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NTSHASAHQMTTEVVIVGFGPVGKLLAVQLGRRGHSVIVVDRNEASYPLPRAVTHCSDAARILQSVGLSP DKIPHITEPYDDMYRWRNGDDDTLLDVDWSGRGESGWYNTYFFNQPALEDALEALVARVDNVRVIRGWEA TALRQCEDRATVAIRSASTGAEMTIDAEWVIGADGANSKVREWAGLGWHNDGYYFDWLVVDVKPSHELNF PHIAVQSCDHRRPATMVPGGPGRRRWEFMRLPHESREELNTDAKAWELLAPYGVGPGNARLERHAVYTFK ACWADRWRDGRVLVAGDAAHLMPPFAGQGLGAGMRDAMNLSWKLDAVLRGRADAGLLDTYGSERLHHAVA FVKFSTSLGQVICITDEHEAAARDERMIADWRAGMAPPAPPRPGLGAGPHVGEAGGTLARQGRIRMGSAE PTLFDDALGGPGAVITRTAATLAEISPDVRSGLADLGMASVALAGTPSAGIVVADDVDGTYRAWLDELGA DTVVIRPDFHVYGAGPADRTHDLITGLLTSVSGQSVVSAHPVSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2485 | mhpA | - | 100% (535) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. smegmatis MC2 155 | MSMEG_4866 | mhpA | 2e-54 | 32.01% (528) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. smegmatis MC2 155 | MSMEG_1499 | - | 7e-23 | 26.07% (514) | oxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0576c | - | 2e-06 | 27.51% (189) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_2401 | mhpA | 1e-57 | 33.09% (538) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. tuberculosis H37Rv | Rv0561c | - | 2e-06 | 27.51% (189) | oxidoreductase |
| M. leprae Br4923 | MLBr_02276 | - | 1e-05 | 25.98% (204) | putative FAD-linked oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2573c | mhpA | 9e-47 | 33.96% (374) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. marinum M | MMAR_1503 | - | 3e-55 | 31.66% (518) | FAD-dependent oxidoreductase |
| M. avium 104 | MAV_0878 | mhpA | 2e-52 | 31.48% (540) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. thermoresistible (build 8) | TH_0968 | - | 1e-53 | 32.70% (529) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_0663 | - | 5e-07 | 27.08% (192) | FAD-linked oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0593 | - | 2e-53 | 31.91% (517) | monooxygenase, FAD-binding |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1503|M.marinum_M MTTAAMTEATSEAATYDVAIIGYGPTGATAANLLGQLGMKVVVIERDPDI
Mvan_0593|M.vanbaalenii_PYR-1 ---------MDDSSTYDVAIVGYGPVGATAANLLGRRGLKVVVIERDPDI
Mflv_2401|M.gilvum_PYR-GCK ---------MTEQTDVDVVIVGAGPAGLTLANILGLEGVRVLVVDERDKL
TH_0968|M.thermoresistible__bu ---------MTER--VDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTL
MAV_0878|M.avium_104 ---MIAPGPRATDHDTDVLVVGAGPVGLTLANILGLQGIRTVVVEERDTL
MSMEG_2485|M.smegmatis_MC2_155 ---MNTSHASAHQMTTEVVIVGFGPVGKLLAVQLGRRGHSVIVVDRNEAS
Mb0576c|M.bovis_AF2122/97 ---------MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFP
Rv0561c|M.tuberculosis_H37Rv ---------MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFP
MUL_0663|M.ulcerans_Agy99 -----METRVPRALGADLVVVGAGPAGSAAAAWAARAGRDVLVIDSAGFP
MLBr_02276|M.leprae_Br4923 ---------MRVETSADVVVVGAGPAGSAAATWAARAGNDVIVIDSVCFP
MAB_2573c|M.abscessus_ATCC_199 -------MNASAQLSFPVVIIGAGPTGVTAATLLAQHGVQCLLLERWATV
: ::* ** * * . * ::::
MMAR_1503|M.marinum_M YGRARAISTDEEVMRIWQSVGLAERLQSDMLP--DRPIAFVDAHGVPFIE
Mvan_0593|M.vanbaalenii_PYR-1 YFRARAISTDEEVMRIWQQIGLAEQLNAEMQP--GCGADFVDADGRSFVK
Mflv_2401|M.gilvum_PYR-GCK IDYPRGVGLDDESLRTFQAIGLVDRVLPHTVP--NQILRFFDAKRNLLAE
TH_0968|M.thermoresistible__bu IDYPRGVGLDDEALRTFQSIGLVDRILPHTVP--NQILRFFDAKRRLLAE
MAV_0878|M.avium_104 IDYPRGVGLDDEALRTFQSIGLVERVLPHTVP--NQILRFMDAKRRVLAE
MSMEG_2485|M.smegmatis_MC2_155 YPLPRAVTHCSDAARILQSVGLSPDKIPHITEPYDDMYRWRNGDDDTLLD
Mb0576c|M.bovis_AF2122/97 RDKPCGDGLTPRAVAELHQLGLGKWLADHIRH---RGLRMSGFGG--EVE
Rv0561c|M.tuberculosis_H37Rv RDKPCGDGLTPRAVAELHQLGLGKWLADHIRH---RGLRMSGFGG--EVE
MUL_0663|M.ulcerans_Agy99 RDKACGDGLTPRAIAELQQLGLGEWLAGRIQH---RGLRMSGFGG--EVE
MLBr_02276|M.leprae_Br4923 RDKACGDGLTPRAVAELKRLGLDDWLNTRIRH---RGLRMSGFGG--EVE
MAB_2573c|M.abscessus_ATCC_199 YPQPRAVHLDDEIYRILAQLGIAEQFATISRP--GAGMRLLDHRGQILSQ
. . :*: . .
