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DDSSTYDVAIVGYGPVGATAANLLGRRGLKVVVIERDPDIYFRARAISTDEEVMRIWQQIGLAEQLNAEM QPGCGADFVDADGRSFVKLLPADRGNGHPPQQFIYQPAVDKTLRAGVDRFPNVTVLLRHECLRLVPRTDD VELMLADLSEDQFKRIRATYVIAADGGSSAVRGQLGIGFTGSTYSERWIVIDTKVLREWPGHDRLRFHCN PARPTVDCPTPLGHHRWEFPVRDEEDERDLLTEDAIWKVLHGQGISKDDVEIIGFACYSHHVRFADRWRV GRIFLAGDAAHAMPPWIGQGMCAGVRDVGNLCWKLEAVLTGALSESVLDSYQAERLPHVREVTKRAVKVG RLIIERNPLRANIRNHFFRAASRLPFFTAWLRDHRWLPDARYRAGLLTSDRHPAVGWLIPQPWVVDEKGD RVRLDDVLAGGWTVLHIGPESLWRSWRSAGVPVIAIAPPGSAPAPGRIVDREGTLIRWIQTKKATVVVVR PDGFVYAAAADQPLPAPPAGFTPRVRQQA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0593 | - | - | 100% (520) | monooxygenase, FAD-binding |
| M. vanbaalenii PYR-1 | Mvan_4245 | mhpA | 5e-72 | 34.62% (520) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. vanbaalenii PYR-1 | Mvan_4906 | mhpA | 3e-54 | 29.56% (504) | 3-(3-hydroxyphenyl)propionate hydroxylase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 4e-07 | 24.21% (318) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_2401 | mhpA | 1e-73 | 33.65% (526) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. tuberculosis H37Rv | Rv1751 | - | 4e-07 | 24.21% (318) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2573c | mhpA | 8e-56 | 30.00% (510) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. marinum M | MMAR_1503 | - | 0.0 | 62.23% (511) | FAD-dependent oxidoreductase |
| M. avium 104 | MAV_2518 | - | 1e-124 | 60.73% (354) | monooxygenase, FAD-binding |
| M. smegmatis MC2 155 | MSMEG_4866 | mhpA | 2e-72 | 33.40% (524) | 3-(3-hydroxyphenyl)propionate hydroxylase |
| M. thermoresistible (build 8) | TH_0968 | - | 6e-74 | 33.21% (524) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1503|M.marinum_M MTTAAMTEATSEAATYDVAIIGYGPTGATAANLLGQLGMKVVVIERDPDI
MAV_2518|M.avium_104 --------------------------------------------------
Mvan_0593|M.vanbaalenii_PYR-1 ---------MDDSSTYDVAIVGYGPVGATAANLLGRRGLKVVVIERDPDI
Mflv_2401|M.gilvum_PYR-GCK ---------MTEQTDVDVVIVGAGPAGLTLANILGLEGVRVLVVDERDKL
TH_0968|M.thermoresistible__bu ---------MTER--VDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTL
MSMEG_4866|M.smegmatis_MC2_155 --------MMNSPGAVDVVIVGAGPVGLTLANILGGQGVRTLIIEERETL
Mb1780|M.bovis_AF2122/97 ----------------MIATMPSMARRSRHDNKITTPAVDCLTIER---L
Rv1751|M.tuberculosis_H37Rv ----------------MIATMPSMARRSRHDNKITTPAVDCLTIER---L
MAB_2573c|M.abscessus_ATCC_199 -------MNASAQLSFPVVIIGAGPTGVTAATLLAQHGVQCLLLERWATV
MMAR_1503|M.marinum_M YGRARAISTDEEVMRIWQSVGLAERLQSDMLPDRPIAFVDAHGVPFIEMK
MAV_2518|M.avium_104 --------------------------------------------------
