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APSPSRDLDLRKLRYFVAVAEELNFGRAAQRLHIAQPVLSRQIRAFENELGVQLFVRGSNGTQLSAAGAQ LLQDAKVLLDDAKALQQRLFQAASPSRTVTVGVMPGLRATAAAAAFGAAGPGRRAIVRQVSWAEQVEAVR SGDVDVVYAREVDGNTPGLGSAPLLQEQYFAVLPADDPLATRPSLTMDDLADRLLLQDPAILAEVRRTAA PGQRWAPPPTAVHTVEDKLEHVAAREGFVVMPRSTTDFYRRPDVRAVPVEGLPPNRVTLIWNAATDNPVR DEFITAALACRDETV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1561 | - | - | 100% (296) | LysR-family protein trancsriptional regulator |
| M. smegmatis MC2 155 | MSMEG_6125 | - | 5e-26 | 32.11% (299) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_1895 | - | 2e-21 | 36.41% (195) | HTH-type transcriptional regulator AlsR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 8e-16 | 31.76% (170) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_1356 | - | 2e-20 | 31.31% (313) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 8e-16 | 31.76% (170) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02663 | oxyS | 4e-15 | 32.35% (170) | putative LysR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0993c | - | 2e-34 | 36.33% (278) | LysR family transcriptional regulator |
| M. marinum M | MMAR_0317 | oxyS | 5e-14 | 31.98% (172) | oxidative stress response regulatory protein OxyS |
| M. avium 104 | MAV_5191 | - | 2e-15 | 31.76% (170) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 8e-19 | 32.64% (239) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_4805 | oxyS | 2e-12 | 31.40% (172) | oxidative stress response regulatory protein OxyS |
| M. vanbaalenii PYR-1 | Mvan_1027 | - | 1e-26 | 34.03% (288) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0317|M.marinum_M MKLLGAPKINPELTLAQIPGSDSLVVIPIPRTSGLARRAAPAVQPRCGVT
MUL_4805|M.ulcerans_Agy99 --------------------------------------------------
Mb0121|M.bovis_AF2122/97 --------------------------------------------------
Rv0117|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02663|M.leprae_Br4923 --------------------------------------------------
MAV_5191|M.avium_104 --------------------------------------------------
MSMEG_1561|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0993c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_1356|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1027|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3504|M.thermoresistible__bu --------------------------------------------------
MMAR_0317|M.marinum_M RTAQWRADLVATVQDLAAQSGTGGRQRSGGGGSLSESVPMTEEVSVLFRQ
MUL_4805|M.ulcerans_Agy99 ---------------------------------------------MLFRQ
Mb0121|M.bovis_AF2122/97 ---------------------------------------------MLFRQ
Rv0117|M.tuberculosis_H37Rv ---------------------------------------------MLFRQ
MLBr_02663|M.leprae_Br4923 ---------------------------------------------MLFRQ
MAV_5191|M.avium_104 ---------------------------------------------MLFRQ
MSMEG_1561|M.smegmatis_MC2_155 -------------------------------------MAPSPSRDLDLRK
MAB_0993c|M.abscessus_ATCC_199 -------------------------------------MAETAPLDLDLRL
Mflv_1356|M.gilvum_PYR-GCK -------------------MVSAVTGRPTNDPPHTWRHRTIKEPPMELRH
