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TDVRPDVAPLFEPFAVKSMTSPNRFAMAPMTRSASPGGVPGENVAAYYRRRAAGGVGLIITEGVFIPHDA AGGQSNVPRLAGADSLAGWSAVTDAVHGEGSVIAAQLWHQGVERGVDPEFNPGVESVSPSGLAGDASPRG RALQTGELAPLAGQYAEAARNAKAAGFDAVELHGAHGYLLDQFLWERTNVRADGYGGSAAQRLRFPVEVV RAVRAAVGPDFPILYRFSQWKQADYTATLADSPAELEGLLAPLVDAGVDVFHPSTRRHYVPAFPELAGAD GELSLAGWTKRLTGLPAVAVGSVGLQTEFKPSEVRDIEPAPVEAVLRQFADNEFDVIAVGRALLSDPEWV NKLRSGRQGEFVGFNIGKALSALY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2740c | - | - | 100% (375) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_0830 | - | 8e-34 | 39.91% (223) | NADH-dependent flavin oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1325c | - | 1e-31 | 32.04% (362) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1208c | fadH | 3e-34 | 32.40% (358) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_1689 | - | 6e-40 | 35.44% (364) | NADH:flavin oxidoreductase/NADH oxidase |
| M. tuberculosis H37Rv | Rv1175c | fadH | 1e-34 | 32.68% (358) | NADPH dependent 2,4-dienoyl-CoA reductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4276 | fadH | 3e-35 | 31.64% (354) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. avium 104 | MAV_4324 | - | 4e-18 | 25.82% (368) | oxidoreductase, FAD/FMN-binding superfamily protein |
| M. smegmatis MC2 155 | MSMEG_3137 | - | 1e-129 | 64.13% (368) | oxidoreductase |
| M. thermoresistible (build 8) | TH_2463 | - | 3e-28 | 31.22% (362) | PUTATIVE NADH:flavin oxidoreductase/nadh oxidase |
| M. ulcerans Agy99 | MUL_1023 | fadH | 3e-35 | 31.64% (354) | NADPH dependent 2,4-dienoyl-CoA reductase FadH |
| M. vanbaalenii PYR-1 | Mvan_5069 | - | 2e-38 | 35.00% (360) | NADH:flavin oxidoreductase/NADH oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2740c|M.abscessus_ATCC_199 MTD-VRPDVAPLFEPFAVKSMTSPNRFAMAPMTR-SASPGGVPGENVAAY
MSMEG_3137|M.smegmatis_MC2_155 MTDSLDTSLDTLFTPLSVGTMRIPNRFAMAPMTR-RASPGGVPGADVAEY
Mflv_1689|M.gilvum_PYR-GCK -MTFTLSEQSALLKPIQVGGTAAGNRLFMAPLTRSRADADGTPSSLAAQY
Mvan_5069|M.vanbaalenii_PYR-1 -MAFTLGAGSALLKPIQVGGVTAENRIFMAPLTRSRADADGTPSSLAAQY
MMAR_4276|M.marinum_M ----MTSPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDR-PKDTDRLAEY
MUL_1023|M.ulcerans_Agy99 ----MTSPYPNLLFPLDLGFTTLRNRVVMGSMHTGLEDR-PKDTDRLAEY
Mb1208c|M.bovis_AF2122/97 ----MTNPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDR-ARHIDRLADY
Rv1175c|M.tuberculosis_H37Rv ----MTNPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDR-ARHIDRLADY
MAV_4324|M.avium_104 -----MPTPPDVFSPAKLGPITLRNRIIKSATFEARTPD-ALVTDDLIEY
TH_2463|M.thermoresistible__bu ----VTHTSLDPFAPAQLGPVRLRNRVIKAATSEGRSPD-GLVTDDLVEF
: * : **. .. :
MAB_2740c|M.abscessus_ATCC_199 YRRRAAGGVGLIITEGVFIPHDAAGGQSNVPRLAGADSLAGWSAVTDAVH
MSMEG_3137|M.smegmatis_MC2_155 YARRAAGGVGLIITEGVRLADPVAAWPHSIPTLAGADAVAGWRAVTDAVH
Mflv_1689|M.gilvum_PYR-GCK YAQRAS--AGLIISEATAVCEQANGAYLNTPGLYTDRQQDKWSEIASAVH
Mvan_5069|M.vanbaalenii_PYR-1 YAQRAE--AGLIISEATAVCEQANGAYLNTPGLYTDRQQEAWAEIASAVH
