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NASAQLSFPVVIIGAGPTGVTAATLLAQHGVQCLLLERWATVYPQPRAVHLDDEIYRILAQLGIAEQFAT ISRPGAGMRLLDHRGQILSQIARAPIGTHGYPQANMFDQPELEQLLRANLTNYPQVSLRGGVEVTTIAHI SASQVQVTFTDRDSGDEHKVTATYVLGCDGANSVVRAAIGASMTARRFAQRWLVVDLNTDADLGHWDGVH HLCDPDRATTFMRVGERRYRWEFKLHPGETAADYDTVEKLRPLIAVWTGASAISELTLIRVTEYTFRAHV ASHWRDRNVFILGDAAHLTPPFVGQGMGAGIRDAANLTWKLAGVLDGQLPTRVLDTYEQERKPHAWKMIT IALAVGAAMTARGTAATAIRNLLVPRLQYIPGLRSRIQHSGTPALTRSALVNKTPRCRQLAGTQIPNLVL SQGHRIDTLLGSGFALVASETVDADQQAQLRRRGAAIIVEPRGSELDRWLRRGGARAALIRPDRTVMQTA RSPSQIAFTTTLFAPTHQPAPTYRETP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2573c | mhpA | - | 100% (518) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. abscessus ATCC 19977 | MAB_4357c | - | 5e-30 | 26.21% (538) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_1496c | - | 6e-24 | 26.89% (357) | putative FAD-binding monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 7e-11 | 23.99% (321) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_2401 | mhpA | 1e-54 | 28.84% (541) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. tuberculosis H37Rv | Rv1751 | - | 4e-11 | 24.36% (312) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2987 | mhpA | 1e-166 | 58.32% (487) | 3-(3-hydroxy-phenyl) propionate hydroxylase |
| M. avium 104 | MAV_1804 | mhpA | 1e-163 | 61.16% (466) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. smegmatis MC2 155 | MSMEG_4866 | mhpA | 3e-52 | 33.18% (440) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. thermoresistible (build 8) | TH_0968 | - | 3e-55 | 32.57% (439) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_3663 | - | 8e-10 | 24.11% (365) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_4906 | mhpA | 1e-160 | 58.47% (484) | 3-(3-hydroxyphenyl)propionate hydroxylase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2987|M.marinum_M -----------------------------------------MSDKPFQTI
MAV_1804|M.avium_104 --------------------------------------------------
Mvan_4906|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2573c|M.abscessus_ATCC_199 --------------------------------------------MNASAQ
Mflv_2401|M.gilvum_PYR-GCK ----------------------------------------------MTEQ
TH_0968|M.thermoresistible__bu ----------------------------------------------MTER
MSMEG_4866|M.smegmatis_MC2_155 ---------------------------------------------MMNSP
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
MUL_3663|M.ulcerans_Agy99 -------------------------------------MPQPS--------
MMAR_2987|M.marinum_M RQVPVVIVGAGPTGITAATLLAQYGVESMVLERWTDVYPQPRAVHLDDEI
MAV_1804|M.avium_104 --MPVVIVGAGPTGITAATLLAQHGIRCLVLERWDDVYPQPRAVHLDDEV
Mvan_4906|M.vanbaalenii_PYR-1 --MPVVVVGGGPTGVTAATLLAQYGVDTLVLDRWSQVYPQPRAVHLDDEI
MAB_2573c|M.abscessus_ATCC_199 LSFPVVIIGAGPTGVTAATLLAQHGVQCLLLERWATVYPQPRAVHLDDEI
Mflv_2401|M.gilvum_PYR-GCK TDVDVVIVGAGPAGLTLANILGLEGVRVLVVDERDKLIDYPRGVGLDDES
TH_0968|M.thermoresistible__bu --VDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTLIDYPRGVGLDDEA
MSMEG_4866|M.smegmatis_MC2_155 GAVDVVIVGAGPVGLTLANILGGQGVRTLIIEERETLIDYPRGVGLDDES
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHAST
: *.** *:. . :*. *: :::. . *. :.