Mvan_0593|M.vanbaalenii_PYR-1 YFRARAISTDEEVMRIWQQIGLAEQLNAEMQPGCGADFVDADGRSFVKLL
Mflv_2401|M.gilvum_PYR-GCK IDYPRGVGLDDESLRTFQAIGLVDRVLPHTVPNQILRFFDAKRNLLAEMA
TH_0968|M.thermoresistible__bu IDYPRGVGLDDEALRTFQSIGLVDRILPHTVPNQILRFFDAKRRLLAEMA
MSMEG_4866|M.smegmatis_MC2_155 IDYPRGVGLDDESLRTFQSIGLVDAILPHTVPNQILRFYDANRRLLAEMA
Mb1780|M.bovis_AF2122/97 DSPASGAPQVTPYARALMGETTTCAIIGGGPAGMVLGLLLARAGVQVTLL
Rv1751|M.tuberculosis_H37Rv DSPASGAPQVTPYARALMGETTTCAIIGGGPAGMVLGLLLARAGVQVTLL
MAB_2573c|M.abscessus_ATCC_199 YPQPRAVHLDDEIYRILAQLGIAEQFATISRPGAGMRLLDHRGQILSQIA
MMAR_1503|M.marinum_M IEPR-GSGHPPQQFLYQPAVDQVLRAGVARFANVEVLVEHECLRVLNNDA
MAV_2518|M.avium_104 --------------------------------------------------
Mvan_0593|M.vanbaalenii_PYR-1 PADR-GNGHPPQQFIYQPAVDKTLRAGVDRFPNVTVLLRHECLRLVPRTD
Mflv_2401|M.gilvum_PYR-GCK PPDA-RFGWPKRNGFVQPMVDAELFGGLQRFDNVEVRFGHRMHQCTQTTD
TH_0968|M.thermoresistible__bu PPDA-RFGWPKRNGFVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEASD
MSMEG_4866|M.smegmatis_MC2_155 PPDA-RFGWPKRNGFVQPMVDAELLAGLDRFDHVEVMWGRRMQTIAEDAD
Mb1780|M.bovis_AF2122/97 EKHG-DFLRDFRGDTVHPTT-MRLLDELGLWERFAALPYSEVRTATLHSN
Rv1751|M.tuberculosis_H37Rv EKHG-DFLRDFRGDTVHPTT-MRLLDELGLWERFAALPYSEVRTATLHSN
MAB_2573c|M.abscessus_ATCC_199 RAPIGTHGYPQANMFDQPELEQLLRANLTNYPQVSLRGGVEVTTIAHISA
MMAR_1503|M.marinum_M A--AELLLADLRTDTFKRLRARYVIAADGGSSPTRGQLGVGYTGRTYAER
MAV_2518|M.avium_104 -----------------------MIAADGGSSPTRGQLGIGYSGRTYAER
Mvan_0593|M.vanbaalenii_PYR-1 D--VELMLADLSEDQFKRIRATYVIAADGGSSAVRGQLGIGFTGSTYSER
Mflv_2401|M.gilvum_PYR-GCK R----VEVEFDG--GQASVSARYVVGCDGGRSVTRRLMGVSFDGTTSSTR
TH_0968|M.thermoresistible__bu AGEDGVTVEFAD--GHPPVRASYVVGCDGGRSTTRRLMGVSFDGTTSSTR
MSMEG_4866|M.smegmatis_MC2_155 G----VTVEVSGPDGPASVHAQYVVGCDGGRSATRHLMGVSFDGTTSSTR
Mb1780|M.bovis_AF2122/97 G--------------------------RAVTYIDFERLHQPYPYVAMVPQ
Rv1751|M.tuberculosis_H37Rv G--------------------------RAVTYIDFERLHQPYPYVAMVPQ
MAB_2573c|M.abscessus_ATCC_199 S-QVQVTFTDRDSGDEHKVTATYVLGCDGANSVVRAAIGASMTARRFAQR
. : :
MMAR_1503|M.marinum_M WVVIDTKVRRAWDAHDRLRFHCDPARPTVDCPTPLGHHRWEYPASADEAD
MAV_2518|M.avium_104 WVVIDTKVLKAWDAHDRLRFWANPARPTVDCPTPLGHHRWEYPARTDEDE
Mvan_0593|M.vanbaalenii_PYR-1 WIVIDTKVLREWPGHDRLRFHCNPARPTVDCPTPLGHHRWEFPVRDEEDE
Mflv_2401|M.gilvum_PYR-GCK WLVVD--IANDPLGHPNSEVGADPRRPYVSIAIAHGIRRFEFMIHPDETD
TH_0968|M.thermoresistible__bu WLVVD--VANDPLGHPNSEVGADPARPYVSISIAHGIRRFEFMIHPHETD
MSMEG_4866|M.smegmatis_MC2_155 WVVID--LANDPLGHPNSEVGADPQRPYASISIAHGIRRFEFMIHADETD
Mb1780|M.bovis_AF2122/97 WDLLN---------LLAEAAQAEPSFTLRMKTEVTGLLREGGKVTG-VRY
