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VNSRLFNSHRVVAGCVTECGIVVTNEEFDMSEHALDELGYYLLAGAGGEGPATLMDEARRGEELGFGTAF ISERWNVKEASSLVGAACAVTTRMQIATAATNHNTRHPLITGSWATTMHRLSGGRFTLGIGRGIAAMYGA FGIPSVTTAQMEDFAQVMRRLWQGEVIFNHDGPIGNYQVLFLDPDFREDIRLAIVAFGPQTLALGGREFD DVILHTYFTPETLQRAVKTVKTAAEQAGRDPGSVRVWSCFATVGDHLPEELRLKKTVARLATYLQGYGDL LVNTNGWDPAVLQRFRDDKVVQSIPGGIDHKATAEQIEHIATLIPDEWLEPSATGSAQQCVARIRKEFDY GADAVIMHGATPDELEPIVAEYRATR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2249 | - | - | 100% (376) | hypothetical protein MSMEG_2249 |
| M. smegmatis MC2 155 | MSMEG_2456 | - | 2e-17 | 25.90% (305) | 5,10-methylenetetrahydromethanopterin reductase |
| M. smegmatis MC2 155 | MSMEG_4013 | - | 2e-12 | 29.30% (273) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2975c | - | 3e-14 | 29.79% (188) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4328 | - | 0.0 | 92.46% (345) | luciferase family protein |
| M. tuberculosis H37Rv | Rv2951c | - | 4e-14 | 29.79% (188) | oxidoreductase |
| M. leprae Br4923 | MLBr_00131 | - | 2e-11 | 29.03% (155) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_2053 | - | 7e-14 | 28.17% (213) | luciferase-like |
| M. marinum M | MMAR_4003 | - | 1e-179 | 87.21% (344) | oxidoreductase |
| M. avium 104 | MAV_1607 | - | 0.0 | 90.59% (340) | hypothetical protein MAV_1607 |
| M. thermoresistible (build 8) | TH_1627 | - | 0.0 | 94.12% (340) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3866 | - | 1e-178 | 86.63% (344) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2018 | - | 0.0 | 91.81% (342) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2249|M.smegmatis_MC2_155 MNSRLFNSHRVVAGCVTECGIVVTNEEFDMSEHALDELGYYLLAG-----
TH_1627|M.thermoresistible__bu MN------------------------------RPLDELGYYLLAG-----
Mflv_4328|M.gilvum_PYR-GCK MTEA-----------------------------KMDELGYYLLAG-----
Mvan_2018|M.vanbaalenii_PYR-1 MTR------------------------------VLDELGFYLLAG-----
MAV_1607|M.avium_104 ---------------------------------MLDELGFYLLAG-----
MMAR_4003|M.marinum_M MSDR-----------------------------TLNELGYYLLAG-----
MUL_3866|M.ulcerans_Agy99 MSDR-----------------------------TLNELGYYLLAG-----
Mb2975c|M.bovis_AF2122/97 MGGLRFG--------------------------FVDALVHSRLPPTLPAR
Rv2951c|M.tuberculosis_H37Rv MGGLRFG--------------------------FVDALVHSRLPPTLPAR
MLBr_00131|M.leprae_Br4923 MAGFRFG--------------------------FVDALVHTLFPPSLPAR
MAB_2053|M.abscessus_ATCC_1997 ----------------------------------MSTYGVSVLGA-----
:. :
MSMEG_2249|M.smegmatis_MC2_155 ---------------AGGEGPATLMDEARRGEELGFGTAFISERWNVKEA
TH_1627|M.thermoresistible__bu ---------------AGGEGPATLMDEARRGEELGFGTAFISERWNVKEA
Mflv_4328|M.gilvum_PYR-GCK ---------------AGGEGPATLMDEARRGEELGFGTGFISERWNVKEA
Mvan_2018|M.vanbaalenii_PYR-1 ---------------AGGEGPATLMDEARRGEELGFGTGFISERWNVKEA
MAV_1607|M.avium_104 ---------------AGGEGPATLMDEARRGEELGFGTAFISERWNVKEA
MMAR_4003|M.marinum_M ---------------AGGEGPATLMDEARRGEELGLGTAFVSERWNVKEA
MUL_3866|M.ulcerans_Agy99 ---------------AGGEGPATLMDEARRGEELGLGTAFVSERWNVKEA
Mb2975c|M.bovis_AF2122/97 SSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEP
Rv2951c|M.tuberculosis_H37Rv SSMAAATVMGADSYWVGDHLNALVPRSIATSEYLGIAAKFVPKIDANYEP
MLBr_00131|M.leprae_Br4923 ASIVSGAVLGADSYWVGDHLNALVPRSVATPKYLGVAAKVVPKIDANYEP
MAB_2053|M.abscessus_ATCC_1997 -------------------DLATLVETAEATDLAGFDAAWASEFYSRSGS
* : . *. : .: .