MMAR_4276|M.marinum_M FAERARGGVGMLITGG-YAPNRTGWLYPFASELVTPAEARRHRRITGAVH
MUL_1023|M.ulcerans_Agy99 FAERARGGVGMLITGG-YAPNRTGWLYPFASELVTPAEARRHRRITGAVH
Mb1208c|M.bovis_AF2122/97 FAERARGGVGLIITGG-YAPNRTGWLLPFASELVTSAQARRHRRINRAVH
Rv1175c|M.tuberculosis_H37Rv FAERARGGVGLIITGG-YAPNRTGWLLPFASELVTSAQARRHRRITRAVH
MAV_4324|M.avium_104 HRLPAAG--GVGMTTVAYCAVSPGGRTEGNGIWMRPEAVPGFRRLTDAIH
TH_2463|M.thermoresistible__bu HRRFARG--GVAMTTVAYCCVSPEAASAPGQIVMADRALPGLRRLTDAVH
. * *: :: : *:*
MAB_2740c|M.abscessus_ATCC_199 GEGSVIAAQLWHQGVERGVDPEFNPGVESVSPSGLAGDASPRG-------
MSMEG_3137|M.smegmatis_MC2_155 AHGSVIAAQLWHQGAER----DDSDGLQPVSPSGVNSVGAAHG-------
Mflv_1689|M.gilvum_PYR-GCK RAGGKMFVQLWHVGRMAH---PEISGFETVGPSPIAADLLTHTPTGKKPL
Mvan_5069|M.vanbaalenii_PYR-1 GAGGKMFVQLWHVGRMAH---PEISGFENVGPSPIAADLVTHTPSGKKPL
MMAR_4276|M.marinum_M DADAKILLQVLHAGRYAY-------HPLSVSASSIKAPINPFRP------
MUL_1023|M.ulcerans_Agy99 DADAKILLQVLHAGRYAY-------HPLSVSASSIKAPINPFRS------
Mb1208c|M.bovis_AF2122/97 DSGAKILLQILHAGRYAY-------HPLAVSASPIKAPITPFRP------
Rv1175c|M.tuberculosis_H37Rv DSGAKILLQILHAGRYAY-------HPLAVSASPIKAPITPFRP------
MAV_4324|M.avium_104 AEGAAVSAQIGHAGPVAN---ARSNKAHALAPVRFFNPIGMRFA------
TH_2463|M.thermoresistible__bu EAGAAVSAQLGHAGVVAP---KKLTGVTAVAPSRFINPTSLAYC------
.. : *: * * :.. .
MAB_2740c|M.abscessus_ATCC_199 ---RALQTGELAPLAGQYAEAARNAKAAGFDAVELHGAHGYLLDQFLWER
MSMEG_3137|M.smegmatis_MC2_155 ---RALRGDELPGLAAQYAEAARNAVEAGFDAVELHGAHGYLLDEFLWDR
Mflv_1689|M.gilvum_PYR-GCK PVPRALTTGEIAEIVGQFRAAARRAVDAGMDGVEIHSANGYLLHEFLSDV
Mvan_5069|M.vanbaalenii_PYR-1 PVPRALTAAEIAEIIGLFRAAARRAVDAGMDGVEIHSANGYLLHEFLSDV
MMAR_4276|M.marinum_M ---RKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAPR
MUL_1023|M.ulcerans_Agy99 ---RKLTSRGVEATIADFARCAQLAQEAGYDGVEIMGSEGYLLNQFLAPR
Mb1208c|M.bovis_AF2122/97 ---RALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFLAPR
Rv1175c|M.tuberculosis_H37Rv ---RALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFLAPR
MAV_4324|M.avium_104 ---KKATREDIDEVIAAHANAARLAIEAGFDAVEIHLGHNYLASSFLSPL
TH_2463|M.thermoresistible__bu ---REITRDEIEAVIDQFGEAARIAAEAGFDAVELHFGHLYLPSSFLSPL
: : . .*: * ** *.**: .. ** .**
MAB_2740c|M.abscessus_ATCC_199 TNVRADGYGGSAAQRLRFPVEVVRAVR---AAVGPDFPILYRFSQ-----
MSMEG_3137|M.smegmatis_MC2_155 TNQRTDGYGGSVAARTRFPVEVVAAVR---AAVGPDFPIIYRFSQ-----
Mflv_1689|M.gilvum_PYR-GCK VNQRTDAYGGSPQNRARLAAEVVEAVV---AEIGPDR-VGLRISP-----
Mvan_5069|M.vanbaalenii_PYR-1 VNQRTDAYGGSPQNRARFTAEVVEAVA---AEIGPER-VGLRISP-----
MMAR_4276|M.marinum_M TNKRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFIICYRMSMADYVE
MUL_1023|M.ulcerans_Agy99 TNQRTDSWGGTPAKRRRFPVEIVRRTR---AAVGPDFIICYRMSMADYVE
Mb1208c|M.bovis_AF2122/97 TNKRTDSWGGTPANRRRFPVEIIRRSR---AAVGSDFIICYRLSMADYVA
Rv1175c|M.tuberculosis_H37Rv TNKRTDSWGGTPANRRRFPVEIIRRSR---AAVGCDFIICYRLSMADYVA
MAV_4324|M.avium_104 INRRNDEFGGSLQNRAKVARGMVMAVRRAVEKEGTPIAVTAKLNMADGVR
TH_2463|M.thermoresistible__bu INRRTDEYGGDIDNRSRFVRRIARRVR---EVVGDRIAVIAKLNMDDGLP
* * * :** * :. : * : ::.