MMAR_1503|M.marinum_M MKIEPRG-SGHPPQQFLYQPAVDQVLRAGVARFANVEVLVEHECLRVLNN
Mvan_0593|M.vanbaalenii_PYR-1 LLPADRG-NGHPPQQFIYQPAVDKTLRAGVDRFPNVTVLLRHECLRLVPR
Mflv_2401|M.gilvum_PYR-GCK MAPPDAR-FGWPKRNGFVQPMVDAELFGGLQRFDNVEVRFGHRMHQCTQT
TH_0968|M.thermoresistible__bu MAPPDAR-FGWPKRNGFVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEA
MAV_0878|M.avium_104 MAPPDAR-FGWPKRNGFVQPLVDAELLAGLDRFAHVQVRWGSPMTGCRED
MSMEG_2485|M.smegmatis_MC2_155 VDWSGRGESGWYNTYFFNQPALEDALEALVARVDNVRVIRGWEATALRQC
Mb0576c|M.bovis_AF2122/97 VDWPGPS---FPSYGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHD
Rv0561c|M.tuberculosis_H37Rv VDWPGPS---FPSYGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHD
MUL_0663|M.ulcerans_Agy99 IGWPGPS---FPAYSSAVARLELDDRIRKVAEESGARMLLGTKAVAAHHD
MLBr_02276|M.leprae_Br4923 VDWPGPS---FPSTSSAVPRLELDDRIRKVAENSGARMLLGTKAVSVYHD
MAB_2573c|M.abscessus_ATCC_199 IARAPIGTHGYPQANMFDQPELEQLLRANLTNYPQVSLRGGVEVTTIAHI
: : . . :
MMAR_1503|M.marinum_M DAA----AELLLADLR--------TDTFKRLRARYVIAADGGSSPTRGQL
Mvan_0593|M.vanbaalenii_PYR-1 TDD----VELMLADLS--------EDQFKRIRATYVIAADGGSSAVRGQL
Mflv_2401|M.gilvum_PYR-GCK TDR----VEVEFDG-----------GQAS-VSARYVVGCDGGRSVTRRLM
TH_0968|M.thermoresistible__bu SDAGEDGVTVEFAD-----------GHPP-VRASYVVGCDGGRSTTRRLM
MAV_0878|M.avium_104 ADG----VNVELGADGGNVGDGGGDGHPAGLRARYVVGCDGGRSMTRRVM
MSMEG_2485|M.smegmatis_MC2_155 EDR----ATVAIRSAS--------TGAEMTIDAEWVIGADGANSKVREWA
Mb0576c|M.bovis_AF2122/97 SSR--RVVSLTLADGT-------------EVGCRQLIVADGARSPLGRKL
Rv0561c|M.tuberculosis_H37Rv SSR--RVVSLTLADGT-------------EVGCRQLIVADGARSPLGRKL
MUL_0663|M.ulcerans_Agy99 SSR--RVVSLTLADRT-------------EVACRQLIVADGARSSLGRKL
MLBr_02276|M.leprae_Br4923 SSR--RAASVTLADGT-------------EVGCRQLIIADGARSPLGRKL
MAB_2573c|M.abscessus_ATCC_199 SAS---QVQVTFTDRD--------SGDEHKVTATYVLGCDGANSVVRAAI
. : : : . :: .**. *
MMAR_1503|M.marinum_M GVGYTGRTYAERWVVIDTKVRRAWDAHDRLRFHCDPARPTVDCPTPLGHH
Mvan_0593|M.vanbaalenii_PYR-1 GIGFTGSTYSERWIVIDTKVLREWPGHDRLRFHCNPARPTVDCPTPLGHH
Mflv_2401|M.gilvum_PYR-GCK GVSFDGTTSSTRWLVVD--IANDPLGHPNSEVGADPRRPYVSIAIAHGIR
TH_0968|M.thermoresistible__bu GVSFDGTTSSTRWLVVD--VANDPLGHPNSEVGADPARPYVSISIAHGIR
MAV_0878|M.avium_104 GVSFDGTTSSTRWLVVD--IANDPLGHPNSEVGADPERPYASISIAHGIR
MSMEG_2485|M.smegmatis_MC2_155 GLGWHNDGYYFDWLVVDVKPSHELNFPHIAVQSCDHRRPATMVPGGPGRR
