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VSASFGEEELLMDMERIAQPIQLRKVEVRNRIWMSPMAQYSATSDGCLSEWHSLHYGARAVGGVGMVMVE STAIGPDDRCTLRDPGIWTGAQVDSHRTVTDIIRRAGAVPAIQLQAAGRKSSHRLPWERRGQNSPVAVEE GGWTPLAPSAIPFGNLTVPRALTRAEIAMTVDRFAQAAVNAHEAGYDVVEVHAAHGYLLHQFLSPLANQR VDEYGGSLQNRLRFPLAVARAVRSALPADKPVFIRISTNDWTGGGFDFAQAVEFAKCLRELDIDLLDVTS GGLLVDAPPPPRPALNVEPADRIRQDVGILVAPVGQIGDPNVLEEAISRTKVDAVFLGRPLLRDPYLALR FLPGDPHDLWPTQYHRALINPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3338 | - | - | 100% (372) | oxidoreductase, FAD/FMN-binding |
| M. smegmatis MC2 155 | MSMEG_6486 | - | 2e-73 | 43.35% (346) | oxidoreductase, FAD/FMN-binding |
| M. smegmatis MC2 155 | MSMEG_2969 | - | 2e-32 | 32.00% (350) | NADH:flavin oxidoreductase/NADH oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1208c | fadH | 9e-28 | 28.61% (339) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 5e-34 | 32.47% (348) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv1175c | fadH | 3e-28 | 28.91% (339) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0485 | - | 6e-69 | 39.40% (368) | putative oxidoreductase |
| M. marinum M | MMAR_4276 | fadH | 1e-27 | 28.86% (343) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. avium 104 | MAV_4324 | - | 3e-24 | 32.85% (277) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. thermoresistible (build 8) | TH_2463 | - | 2e-26 | 32.71% (266) | PUTATIVE NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 1e-27 | 29.41% (340) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. vanbaalenii PYR-1 | Mvan_5069 | - | 3e-34 | 33.43% (344) | NADH:flavin oxidoreductase/NADH oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4276|M.marinum_M ---------MTSPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDRPKDTDR
MUL_1023|M.ulcerans_Agy99 ---------MTSPYPNLLFPLDLGFTTLRNRVVMGSMHTGLEDRPKDTDR
Mb1208c|M.bovis_AF2122/97 ---------MTNPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDRARHIDR
Rv1175c|M.tuberculosis_H37Rv ---------MTNPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDRARHIDR
MAV_4324|M.avium_104 ----------MPTPPDVFSPAKLGPITLRNRIIKSATFEARTPDALVTDD
TH_2463|M.thermoresistible__bu ---------VTHTSLDPFAPAQLGPVRLRNRVIKAATSEGRSPDGLVTDD
MSMEG_3338|M.smegmatis_MC2_155 MSASFGEEELLMDMERIAQPIQLRKVEVRNRIWMSPMAQYSATSDGCLS-
MAB_0485|M.abscessus_ATCC_1997 -------------MSLLFEPYRLRDITVPNRIWMSPMCQYSAAPAGPLLG
Mflv_1689|M.gilvum_PYR-GCK ------MTFTLSEQSALLKPIQVGGTAAGNRLFMAPLTRSRADADGTPS-
Mvan_5069|M.vanbaalenii_PYR-1 ------MAFTLGAGSALLKPIQVGGVTAENRIFMAPLTRSRADADGTPS-
* : **: ..