MSMEG_2249|M.smegmatis_MC2_155 SSLVG--AACAVTTRMQIATAATNHNTRHPLITGSWATTMHRLSGGRFTL
TH_1627|M.thermoresistible__bu SSLVG--AACAVTERMQIATAATNHNTRHPLITGSWATTMHRLSGGRFTL
Mflv_4328|M.gilvum_PYR-GCK SSLTG--AALAVTSRMQIATAATNHNTRHPLITGSWATTMHRLSGGRFTL
Mvan_2018|M.vanbaalenii_PYR-1 SSLTG--AALAVTSRMQIATAATNHNTRHPLITGSWATTMHRLSGGRFTL
MAV_1607|M.avium_104 SSLVG--AACAVTHRMQIATAATNHNTRHPLITGSWATTMHRLSGGRFTL
MMAR_4003|M.marinum_M SSLVG--AACAVTSRMQIATAATNHNTRHPLVTASWATTMHRLSGGRFTL
MUL_3866|M.ulcerans_Agy99 SSLVG--AACAVTSRMQIATAATNHNTRHPVVTASWATTMHRLSGGRFTL
Mb2975c|M.bovis_AF2122/97 WTMLGNLAFG-LPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAIL
Rv2951c|M.tuberculosis_H37Rv WTMLGNLAFG-LPSRLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGRAIL
MLBr_00131|M.leprae_Br4923 WTMLGNLAAGNRLNGLRLGVCVTDAGRRNPAVTAQAAATLHLLTRGKAML
MAB_2053|M.abscessus_ATCC_1997 ISMAA---MAARTKRCRIGSSILYGVGRSPLVLATEARDLDELSGGRVVL
:: . ::. . * * : . * :. *: *: *
MSMEG_2249|M.smegmatis_MC2_155 GIGRGIAAMYGAFG--IPSVT-TAQMEDFAQVMRRLWQ--GEVIFNHDGP
TH_1627|M.thermoresistible__bu GIGRGVAAMYAAFG--IPPVT-TAQMEDFAQVMRRLWR--GEVIFDHDGP
Mflv_4328|M.gilvum_PYR-GCK GIGRGIGAIYNAFG--IPTVT-TAQMEDFAQVMRKLWH--GELIFNHDGP
Mvan_2018|M.vanbaalenii_PYR-1 GIGRGIGAIYNAFG--IPTVT-TAQMEDFAQVMRKLWH--GELIFNHDGP
MAV_1607|M.avium_104 GVGRGIAAIYGAFG--IPAVT-TAQMEDWAGVMRRLWH--GELIFNHDGP
MMAR_4003|M.marinum_M GIGRGIAAIYGAFG--IPAVT-TAQMEDWAQVMRRLWK--GEMIFNHDGP
MUL_3866|M.ulcerans_Agy99 GIGRGIAAIYGAFG--IPAVT-TAQMEDWAQVMRRLWK--GEMVFNHDGP
Mb2975c|M.bovis_AF2122/97 GIGVGEREGNEPYG--VEWTKPVARFEEALATIRALWNSNGELISRESPY
Rv2951c|M.tuberculosis_H37Rv GIGVGEREGNEPYG--VEWTKPVARFEEALATIRALWNSNGELISRESPY
MLBr_00131|M.leprae_Br4923 GIGVGEREGNEPYG--VEWTKPVARFQEALATIRALWDSNGELVSRESQF
MAB_2053|M.abscessus_ATCC_1997 GLGNGTRRMMSDWHGVEDTSAPALRMEELVPLVRRIWNLHEGPVRHEGRF
*:* * : . :::: :* :* : ..