Mb0576c|M.bovis_AF2122/97 GRRWHRETVYG--VAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYG--
Rv0561c|M.tuberculosis_H37Rv GRRWHRETVYG--VAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYG--
MUL_0663|M.ulcerans_Agy99 GRRWHQETVYG--VAARGYLTTARSEDPWLTSHLELRSPDGAVLPGYG--
MLBr_02276|M.leprae_Br4923 GRSWHQKTVYG--VAARGYLTTPRSDDLWLTSHLELRSPDGAVLPGYG--
MAB_2573c|M.abscessus_ATCC_199 GASMTARRFAQRWLVVDLNTDADLGHWDGVHHLCDPDRATTFMRVGERRY
* :. : .
MMAR_1503|M.marinum_M RWEYPASADEADQKLVREEAIWRVLNAQGIT--DNEVEILRAVIYCHHVR
Mvan_0593|M.vanbaalenii_PYR-1 RWEFPVRDEEDERDLLTEDAIWKVLHGQGIS--KDDVEIIGFACYSHHVR
Mflv_2401|M.gilvum_PYR-GCK RFEFMIHPDETDEEADDPAFVRRMLGQLIPY--PERVDMIRHRVYTHHSR
TH_0968|M.thermoresistible__bu RFEFMIHPHETDAEVDDPAFVRRMLGRRIPY--PERVDMIRYRVYTHHSR
MAV_0878|M.avium_104 RFEFMIHADESDEQAEDPEFLTRMLARMVPH--PDRVDVIRRRVYTHHSR
MSMEG_2485|M.smegmatis_MC2_155 RWEFMRLPHESREELNTDAKAWELLAPYGVG--PGNARLERHAVYTFKAC
Mb0576c|M.bovis_AF2122/97 -WIFPLGNGEVNIGVG----------ALSTS--RRPADLALRPLISYYT-
Rv0561c|M.tuberculosis_H37Rv -WIFPLGNGEVNIGVG----------ALSTS--RRPADLALRPLISYYT-
MUL_0663|M.ulcerans_Agy99 -WIFPLGNGEVNIGVG----------GLSTT--KRPADLALRPLMSYYT-
MLBr_02276|M.leprae_Br4923 -WIFPLGNGEVNIGVG----------ALSTS--KRPADLALRSLISYYT-
MAB_2573c|M.abscessus_ATCC_199 RWEFKLHPGETAADYDTVEKLRPLIAVWTGASAISELTLIRVTEYTFRAH
: : * : .
MMAR_1503|M.marinum_M VADRWRIGRVFLAGDAAHAMPPWIGQGMSAGVRDAANLCWKLAAVLNGNA
Mvan_0593|M.vanbaalenii_PYR-1 FADRWRVGRIFLAGDAAHAMPPWIGQGMCAGVRDVGNLCWKLEAVLTGAL
Mflv_2401|M.gilvum_PYR-GCK IAGSFREGRLMLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVTGRA
TH_0968|M.thermoresistible__bu IAGSFRKGRLLLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVNGHA
MAV_0878|M.avium_104 IAGEFRRGRLLLAGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVSGRA
MSMEG_2485|M.smegmatis_MC2_155 WADRWRDGRVLVAGDAAHLMPPFAGQGLGAGMRDAMNLSWKLDAVLRGRA
Mb0576c|M.bovis_AF2122/97 ---DLRRDEWGFTGQPRAVSSALLP--MGGAVSGVAGSNWMLIG-----D
Rv0561c|M.tuberculosis_H37Rv ---DLRRDEWGFTGQPRAVSSALLP--MGGAVSGVAGSNWMLIG-----D
MUL_0663|M.ulcerans_Agy99 ---DLRRDEWGFTGQPRAVASALLP--MGGAVSGVAGPNWMLIG-----D
MLBr_02276|M.leprae_Br4923 ---DLRRHEWGFSGQPRAVSSALLP--MGGAVSGVAGPNWMLIG-----D
MAB_2573c|M.abscessus_ATCC_199 VASHWRDRNVFILGDAAHLTPPFVGQGMGAGIRDAANLTWKLAGVLDGQL
* . . *:. . ..: .. . * * .
