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AFTLGAGSALLKPIQVGGVTAENRIFMAPLTRSRADADGTPSSLAAQYYAQRAEAGLIISEATAVCEQAN GAYLNTPGLYTDRQQEAWAEIASAVHGAGGKMFVQLWHVGRMAHPEISGFENVGPSPIAADLVTHTPSGK KPLPVPRALTAAEIAEIIGLFRAAARRAVDAGMDGVEIHSANGYLLHEFLSDVVNQRTDAYGGSPQNRAR FTAEVVEAVAAEIGPERVGLRISPGNNAGDMTEVDQISAYELLLCRIASLNIAYLHVVSEPSAPAFAAIR TQWEGTLVLNTPRAVDTDFAELENLATWGVISAAAVGRAFLANPDLVQRLTSGAELNEPDVATFYAPGPA GYIDYPTLDELAEPQSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5069 | - | - | 100% (368) | NADH:flavin oxidoreductase/NADH oxidase |
| M. vanbaalenii PYR-1 | Mvan_4790 | - | 8e-62 | 39.24% (367) | NADH:flavin oxidoreductase/NADH oxidase |
| M. vanbaalenii PYR-1 | Mvan_2887 | - | 9e-21 | 30.66% (212) | NADH:flavin oxidoreductase/NADH oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1208c | fadH | 2e-25 | 32.64% (242) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 0.0 | 86.96% (368) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv1175c | fadH | 2e-25 | 34.26% (216) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0830 | - | 1e-133 | 64.44% (360) | NADH-dependent flavin oxidoreductase |
| M. marinum M | MMAR_4276 | fadH | 4e-24 | 33.03% (218) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. avium 104 | MAV_4324 | - | 6e-18 | 26.81% (235) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2969 | - | 1e-48 | 35.94% (345) | NADH:flavin oxidoreductase/NADH oxidase |
| M. thermoresistible (build 8) | TH_3970 | - | 2e-30 | 33.20% (256) | PUTATIVE putative NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 2e-23 | 33.03% (218) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5069|M.vanbaalenii_PYR-1 ----MAFTLGAGSALLKPIQVG-GVTAENRIFMAPLTRSRADADGTPSSL
Mflv_1689|M.gilvum_PYR-GCK ----MTFTLSEQSALLKPIQVG-GTAAGNRLFMAPLTRSRADADGTPSSL
MAB_0830|M.abscessus_ATCC_1997 ----MAFTLDPQAALLKPIRMG-EVVASNRILMAPMTRSRAQGDGTPSEF
MSMEG_2969|M.smegmatis_MC2_155 --------MTNTHPALTSVRLG-GLKLDNRFAVAPMTRVSATADGAPTDA
Mb1208c|M.bovis_AF2122/97 -------MTNPYPNLLSPLDLG-FTTLRNRVVMGSMHTG-LEDRARHIDR
Rv1175c|M.tuberculosis_H37Rv -------MTNPYPNLLSPLDLG-FTTLRNRVVMGSMHTG-LEDRARHIDR
MMAR_4276|M.marinum_M -------MTSPYPNLLSPLDLG-FTTLRNRVVMGSMHTG-LEDRPKDTDR
MUL_1023|M.ulcerans_Agy99 -------MTSPYPNLLFPLDLG-FTTLRNRVVMGSMHTG-LEDRPKDTDR
TH_3970|M.thermoresistible__bu MCGRRRDEMVPMTDLSAPLRFAHGPTWRNRLALAPLTNMQSNADGTLHDD
MAV_4324|M.avium_104 --------MPTPPDVFSPAKLG-PITLRNRIIKS-ATFEARTPDALVTDD
. .. **. . .