MMAR_4276|M.marinum_M -----LAEYFAERARGGVGMLITGGYAPNRTGW-LYPFASELVTPAEARR
MUL_1023|M.ulcerans_Agy99 -----LAEYFAERARGGVGMLITGGYAPNRTGW-LYPFASELVTPAEARR
Mb1208c|M.bovis_AF2122/97 -----LADYFAERARGGVGLIITGGYAPNRTGW-LLPFASELVTSAQARR
Rv1175c|M.tuberculosis_H37Rv -----LADYFAERARGGVGLIITGGYAPNRTGW-LLPFASELVTSAQARR
MAV_4324|M.avium_104 -----LIEYHRLPAAGGVGMTTVAYCAVSPGGR-TEGNGIWMRPEAVPG-
TH_2463|M.thermoresistible__bu -----LVEFHRRFARGGVAMTTVAYCCVSPEAA-SAPGQIVMADRALPG-
MSMEG_3338|M.smegmatis_MC2_155 ---EWHSLHYGARAVGGVGMVMVESTAIGPDDR-CTLRDPGIWTGAQVDS
MAB_0485|M.abscessus_ATCC_1997 TPNDWHRTHLISRAIGGAGLVFTEATSVNAQGR-LSPYDTGLWNDTQEQA
Mflv_1689|M.gilvum_PYR-GCK ---SLAAQYYAQRAS--AGLIISEATAVCEQANGAYLNTPGLYTDRQQDK
Mvan_5069|M.vanbaalenii_PYR-1 ---SLAAQYYAQRAE--AGLIISEATAVCEQANGAYLNTPGLYTDRQQEA
. * ..: . :
MMAR_4276|M.marinum_M HRRITGAVHDADAKILLQVLHAGRYAYHP----LSVSASSIKAPINPFR-
MUL_1023|M.ulcerans_Agy99 HRRITGAVHDADAKILLQVLHAGRYAYHP----LSVSASSIKAPINPFR-
Mb1208c|M.bovis_AF2122/97 HRRINRAVHDSGAKILLQILHAGRYAYHP----LAVSASPIKAPITPFR-
Rv1175c|M.tuberculosis_H37Rv HRRITRAVHDSGAKILLQILHAGRYAYHP----LAVSASPIKAPITPFR-
MAV_4324|M.avium_104 FRRLTDAIHAEGAAVSAQIGHAGPVANARSNKAHALAPVRFFNPIGMRF-
TH_2463|M.thermoresistible__bu LRRLTDAVHEAGAAVSAQLGHAGVVAPKKLTGVTAVAPSRFINPTSLAY-
MSMEG_3338|M.smegmatis_MC2_155 HRTVTDIIRRAGAVPAIQLQAAGRKSSHRLPWERRGQNSPVAVEEGGWTP
MAB_0485|M.abscessus_ATCC_1997 WAAIVDGIKHFGAVPAIQLGHAGRKASTVAPWD--GHRSLEPTDPLSWGT
Mflv_1689|M.gilvum_PYR-GCK WSEIASAVHRAGGKMFVQLWHVGRMAHPEISGFETVGPSPIAADLLTHTP
Mvan_5069|M.vanbaalenii_PYR-1 WAEIASAVHGAGGKMFVQLWHVGRMAHPEISGFENVGPSPIAADLVTHTP
: :: .. *: .* :
MMAR_4276|M.marinum_M -------------PRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSE
MUL_1023|M.ulcerans_Agy99 -------------SRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSE
Mb1208c|M.bovis_AF2122/97 -------------PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSE
Rv1175c|M.tuberculosis_H37Rv -------------PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSE
MAV_4324|M.avium_104 -------------AKKATREDIDEVIAAHANAARLAIEAGFDAVEIHLGH
TH_2463|M.thermoresistible__bu -------------CREITRDEIEAVIDQFGEAARIAAEAGFDAVELHFGH
MSMEG_3338|M.smegmatis_MC2_155 LAPSAIPFGNLTVPRALTRAEIAMTVDRFAQAAVNAHEAGYDVVEVHAAH
MAB_0485|M.abscessus_ATCC_1997 VGPTDAPYGDFVPPVAATTADLTAIIEDYVSAAQRALRAGFQVLEVHAAH
Mflv_1689|M.gilvum_PYR-GCK TGKKPLP-----VPRALTTGEIAEIVGQFRAAARRAVDAGMDGVEIHSAN
Mvan_5069|M.vanbaalenii_PYR-1 SGKKPLP-----VPRALTAAEIAEIIGLFRAAARRAVDAGMDGVEIHSAN
: : : . .* * ** : :*: ..