MMAR_2987|M.marinum_M YRVIARLGIADEFAAISRPTQGLRLLDNRFNVLTEFHRDPARSLHGFPQA
MAV_1804|M.avium_104 RRILARLGINDEFAAISRPALGLRLLDPEFGVLAQFNRDPAESVHGFPQA
Mvan_4906|M.vanbaalenii_PYR-1 CRILARLGVAEEFARISRPARGLRLVDRNLAVLAEFRRDTAVTRSGYPAA
MAB_2573c|M.abscessus_ATCC_199 YRILAQLGIAEQFATISRPGAGMRLLDHRGQILSQIARAPIG-THGYPQA
Mflv_2401|M.gilvum_PYR-GCK LRTFQAIGLVDRVLPHTVPNQILRFFDAKRNLLAEMAPPDAR--FGWPKR
TH_0968|M.thermoresistible__bu LRTFQSIGLVDRILPHTVPNQILRFFDAKRRLLAEMAPPDAR--FGWPKR
MSMEG_4866|M.smegmatis_MC2_155 LRTFQSIGLVDAILPHTVPNQILRFYDANRRLLAEMAPPDAR--FGWPKR
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLH--QPYPYV
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALPYSEVRTATLHSNGRAVTYIDFERLH--QPYPYV
MUL_3663|M.ulcerans_Agy99 LRLLDELGLGSQFAQIPHRLIDTISMKVQGQPVD-LDLKHLP--GAHQHI
* : :*: . . . . . : :
MMAR_2987|M.marinum_M NMFDQPELETLLRANLKRYAHAQLRGGAEVIEICDTN---ELLRVTFTDR
MAV_1804|M.avium_104 NMFDQPEFEALLRRNLKNFPGAVMRGNSEVTDVTQTEV--GRVRVTFADR
Mvan_4906|M.vanbaalenii_PYR-1 NMFDQPELENLLRRNLTRFRRARFRGDVEVLDIAVDAA--GVTRVAFSDR
MAB_2573c|M.abscessus_ATCC_199 NMFDQPELEQLLRANLTNYPQVSLRGGVEVTTIAHISA--SQVQVTFTDR
Mflv_2401|M.gilvum_PYR-GCK NGFVQPMVDAELFGGLQRFDNVEVRFGHRMHQCTQTTD--R----VEVEF
TH_0968|M.thermoresistible__bu NGFVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEASD--AGEDGVTVEF
MSMEG_4866|M.smegmatis_MC2_155 NGFVQPMVDAELLAGLDRFDHVEVMWGRRMQTIAEDAD--G----VTVEV
Mb1780|M.bovis_AF2122/97 AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVRYQ
Rv1751|M.tuberculosis_H37Rv AMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVRYQ
MUL_3663|M.ulcerans_Agy99 ALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSATYR
. * . * . .:
MMAR_2987|M.marinum_M SD-GRVHHVDAEYVLGCDGANSMVRSHVGSTMADLNFQQRWLVVDVATEC
MAV_1804|M.avium_104 AT-GEGHVVDADYVLGCDGANSVVRSAIGAAMDDLHFEQRWLVVDVATDV
Mvan_4906|M.vanbaalenii_PYR-1 LS-GRRSVITADYVLGCDGANSMVRNAIGATMRNLKFDQRWLVVDVATTA
MAB_2573c|M.abscessus_ATCC_199 DS-GDEHKVTATYVLGCDGANSVVRAAIGASMTARRFAQRWLVVDLNTDA
Mflv_2401|M.gilvum_PYR-GCK DG--GQASVSARYVVGCDGGRSVTRRLMGVSFDGTTSSTRWLVVDIANDP
TH_0968|M.thermoresistible__bu AD--GHPPVRASYVVGCDGGRSTTRRLMGVSFDGTTSSTRWLVVDVANDP
MSMEG_4866|M.smegmatis_MC2_155 SGPDGPASVHAQYVVGCDGGRSATRHLMGVSFDGTTSSTRWVVIDLANDP