Mvan_5069|M.vanbaalenii_PYR-1 AAQYYAQRAEA--GLIISEATAVCEQANGAYLNTPGLYTDRQQEAWAEIA
Mflv_1689|M.gilvum_PYR-GCK AAQYYAQRASA--GLIISEATAVCEQANGAYLNTPGLYTDRQQDKWSEIA
MAB_0830|M.abscessus_ATCC_1997 APVYYGQRASA--GLIISEATAISQAGNGAYMNTPGIYTDRHQHKWAEIA
MSMEG_2969|M.smegmatis_MC2_155 MAGYYAEFARGGFGLVITEGTYTDTTHSQGYLNQPGLATDAHAAGWRPVT
Mb1208c|M.bovis_AF2122/97 LADYFAERARGGVGLIITGGYAPNRTG-WLLPFASELVTSAQARRHRRIN
Rv1175c|M.tuberculosis_H37Rv LADYFAERARGGVGLIITGGYAPNRTG-WLLPFASELVTSAQARRHRRIT
MMAR_4276|M.marinum_M LAEYFAERARGGVGMLITGGYAPNRTG-WLYPFASELVTPAEARRHRRIT
MUL_1023|M.ulcerans_Agy99 LAEYFAERARGGVGMLITGGYAPNRTG-WLYPFASELVTPAEARRHRRIT
TH_3970|M.thermoresistible__bu EHHWLVRRAEGGFAMVMTCAAHVSQAG-QAFPGQLGVWHDRHLPGLTRLA
MAV_4324|M.avium_104 LIEYHRLPAAGGVGMTTVAYCAVSPGG--RTEGNGIWMRPEAVPGFRRLT
: * . .: :
Mvan_5069|M.vanbaalenii_PYR-1 SAVHGAGGKMFVQLWHVGRMAHPEISG-FENVGPSPIAADLVTHTPSGKK
Mflv_1689|M.gilvum_PYR-GCK SAVHRAGGKMFVQLWHVGRMAHPEISG-FETVGPSPIAADLLTHTPTGKK
MAB_0830|M.abscessus_ATCC_1997 ETVHSEGSKMFLQIWHVGRLGHPAVSGGFEPVAPSAVAAQMTTHTPSGKV
MSMEG_2969|M.smegmatis_MC2_155 DAVHAAGVPIVAQLMHAGALSQGNSHG-VETIAPSAVAPRGTMLEEYGGA
Mb1208c|M.bovis_AF2122/97 RAVHDSGAKILLQILHAGRYAYH-----PLAVSASPIKAPITPFR-----
Rv1175c|M.tuberculosis_H37Rv RAVHDSGAKILLQILHAGRYAYH-----PLAVSASPIKAPITPFR-----
MMAR_4276|M.marinum_M GAVHDADAKILLQVLHAGRYAYH-----PLSVSASSIKAPINPFR-----
MUL_1023|M.ulcerans_Agy99 GAVHDADAKILLQVLHAGRYAYH-----PLSVSASSIKAPINPFR-----
TH_3970|M.thermoresistible__bu AGIRAAGAVATVQLHHGGRRAEARLTG-LPVVAPWDDPDKG---------
MAV_4324|M.avium_104 DAIHAEGAAVSAQIGHAGPVANARSNK-AHALAPVRFFNPIGMRF-----
:: . *: * * . :..
Mvan_5069|M.vanbaalenii_PYR-1 -PLPVPRALTAAEIAEIIGLFRAAARRAVDAGMDGVEIHSANGYLLHEFL
Mflv_1689|M.gilvum_PYR-GCK -PLPVPRALTTGEIAEIVGQFRAAARRAVDAGMDGVEIHSANGYLLHEFL
MAB_0830|M.abscessus_ATCC_1997 -PLVIPRELRIDEIAEIVDDFRAAARRAIDAGLDGVEIHGANGYLLHQFS
MSMEG_2969|M.smegmatis_MC2_155 GTWPTPREMSAADIDAAIAGFVDAAVRARAAGFDGVEIHAANGYLLDQFL
Mb1208c|M.bovis_AF2122/97 -----PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFL
Rv1175c|M.tuberculosis_H37Rv -----PRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFL
MMAR_4276|M.marinum_M -----PRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFL
MUL_1023|M.ulcerans_Agy99 -----SRKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFL
TH_3970|M.thermoresistible__bu -----VTALTTAQVEQVVQDFVDAAVRAEKAGFDGAEIHGAHGYLVAQFL
MAV_4324|M.avium_104 -----AKKATREDIDEVIAAHANAARLAIEAGFDAVEIHLGHNYLASSFL
: : . .* * ** *..** ...** .*
Mvan_5069|M.vanbaalenii_PYR-1 SDVVNQRTDAYGGSPQNRARFTAEVVEAVAAEI---GPE-RVGLRISPGN
Mflv_1689|M.gilvum_PYR-GCK SDVVNQRTDAYGGSPQNRARLAAEVVEAVVAEI---GPD-RVGLRISPGN
MAB_0830|M.abscessus_ATCC_1997 SDVINQRTDIYGGSPENRARLTAEVVEAVAAEV---GPT-RVGVRISPGT
MSMEG_2969|M.smegmatis_MC2_155 TTYTNHRTDEYGGTVAHRIRLAAQISAAVRTAV---GADFLVGVRLSQTK
Mb1208c|M.bovis_AF2122/97 APRTNKRTDSWGGTPANRRRFPVEIIRRSRAAV---GSDFIICYRLSMAD
