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SAQNTRTLPEIVVDEAGEQGGTPVLLLHGGGVAGWMWRPLIEQMGSGYRFLVPDLPGHDRSAHTDYESHD QAVDALALILQRCESRPAAVVGFSLGAQLAVLLAVRRPDLVTQVGVISAQAKPSKWPGATLALLRLTAPL AKNEWFGRAQAKELFVPPALFPDYLRTARRLSTRTLLRSVGENMRFTVPPAWAAFTGKTLVLVGERERAI MADSARNLTRDRHDGDFETIAGCGHGAPLQKPRWLAARLRAWLT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4079 | - | - | 100% (255) | putative hydrolase |
| M. smegmatis MC2 155 | MSMEG_1940 | - | 4e-09 | 39.00% (100) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_6106 | - | 3e-08 | 31.52% (165) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0046c | - | 2e-08 | 34.45% (119) | hydrolase |
| M. gilvum PYR-GCK | Mflv_0909 | - | 3e-10 | 30.71% (140) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv0045c | - | 2e-08 | 34.45% (119) | hydrolase |
| M. leprae Br4923 | MLBr_02269 | - | 8e-08 | 29.57% (115) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3517 | - | 1e-11 | 38.83% (103) | putative hydrolase, alpha/beta fold LipV |
| M. marinum M | MMAR_1355 | lipV | 3e-08 | 27.20% (261) | lipase LipV |
| M. avium 104 | MAV_5163 | - | 2e-09 | 36.54% (104) | hydrolase, alpha/beta fold family protein |
| M. thermoresistible (build 8) | TH_2963 | - | 1e-10 | 27.56% (254) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_2524 | lipV | 1e-08 | 27.20% (261) | lipase LipV |
| M. vanbaalenii PYR-1 | Mvan_1800 | - | 1e-08 | 35.14% (111) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0046c|M.bovis_AF2122/97 MLSDDELTGLDEFALLAENAEQAGVNGPLPEVERVQAGAISALRWGGSAP
Rv0045c|M.tuberculosis_H37Rv MLSDDELTGLDEFALLAENAEQAGVNGPLPEVERVQAGAISALRWGGSAP
MMAR_1355|M.marinum_M -----------------------------------MSTDLHVHRYGPEEP
MUL_2524|M.ulcerans_Agy99 -----------------------------------MSTDLHVHRYGPEEP
Mvan_1800|M.vanbaalenii_PYR-1 -----------------------------------MTDLLCTYRFGPPGP
MAB_3517|M.abscessus_ATCC_1997 -----------------------------------MTPTLNIHRYGPVEP
MSMEG_4079|M.smegmatis_MC2_155 ----------------------------MSAQNTRTLPEIVVDEAGEQGG
TH_2963|M.thermoresistible__bu -------------------------MPRFSRAGTTIDYTDTGAPAGRLEA
MAV_5163|M.avium_104 -----------------MVTMPELDGVEHRYVDLGDDVTIHVADAGPASG
MLBr_02269|M.leprae_Br4923 --------------------------------------MINLAYEDRGTG
Mflv_0909|M.gilvum_PYR-GCK -----------------------------MRTLHVGDDGWPLMGEVIGRG
Mb0046c|M.bovis_AF2122/97 -RVIFLHGGGQNAHTWD-TVIV---GLGEPALAVDLPGHGHSAWREDGNY
Rv0045c|M.tuberculosis_H37Rv -RVIFLHGGGQNAHTWD-TVIV---GLGEPALAVDLPGHGHSAWREDGNY