Mb1780|M.bovis_AF2122/97 GAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREG
Rv1751|M.tuberculosis_H37Rv GAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPREG
MUL_3663|M.ulcerans_Agy99 AQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPRRP
: * .:.*** * .* * . :
MMAR_2987|M.marinum_M DLAQWDGVYQVCDPFRAATYMRIGQSRYRWEFQLRPGERTEDFNSISALR
MAV_1804|M.avium_104 DLNQWDGVYQVCSPVRAATYMRIGATRYRWEFRLLPGETADDYRSCAALR
Mvan_4906|M.vanbaalenii_PYR-1 DLQQWEGVHQICDPRRAGTYMRIGDTRYRWEFALSAGESADDFATLSALL
MAB_2573c|M.abscessus_ATCC_199 DLGHWDGVHHLCDPDRATTFMRVGERRYRWEFKLHPGETAADYDTVEKLR
Mflv_2401|M.gilvum_PYR-GCK LGHPNSEVG--ADPRRPYVSIAIAHGIRRFEFMIHPDETDEEADDPAFVR
TH_0968|M.thermoresistible__bu LGHPNSEVG--ADPARPYVSISIAHGIRRFEFMIHPHETDAEVDDPAFVR
MSMEG_4866|M.smegmatis_MC2_155 LGHPNSEVG--ADPQRPYASISIAHGIRRFEFMIHADETDEQAEDPEFVA
Mb1780|M.bovis_AF2122/97 DAE--FSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEFR
Rv1751|M.tuberculosis_H37Rv DAE--FSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEFR
MUL_3663|M.ulcerans_Agy99 DDP--TGLAGIFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEALH
. .. : : : : .
MMAR_2987|M.marinum_M PLIAPWTTDIAEGDLTLLRVAEYTFRAQIAD---QWRRGNIFILGDAAHL
MAV_1804|M.avium_104 SLISPWVGDVADEDLELVRVAEYTFRAQLAN---RWRDRNVFLLGDAAHL
Mvan_4906|M.vanbaalenii_PYR-1 PLLAPWTRHVAEADLQLVRVAEYTFRAQIAD---HWRSGSIFLLGDAAHL
MAB_2573c|M.abscessus_ATCC_199 PLIAVWTGASAISELTLIRVTEYTFRAHVAS---HWRDRNVFILGDAAHL
Mflv_2401|M.gilvum_PYR-GCK RMLGQLIPYPER--VDMIRHRVYTHHSRIAG---SFREGRLMLAGDAAHL
TH_0968|M.thermoresistible__bu RMLGRRIPYPER--VDMIRYRVYTHHSRIAG---SFRKGRLLLAGDAAHL
MSMEG_4866|M.smegmatis_MC2_155 ELLRPFVPHPDR--VDVIRRRVYTHHSRIAG---SFRKGRMLLAGDAAHL
Mb1780|M.bovis_AF2122/97 RDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAHA
Rv1751|M.tuberculosis_H37Rv RDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAHA
MUL_3663|M.ulcerans_Agy99 RALADLMPWLADRVDALKSFDDVKLLDVQLNRLRRWYCDGALCIGDAAHA
: : . . : : *****
MMAR_2987|M.marinum_M TPPFIGQGMGAGLRDAMNLSWKIAAVRCGTLTADALDTYQQERKPHTRQL
MAV_1804|M.avium_104 TPPFIGQGMGAGLRDAMNLAWKLAGVLGEDLPEEVLETYEQERKPHARAL
Mvan_4906|M.vanbaalenii_PYR-1 TPPFIGQGMGAGLRDAMNLAWKLAGVHHGSLPPTVLDSYEQERKPHARHM