MSMEG_2249|M.smegmatis_MC2_155 IGNYQVLFLDPDFR-EDIRLAIVAFGPQTLALGGREFDDVILHTYFTPET
TH_1627|M.thermoresistible__bu IGRYQVLFLDPDFN-EDIRLAIVAFGPQTLALGGRMFDDVILHTYFTPET
Mflv_4328|M.gilvum_PYR-GCK LGKYQVLFLDPDFR-EDIRLAIVAFGPQTLALGGREFDDVILHTYFTPET
Mvan_2018|M.vanbaalenii_PYR-1 LGKYQVLFLDPDFR-EDIRLAIVAFGPQTLALGGREFDDVILHTYFTPET
MAV_1607|M.avium_104 MGKYPILFLDPDFN-EDIRLALVAFGPNTLALGGRVFDDVILHTYFTPET
MMAR_4003|M.marinum_M MGRYPVLFLDPDFN-EDIRLALVALGPKSLALGGRVFDDVILHTYFTPET
MUL_3866|M.ulcerans_Agy99 MGRYPVLFLDPDFN-EDIRLALVALGPKSLALGGRVFDDVILHTYFTPET
Mb2975c|M.bovis_AF2122/97 FPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSD
Rv2951c|M.tuberculosis_H37Rv FPLHNALFDLPPYRGKWPEIWVAAHGPRMLRATGRYADAWIPIVVVRPSD
MLBr_00131|M.leprae_Br4923 FPLHNALFDLPPYRGKWPEIWVAAHGPRMLQATGRYADAWIPIVLVRPTD
MAB_2053|M.abscessus_ATCC_1997 YRMNLVPTGDVAPPQRAIPIITAGVRPRMCEVAGRVADGLAGHPLFTTTY
. : .. *. ** * . .
MSMEG_2249|M.smegmatis_MC2_155 LQRAVK-TVKTAAEQAGRDPGSVRVWSCFATVGDHLPEELRLKKTVARLA
TH_1627|M.thermoresistible__bu LQRAVK-TVKDAAEQAGRDPAEVRVWSCFATVGDHLPEELRLKKTVARLA
Mflv_4328|M.gilvum_PYR-GCK LQRAVK-TVKDAAEQAGRDPASVRVWSCFATVGDHLPEELRLKKTVARLA
Mvan_2018|M.vanbaalenii_PYR-1 LQRAVR-TVKDAAEQAGRDPASVRVWSCFATVGDHLPEELRLKKTVARLA
MAV_1607|M.avium_104 LQRSVK-TVKSAAEKAGRDPDSVRVWSCFATVGDHLPEQLRLKKTVARLA
MMAR_4003|M.marinum_M LQRCVS-IVKTAADRAGRDPASVRVWSCFATVGDHLPEQLRLKKTVARLA
MUL_3866|M.ulcerans_Agy99 LQRCVS-IVKTAADRAGRDPASVRVWSCFATVGDHLPEQLRLKKTVARLA
Mb2975c|M.bovis_AF2122/97 YSRALE-AVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVK
Rv2951c|M.tuberculosis_H37Rv YSRALE-AVRSAASDAGRDPMSITPAAVRGIITGRNRDDVEEALESVVVK
MLBr_00131|M.leprae_Br4923 YSCALE-VVRTAASDAGRDPMSITPAAVRGIITGRTRDDVDEALDSVLVR
MAB_2053|M.abscessus_ATCC_1997 VEEVARPAVVRGAERAGRDPADIEIVSMVICAVHDDPQIARREAAQQIAF
. * .*. ***** .: : :
MSMEG_2249|M.smegmatis_MC2_155 TYLQGYGDLLVNTNGWD---PAVLQRFRDDKVVQSIPGGIDHKATAEQIE
TH_1627|M.thermoresistible__bu TYLQGYGDLLVETNGWD---PAVLRKFRDDPVVQSIPGGIDHKATPEQIE
Mflv_4328|M.gilvum_PYR-GCK TYLQGYGDLLVNTNGWD---PAVLQRFRDDKVVQSIGGGIDHKATAEQIE
