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APLLAQATTNLKIGWGIIGSYARHPLVTAMDVRVVQEMAGPDRFYCGIGASKILMNAIGQGDDTKSRPRT NVEETLRIVRATLDGKKVDFVGREYIATAPELDPNAEVPDWKIPLYVGGGGPRMMQTAGELADGLITPSL TSPAFYPYAIEHMRRGAEKANRKVEELDLGATLIASCGPDRESGRRGARELLGRYLINKARNIRGSGDVL FEKAGLSPAELMPVVEAIERGGNKVIPDVVTDEIMDKTKVIAGTPEEVADLIIEHRDSGCRHVQLELWGD DREAQIKLIGEKVLPRVQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2103 | - | - | 100% (299) | 5,10-methylenetetrahydromethanopterin reductase |
| M. smegmatis MC2 155 | MSMEG_0528 | - | 1e-15 | 29.05% (179) | hypothetical protein MSMEG_0528 |
| M. smegmatis MC2 155 | MSMEG_4013 | - | 1e-11 | 25.08% (303) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0415 | fgd1 | 3e-12 | 21.59% (301) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0211 | - | 2e-14 | 22.00% (300) | luciferase family protein |
| M. tuberculosis H37Rv | Rv0407 | fgd1 | 3e-12 | 21.59% (301) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. leprae Br4923 | MLBr_00269 | - | 3e-10 | 22.14% (262) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2053 | - | 3e-14 | 28.52% (263) | luciferase-like |
| M. marinum M | MMAR_0338 | - | 2e-16 | 25.41% (307) | coenzyme F420-dependent oxidoreductase |
| M. avium 104 | MAV_4761 | - | 4e-14 | 22.07% (299) | F420-dependent glucose-6-phosphate dehydrogenase |
| M. thermoresistible (build 8) | TH_1683 | - | 3e-14 | 22.07% (299) | PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1 |
| M. ulcerans Agy99 | MUL_4782 | - | 1e-16 | 25.41% (307) | coenzyme F420-dependent oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0698 | - | 2e-13 | 22.41% (299) | luciferase family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0211|M.gilvum_PYR-GCK -MAELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGG
Mvan_0698|M.vanbaalenii_PYR-1 -MAELKLGYKASAEQFAPRELVELAVAAEEHGMDSATVSDHFQPWRHEGG
MAV_4761|M.avium_104 -MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHEGG
Mb0415|M.bovis_AF2122/97 -MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHQGG
Rv0407|M.tuberculosis_H37Rv -MAELKLGYKASAEQFAPRELVELAVAAEAHGMDSATVSDHFQPWRHQGG
MLBr_00269|M.leprae_Br4923 -MAELRLGYKASAEQFAPRELVELGVAAEAHGMDSATVSDHFQPWRHQGG
TH_1683|M.thermoresistible__bu --VNLKLGYKASAEQFSPRELVELGVLAEAHGMDSAAVSDHFQPWRHNGG
MMAR_0338|M.marinum_M MRTATTVELSGGKDSKDGKDVVDFVVEAEKLGLHTCWVAEAWG------S
MUL_4782|M.ulcerans_Agy99 MRTATTVELSGGK---DGKDTVDFVVEAEKLGLHTCWVAEAWG------S
MAB_2053|M.abscessus_ATCC_1997 -----MSTYGVSVLGADLATLVETAEATDLAGFDAAWASEFYS------R
MSMEG_2103|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_0211|M.gilvum_PYR-GCK HAPFSLAWMTAVGERTTRLQLGTSVLTPTFRYNPAVIAQAFATMGCLYPD
Mvan_0698|M.vanbaalenii_PYR-1 HAPFSLAWMTAVGERTKRLQLGTSVLTPTFRYNPAVIAQAFATMGCLYPG
MAV_4761|M.avium_104 HAPFSLAWMTAVGERTTRITLGTSVLTPTFRYNPAVVAQAFATMACLYPG
Mb0415|M.bovis_AF2122/97 HAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPN
Rv0407|M.tuberculosis_H37Rv HAPFSLSWMTAVGERTNRLLLGTSVLTPTFRYNPAVIAQAFATMGCLYPN
MLBr_00269|M.leprae_Br4923 HASFSLSWMTAVGERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPN
TH_1683|M.thermoresistible__bu HAPFALAWMAAVGERTTTLALGTSVLTPTFRYNPAVIAQAFATMGCLFPG
MMAR_0338|M.marinum_M DAPSALGYIAAR---TERMQLGSGVLQVGTRS-PVLVAQTAITLSNLSCG
MUL_4782|M.ulcerans_Agy99 DAPSALGYIAAR---TERMQLGSGVLQVGTRS-PVLVAQTAITLSNLSCG
MAB_2053|M.abscessus_ATCC_1997 SGSISMAAMAAR---TKRCRIGSSILYGVGRS-PLVLATEARDLDELSGG
MSMEG_2103|M.smegmatis_MC2_155 -------MAPLLAQATTNLKIGWGIIGSYARHPLVTAMDVRVVQEMAGPD
. * :* .:: * .