Rv1751|M.tuberculosis_H37Rv WDLLN---------LLAEAAQAEPSFTLRMKTEVTGLLREGGKVTG-VRY
MAB_2573c|M.abscessus_ATCC_199 WLVVDLNTDADLGHWDGVHHLCDPDRATTFMRVGERRYRWEFKLHPGETA
* ::: .:* . *
MMAR_1503|M.marinum_M QKLVREEAIWRVLNAQG--ITDNEVEILRAVIYCHHVRVADRWRIGRVFL
MAV_2518|M.avium_104 RELLREEAIWQVLGDQG--ITAEHVEILRAVIYSHHVRVAERWRVGRIFL
Mvan_0593|M.vanbaalenii_PYR-1 RDLLTEDAIWKVLHGQG--ISKDDVEIIGFACYSHHVRFADRWRVGRIFL
Mflv_2401|M.gilvum_PYR-GCK EEADDPAFVRRMLGQLI--PYPERVDMIRHRVYTHHSRIAGSFREGRLML
TH_0968|M.thermoresistible__bu AEVDDPAFVRRMLGRRI--PYPERVDMIRYRVYTHHSRIAGSFRKGRLLL
MSMEG_4866|M.smegmatis_MC2_155 EQAEDPEFVAELLRPFV--PHPDRVDVIRRRVYTHHSRIAGSFRKGRMLL
Mb1780|M.bovis_AF2122/97 QGAEGPGELRAELTVAC--DGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Rv1751|M.tuberculosis_H37Rv QGAEGPGELRAELTVAC--DGRWSIARHEAGLKAREFPVNFDVWWFKLPR
MAB_2573c|M.abscessus_ATCC_199 ADYDTVEKLRPLIAVWTGASAISELTLIRVTEYTFRAHVASHWRDRNVFI
: : : . . .:
MMAR_1503|M.marinum_M AGDAAHAMPPWIGQGMSAGVRDAANLCWKLAAVLNGNAPDSLLDSYQDER
MAV_2518|M.avium_104 AGDAAHAMPPWIGQGMSAGVRDAANLCWKLAAVLRGQAPESLLDSYQTER
Mvan_0593|M.vanbaalenii_PYR-1 AGDAAHAMPPWIGQGMCAGVRDVGNLCWKLEAVLTGALSESVLDSYQAER
Mflv_2401|M.gilvum_PYR-GCK AGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVTGRAGEELLDTYDVER
TH_0968|M.thermoresistible__bu AGDAAHLMPVWQGQGYNSGIRDAANLGWKLAAVVNGHAHDALLDTYDLER
MSMEG_4866|M.smegmatis_MC2_155 AGDAAHLMPVWQGQGYNSGIRDAFNLGWKLAAVVRGQAGDALLDTYDAER
Mb1780|M.bovis_AF2122/97 EGDAEFSFLPRFSPGKGLGVIPRE-----------GYFQIAYLGPKGTDA
Rv1751|M.tuberculosis_H37Rv EGDAEFSFLPRFSPGKGLGVIPRE-----------GYFQIAYLGPKGTDA
MAB_2573c|M.abscessus_ATCC_199 LGDAAHLTPPFVGQGMGAGIRDAANLTWKLAGVLDGQLPTRVLDTYEQER
*** . . * *: * *.. :
MMAR_1503|M.marinum_M KPHVTEVTRRAVFTGRLITERRRAVAAVRNGLGRALTRFPSAMARLQRAM
MAV_2518|M.avium_104 EPHVREVTRRACRVGRVITERNRAVVALRNHGLRALTRVPGVNAGLQKLT
Mvan_0593|M.vanbaalenii_PYR-1 LPHVREVTKRAVKVGRLIIERNPLRANIRNHFFRAASRLPFFTAWLRDHR
Mflv_2401|M.gilvum_PYR-GCK RKHARAMIDLSTMVGRVISPTNRKVAALRDRVIHAASAVPSLKRYVLEMR
TH_0968|M.thermoresistible__bu REHARAMIDLSTMVGRVISPTNRRVAALRDRLIHAASVVPTLKRYVLEMR
MSMEG_4866|M.smegmatis_MC2_155 RKHARAMIDLSTMVGRVISPTNRKVAALRDKLIRGASIVPTLKRYVLEMR
Mb1780|M.bovis_AF2122/97 QLRERGIEEFRRDVSELLPEATASVAALAS-----TDEVKHLNVKVNRLR
Rv1751|M.tuberculosis_H37Rv QLRERGIEEFRRDVSELLPEATASVAALAS-----MDEVKHLNVKVNRLR
MAB_2573c|M.abscessus_ATCC_199 KPHAWKMITIALAVGAAMTARGTAATAIRNLLVPRLQYIPGLRSRIQHSG
: : .. : . : . . :
MMAR_1503|M.marinum_M WIPPARYQDGFLARG-----HRAVGWQIPQPWVIDGNGATARLDDILGSQ
MAV_2518|M.avium_104 WIPGARYRDGFFAAGK----TRAVGWQIPQPWVAEPNGARIRLDDLLGGQ
Mvan_0593|M.vanbaalenii_PYR-1 WLPDARYRAGLLTSDR----HPAVGWLIPQPWVVDEKGDRVRLDDVLAGG
