALY---------------------------------------
Mflv_1689|M.gilvum_PYR-GCK YPTLDEMVTPRSA-------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 YPTLDELAEPQSA-------------------------------------
MMAR_4276|M.marinum_M IPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTL
MUL_1023|M.ulcerans_Agy99 IPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLITESSPTL
Mb1208c|M.bovis_AF2122/97 IPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVTDSSPTL
Rv1175c|M.tuberculosis_H37Rv IPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVTDSSPTL
MAV_4324|M.avium_104 ------HCVVTG-------APDRHTSAAT---------------------
TH_2463|M.thermoresistible__bu ------HCVLDPDQRYGAATPMRPTRSATSAQT-----------------
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M NLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKRLGKT
MUL_1023|M.ulcerans_Agy99 NLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKRLGKT
Mb1208c|M.bovis_AF2122/97 NLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKRLGKT
Rv1175c|M.tuberculosis_H37Rv NLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKRLGKT
MAV_4324|M.avium_104 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M SGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPERQRPQLLAVDSVV
MUL_1023|M.ulcerans_Agy99 SGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPDRQRPQLLAVDSVV
Mb1208c|M.bovis_AF2122/97 TGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVV
Rv1175c|M.tuberculosis_H37Rv TGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVV
MAV_4324|M.avium_104 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M ICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL
MUL_1023|M.ulcerans_Agy99 ICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTELAARL
Mb1208c|M.bovis_AF2122/97 VCAGQEPVRDLESELRRHGINPHISGGAAVAAELDAKRAIKQGTELAARL
Rv1175c|M.tuberculosis_H37Rv VCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAIKQGTELAARL
MAV_4324|M.avium_104 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------