MMAR_1355|M.marinum_M VRVLTIHGVTEHGQSWE-YLAG--YLPEVSIAAPDLLGHGRSSWAAP--W
MUL_2524|M.ulcerans_Agy99 VRVLTIHGVTEHGQSWE-YLAG--YLPEVNIAAPDLLGHGRSSWAAP--W
Mvan_1800|M.vanbaalenii_PYR-1 ARVLAIHGLTGHGKRWE-TLFTR-HLPDVTALAPDLLGHGRSSWDAP--W
MAB_3517|M.abscessus_ATCC_1997 ARLLALHGLTGHGRRWA-PLFDE-YLADVPVLAPDLLGHGRSPATAP--W
MSMEG_4079|M.smegmatis_MC2_155 TPVLLLHGGGVAGWMWR-PLIEQ-MGSGYRFLVPDLPGHDRSAHTDY--E
TH_2963|M.thermoresistible__bu PTILFGHGLLFSGWQFN-LQIYA-LRRYYRCLAIDWRGQGASSGAAR-PY
MAV_5163|M.avium_104 PAVMLVHGFPQNWWEWR-ALIGPLAADGYRVLCPDLRGAGWSSAPRS-SY
MLBr_02269|M.leprae_Br4923 EPVVFIAGRGGAGRTWQPHQVPAFLAAGYRVITFDNRGIGATENTEG--F
Mflv_0909|M.gilvum_PYR-GCK ELIIMLHGGGPDHHSMR--PLADRLTGRYRVALPDIRGYGASRCPDPTLH
:: * * * . :
Mb0046c|M.bovis_AF2122/97 SPQLNSETLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLV
Rv0045c|M.tuberculosis_H37Rv SPQLNSETLAPVLRELAPGAEFVVGMSLGGLTAIRLAAMAPDLVGELVLV
MMAR_1355|M.marinum_M SIDANVSALAALLKDQADGPVVVVGHSFGGAVALQLAAAHPDLVAALILL
MUL_2524|M.ulcerans_Agy99 SIDANVSALAALLKDQADGPVVVVGHSFGGAVALQLAAAHPDLVAALILL
Mvan_1800|M.vanbaalenii_PYR-1 TIDANVAALAALVDAEADGPVVVVGHSFGGAIALNLAAVRPDLVAGLVLL
MAB_3517|M.abscessus_ATCC_1997 SLEAHADAVAAELDTAETGPIVVVGHSFGGAIALHLAARRPDLVKSLVLL
MSMEG_4079|M.smegmatis_MC2_155 SHDQAVDALALILQRCESRPAAVVGFSLGAQLAVLLAVRRPDLVTQVGVI
TH_2963|M.thermoresistible__bu DMDTLTEDAAHLVRSLGVAPAHYVGLSMGGFVGIRLAARHPELVRSLVLM
MAV_5163|M.avium_104 RKDEMADDLAGVLDRLGVRSVDLVAHDWGGPVAFIMMLRHPEKVTGFFGV
MLBr_02269|M.leprae_Br4923 TTQTMVADTAVLIESLGAVPARIVGVSMGSFIAQELMVARPELVRAAVLM
Mflv_0909|M.gilvum_PYR-GCK RWDQYVTDTLAIMHALDATSAHLVGAGLGGTIALRTCLQHPQIARSAVII
: : . *. . *. . *: . :
Mb0046c|M.bovis_AF2122/97 DVTPSALQRHAELTAEQR------GTVALMHGEREFPSFQAMLDLTIAAA
Rv0045c|M.tuberculosis_H37Rv DVTPSALQRHAELTAEQR------GTVALMHGEREFPSFQAMLDLTIAAA
MMAR_1355|M.marinum_M DPAIGLNGSRVREVVDAM------VAFPDYTDPA-----EARMERAYGAW
MUL_2524|M.ulcerans_Agy99 DPAIGLDGSRVREVVDAM------VAFPDYTDPA-----EARMERAYGAW
Mvan_1800|M.vanbaalenii_PYR-1 DPAVALDGRWMREVADDM------YNSPDYTDRE-----EARQEKIGGSW
MAB_3517|M.abscessus_ATCC_1997 DPAIGLDGDWMRQIADQM------VTYPDYTDRA-----EAKSDKVAGAW
MSMEG_4079|M.smegmatis_MC2_155 SAQAKPSKWPGATLALLR------LTAPLAKNEWFG---RAQAKELFVPP
TH_2963|M.thermoresistible__bu NTSAGPEDPAKADRYRTM------ARIYRFTGIG---PLRRAVLPLMFGP
MAV_5163|M.avium_104 NTSAPFVKRSLSTIRNVWRFWYQIPISLPVIGPRVISTPDSRFVRLLGSW
MLBr_02269|M.leprae_Br4923 ATRGRLDRTRQFFHAAEA----------EFHDSGIQLPSGYNAKVRLLEN
Mflv_0909|M.gilvum_PYR-GCK SAEAIEDDEDKAADAELMG---------RFADRA-------RSRGLQAAW
.