Mvan_2018|M.vanbaalenii_PYR-1 TYLQGYGDLLVNTNGWD---PAVLQRFRDDKVVQSVGGGIDHKATAEQIE
MAV_1607|M.avium_104 TYLQGYGDLLVRTNDWD---SAVLQRFRDDPVVTSIAGGIDHKATPEQIE
MMAR_4003|M.marinum_M TYLQGYGDLLVHTNNWD---PAVLQRFREDPVVTSVRGGIDHKATAEQIE
MUL_3866|M.ulcerans_Agy99 TYLQGYGDLLVHTNNWD---PAVLQRFREDPVVTSVRGGIDHKATAEQIE
Mb2975c|M.bovis_AF2122/97 MTALGVPGEAWARHGVE---HPMGADFSG--VQDIIPQTMDKQTVLSYAA
Rv2951c|M.tuberculosis_H37Rv MTALGVPGEAWARHGVE---HPMGADFSG--VQDIIPQTMDKQTVLSYAA
MLBr_00131|M.leprae_Br4923 MIALGVPGEAWARHGVE---HPMGADFAG--VQDIIPQTIDEETVVSYAA
MAB_2053|M.abscessus_ATCC_1997 YSSVKTYEHVLDVSGFARQGAAIRDAFARRDLPAMFAAVTDDMIDAMAVA
. .: * : . *.
MSMEG_2249|M.smegmatis_MC2_155 HIATLIPDEWLEPSATGSAQQCVARIRKEFDYGADAVIMHG---------
TH_1627|M.thermoresistible__bu HIATLIPDEWLEPAATGSARQCVERIRKEFDYGADAVIMHG---------
Mflv_4328|M.gilvum_PYR-GCK HIATLIPDEWLEPSATGSPQQCADRVRKEFDYGADAVIMHG---------
Mvan_2018|M.vanbaalenii_PYR-1 HIATLIPDEWLAPSATGSPQQCADRVRQELDYGADAVIMHG---------
MAV_1607|M.avium_104 HIATLIPDEWLEPSATGSAQQCVARIRQEFDYGADAVILHG---------
MMAR_4003|M.marinum_M HIATLLPDEWLEPSATGSAQQCVDRIRAEFGYGADAVIMHG---------
MUL_3866|M.ulcerans_Agy99 HIATLLPDEWLEPSATGSAQQCVDRIRAEFGYGADAVIMHG---------
Mb2975c|M.bovis_AF2122/97 KVPAALMKEVVFS---GTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLR
Rv2951c|M.tuberculosis_H37Rv KVPAALMKEVVFS---GTPDEVIDQVAEWRDHGLRYVVLINGSLVNPSLR
MLBr_00131|M.leprae_Br4923 KVPAALMKEVLFS---GTPEEVIDQVAEWRDHGLKYLVVINGSLVNSSLR
MAB_2053|M.abscessus_ATCC_1997 GTAAEVREGLRRY--EGVLDHIVLYSPSIGLAPERIAENLG---------
.: : . * . .
MSMEG_2249|M.smegmatis_MC2_155 ATPDELEPIVAEYRATR--
TH_1627|M.thermoresistible__bu ATPDELEPIVAEYRAVVG-
Mflv_4328|M.gilvum_PYR-GCK ATPDELEPIVAAYRAGQS-
Mvan_2018|M.vanbaalenii_PYR-1 ATPDELEPIVAAYRAGRS-
MAV_1607|M.avium_104 ATPDELEPIVAAYRAG---
MMAR_4003|M.marinum_M ATPDELEPVVAAYRQKAQ-
MUL_3866|M.ulcerans_Agy99 ATPDELEPVVAAYRQKAQ-
Mb2975c|M.bovis_AF2122/97 KTVTAVLPHAKVLRGLKKL
Rv2951c|M.tuberculosis_H37Rv KTVTAVLPHAKVLRGLKKL
MLBr_00131|M.leprae_Br4923 KTVSALLPHARVLRGLKKL
MAB_2053|M.abscessus_ATCC_1997 SLIRDCAPAFAGGKGDQSG
* :