For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LHVHRYGPAGAAQVLLIHGLTGHGQRWQTLATEHLPEVGVLAPDLIGHGRSSWAAPWTIDANVAALAALL DRPTLVVGHSFGGALALNLSAAHPDLVSGLVLLDPAIGLDGEWMRDIADDMLSSPDYPDREEARLDKVNG SWGEVDPAEVERELDEHLVEVGEGRVGWRISIPAAMSYWSELARPVVLPHNPIPTVLVRAKRCRPPFVAD ALIDGLTDRLGSKFTLLDWDCDHMVAQAKPAETAELIRRQLG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1940 | - | - | 100% (253) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_4079 | - | 4e-09 | 39.00% (100) | putative hydrolase |
| M. smegmatis MC2 155 | MSMEG_6906 | - | 3e-08 | 27.41% (259) | putative hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3228 | lipV | 1e-74 | 60.36% (222) | lipase LipV |
| M. gilvum PYR-GCK | Mflv_4667 | - | 9e-98 | 65.87% (252) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3203 | lipV | 1e-74 | 60.36% (222) | lipase LipV |
| M. leprae Br4923 | MLBr_02603 | - | 3e-06 | 31.48% (108) | hypothetical protein MLBr_02603 |
| M. abscessus ATCC 19977 | MAB_3517 | - | 2e-84 | 58.04% (255) | putative hydrolase, alpha/beta fold LipV |
| M. marinum M | MMAR_1355 | lipV | 7e-86 | 60.00% (255) | lipase LipV |
| M. avium 104 | MAV_4150 | - | 1e-94 | 64.71% (255) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_0447 | lipV | 1e-104 | 70.47% (254) | POSSIBLE LIPASE LIPV |
| M. ulcerans Agy99 | MUL_2524 | lipV | 1e-86 | 60.39% (255) | lipase LipV |
| M. vanbaalenii PYR-1 | Mvan_1800 | - | 3e-98 | 66.41% (256) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3228|M.bovis_AF2122/97 --------------------------------------------------
Rv3203|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_1355|M.marinum_M ---------------MSTDLHVHRYGPEEPVRVLTIHGVTEHGQSWEYLA
MUL_2524|M.ulcerans_Agy99 ---------------MSTDLHVHRYGPEEPVRVLTIHGVTEHGQSWEYLA
MAV_4150|M.avium_104 ---------------MTATLHVHRYGPPGPARILALHGLTGHGQRWQHLA
TH_0447|M.thermoresistible__bu ---------------------VYRYGPAGPPRLLAIHGLTGHGRRWQTLA
MSMEG_1940|M.smegmatis_MC2_155 ------------------MLHVHRYGPAGAAQVLLIHGLTGHGQRWQTLA
Mflv_4667|M.gilvum_PYR-GCK ---------------MTEQLCTYRFGPAGPARVLAIHGLTGHGKRWESLF
Mvan_1800|M.vanbaalenii_PYR-1 ---------------MTDLLCTYRFGPPGPARVLAIHGLTGHGKRWETLF
MAB_3517|M.abscessus_ATCC_1997 ---------------MTPTLNIHRYGPVEPARLLALHGLTGHGRRWAPLF
MLBr_02603|M.leprae_Br4923 MTITRTERNFYGVGGVRIVYDVWMPDTRPRAVIILAHGFGEHARRYDHVA
Mb3228|M.bovis_AF2122/97 ----MPEIPIAAPDLLGHGRSP-----WAAPWTIDANVSALAALLDNQGD
Rv3203|M.tuberculosis_H37Rv ----MPEIPIAAPDLLGHGRSP-----WAAPWTIDANVSALAALLDNQGD
MMAR_1355|M.marinum_M G--YLPEVSIAAPDLLGHGRSS-----WAAPWSIDANVSALAALLKDQAD
MUL_2524|M.ulcerans_Agy99 G--YLPEVNIAAPDLLGHGRSS-----WAAPWSIDANVSALAALLKDQAD
MAV_4150|M.avium_104 G--LLPEFAWAAPDLVGHGRSS-----WSAPWTIDANISALADLLDAQAG
TH_0447|M.thermoresistible__bu TR-HLPEIAVAAPDLIGHGRSS-----WAAPWTFEANVGALVALLEDQAD
MSMEG_1940|M.smegmatis_MC2_155 TE-HLPEVGVLAPDLIGHGRSS-----WAAPWTIDANVAALAALLDR---
Mflv_4667|M.gilvum_PYR-GCK TR-HLSDIPAVAPDLVGHGRSS-----WDAPWTIEANVAALTALLDAEAE
Mvan_1800|M.vanbaalenii_PYR-1 TR-HLPDVTALAPDLLGHGRSS-----WDAPWTIDANVAALAALVDAEAD
MAB_3517|M.abscessus_ATCC_1997 DE-YLADVPVLAPDLLGHGRSP-----ATAPWSLEAHADAVAAELDTAET
MLBr_02603|M.leprae_Br4923 HYFAAAGLATYALDLRGHGRSAGKRVLVRDLSEYNADFDILVGIATRDHP
. . * ** *****. :*. :.