Mflv_0211|M.gilvum_PYR-GCK RIFLGVGTGEALNEIATGYEGEWPEFKERYARLRESVRLMRELWLGDR--
Mvan_0698|M.vanbaalenii_PYR-1 RIFLGVGTGEALNEIATGYEGDWPEFKERYARLRESVRLMRDLWLGDR--
MAV_4761|M.avium_104 RIFLGVGTGEALNEIATGYQGEWPEFKERFARLRESVRLMRELWRGDR--
Mb0415|M.bovis_AF2122/97 RVFLGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDR--
Rv0407|M.tuberculosis_H37Rv RVFLGVGTGEALNEIATGYEGAWPEFKERFARLRESVGLMRQLWSGDR--
MLBr_00269|M.leprae_Br4923 RVFLGVGTGEALNEVATGYQGAWPEFKERFARLRESVRLMRELWRGDR--
TH_1683|M.thermoresistible__bu RIMLGVGTGEALNEIATGGAGEWPRFTERFARLREAVTLMRALWSGDR--
MMAR_0338|M.marinum_M RFLLGLGASGPQ--VIEGLHG--VAFDRPLARLKETVEIVRQVFAGGK--
MUL_4782|M.ulcerans_Agy99 RFLLGLGASGPR--VIEGLHG--VAFDRPLARLKETVEIVRQVFAGGK--
MAB_2053|M.abscessus_ATCC_1997 RVVLGLGNGTRR--MMSDWHG-VEDTSAPALRMEELVPLVRRIWNLHEGP
MSMEG_2103|M.smegmatis_MC2_155 RFYCGIGASKILMNAIGQGDD---TKSRPRTNVEETLRIVRATLDGKK--
*. *:* . . .:.* : ::* .
Mflv_0211|M.gilvum_PYR-GCK VDFEGEYYKTKG-------ASIYDVPEGGIPIYIAAGGPQVAKYAGRAGD
Mvan_0698|M.vanbaalenii_PYR-1 VDFEGEYYKTKG-------ASIYDVPEGGIPIYIAAGGPQVAKYAGRAGD
MAV_4761|M.avium_104 VDFDGEYYRLKG-------ASIYDVPDGGVPIYIAAGGPAVAKYAGRAGD
Mb0415|M.bovis_AF2122/97 VDFDGDYYRLKG-------ASIYDVPDGGVPVYIAAGGPAVAKYAGRAGD
Rv0407|M.tuberculosis_H37Rv VDFDGDYYRLKG-------ASIYDVPDGGVPVYIAAGGPAVAKYAGRAGD
MLBr_00269|M.leprae_Br4923 VDFDGDYYQLKG-------ASIYDVPEGGVPIYIAAGGPEVAKYAGRAGE
TH_1683|M.thermoresistible__bu VDFDGDYYTARG-------ASIYDVPDDGIPVYIAAGGPTVARYAGTAGD
MMAR_0338|M.marinum_M VTYSGSEFQIPRRGGEARPMRLSTRPEYDIPIYLAALSPAMLRLTGRIAD
MUL_4782|M.ulcerans_Agy99 VTYSGSEFQIPRRGGEARPMRLSTRPEYDIPIYLAALSPAMLRLTGRIAD
MAB_2053|M.abscessus_ATCC_1997 VRHEGRFYRMNLVP-----TGDVAPPQRAIPIITAGVRPRMCEVAGRVAD
MSMEG_2103|M.smegmatis_MC2_155 VDFVGREYIATAP----ELDPNAEVPDWKIPLYVGGGGPRMMQTAGELAD
* . * : *: :*: .. * : . :* .:
Mflv_0211|M.gilvum_PYR-GCK GFICTSGKGEELYKEKLIPAMREGAEAAGKNPDDVDRMIEIKISYDT---
Mvan_0698|M.vanbaalenii_PYR-1 GFICTSGKGEELYKDKLIPAMREGAEAAGKNPDDIDRMIEIKISYDT---
MAV_4761|M.avium_104 GFICTSGKGEELYKDKLIPAVKEGAAINDRNVDDIDKMIEIKISYDP---
Mb0415|M.bovis_AF2122/97 GFICTSGKGEELYTEKLMPAVREGAAAADRSVDGIDKMIEIKISYDP---
Rv0407|M.tuberculosis_H37Rv GFICTSGKGEELYTEKLMPAVREGAAAADRSVDGIDKMIEIKISYDP---
MLBr_00269|M.leprae_Br4923 GFVCTSGKGEELYTEKLIPAVLEGAAVAGRDADDIDKMIEIKMSYDP---
TH_1683|M.thermoresistible__bu GFICTSGKGMDLYTQKLMPAVTEGARAAGREPDQIDRMIEIKISYDP---
MMAR_0338|M.marinum_M GWLGTS-FVPEGAGDAYFTHLDAGLAAAGRSRADIDFCQGAEVAFASGVE
MUL_4782|M.ulcerans_Agy99 GWLGTS-FVPEGAGDAYFTHLDAGLAAAGRSRADIDFCQGAEVAFASGVE
MAB_2053|M.abscessus_ATCC_1997 GLAGHPLFTTTYVEEVARPAVVRGAERAGRDPADIEIVSMVICAVHD---