Rv1175c|M.tuberculosis_H37Rv APRTNKRTDSWGGTPANRRRFPVEIIRRSRAAV---GCDFIICYRLSMAD
MMAR_4276|M.marinum_M APRTNKRTDSWGGTPAKRRRFPVEIVRRTRAAV---GPDFIICYRMSMAD
MUL_1023|M.ulcerans_Agy99 APRTNQRTDSWGGTPAKRRRFPVEIVRRTRAAV---GPDFIICYRMSMAD
TH_3970|M.thermoresistible__bu DVRHNHRTDRYGGSPENRFRIVHEIIAGIRAAT---SPDFQLGLRLSPER
MAV_4324|M.avium_104 SPLINRRNDEFGGSLQNRAKVARGMVMAVRRAVEKEGTPIAVTAKLNMAD
*:*.* :**: :* :. : . : ::.
Mvan_5069|M.vanbaalenii_PYR-1 N-AGDMTEVDQISAYELLLCR---IASLNIAYLHVVSE----------PS
Mflv_1689|M.gilvum_PYR-GCK S-AGDMREIDDVSAYEALLCR---IASLGIAYLHVLVE----------PS
MAB_0830|M.abscessus_ATCC_1997 S-AGDMHENDTVSTYAALLER---IDPLGLAYLHVVID----------PG
MSMEG_2969|M.smegmatis_MC2_155 VNDFEYRWPGGAQDAEVIFTA---LAATGIDYLHIASEGRDFIDGARLDD
Mb1208c|M.bovis_AF2122/97 YVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVP----TIVTSVPG
Rv1175c|M.tuberculosis_H37Rv YVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVP----TIVTSVPG
MMAR_4276|M.marinum_M YVEGGQSWDEIVALASELETAGATIINSGFGWHEARIP----TIVTSVPS
MUL_1023|M.ulcerans_Agy99 YVEGGQSWDEIVALATELESAGATIINSGFGWHEARIP----TIVTSVPS
TH_3970|M.thermoresistible__bu Y---GIVLDEARALAGEVLADG-QLDYLDLSLWDAFKEP-----YEEAHR
MAV_4324|M.avium_104 GVRGGISTEESLTTAKWLESDG-GLDAIELTAGSSLVNP-MYLFRGDAPL
: : :
Mvan_5069|M.vanbaalenii_PYR-1 APAFAAIRTQWEGTLVLNTPRAVDTDFAELENLATWGVISAAAVGRAFLA
Mflv_1689|M.gilvum_PYR-GCK APAFAAVRTQWEGTLVLNTPRTVETDFATLENLADWGVISAAAVGRAFLA
MAB_0830|M.abscessus_ATCC_1997 AVELRAMGAMWSNNLVLNSSTETETEFCVLEGLVESGAVNAVALGRKFLA
MSMEG_2969|M.smegmatis_MC2_155 GRTITALARQVTGLPVIAN--GGMHDTTQAAGVLDGGHADVLSIGRGALA
Mb1208c|M.bovis_AF2122/97 GAFVDISSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLS
Rv1175c|M.tuberculosis_H37Rv GAFVDISSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLS
MMAR_4276|M.marinum_M GAFVDISNAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMARPMLS
MUL_1023|M.ulcerans_Agy99 GAFVEISNAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMARPMLS
TH_3970|M.thermoresistible__bu GRRLIELFMDLPRGDTRVGVAGKITDAESARRCLDSG-ADFVLIGKAAIV
MAV_4324|M.avium_104 KEFAGAFKPPLRWGMRMTGKKFLREYPYREAYLLRDAKLFRAELKMPLIL
: :
Mvan_5069|M.vanbaalenii_PYR-1 NPDLVQRLTSG---------------------------------------
Mflv_1689|M.gilvum_PYR-GCK NPDLIERLKLG---------------------------------------
MAB_0830|M.abscessus_ATCC_1997 NPDLIDRLLLG---------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 NPDLPQRVSSG---------------------------------------
Mb1208c|M.bovis_AF2122/97 DPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQL
Rv1175c|M.tuberculosis_H37Rv DPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQL
MMAR_4276|M.marinum_M DPEWVLKAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLL
MUL_1023|M.ulcerans_Agy99 DPEWVLKAQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLL
TH_3970|M.thermoresistible__bu HHDFARQVLADPAYR-----------------------------------
MAV_4324|M.avium_104 LGGITNRETMDLAMAEG---------------------------------
: .