Mvan_1027|M.vanbaalenii_PYR-1 --------------------------------------------MFSLAR
TH_3504|M.thermoresistible__bu ----------------------------------------VPSPKIDLRR
. :
MMAR_0317|M.marinum_M LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MUL_4805|M.ulcerans_Agy99 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELHVTLINRGHSFE
Mb0121|M.bovis_AF2122/97 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
Rv0117|M.tuberculosis_H37Rv LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MLBr_02663|M.leprae_Br4923 LEYFVAVAQERHFARAAERCYVSQPALSSAIAKLERELNVTLINRGHSFE
MAV_5191|M.avium_104 LEYFVAVASERHFARAAEKCFVSQPALSAAIAKLEKELNVTLINRGHSFE
MSMEG_1561|M.smegmatis_MC2_155 LRYFVAVAEELNFGRAAQRLHIAQPVLSRQIRAFENELGVQLFVRGSNGT
MAB_0993c|M.abscessus_ATCC_199 VRYFTVVAEQRHFGRASTELRVAQPSLSRQISRLEQQLGVRLLDRTPQGT
Mflv_1356|M.gilvum_PYR-GCK LRYFLAVAETCHFGQAAEQLHIAQPALSYAIRQLENSLDATLFTRTTRHV
Mvan_1027|M.vanbaalenii_PYR-1 LSCFVAVAEELHFGRAAERLHMTQPPLSRQVQQLENELGVQLIDRTTRNV
TH_3504|M.thermoresistible__bu LAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDVGADLFTRDGRRI
: * .**. * :*: ::* ** : :*..: . *: *
MMAR_0317|M.marinum_M GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVPSASTTA
MUL_4805|M.ulcerans_Agy99 GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVRSASTTA
Mb0121|M.bovis_AF2122/97 GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTTA
Rv0117|M.tuberculosis_H37Rv GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTTA
MLBr_02663|M.leprae_Br4923 GLTPEGERLVVWAKRILAEHDAFKAEVHAVRSGITGTLRLGTVPTASTTA
MAV_5191|M.avium_104 GLTPEGERLVVWARRILAEHDAFKAEVDAVRSGVTGTLRLGTVPTASTTA
MSMEG_1561|M.smegmatis_MC2_155 QLSAAGAQLLQDAKVLLDDAKALQQRLFQAASPSRTVTVGVMPGLRATAA
MAB_0993c|M.abscessus_ATCC_199 TLTEAGEVFLPKAKTLLRSADQAAAHARAAAQPS-HLTVGYSMGIIVTPA
Mflv_1356|M.gilvum_PYR-GCK ALTPAGEFLRVEATRILNGVDAAQRGVRRIAAGRSGLLRLGLTGTAAFSH
Mvan_1027|M.vanbaalenii_PYR-1 TLTPAGAAFLPDARRILQLAEGAAQTVKRIPAGDLGTVVVGFTAASAHAV
TH_3504|M.thermoresistible__bu SLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHYVIGHTPALSGAE
*: * : . :: .
MMAR_0317|M.marinum_M SLVLSDFCS-AHPLVKAQICSRLAVTELYRRLRDFELDAAIVYTSSDDGH
MUL_4805|M.ulcerans_Agy99 SLVLSDFCS-AHPLVKAQICSRLAVTELYRRLRDFERDAAIVYTSSDDGH
Mb0121|M.bovis_AF2122/97 SLVLSAFCS-AHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQDSD
Rv0117|M.tuberculosis_H37Rv SLVLSAFCS-AHPLAKVQVCSRLAATELYRRLREFELDAVIVHPETQDSD
MLBr_02663|M.leprae_Br4923 SLVLSAFCS-EHPLIKVQICSRLPVTELHRRLGDFELDAVIVHSAPDDTH
MAV_5191|M.avium_104 SLLLSAFCS-AHPLVKVQILSRLSAGELYRRLREFELDAAIAHTAPDDIP
MSMEG_1561|M.smegmatis_MC2_155 AAAFGAAG----PGRRAIVR-QVSWAEQVEAVRSGDVDVVYAREVDGNTP
MAB_0993c|M.abscessus_ATCC_199 VLQMRQKH----PDADIRAT-HLKWDEARAALLDHRVDAVVAR-LPFSTD
Mflv_1356|M.gilvum_PYR-GCK LPKIARIVRQELPAVALDIHADLLTPDQCEGLRTGALDVGVLR-PPAVGG
Mvan_1027|M.vanbaalenii_PYR-1 LPRLLERARERLPDVKLDLR-EMVTAAQIEGLMTGELDLGMAR-PPLKRP
TH_3504|M.thermoresistible__bu AYALIEPAVTAYPSTSFTLR-QLYPDALTDAVFDGTVQLGLRR-GVVPTP
: * : : :
MMAR_0317|M.marinum_M DVDLVPLYEERYVLLAPPEMLPPGVS---TLSWLDAAQLPLALLSSDMRD