MAB_2740c|M.abscessus_ATCC_199 ----------------------------WKQADYTATLADSPAELEGLLA
MSMEG_3137|M.smegmatis_MC2_155 ----------------------------WKANAYDARIAEDPAQLEAILG
Mflv_1689|M.gilvum_PYR-GCK ----------------------------GNSAG-DMREIDDVSAYEALLC
Mvan_5069|M.vanbaalenii_PYR-1 ----------------------------GNNAG-DMTEVDQISAYELLLC
MMAR_4276|M.marinum_M GGQSWDEIVALASELETAGATIINSGFGWHEARIPTIVTSVPSGAFVDIS
MUL_1023|M.ulcerans_Agy99 GGQSWDEIVALATELESAGATIINSGFGWHEARIPTIVTSVPSGAFVEIS
Mb1208c|M.bovis_AF2122/97 EGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDIS
Rv1175c|M.tuberculosis_H37Rv EGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDIS
MAV_4324|M.avium_104 GG------------------------ISTEESLTTAKWLESDGGLDAIEL
TH_2463|M.thermoresistible__bu GG------------------------IWIDEALRTAQLLDADATLDALEL
. . .
MAB_2740c|M.abscessus_ATCC_199 PLVDAGVDVFHPSTRRHYVPAFPELAGADGELSLAGWTKRLTG-------
MSMEG_3137|M.smegmatis_MC2_155 RLVTAGVDVLHPSTRRHYLPAFP---GSD--LSLAGWTRKITG-------
Mflv_1689|M.gilvum_PYR-GCK RIASLGIAYLHVLVE----PSAP---------AFAAVRTQWEG-------
Mvan_5069|M.vanbaalenii_PYR-1 RIASLNIAYLHVVSE----PSAP---------AFAAIRTQWEG-------
MMAR_4276|M.marinum_M NAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVLK
MUL_1023|M.ulcerans_Agy99 NAVAEQVSIPVMTSNRINMPQAAEQILADTDVALISMARPMLSDPEWVLK
Mb1208c|M.bovis_AF2122/97 SAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLK
Rv1175c|M.tuberculosis_H37Rv SAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLK
MAV_4324|M.avium_104 TAGSSLVNPMYLFRGDAPLKEFAGAFKPPLRWGMRMTGKKFLR-------
TH_2463|M.thermoresistible__bu TQGSSVFKPMYLFRGDVPVREFAEVMPAMMRPGVRLMGKRFMG-------
. . .
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M AQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTLSPTQR
MUL_1023|M.ulcerans_Agy99 AQSGRVDEINTCIACNQACLDHVFVKKKVSCLLNPRAGHETLLTMSPTQR
Mb1208c|M.bovis_AF2122/97 AQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRR
Rv1175c|M.tuberculosis_H37Rv AQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRR
MAV_4324|M.avium_104 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 ---LPAVAVGSVGLQTEFKPSE----------------------------
MSMEG_3137|M.smegmatis_MC2_155 ---IPVIGVGSVGLATEFRPGR----------------------------
Mflv_1689|M.gilvum_PYR-GCK ---TLVLNT-PRTVETDFATLE----------------------------
Mvan_5069|M.vanbaalenii_PYR-1 ---TLVLNT-PRAVDTDFAELE----------------------------
MMAR_4276|M.marinum_M ARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKE
MUL_1023|M.ulcerans_Agy99 ARTVAVVGAGPAGLAAAVAAAQRGHRVTLFEANDFIGGQFDLARRIPGKE
Mb1208c|M.bovis_AF2122/97 ARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGKE
Rv1175c|M.tuberculosis_H37Rv ARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGKE
MAV_4324|M.avium_104 --EYPYREAYLLRDAKLFRAEL----------------------------
TH_2463|M.thermoresistible__bu --SYPYEDLYMLPAARQFVPVM----------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------VRD--IEPAPVEA--VLR
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------RDGDIIAAAPVEK--VVE
Mflv_1689|M.gilvum_PYR-GCK --------------------------------NLADWGVISAAAV--GRA
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------NLATWGVISAAAV--GRA
MMAR_4276|M.marinum_M EFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAP--RIP