MSMEG_2103|M.smegmatis_MC2_155 GLITPSLTSPAFYP-YAIEHMRRGAEKANRKVEELDLGATLIASCGP---
* . : * .:. :: :
Mflv_0211|M.gilvum_PYR-GCK ---------DPELALENTRFWAPLS---------LTAEQKHSID--DPME
Mvan_0698|M.vanbaalenii_PYR-1 ---------DPELALENTRFWAPLS---------LTAEQKHSID--DPIE
MAV_4761|M.avium_104 ---------DPELALENTRFWAPLS---------LTAEQKHSID--DPIE
Mb0415|M.bovis_AF2122/97 ---------DPELALNNTRFWAPLS---------LTAEQKHSID--DPIE
Rv0407|M.tuberculosis_H37Rv ---------DPELALNNTRFWAPLS---------LTAEQKHSID--DPIE
MLBr_00269|M.leprae_Br4923 ---------DPEQALSNIRFWAPLS---------LAAEQKHSID--DPIE
TH_1683|M.thermoresistible__bu ---------DPAQALENTRFWAPLS---------LTPEQKHSID--DPVE
MMAR_0338|M.marinum_M ELRDMVAARKTELAFSLGGMGSAST---------NYYNQAYSRQ--GWSE
MUL_4782|M.ulcerans_Agy99 ELRDMVAARKTELAFSLGGMGSAST---------NYYNQAYSRQ--GWSE
MAB_2053|M.abscessus_ATCC_1997 ---------DPQIARREAAQQIAFYSS------VKTYEHVLDVS--GFAR
MSMEG_2103|M.smegmatis_MC2_155 ---------DRESGRRGARELLGRYLINKARNIRGSGDVLFEKAGLSPAE
. . : . . .
Mflv_0211|M.gilvum_PYR-GCK MEKAADE------------LPIEQVAKRWIVASDPDEAVAKVADYVDYGL
Mvan_0698|M.vanbaalenii_PYR-1 MEKAADA------------LPIEQVAKRWIVASDPDEAVAKVKDYVDWGL
MAV_4761|M.avium_104 MEKAADA------------LPIEQVAKRWIVASDPDEAVAKVKDYVDWGL
Mb0415|M.bovis_AF2122/97 MEKAADA------------LPIEQIAKRWIVASDPDEAVEKVGQYVTWGL
Rv0407|M.tuberculosis_H37Rv MEKAADA------------LPIEQIAKRWIVASDPDEAVEKVGQYVTWGL
MLBr_00269|M.leprae_Br4923 MEKVADA------------LPIEQVAKRWIVVSDPDEAVARVGQYVTWGL
TH_1683|M.thermoresistible__bu MERIADR------------LPIEQIARRWIVASDPDQAVDEIKQYVDAGF
MMAR_0338|M.marinum_M VAAAVRERWQRGDREGAARLVTDEMVLATTLIGTEEMVRSRLVAWRDAGV
MUL_4782|M.ulcerans_Agy99 VAAAVRERWQRGDREGAARLVTDEMVLATTLIGTEEMVRSRLVAWRDAGV
MAB_2053|M.abscessus_ATCC_1997 QGAAIRDAFARRDLPAMFAAVTDDMIDAMAVAGTAAEVREGLRRYEGV-L
MSMEG_2103|M.smegmatis_MC2_155 LMPVVEAIERGGNKVIPDVVTDEIMDKTKVIAGTPEEVADLIIEHRDSGC
: : : . . :
Mflv_0211|M.gilvum_PYR-GCK NHLVFHAP-----GHDQRRFLELFQRDLEPRLRKLG-----
Mvan_0698|M.vanbaalenii_PYR-1 NHLVFHAP-----GHDQRRFLELFRRDLEPRLRKLG-----
MAV_4761|M.avium_104 NHLVFHAP-----GHDQRRFLELFEKDLAPRLRRLG-----
Mb0415|M.bovis_AF2122/97 NHLVFHAP-----GHDQRRFLELFQSDLAPRLRRLG-----
Rv0407|M.tuberculosis_H37Rv NHLVFHAP-----GHDQRRFLELFQSDLAPRLRRLG-----
MLBr_00269|M.leprae_Br4923 NHLVFHAP-----GHNQRRFLELFEKDLAPRLRRLG-----
TH_1683|M.thermoresistible__bu NHLVFHAP-----GSDQPRFLTLFEKDLAPRLRSLQ-----
MMAR_0338|M.marinum_M NTVRLYPA-----GDTMDAKLSTLGRAIELVRAVR------
MUL_4782|M.ulcerans_Agy99 NTVRLYPA-----GDTMDAKLSTLGRAIELVRAVR------
MAB_2053|M.abscessus_ATCC_1997 DHIVLYSPSIGLAPERIAENLGSLIRDCAPAFAGGKGDQSG
MSMEG_2103|M.smegmatis_MC2_155 RHVQLELW-----GDDREAQIKLIGEKVLPRVQ--------
: : : :