MMAR_4276|M.marinum_M GYLLNQFLAPRTNKRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFII
MUL_1023|M.ulcerans_Agy99 GYLLNQFLAPRTNQRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFII
Mb1208c|M.bovis_AF2122/97 GYLLNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSR---AAVGSDFII
Rv1175c|M.tuberculosis_H37Rv GYLLNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSR---AAVGCDFII
MAV_4324|M.avium_104 NYLASSFLSPLINRRNDEFGGSLQNRAKVARGMVMAVRRAVEKEGTPIAV
TH_2463|M.thermoresistible__bu LYLPSSFLSPLINRRTDEYGGDIDNRSRFVRRIARRVR---EVVGDRIAV
MSMEG_3338|M.smegmatis_MC2_155 GYLLHQFLSPLANQRVDEYGGSLQNRLRFPLAVARAVR---SALPADKPV
MAB_0485|M.abscessus_ATCC_1997 GYIQHQFLSPASNTRTDEYGGSFSGRAKLTLDTVTAVR---TVWPEHLPL
Mflv_1689|M.gilvum_PYR-GCK GYLLHEFLSDVVNQRTDAYGGSPQNRARLAAEVVEAVV---AEIGPDR-V
Mvan_5069|M.vanbaalenii_PYR-1 GYLLHEFLSDVVNQRTDAYGGSPQNRARFTAEVVEAVA---AEIGPER-V
*: .**: * * * :** * :. :
MMAR_4276|M.marinum_M CYRMSMADYVEGGQSWDEIVALASELETAGATIINSGFGWHEARIPTIVT
MUL_1023|M.ulcerans_Agy99 CYRMSMADYVEGGQSWDEIVALATELESAGATIINSGFGWHEARIPTIVT
Mb1208c|M.bovis_AF2122/97 CYRLSMADYVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVT
Rv1175c|M.tuberculosis_H37Rv CYRLSMADYVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVT
MAV_4324|M.avium_104 TAKLNMADGVRGGISTEESLTTAKWLE-----------------------
TH_2463|M.thermoresistible__bu IAKLNMDDGLPGGIWIDEALRTAQLLD-----------------------
MSMEG_3338|M.smegmatis_MC2_155 FIRISTNDWTG---------------------------------------
MAB_0485|M.abscessus_ATCC_1997 FVRVSATDWLSEEP------------------------------------
Mflv_1689|M.gilvum_PYR-GCK GLRISPGNSAG---------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 GLRISPGNNAG---------------------------------------
::. :
MMAR_4276|M.marinum_M SVPSGAFVDISNAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMAR
MUL_1023|M.ulcerans_Agy99 SVPSGAFVEISNAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMAR
Mb1208c|M.bovis_AF2122/97 SVPGGAFVDISSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMAR
Rv1175c|M.tuberculosis_H37Rv SVPGGAFVDISSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMAR
MAV_4324|M.avium_104 ----------SDGGLDAIELTAGSS-------------------------
TH_2463|M.thermoresistible__bu ----------ADATLDALELTQGSS-------------------------
MSMEG_3338|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M PMLSDPEWVLKAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGH
MUL_1023|M.ulcerans_Agy99 PMLSDPEWVLKAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGH
Mb1208c|M.bovis_AF2122/97 PMLSDPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGR
Rv1175c|M.tuberculosis_H37Rv PMLSDPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGR
MAV_4324|M.avium_104 --LVNPMYLFRG--------------------------------------
TH_2463|M.thermoresistible__bu --VFKPMYLFRG--------------------------------------
MSMEG_3338|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M ETLLTLSPTQRARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQ
MUL_1023|M.ulcerans_Agy99 ETLLTMSPTQRARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQ
Mb1208c|M.bovis_AF2122/97 ETQLVLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQ
Rv1175c|M.tuberculosis_H37Rv ETQLVLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQ
MAV_4324|M.avium_104 -------------------DAPLKEFAGAFKPPLRWGMRMTGKKFLREYP
TH_2463|M.thermoresistible__bu -------------------DVPVREFAEVMPAMMRPGVRLMGKRFMGSYP
MSMEG_3338|M.smegmatis_MC2_155 -----------------------GGFDFAQAVEFAKCLRELDIDLLDVTS
MAB_0485|M.abscessus_ATCC_1997 -------------------GHEADSWTPDQTVELARMLQPRGVDLVDVST
Mflv_1689|M.gilvum_PYR-GCK -----------------------DMREIDDVSAYEALLCR--IASLGIAY
Mvan_5069|M.vanbaalenii_PYR-1 -----------------------DMTEVDQISAYELLLCR--IASLNIAY
: .