MUL_1023|M.ulcerans_Agy99 EFNETIRYFSTMLAKHGVDVRLATRATADELTGYDEVVLATGVAP--RIP
Mb1208c|M.bovis_AF2122/97 EFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAP--RIP
Rv1175c|M.tuberculosis_H37Rv EFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAP--RIP
MAV_4324|M.avium_104 --------------------------------KMP-LILLGGITNRETMD
TH_2463|M.thermoresistible__bu --------------------------------RHTKLILLGGITNRDHLE
MAB_2740c|M.abscessus_ATCC_199 QFADNEFDVIAVGRALLSDPEWVNKLRSGRQ---GEFVGFNIGKALSALY
MSMEG_3137|M.smegmatis_MC2_155 QFTAGEFDIVAVGRALLAEPAWVNRLRDNSL---DGFAGYHAETALARLY
Mflv_1689|M.gilvum_PYR-GCK FLANPDLIERLKLGAELNEPDVATFYAPGP----DGYLDYPTLDEMVTPR
Mvan_5069|M.vanbaalenii_PYR-1 FLANPDLVQRLTSGAELNEPDVATFYAPGP----AGYIDYPTLDELAEPQ
MMAR_4276|M.marinum_M AIPGIAHAKVLTYTEAITGAKPVGPSVAVVG---AGGIGFDVTELLITES
MUL_1023|M.ulcerans_Agy99 AIPGIAHAKVLTYTEAITGAKPVGPSVAVVG---AGGIGFDVTELLITES
Mb1208c|M.bovis_AF2122/97 AIPGIDHPMVLTYAEAITGVRPVGRTVAVVG---AGGIGFDVTELLVTDS
Rv1175c|M.tuberculosis_H37Rv AIPGIDHPMVLTYAEAITGVRPVGRTVAVVG---AGGIGFDVTELLVTDS
MAV_4324|M.avium_104 LAMAEGFEFVAMARALLAEPDLINRIAADGAAHRVHSACTHCNQCMPTIY
TH_2463|M.thermoresistible__bu TGLREGFDFLAMGRALLREPDLVNKMIADGS---VRSRCNHNNKCMVTVF
: :
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK SA------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 SA------------------------------------------------
MMAR_4276|M.marinum_M SPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKR
MUL_1023|M.ulcerans_Agy99 SPTLNLKEWKAEWGVVDPQEARGALTTALPTPAAREVYLLQRTKGPQGKR
Mb1208c|M.bovis_AF2122/97 SPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKR
Rv1175c|M.tuberculosis_H37Rv SPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKR
MAV_4324|M.avium_104 SRTHCVVTG-------APDRHTSAAT------------------------
TH_2463|M.thermoresistible__bu GRTHCVLDPDQRYGAATPMRPTRSATSAQT--------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M LGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPERQRPQLLAV
MUL_1023|M.ulcerans_Agy99 LGKTSGWVHRASVKAKGVHQLSGVNYERISDDGLHISFGPDRQRPQLLAV
Mb1208c|M.bovis_AF2122/97 LGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAV
Rv1175c|M.tuberculosis_H37Rv LGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAV
MAV_4324|M.avium_104 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3137|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_1689|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5069|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4276|M.marinum_M DSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTEL
MUL_1023|M.ulcerans_Agy99 DSVVICAGQEPVRDLETDLRSNGVDPHIIGGAALAAELDAKRAIKQGTEL
Mb1208c|M.bovis_AF2122/97 DNVVVCAGQEPVRDLESELRRHGINPHISGGAAVAAELDAKRAIKQGTEL
Rv1175c|M.tuberculosis_H37Rv DNVVVCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAIKQGTEL
MAV_4324|M.avium_104 --------------------------------------------------
TH_2463|M.thermoresistible__bu --------------------------------------------------
MAB_2740c|M.abscessus_ATCC_199 ----
MSMEG_3137|M.smegmatis_MC2_155 ----
Mflv_1689|M.gilvum_PYR-GCK ----
Mvan_5069|M.vanbaalenii_PYR-1 ----
MMAR_4276|M.marinum_M AARL
MUL_1023|M.ulcerans_Agy99 AARL
Mb1208c|M.bovis_AF2122/97 AARL
Rv1175c|M.tuberculosis_H37Rv AARL
MAV_4324|M.avium_104 ----
TH_2463|M.thermoresistible__bu ----