MMAR_1503|M.marinum_M PDSLLDSYQDERKPHVTEVTRRAVFTGRLITERRRAVAAVRNGLGRALTR
Mvan_0593|M.vanbaalenii_PYR-1 SESVLDSYQAERLPHVREVTKRAVKVGRLIIERNPLRANIRNHFFRAASR
Mflv_2401|M.gilvum_PYR-GCK GEELLDTYDVERRKHARAMIDLSTMVGRVISPTNRKVAALRDRVIHAASA
TH_0968|M.thermoresistible__bu HDALLDTYDLERREHARAMIDLSTMVGRVISPTNRRVAALRDRLIHAASV
MAV_0878|M.avium_104 GDKLLDTYDMERRKHARAMIDLSTMVGRVISPTNRRVAGARDLLVRSASI
MSMEG_2485|M.smegmatis_MC2_155 DAGLLDTYGSERLHHAVAFVKFSTSLGQVICITDEHEAAARD--------
Mb0576c|M.bovis_AF2122/97 AAACVNPLNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRYGRGFSV
Rv0561c|M.tuberculosis_H37Rv AAACVNPLNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRYGRGFSV
MUL_0663|M.ulcerans_Agy99 AAACVNPLNGEGIDYGLDTGRLAAELLDSPDLSQLWPSLLQAHYGRGFSV
MLBr_02276|M.leprae_Br4923 AAACVNPLNGEGIDYGLETGRLAAELLDLRDLSYVWPSLLQQHYGRGFSV
MAB_2573c|M.abscessus_ATCC_199 PTRVLDTYEQERKPHAWKMITIALAVGAAMTARGTAATAIRNLLVPRLQY
::. * : : :
MMAR_1503|M.marinum_M FPSAMARLQRAMWIPPARYQDGFLARG-----HRAVGWQIPQPWVIDGNG
Mvan_0593|M.vanbaalenii_PYR-1 LPFFTAWLRDHRWLPDARYRAGLLTSDR----HPAVGWLIPQPWVVDEKG
Mflv_2401|M.gilvum_PYR-GCK VPSLKRYVLEMRFKPMPRYQQGAVLHHAHAAPNSPTGTLFIQPRVDTRDT
TH_0968|M.thermoresistible__bu VPTLKRYVLEMRFKPMPRYLQGAVYHGGPRSKSSPTGTLFIQPRVDTRDA
MAV_0878|M.avium_104 VPTLKRYVLEMRFKPMPRYEHGAVVHANPGRADSPVGTLFIQPRVDTRDQ
MSMEG_2485|M.smegmatis_MC2_155 ERMIADWRAGMAPPAPPRPGLGAGPHVG-----EAGGTLARQGRIRMGSA
Mb0576c|M.bovis_AF2122/97 ARRLALLLTFPRFLP-------------------TTGPITMRSTALMNIA
Rv0561c|M.tuberculosis_H37Rv ARRLALLLTFPRFLP-------------------TTGPITMRSTALMNIA
MUL_0663|M.ulcerans_Agy99 ARRLALLLTYQRFLP-------------------TTGPVAMRSTALMKVA
MLBr_02276|M.leprae_Br4923 ARRLALLLTFKRCLP-------------------AIGPSAMRSTSLITIA
MAB_2573c|M.abscessus_ATCC_199 IPGLRSRIQHSGTPALTRSALVN--------KTPRCRQLAGTQIPNLVLS
.