Mb0046c|M.bovis_AF2122/97 PHRDVKSLRRGVFHNSRRLDN---GNWVWRYDAIRTFGDFAGLWDDVDAL
Rv0045c|M.tuberculosis_H37Rv PHRDVKSLRRGVFHNSRRLDN---GNWVWRYDAIRTFGDFAGLWDDVDAL
MMAR_1355|M.marinum_M ADVDPAVLDAELDEHLITLPN---GRYSWRISLPAMVCYWSELARDAALP
MUL_2524|M.ulcerans_Agy99 ADVDPAVLDAELDEHLITLPN---GRYSWRISLPAMVCYWSELARDAALP
Mvan_1800|M.vanbaalenii_PYR-1 GEVAEDELDRELDEHLVEQTD---GRVGWRISIPATLSYWSELTRAVPVP
MAB_3517|M.abscessus_ATCC_1997 SDVPDHVIEAELDEHLIQLSN---GRCGWRMNLPAAVTAWSELARDIVLP
MSMEG_4079|M.smegmatis_MC2_155 ALFPDYLRTARRLSTRTLLRS---VGENMRFTVPPAWAAFTG--------
TH_2963|M.thermoresistible__bu AFLADPDSEDVIDEWERRLRR---YPRSSVRDAVLAVANRAGVEDELAAI
MAV_5163|M.avium_104 VGGGYTLPEEDVRLYLECMRQPGHAEAGSRWYRSFQTREMLSWMRGEYDG
MLBr_02269|M.leprae_Br4923 LSRKTLNDDVAVADWIAMFNMWP----IKSTPGLRCQTDVAPQNNRLPAY
Mflv_0909|M.gilvum_PYR-GCK ELFVPYLQPLIANLVTEAIPR-----ADAQSAAAAAAIGHDRAFATIEEL
Mb0046c|M.bovis_AF2122/97 S--APITLVRGGSSG--FVTDQDTAELHRRATHFRGVHIVEKSGHSVQSD
Rv0045c|M.tuberculosis_H37Rv S--APITLVRGGSSG--FVTDQDTAELHRRATHFRGVHIVEKSGHSVQSD
MMAR_1355|M.marinum_M PPGIATTLVRAVRADPQYVSDELIAALRERLGADFALREFE-CGHMVPQA
MUL_2524|M.ulcerans_Agy99 PPGIATTLVRAVRADPQYVSDELIAALRERLGADFALREFE-CGHMVPQA
Mvan_1800|M.vanbaalenii_PYR-1 RDGTPTTLVRATHTDPPYASDELIATLDAGLGASLTVLEWD-CDHMVPLA
MAB_3517|M.abscessus_ATCC_1997 VNVIRTTLLLATRTSPPYVLPKLLDALQATLGSQFELIDID-CDHMVSQS
MSMEG_4079|M.smegmatis_MC2_155 -----KTLVLVGERERAIMADSARNLTRDRHDGDFET--IAGCGHGAPLQ
TH_2963|M.thermoresistible__bu D---VPTLVIGGAQDAATPPAHAQALAAGIRGARLEI--IDDCGHSSPLE
MAV_5163|M.avium_104 ARVHVPVRWLSGTEDPVLTPDLLDGYAERIDDFQLEL--VDGVGHWIVDQ
MLBr_02269|M.leprae_Br4923 RSIAAPVLVIGFAEDVVTPPSLGREVADVLPNGRYLQ--IPDAGHLGFFE
Mflv_0909|M.gilvum_PYR-GCK RRVNAPTLVIAGNDPR-HPTQLARTLADTLPHGVLAKATMS-DLLVDADD
.
Mb0046c|M.bovis_AF2122/97 QPRALIEIVRGVLDTR-----
Rv0045c|M.tuberculosis_H37Rv QPRALIEIVRGVLDTR-----
MMAR_1355|M.marinum_M KPTEVATLIREQLKTP-----
MUL_2524|M.ulcerans_Agy99 KPTEVATLIREQLKTP-----
Mvan_1800|M.vanbaalenii_PYR-1 KPAETAAAIRDRLV-------
MAB_3517|M.abscessus_ATCC_1997 RPAETAAAIRSHLE-------
MSMEG_4079|M.smegmatis_MC2_155 KPRWLAARLRAWLT-------
TH_2963|M.thermoresistible__bu RPDVVTELLRGFLLEHT----
MAV_5163|M.avium_104 RPDLVLDRVRAFLRRET----
MLBr_02269|M.leprae_Br4923 RPEAVNAAALQFFAGVKGEWP
Mflv_0909|M.gilvum_PYR-GCK IAQAFGPAIEQFLATTSDPDA
. :