Mb3228|M.bovis_AF2122/97 GPVVVVG-HSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDA
Rv3203|M.tuberculosis_H37Rv GPVVVVG-HSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDA
MMAR_1355|M.marinum_M GPVVVVG-HSFGGAVALQLAAAHPDLVAALILLDPAIGLNGSRVREVVDA
MUL_2524|M.ulcerans_Agy99 GPVVVVG-HSFGGAVALQLAAAHPDLVAALILLDPAIGLDGSRVREVVDA
MAV_4150|M.avium_104 APVLVVG-HSFGAGLAMHLAAVRPDRVAGLLLLDPAIGLDGAWMREIAEA
TH_0447|M.thermoresistible__bu GPVVVVG-HSFGGAVAMHLAAARPDLVAGLVLLDPAIGLDGEWMREIAES
MSMEG_1940|M.smegmatis_MC2_155 -PTLVVG-HSFGGALALNLSAAHPDLVSGLVLLDPAIGLDGEWMRDIADD
Mflv_4667|M.gilvum_PYR-GCK GPVVVVG-HSFGGAIALNLAAARPDLIAGLVLLDPAVGLDGRWMREIADE
Mvan_1800|M.vanbaalenii_PYR-1 GPVVVVG-HSFGGAIALNLAAVRPDLVAGLVLLDPAVALDGRWMREVADD
MAB_3517|M.abscessus_ATCC_1997 GPIVVVG-HSFGGAIALHLAARRPDLVKSLVLLDPAIGLDGDWMRQIADQ
MLBr_02603|M.leprae_Br4923 GLKRIVAGHSMGGAIVFAYGVERPDNYDLMVLSGPAVAAQD--MVSPLRA
:*. **:*..:.: .. :** ::* .**:. :. : .
Mb3228|M.bovis_AF2122/97 MLASPDYLDPAEARAEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRI
Rv3203|M.tuberculosis_H37Rv MLASPDYLDPAEARAEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRI
MMAR_1355|M.marinum_M MVAFPDYTDPAEARMERAYGAWADVDPAVLDAELDEHLITLPNGRYSWRI
MUL_2524|M.ulcerans_Agy99 MVAFPDYTDPAEARMERAYGAWADVDPAVLDAELDEHLITLPNGRYSWRI
MAV_4150|M.avium_104 MLASPDYPDAEEARLEKLHGSWSDVEPALLDAEIDEHLIELPNGRYGWRV
TH_0447|M.thermoresistible__bu MLASPDYPDREEARTEKFTGSWADVEPAELDRDLDEHLIALPGGRFGWRI
MSMEG_1940|M.smegmatis_MC2_155 MLSSPDYPDREEARLDKVNGSWGEVDPAEVERELDEHLVEVGEGRVGWRI
Mflv_4667|M.gilvum_PYR-GCK MYTSPDYTDREEARQEKIGGSWGEVAEDELDRELDEHLVASAGGRVGWRI
Mvan_1800|M.vanbaalenii_PYR-1 MYNSPDYTDREEARQEKIGGSWGEVAEDELDRELDEHLVEQTDGRVGWRI
MAB_3517|M.abscessus_ATCC_1997 MVTYPDYTDRAEAKSDKVAGAWSDVPDHVIEAELDEHLIQLSNGRCGWRM
MLBr_02603|M.leprae_Br4923 VVGKGLGLVAPGLPVHQLEVDAISRNRAVVAAYKDDPLVYHGKVPAGVGR
: .: . : *: *: .