Mvan_5069|M.vanbaalenii_PYR-1 --AELNEPDVATFYAPGPAGYIDYPTLDELAEPQSA--------------
Mflv_1689|M.gilvum_PYR-GCK --AELNEPDVATFYAPGPDGYLDYPTLDEMVTPRSA--------------
MAB_0830|M.abscessus_ATCC_1997 --AELNEANAATFYSPGKEGYIDYPSLSAGR-------------------
MSMEG_2969|M.smegmatis_MC2_155 --APLERFDHGMLSPMATIVNAAAWTAARHRERVPR--------------
Mb1208c|M.bovis_AF2122/97 VLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMA
Rv1175c|M.tuberculosis_H37Rv VLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMA
MMAR_4276|M.marinum_M TLSPTQRARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLA
MUL_1023|M.ulcerans_Agy99 TMSPTQRARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLA
TH_3970|M.thermoresistible__bu -AAPLPVSAEHLAAEAVGPRFVDYLASNWDDFVSTG--------------
MAV_4324|M.avium_104 --FEFVAMARALLAEPDLINRIAADGAAHRVHSACTHCNQCMPTIYSRTH
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 RRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGV
Rv1175c|M.tuberculosis_H37Rv RRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGV
MMAR_4276|M.marinum_M RRIPGKEEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGV
MUL_1023|M.ulcerans_Agy99 RRIPGKEEFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGV
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 CVVTGAPDRHTSAAT-----------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 APRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVT
Rv1175c|M.tuberculosis_H37Rv APRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVT
MMAR_4276|M.marinum_M APRIPAIPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLIT
MUL_1023|M.ulcerans_Agy99 APRIPAIPGIAHAKVLTYTEAITGAKPVGPSVAVVGAGGIGFDVTELLIT
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 DSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQG
Rv1175c|M.tuberculosis_H37Rv DSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQG
MMAR_4276|M.marinum_M ESSPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQG
MUL_1023|M.ulcerans_Agy99 ESSPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQG
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 KRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLL
Rv1175c|M.tuberculosis_H37Rv KRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLL
MMAR_4276|M.marinum_M KRLGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPERQRPQLL
MUL_1023|M.ulcerans_Agy99 KRLGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPDRQRPQLL
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0830|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_2969|M.smegmatis_MC2_155 --------------------------------------------------
Mb1208c|M.bovis_AF2122/97 AVDNVVVCAGQEPVRDLESELRRHGINPHISGGAAVAAELDAKRAIKQGT
Rv1175c|M.tuberculosis_H37Rv AVDNVVVCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAIKQGT
MMAR_4276|M.marinum_M AVDSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGT
MUL_1023|M.ulcerans_Agy99 AVDSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGT
TH_3970|M.thermoresistible__bu --------------------------------------------------
MAV_4324|M.avium_104 --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 ------
Mflv_1689|M.gilvum_PYR-GCK ------
MAB_0830|M.abscessus_ATCC_1997 ------
MSMEG_2969|M.smegmatis_MC2_155 ------
Mb1208c|M.bovis_AF2122/97 ELAARL
Rv1175c|M.tuberculosis_H37Rv ELAARL
MMAR_4276|M.marinum_M ELAARL
MUL_1023|M.ulcerans_Agy99 ELAARL
TH_3970|M.thermoresistible__bu ------
MAV_4324|M.avium_104 ------