Mflv_2401|M.gilvum_PYR-GCK FKPMPRYQQGAVLHHAHAAPNSPTGTLFIQPRVDTRDTQNALLDDVLGTG
TH_0968|M.thermoresistible__bu FKPMPRYLQGAVYHGGPRSKSSPTGTLFIQPRVDTRDAENVLLDDVLGPG
MSMEG_4866|M.smegmatis_MC2_155 FKPMPRYHEGAVYHAKPPTPASPVGTLFIQPRVDTREQDNVLLDDVLGTG
Mb1780|M.bovis_AF2122/97 ----RWHIDGLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREH
Rv1751|M.tuberculosis_H37Rv ----RWHIDGLLCIGDAAHAMSPVAGVGINLAVQDAVAAATILAEPLREH
MAB_2573c|M.abscessus_ATCC_199 ----TPALTRSALVNKTPRCRQLAGTQIPNLVLSQG----HRIDTLLGSG
.. : : : *
MMAR_1503|M.marinum_M WVLLHTGDAP------TGSQAWTQRGVPAVRLGPPESGARPDG-------
MAV_2518|M.avium_104 WAILHIGPAP------AGAQEWTRLDVPLIQIT-----------------
Mvan_0593|M.vanbaalenii_PYR-1 WTVLHIGPE-------SLWRSWRSAGVPVIAIAPPGSAPAPGR-------
Mflv_2401|M.gilvum_PYR-GCK FAVVCWSNNLRAVLGEEAFGRWKALGAKFVEVRPMSQLRWPGHDDPDVAV
TH_0968|M.thermoresistible__bu FAVLCWSNNLRAVLGEDAFSHWKSLGATFVEARPITQLHWPGHDDPDVVV
MSMEG_4866|M.smegmatis_MC2_155 FAVLCWNNNPRTLLGEAAFTRWKALGATFIAARPSTQLHWTKDDDPDVVI
Mb1780|M.bovis_AF2122/97 RVSSRHLAAVR------RRRAFPTAVTQAVQRVLHRR-------------
Rv1751|M.tuberculosis_H37Rv RVSSRHLAAVR------RRRAFPTAVTQAVQRVLHRR-------------
MAB_2573c|M.abscessus_ATCC_199 FALVASETVDA-----DQQAQLRRRGAAIIVEP-----------------
. . :
MMAR_1503|M.marinum_M IRDSGGTLLRWLARKHASAVVLRPDGFVYAAAESGSPLPPPP--------
MAV_2518|M.avium_104 ----DAPLIRWLGHKKAAAVVLRPDGFIYAAAQSGHRLPKPP--------
Mvan_0593|M.vanbaalenii_PYR-1 IVDREGTLIRWIQTKKATVVVVRPDGFVYAAAAD-QPLPAPP--------
Mflv_2401|M.gilvum_PYR-GCK IGDRTGALKAWFDVHTESVLFVRPDRCIAAACIAQRAPEISEGLFAALHL
TH_0968|M.thermoresistible__bu VGDRTGALKGWFDVHTDSVLFLRPDRCIAAACIAQRAPETSAALSEVMCL
MSMEG_4866|M.smegmatis_MC2_155 VGDRTGALKAFFDAHTESVLVLRPDRCIAGADIAQRAPELSTALFGILHL
Mb1780|M.bovis_AF2122/97 ---LLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGVR-------
Rv1751|M.tuberculosis_H37Rv ---LLGPLLQGRDPTPPAALLGLVERLPWLSAVPAYFVGVGVR-------
MAB_2573c|M.abscessus_ATCC_199 ---RGSELDRWLRRGGARAALIRPDRTVMQTARSPSQIAFTT--------
. * . . : :
MMAR_1503|M.marinum_M --------------------AGHFGNTLPTSMKIEALA-
MAV_2518|M.avium_104 --------------------PGYSGNTITTPSKTEVSA-
Mvan_0593|M.vanbaalenii_PYR-1 --------------------AGFTPRVRQQA--------
Mflv_2401|M.gilvum_PYR-GCK TSGAHLTQGGGTDGEKPDRAVLHVAQPAAESSGTGAGTS
TH_0968|M.thermoresistible__bu T------QGGGNGAASP---VLHVAQSAAEPSGTATRST
MSMEG_4866|M.smegmatis_MC2_155 R------QGGENGATGP---VLYVPQPTAESSGTVGRAS
Mb1780|M.bovis_AF2122/97 --------------------PEHAPAFARRGPGNRKGP-
Rv1751|M.tuberculosis_H37Rv --------------------PEHAPAFARRGPGNRKGP-
MAB_2573c|M.abscessus_ATCC_199 --------------------TLFAPTHQPAPTYRETP--
.