MMAR_4276|M.marinum_M FDLARRIPGKEEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVL
MUL_1023|M.ulcerans_Agy99 FDLARRIPGKEEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVL
Mb1208c|M.bovis_AF2122/97 FDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVL
Rv1175c|M.tuberculosis_H37Rv FDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVL
MAV_4324|M.avium_104 YREAYLLRDAKLFRAELKMP-LILLGG---ITNRETMDLAMAEGFEFVAM
TH_2463|M.thermoresistible__bu YEDLYMLPAARQFVPVMRHTKLILLGG---ITNRDHLETGLREGFDFLAM
MSMEG_3338|M.smegmatis_MC2_155 GGLLVDAPPPPRPALNVEPADRIRQDVGILVAPVGQIGDPNVLEEAISRT
MAB_0485|M.abscessus_ATCC_1997 GGNVPHVHIPTGPGYQVRFARRIQTETPLPAAAVGMITEPHQAESILAAG
Mflv_1689|M.gilvum_PYR-GCK LHVLVEPSAPAFAAVRTQWEGTLVLNTPRTVETDFATLENLADWGVISAA
Mvan_5069|M.vanbaalenii_PYR-1 LHVVSEPSAPAFAAIRTQWEGTLVLNTPRAVDTDFAELENLATWGVISAA
. :
MMAR_4276|M.marinum_M ATGVAPRIPAIPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTE
MUL_1023|M.ulcerans_Agy99 ATGVAPRIPAIPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTE
Mb1208c|M.bovis_AF2122/97 ATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTE
Rv1175c|M.tuberculosis_H37Rv ATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTE
MAV_4324|M.avium_104 AR---------------ALLAEPDLINRIAADGAAHRVHSACTH---CNQ
TH_2463|M.thermoresistible__bu GR---------------ALLREPDLVNKMIADGS---VRSRCNH---NNK
MSMEG_3338|M.smegmatis_MC2_155 KVD-------------AVFLGRPLLRDPYL---------ALRFLPGDPHD
MAB_0485|M.abscessus_ATCC_1997 DAS-------------AVLLGRELLRDPYWP------RRAARELGADLSP
Mflv_1689|M.gilvum_PYR-GCK AVG-------------RAFLANPDLIERLKLGAELNEPDVATFYAPGPDG
Mvan_5069|M.vanbaalenii_PYR-1 AVG-------------RAFLANPDLVQRLTSGAELNEPDVATFYAPGPAG
.*
MMAR_4276|M.marinum_M LLITESSPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTK
MUL_1023|M.ulcerans_Agy99 LLITESSPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTK
Mb1208c|M.bovis_AF2122/97 LLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTK
Rv1175c|M.tuberculosis_H37Rv LLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTK
MAV_4324|M.avium_104 CMPTIYSRTHCVVTG-------APDRHTSAAT------------------
TH_2463|M.thermoresistible__bu CMVTVFGRTHCVLDPDQRYGAATPMRPTRSATSAQT--------------
MSMEG_3338|M.smegmatis_MC2_155 LWPTQYHRALINPR------------------------------------
MAB_0485|M.abscessus_ATCC_1997 AVPKQYARAF----------------------------------------
Mflv_1689|M.gilvum_PYR-GCK YLDYPTLDEMVTPRSA----------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 YIDYPTLDELAEPQSA----------------------------------
MMAR_4276|M.marinum_M GPQGKRLGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPERQR
MUL_1023|M.ulcerans_Agy99 GPQGKRLGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPDRQR
Mb1208c|M.bovis_AF2122/97 GPQGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRR
Rv1175c|M.tuberculosis_H37Rv GPQGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRR
MAV_4324|M.avium_104 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
MSMEG_3338|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M PQLLAVDSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAI
MUL_1023|M.ulcerans_Agy99 PQLLAVDSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAI
Mb1208c|M.bovis_AF2122/97 PQLLAVDNVVVCAGQEPVRDLESELRRHGINPHISGGAAVAAELDAKRAI
Rv1175c|M.tuberculosis_H37Rv PQLLAVDNVVVCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAI
MAV_4324|M.avium_104 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
MSMEG_3338|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0485|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M KQGTELAARL
MUL_1023|M.ulcerans_Agy99 KQGTELAARL
Mb1208c|M.bovis_AF2122/97 KQGTELAARL
Rv1175c|M.tuberculosis_H37Rv KQGTELAARL
MAV_4324|M.avium_104 ----------
TH_2463|M.thermoresistible__bu ----------
MSMEG_3338|M.smegmatis_MC2_155 ----------
MAB_0485|M.abscessus_ATCC_1997 ----------
Mflv_1689|M.gilvum_PYR-GCK ----------
Mvan_5069|M.vanbaalenii_PYR-1 ----------