MAB_2573c|M.abscessus_ATCC_199 TPPFVGQGMGAGIRDAANLTWKLAGVLDGQLPTRVLDTYEQERKPHAWKM
Mflv_2401|M.gilvum_PYR-GCK MPVWQGQGYNSGIRDAANLGWKLAAVVTGRAGEELLDTYDVERRKHARAM
TH_0968|M.thermoresistible__bu MPVWQGQGYNSGIRDAANLGWKLAAVVNGHAHDALLDTYDLERREHARAM
MSMEG_4866|M.smegmatis_MC2_155 MPVWQGQGYNSGIRDAFNLGWKLAAVVRGQAGDALLDTYDAERRKHARAM
Mb1780|M.bovis_AF2122/97 MSPVAGVGINLAVQDAVAAATILAEPLR-------------EHRVSSRHL
Rv1751|M.tuberculosis_H37Rv MSPVAGVGINLAVQDAVAAATILAEPLR-------------EHRVSSRHL
MUL_3663|M.ulcerans_Agy99 MSPVGGVGINLALADAVATARMLAPSLR-------------VGRVSTGQL
. * * . .: ** :* : : :
MMAR_2987|M.marinum_M IRLALAIGQFMTGGGRLGNVVRRALLPRVRFVPGLRDKISDS---TTPAL
MAV_1804|M.avium_104 IALALGMGWAMTAGGGIGDAIRRTVVPRLHLVPGMRGRIVNS---RTPAL
Mvan_4906|M.vanbaalenii_PYR-1 ISLALNMGRAMTAGGRLGAAVRRLIVPRLHLIPGMRGKVIDS---ETPAL
MAB_2573c|M.abscessus_ATCC_199 ITIALAVGAAMTARGTAATAIRNLLVPRLQYIPGLRSRIQHS---GTPAL
Mflv_2401|M.gilvum_PYR-GCK IDLSTMVGRVISPTNRKVAALRDRVIHAASAVPSLKRYVLEMRFKPMPRY
TH_0968|M.thermoresistible__bu IDLSTMVGRVISPTNRRVAALRDRLIHAASVVPTLKRYVLEMRFKPMPRY
MSMEG_4866|M.smegmatis_MC2_155 IDLSTMVGRVISPTNRKVAALRDKLIRGASIVPTLKRYVLEMRFKPMPRY
Mb1780|M.bovis_AF2122/97 AAVRRRRAFPTAVTQAVQRVLHRRLLGPLLQGR-----------DPTPPA
Rv1751|M.tuberculosis_H37Rv AAVRRRRAFPTAVTQAVQRVLHRRLLGPLLQGR-----------DPTPPA
MUL_3663|M.ulcerans_Agy99 ARVQARRWAPTAFLQGIQRAIHAAIVAVAVTGG-----------PPQPPP
: : .:: :: *
MMAR_2987|M.marinum_M HASALVHKTHRLCRSRQLAGTLCPNPLLPEGQR----LDAVIGTRFAVIT
MAV_1804|M.avium_104 RRSALVVKSR---LRRDLAGTLCPNPLLDNGAR----FDNVVGNRFALIA
Mvan_4906|M.vanbaalenii_PYR-1 KASSLVRRTP---ASRRVAGRLCPNPVLADGRR----LDEALGSGFGVVT
MAB_2573c|M.abscessus_ATCC_199 TRSALVNKTP---RCRQLAGTQIPNLVLSQGHR----IDTLLGSGFALVA
Mflv_2401|M.gilvum_PYR-GCK QQGAVLHHAHA--APNSPTGTLFIQPRVDTRDTQNALLDDVLGTGFAVVC
TH_0968|M.thermoresistible__bu LQGAVYHGGPR--SKSSPTGTLFIQPRVDTRDAENVLLDDVLGPGFAVLC
MSMEG_4866|M.smegmatis_MC2_155 HEGAVYHAKPP--TPASPVGTLFIQPRVDTREQDNVLLDDVLGTGFAVLC
Mb1780|M.bovis_AF2122/97 ALLGLVERLPW---------------------------------------
Rv1751|M.tuberculosis_H37Rv ALLGLVERLPW---------------------------------------
MUL_3663|M.ulcerans_Agy99 VVR-LVSRSVP---------------------------------------
:
MMAR_2987|M.marinum_M S-----TSLGEAQELLLRRRDVLVVVTPPASSLADWLRRGGVKAALVRPD
MAV_1804|M.avium_104 S-----LPLTKGQRIELDHRGAVVLSVKPGCELDRWLRRGRVTSRGVV--
Mvan_4906|M.vanbaalenii_PYR-1 T-----GALTPAQQALVERCGARALCVAPATELASWLRRGRVTTAMIRPD
MAB_2573c|M.abscessus_ATCC_199 S-----ETVDADQQAQLRRRGAAIIVEPRGSELDRWLRRGGARAALIRPD
Mflv_2401|M.gilvum_PYR-GCK WSNNLRAVLGEEAFGRWKALGAKFVEVRPMSQLR-WPGHDDPDVAVIGDR
TH_0968|M.thermoresistible__bu WSNNLRAVLGEDAFSHWKSLGATFVEARPITQLH-WPGHDDPDVVVVGDR
MSMEG_4866|M.smegmatis_MC2_155 WNNNPRTLLGEAAFTRWKALGATFIAARPSTQLH-WTKDDDPDVVIVGDR
Mb1780|M.bovis_AF2122/97 ----------------LSAVPAYFVGVGVRPEHAPAFARRGPGNRKGP--
Rv1751|M.tuberculosis_H37Rv ----------------LSAVPAYFVGVGVRPEHAPAFARRGPGNRKGP--
MUL_3663|M.ulcerans_Agy99 ----------------VRRIMGYLVAIGPLPEHAPKYPRRAR--------
: .
MMAR_2987|M.marinum_M RTVMRAARDTVALC----------SWADRALQAS----------------
MAV_1804|M.avium_104 --------------------------------------------------
Mvan_4906|M.vanbaalenii_PYR-1 RTVMSAGRDVDALCRQFLSGNLVGVWNSVAATPD----------------
MAB_2573c|M.abscessus_ATCC_199 RTVMQTARSPSQIAFTTTLFAPTHQPAPTYRETP----------------
Mflv_2401|M.gilvum_PYR-GCK TGALKAWFDVHTESVLFVRPDRCIAAACIAQRAPEISEGLFAALHLTSGA
TH_0968|M.thermoresistible__bu TGALKGWFDVHTDSVLFLRPDRCIAAACIAQRAPETSAALSEVMCLT---
MSMEG_4866|M.smegmatis_MC2_155 TGALKAFFDAHTESVLVLRPDRCIAGADIAQRAPELSTALFGILHLR---
Mb1780|M.bovis_AF2122/97 --------------------------------------------------
Rv1751|M.tuberculosis_H37Rv --------------------------------------------------
MUL_3663|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2987|M.marinum_M -----------------------------------
MAV_1804|M.avium_104 -----------------------------------
Mvan_4906|M.vanbaalenii_PYR-1 -----------------------------------
MAB_2573c|M.abscessus_ATCC_199 -----------------------------------
Mflv_2401|M.gilvum_PYR-GCK HLTQGGGTDGEKPDRAVLHVAQPAAESSGTGAGTS
TH_0968|M.thermoresistible__bu ---QGGGNGAASP---VLHVAQSAAEPSGTATRST
MSMEG_4866|M.smegmatis_MC2_155 ---QGGENGATGP---VLYVPQPTAESSGTVGRAS
Mb1780|M.bovis_AF2122/97 -----------------------------------
Rv1751|M.tuberculosis_H37Rv -----------------------------------
MUL_3663|M.ulcerans_Agy99 -----------------------------------