MUL_4805|M.ulcerans_Agy99 DVDLVPLYEERYVLLAPPEMLPPGVS---TLSWLDAAQLPLALLSSDMRD
Mb0121|M.bovis_AF2122/97 DVDLVPLYEEQYVLLSPADMLPPGTS---TLVWRDAAQLPLALLTADMRD
Rv0117|M.tuberculosis_H37Rv DVDLVPLYEEQYVLLSPADMLPPGTS---TLVWRDAAQLPLALLTADMRD
MLBr_02663|M.leprae_Br4923 AVDLVPLYHEHYVLVSPADMLPPGAS---VLAWPEASQLPLALLTPDMRD
MAV_5191|M.avium_104 DVNLVPVYRERYVLLAPADLLASGAA---TMTWVQAAQLPLALLTPDMRD
MSMEG_1561|M.smegmatis_MC2_155 GLGSAPLLQEQYFAVLPADDPLATRP-SLTMDDLA----DRLLLQDPAIL
MAB_0993c|M.abscessus_ATCC_199 QLHVTILYDEPRVVLLPSDHPLAQHD-SLTLADIANEPMPRIRNADPSWS
Mflv_1356|M.gilvum_PYR-GCK DVATRTIAAEPLVLAVSADHRLAAEP-VVSLADLRSEPFIGYT-GQDSAV
Mvan_1027|M.vanbaalenii_PYR-1 GLVSRPLLHEQLLAALPEGHPLADMTRELTLIDLDGQDFVMYSPVQARYF
TH_3504|M.thermoresistible__bu ELATAVIGYHRVRVAFVDSHPLAARES-VDITELAREQVALWAPPGTSYY
: : . . :
MMAR_0317|M.marinum_M RQIIDAAFADHAITVSPQVETDSVASLFAQVATGNSASIVPHTWLWTT--
MUL_4805|M.ulcerans_Agy99 RQIIDAAFADHAITVSPQVETDSVASLFAQVATGNSASIVPHTWLWTT--
Mb0121|M.bovis_AF2122/97 RQVIDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWAMPM
Rv0117|M.tuberculosis_H37Rv RQVIDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWAMPM
MLBr_02663|M.leprae_Br4923 RQLIDRAFAGHAITATPQVETDSVASLFAQVATGNWACIVPHTWLWTT--
MAV_5191|M.avium_104 RQIIDRAFADHGITLHPQVETDSVASLFAQASAGSWASIVPHTWLWAS--
MSMEG_1561|M.smegmatis_MC2_155 AEVRRTAAPGQRWAPP-PTAVHTVEDKLEHVAAREGFVVMPRSTTDFYRR
MAB_0993c|M.abscessus_ATCC_199 AYWRVEPRPDGSLAPD-GPVIDAIEDKFEVIASGQAISLSAGAHGSTMR-
Mflv_1356|M.gilvum_PYR-GCK NDAVTRSCRAAGFVPHREHSAPGTAVLLALVAADLGVSVVPASVRALPLH
Mvan_1027|M.vanbaalenii_PYR-1 NELLISTFTIAGTTPRYVQYVTQVHTMLVLVRSGIGIALVPASAATLHPE
TH_3504|M.thermoresistible__bu SDFLMGACRRAGFEPDYVVSRVQGAATVAAPLTTGGIAFVTAAAGPTMNG
. . : . . :
MMAR_0317|M.marinum_M --PAGGEIRPVQLVSPVVKAQVALATSSTGPGSPVARALMTSAQGLALDE
MUL_4805|M.ulcerans_Agy99 --PGR---------------------------------------------
Mb0121|M.bovis_AF2122/97 SGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQALALNE
Rv0117|M.tuberculosis_H37Rv SGPTGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQALALNE
MLBr_02663|M.leprae_Br4923 --PIGAEIRAVEMVDPVLKADVALATNSAGPGSPVARALVASAKQLALNE
MAV_5191|M.avium_104 --PLGPGIRAVELVDPVLTADVVLAIKSHGPGSPIARALAASAGRLQLND
MSMEG_1561|M.smegmatis_MC2_155 -----PDVRAVPVEGLPP-NRVTLIWNAATDNPVRDEFITAALACRDETV
MAB_0993c|M.abscessus_ATCC_199 -----PDIVAVPLEGVEP-SHVAIATRADDRGRLVAAFRKVAQAVLTGPG
Mflv_1356|M.gilvum_PYR-GCK ----GVVFRDL--VDGGT-VDLALAWRDGVDNPVVDAVVAVLAGALTSLD
Mvan_1027|M.vanbaalenii_PYR-1 ----GVVFRTIGAFRERP-VELDAVWRGDSTNP---ALLRVLKDVLPQQE
TH_3504|M.thermoresistible__bu -------RVQVVDLTPPLLVPVQALWQRHTLSAIRDRILEGLG-------
MMAR_0317|M.marinum_M FFQTRLMEISRRR
MUL_4805|M.ulcerans_Agy99 -------------
Mb0121|M.bovis_AF2122/97 FFDTQLRGITRRR
Rv0117|M.tuberculosis_H37Rv FFDTQLRGITRRR
MLBr_02663|M.leprae_Br4923 FFEAQLAGITRRR
MAV_5191|M.avium_104 FFDAQLLGVTRRR
MSMEG_1561|M.smegmatis_MC2_155 -------------
MAB_0993c|M.abscessus_ATCC_199 -------------
Mflv_1356|M.gilvum_PYR-GCK HPALQEQS-----
Mvan_1027|M.vanbaalenii_PYR-1 WTT----------
TH_3504|M.thermoresistible__bu -------------