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MTGYEPIVGRYLTADIDGVPNRMYIEESGDGVPVVCLHTAGSDSRQYRHMQTDDEVLSRFRVLAFDLPWH GKSLPPDRWWRREYLLTSELYIASVMAVIDALDLEQPIVVGCSMAGSLVLELALTHGDRIGGVIGFSGAA KVEGRFDDWSLKPDINSNQAVPSWTYGLMAPQSPEPARREVWWTYAQGGPGVYRGDTYYYSNGMDLRGRE REIDTARCPVYLFAGEYDYACSPEETEATIAAIPGARGGVMRGIGHFPVAENYPLCKTYLWPALLDLADR RAGNGIA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2534 | - | - | 100% (287) | putative carboxylesterase protein |
| M. smegmatis MC2 155 | MSMEG_3289 | - | 3e-07 | 33.05% (118) | gp61 protein |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 2e-05 | 23.89% (226) | 3-oxoadipate enol-lactonase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2318 | - | 3e-05 | 32.65% (147) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_1348 | - | 2e-10 | 24.44% (266) | 3-oxoadipate enol-lactonase |
| M. tuberculosis H37Rv | Rv2296 | - | 3e-05 | 32.65% (147) | haloalkane dehalogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3810 | - | 9e-05 | 28.57% (112) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_1997 | - | 1e-05 | 23.62% (254) | hydrolase |
| M. avium 104 | MAV_4567 | - | 3e-07 | 23.70% (270) | dihydrolipoyllysine-residue acetyltransferase component of |
| M. thermoresistible (build 8) | TH_3363 | - | 2e-06 | 28.32% (113) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_3358 | - | 7e-06 | 23.62% (254) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_4414 | - | 8e-12 | 29.20% (137) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1997|M.marinum_M --MTERKRNLRPVREVTAPSLQFRTIHGY-----KRAFRIAG---SGPAI
MUL_3358|M.ulcerans_Agy99 --MTERKRNLRPVREVTAPSLQFRTIHGY-----KRAFRIAG---SGPAI
MAV_4567|M.avium_104 -----------------MSELKFLELHGD-----RVAFRDQG---EGEVL
MAB_3810|M.abscessus_ATCC_1997 ------------MDVTYEGTKRELATDEG-----TLRYHEAGTAGEGEPL
TH_3363|M.thermoresistible__bu -----------MRTFDYQETLREVRTPAG-----VLRYHEAG---DGPPL
Mvan_4414|M.vanbaalenii_PYR-1 ----------MSSEITEQYTSRDIETKSG-----TIHYNEAG---EGYPI
Mb2318|M.bovis_AF2122/97 MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEG-PGDGPPI
Rv2296|M.tuberculosis_H37Rv MDVLRTPDSRFEHLVGYPFAPHYVDVTAGDTQPLRMHYVDEG-PGDGPPI
Mflv_1348|M.gilvum_PYR-GCK -----------------MSAVDVHVIESG--------------LPDGPAV
MSMEG_2534|M.smegmatis_MC2_155 -------MTGYEPIVGRYLTADIDGVPNR------MYIEESG---DGVPV
.* :
MMAR_1997|M.marinum_M LLIHGIGDNSTTWT---GIHAKLAQRFTVIAPDLLGHGRSD------KPR
MUL_3358|M.ulcerans_Agy99 LLIHGIGDNSTTWT---GIHAKLAQRFTVIAPDLLGHGRSD------KPR
MAV_4567|M.avium_104 LLIHGMAGSSETWR---SVIPPLAKKFRVIAPDLLGHGESA------KPR