Mb3228|M.bovis_AF2122/97 SLPAMVCYWSELARDIVLPPVGTATTLVRAVRASPAYVSDQLLAALDKRL
Rv3203|M.tuberculosis_H37Rv SLPAMVCYWSELARDIVLPPVGTATTLVRAVRASPAYVSDQLLAALDKRL
MMAR_1355|M.marinum_M SLPAMVCYWSELARDAALPPPGIATTLVRAVRADPQYVSDELIAALRERL
MUL_2524|M.ulcerans_Agy99 SLPAMVCYWSELARDAALPPPGIATTLVRAVRADPQYVSDELIAALRERL
MAV_4150|M.avium_104 CLPAMMSYWSELARDPVLPPAQTATILVRAKRTAPPYVGDELIAALQDRL
TH_0447|M.thermoresistible__bu CVPAMMAYWSELARDVVLPPSGIPTTLVRAAWTDPPYVTGELLDGLSQRL
MSMEG_1940|M.smegmatis_MC2_155 SIPAAMSYWSELARPVVLPHNPIPTVLVRAKRCRPPFVADALIDGLTDRL
Mflv_4667|M.gilvum_PYR-GCK SIPAMLCYWSELTRPAVIPRDGTPTTLVRATRTDPPYAGDELVAALDAGL
Mvan_1800|M.vanbaalenii_PYR-1 SIPATLSYWSELTRAVPVPRDGTPTTLVRATHTDPPYASDELIATLDAGL
MAB_3517|M.abscessus_ATCC_1997 NLPAAVTAWSELARDIVLPVNVIRTTLLLATRTSPPYVLPKLLDALQATL
MLBr_02603|M.leprae_Br4923 VMLQVGETMTRRAPVLTTPLLVVHGSEDRLVLVDGSHRLVECVGSTDVEL
: :. : * . : *
Mb3228|M.bovis_AF2122/97 GADFELLDFDCGHMVPQAKPTEVAAVIRSRLGPR
Rv3203|M.tuberculosis_H37Rv GADFELLDFDCGHMVPQAKPTEVAAVIRSRLGPR
MMAR_1355|M.marinum_M GADFALREFECGHMVPQAKPTEVATLIREQLKTP
MUL_2524|M.ulcerans_Agy99 GADFALREFECGHMVPQAKPTEVATLIREQLKTP
MAV_4150|M.avium_104 GSRFRLLDFDCNHMVPYAKPDDVAALARELLKAR
TH_0447|M.thermoresistible__bu GADLTLVDLDCLHMVAQAKPAETAELIRRHLG--
MSMEG_1940|M.smegmatis_MC2_155 GSKFTLLDWDCDHMVAQAKPAETAELIRRQLG--
Mflv_4667|M.gilvum_PYR-GCK GPNFTLLEWDCDHMVPLARPTETARLIRDLLP--
Mvan_1800|M.vanbaalenii_PYR-1 GASLTVLEWDCDHMVPLAKPAETAAAIRDRLV--
MAB_3517|M.abscessus_ATCC_1997 GSQFELIDIDCDHMVSQSRPAETAAAIRSHLE--
MLBr_02603|M.leprae_Br4923 KVYPGLYHEVFNEPERDQVLEDVVCWILKRL---
: . . :.. *