MMAR_1503|M.marinum_M ATARLDDILGSQWVLLHTGDAP------TGSQAWTQRGVPAVRLGPPESG
Mvan_0593|M.vanbaalenii_PYR-1 DRVRLDDVLAGGWTVLHIGPE-------SLWRSWRSAGVPVIAIAPPGSA
Mflv_2401|M.gilvum_PYR-GCK QNALLDDVLGTGFAVVCWSNNLRAVLGEEAFGRWKALGAKFVEVRPMSQL
TH_0968|M.thermoresistible__bu ENVLLDDVLGPGFAVLCWSNNLRAVLGEDAFSHWKSLGATFVEARPITQL
MAV_0878|M.avium_104 QDVLLDDVLGPWFAVLCWNNNPRKILGETAFANWKALGARFFALRPATQL
MSMEG_2485|M.smegmatis_MC2_155 EPTLFDDALGGPGAVITRTAATLAEISPDVRSGLADLGMASVALAGTPSA
Mb0576c|M.bovis_AF2122/97 VRVMSNLVTD----------------------------------------
Rv0561c|M.tuberculosis_H37Rv VRVMSNLVTD----------------------------------------
MUL_0663|M.ulcerans_Agy99 MRVMANLVTE----------------------------------------
MLBr_02276|M.leprae_Br4923 VRVMANLVTD----------------------------------------
MAB_2573c|M.abscessus_ATCC_199 QGHRIDTLLGSGFALVASETVD-----ADQQAQLRRRGAAIIVE------
:
MMAR_1503|M.marinum_M ARPDG-------IRDSGGTLLRWLARKHASAVVLRPDGFVYAAAESGSPL
Mvan_0593|M.vanbaalenii_PYR-1 PAPGR-------IVDREGTLIRWIQTKKATVVVVRPDGFVYAAAAD-QPL
Mflv_2401|M.gilvum_PYR-GCK RWPGHDDPDVAVIGDRTGALKAWFDVHTESVLFVRPDRCIAAACIAQRAP
TH_0968|M.thermoresistible__bu HWPGHDDPDVVVVGDRTGALKGWFDVHTDSVLFLRPDRCIAAACIAQRAP
MAV_0878|M.avium_104 RWTGHDDPDVVVVGDRRGDLKSWFDIHAESVLFLRPDRCIAGACIAQRAP
MSMEG_2485|M.smegmatis_MC2_155 G--------IVVADDVDGTYRAWLDELGADTVVIRPDFHVYGAGPADRTH
Mb0576c|M.bovis_AF2122/97 -------------DDRDWVARVWRGGGQLSRLVDRRPPFS----------
Rv0561c|M.tuberculosis_H37Rv -------------DDRDWVARVWRGGGQLSRLVDRRPPFS----------
MUL_0663|M.ulcerans_Agy99 -------------EDSDWVARLWRGGGRASRLIDRRPPFH----------
MLBr_02276|M.leprae_Br4923 -------------DDADWVARVWRSGGWASWLVDRRPPFS----------
MAB_2573c|M.abscessus_ATCC_199 --------------PRGSELDRWLRRGGARAALIRPDRTVMQTARSPSQI
* . *
MMAR_1503|M.marinum_M PP--------------------PPAGHFGNTLPTSMKIEALA--------
Mvan_0593|M.vanbaalenii_PYR-1 PA--------------------PPAG-----FTPRVRQQA----------
Mflv_2401|M.gilvum_PYR-GCK EISEGLFAALHLTSGAHLTQGGGTDGEKPDRAVLHVAQPAAESSGTGAGT
TH_0968|M.thermoresistible__bu ETSAALSEVMCLT------QGGGNGAASP---VLHVAQSAAEPSGTATRS
MAV_0878|M.avium_104 DLSAALFDALTLTP-----RGGDPQSGTG--SVLYVAQPAPESSGAVAGP
MSMEG_2485|M.smegmatis_MC2_155 DLITG--------------------------LLTSVSGQSVVSAHPVSR-
Mb0576c|M.bovis_AF2122/97 --------------------------------------------------
Rv0561c|M.tuberculosis_H37Rv --------------------------------------------------
MUL_0663|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02276|M.leprae_Br4923 --------------------------------------------------
MAB_2573c|M.abscessus_ATCC_199 AFTTT--------------------------LFAPTHQPAPTYRETP---
MMAR_1503|M.marinum_M -
Mvan_0593|M.vanbaalenii_PYR-1 -
Mflv_2401|M.gilvum_PYR-GCK S
TH_0968|M.thermoresistible__bu T
MAV_0878|M.avium_104 A
MSMEG_2485|M.smegmatis_MC2_155 -
Mb0576c|M.bovis_AF2122/97 -
Rv0561c|M.tuberculosis_H37Rv -
MUL_0663|M.ulcerans_Agy99 -
MLBr_02276|M.leprae_Br4923 -
MAB_2573c|M.abscessus_ATCC_199 -