MAB_3810|M.abscessus_ATCC_1997 ILLHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPGFGVSD------AVP
TH_3363|M.thermoresistible__bu LLLHGSGPGVTGWRNFRGNLGVFAEHFRCLVLEFPGFGVSD------DFG
Mvan_4414|M.vanbaalenii_PYR-1 VMLHGSGPGATGWSNFGSNIKGLADRFRVIAADMPGWGQSE------AVK
Mb2318|M.bovis_AF2122/97 VLLHGEPTWSYLYR--TMIPPLSAAGHRVLAPDLIGFGRSDKP----TRI
Rv2296|M.tuberculosis_H37Rv VLLHGEPTWSYLYR--TMIPPLSAAGHRVLAPDLIGFGRSDKP----TRI
Mflv_1348|M.gilvum_PYR-GCK VLSNSLGATHRMWD---AQLDALERRFRVLRYDTRGHGASP------VPD
MSMEG_2534|M.smegmatis_MC2_155 VCLHTAGSDSRQYR-HMQTDDEVLSRFRVLAFDLPWHGKSLPPDRWWRRE
: : : . : * *
MMAR_1997|M.marinum_M ADYSIAAYANGMRDLLSVLDIERVTIIGHSLGGGVAMQFAYQFPQLVDRL
MUL_3358|M.ulcerans_Agy99 ADYSIAAYANGMRDLLSVLDIERVTIIGHSLGGGVAMQFAYQFPQLVDRL
MAV_4567|M.avium_104 TDYSLGAFAVWLRDFLDELGVSRATVVGHSLGGGVAMQFVYQHPDYAQRL
MAB_3810|M.abscessus_ATCC_1997 GHPVLTAGASVIR-FMDGLGISSAAVVGNSMGGVVGINLAIKHPDRITKL
TH_3363|M.thermoresistible__bu GHPMIDAQGAALA-FADALGLDRVDIIGNSMGGGVGVSLAVRHPDRVNRL
Mvan_4414|M.vanbaalenii_PYR-1 -PDARDHVAAALQ-LLDGLGIEKAAFVGNSMGGGTAIQFAVAHPDRISHL
Mb2318|M.bovis_AF2122/97 EDYTYLRHVEWVTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARL
Rv2296|M.tuberculosis_H37Rv EDYTYLRHVEWVTSWFENLDLHDVTLFVQDWGSLIGLRIAAEHGDRIARL
Mflv_1348|M.gilvum_PYR-GCK GPYSIDDLADDVVGILDRRGIDTAHLVGLSLGGMTAMRVAARNPDRVNRM
MSMEG_2534|M.smegmatis_MC2_155 YLLTSELYIASVMAVIDALDLEQPIVVGCSMAGSLVLELALTHGDRIGGV
: . .: .. . .. : .. : :
MMAR_1997|M.marinum_M ILVGAGGVTKDVNVVFRLASLPMGAEALALLRLPMVLPTVQLAG--KVLG
MUL_3358|M.ulcerans_Agy99 ILVGAGGVTKDVNVVFRLASLPMGAEALALLRLPMVLPTVQLAG--KVLG
MAV_4567|M.avium_104 ILISSGGLGPDVGWVLRLLSAPG-----AELVLPVIAPTPVLSVGNKLRS
MAB_3810|M.abscessus_ATCC_1997 VTIGG--VGPNIFSP-SPSEGLR-------LLQEFTDNPDRDKLIRWLNS
TH_3363|M.thermoresistible__bu VTIGG--IGTNIFSP-GPSEGIR-------LLQEFTDDPTRDRLIAWLNS
Mvan_4414|M.vanbaalenii_PYR-1 ITMGSRAPGPTIIGPDGLTEGLK-------TLLKGYTDPSPTSMRELVEI
Mb2318|M.bovis_AF2122/97 VVANGFLPAAQGRTPLPFYVWRA---------FARYSPVLPAGRLVNFGT
Rv2296|M.tuberculosis_H37Rv VVANGFLPAAQGRTPLPFYVWRA---------FARYSPVLPAGRLVNFGT
Mflv_1348|M.gilvum_PYR-GCK VLLCTAAELAPAQAWTDRAAAVR----------AGGAESVAPAVIARWFT
MSMEG_2534|M.smegmatis_MC2_155 IGFSGAAKVEGRFDDWSLKPDIN----------------SNQAVPSWTYG
:
MMAR_1997|M.marinum_M MALGSTALGQDLPNVLRILDDLPEPTASSAFTRTLRAVVDWRGQIVTMLD
MUL_3358|M.ulcerans_Agy99 MALGSTALGQDLPNVLRILDDLPEPTASSAFTRTLRAVVDWRGQIVTMLD
MAV_4567|M.avium_104 WLRGAGIQSPRGAELWNAYSSLSDGETRQSFLKTLRSVVDYRGQAVSALN
MAB_3810|M.abscessus_ATCC_1997 MVWDPAVVTDELIEERWEAAINPDAHKTAQLMYGSKAFAMQQQFLANADI
TH_3363|M.thermoresistible__bu MVYDPTLITEELIEERWAAATDPATLAAARRMYSKAAFAAMMAMMRDSDT
Mvan_4414|M.vanbaalenii_PYR-1 MTYDSANATDELVQQRYAAAIGRPDHLENFMIAGLLGIPQATVEEIAG--
Mb2318|M.bovis_AF2122/97 VHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDDPAVPANRAAWEA
Rv2296|M.tuberculosis_H37Rv VHRVPAGVRAGYDAPFPDKTYQAGARAFPRLVPTSPDDPAVPANRAAWEA
Mflv_1348|M.gilvum_PYR-GCK LSHLETHPAERAEWVDMIAATPAEGYASCCEAIAELDLREQLP-------
MSMEG_2534|M.smegmatis_MC2_155 LMAPQSPEPARREVWWTYAQGGPGVYRGDTYYYSNGMDLRGREREIDT--
MMAR_1997|M.marinum_M R----CYLTQAIPVQIIWGSRDAVV-PVRHAEMAHAAMPGSKLEVFEGSG
MUL_3358|M.ulcerans_Agy99 R----CYLTQAIPVQIIWGSRDAVV-PVRHAEMAHAAMPGSKLEVFEGSG
MAV_4567|M.avium_104 R----LRLREELPVMAIWGERDGII-PVDHAYAAHEARTDARLEVLPDVG
MAB_3810|M.abscessus_ATCC_1997 PPYWAMMHKIKCPTLLTWGRDDRVS-PPDMAIVPMRLIPNAELHIFPNSG
TH_3363|M.thermoresistible__bu PPPWATMHKVQAPTLLTWGRDDRVS-PLDMALLPMRTIPGAELHVFPNCG
Mvan_4414|M.vanbaalenii_PYR-1 ---------IETPTLIFHGKDDRVV-SYEAALKLVSLIRDSRVVLINRCG
Mb2318|M.bovis_AF2122/97 LG------RWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIKAS
Rv2296|M.tuberculosis_H37Rv LG------RWDKPFLAIFGYRDPILGQADGPLIKHIPGAAGQPHARIKAS
Mflv_1348|M.gilvum_PYR-GCK --------TITAPTLAIAGADDPAT-PPAKLEQIVSAIPGARLLVVDGAA
MSMEG_2534|M.smegmatis_MC2_155 ---------ARCPVYLFAGEYDYAC-SPEETEATIAAIPGARGGVMRGIG
* * * .. .
MMAR_1997|M.marinum_M HFPFHD----DPARFIDIVLRFIDSTQPPEYDQAALRELLRTGGGERTVS
MUL_3358|M.ulcerans_Agy99 HFPFHD----DPARFIDIVLRFIDSTQPPEYDQAALRELLRTGGGERTVS
MAV_4567|M.avium_104 HFAQVE----APMRVVELIEDFIAT------------------GERRDAT
MAB_3810|M.abscessus_ATCC_1997 HWVMIE----AKQAFEQTVVDFLRR-------------------------
TH_3363|M.thermoresistible__bu HWVMIE----AKSAFERTVLAFLTDPARG---------------------
Mvan_4414|M.vanbaalenii_PYR-1 HWLQTE----HSDEFNRLVADFVSNR------------------------
Mb2318|M.bovis_AF2122/97 HFIQED----SGTELAERMLSWQQAT------------------------
Rv2296|M.tuberculosis_H37Rv HFIQED----SGTELAERMLSWQQAT------------------------
Mflv_1348|M.gilvum_PYR-GCK HLANAE----QPEQITPAIIEHLEQR------------------------
MSMEG_2534|M.smegmatis_MC2_155 HFPVAENYPLCKTYLWPALLDLADRRAGNGIA------------------
* : . :
MMAR_1997|M.marinum_M GPADTRVAVLSAMGSDERSAT
MUL_3358|M.ulcerans_Agy99 DPADTRVAVLSAMGSDERSAT
MAV_4567|M.avium_104 SPQPG----------------
MAB_3810|M.abscessus_ATCC_1997 ---------------------
TH_3363|M.thermoresistible__bu ---------------------
Mvan_4414|M.vanbaalenii_PYR-1 ---------------------
Mb2318|M.bovis_AF2122/97 ---------------------
Rv2296|M.tuberculosis_H37Rv ---------------------
Mflv_1348|M.gilvum_PYR-GCK ---------------------
MSMEG_2534|M.smegmatis_MC2_155 ---------------------