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MAFAGLDVGTTSSKAVVYDGEGTVLGTGRAPMHWDTGSFGTQTDSERLCRSAFDALNAAAQAAGVPVQAV GVTSMGESGVLVDAQGQSLTPVIAWHDDRDGAEVADLVATIGPDTFGGVAGKPLRGQWSLTKHRWLLTHD PAARAAVRRFDVAGWVVHRLGGDPALEMSLAGRTGWFDIAAGDWWDDALAWSGATRSLMPPVVPAGAPVG MITSDDVNLLLRNAVLTFAGHDHQASALGARATGPGHELDSSGTAEALVRTIDALPSRGDVARLAEAGIT TDPSVEAGHWSLLGGTEGGLAQQRAMERLGMDLAELDRAAESPGSEAGAQWRAVVEKAADEALTLHRAMD EVVGPAARVVVTGGWRHSSEVMRAKRSRFANLEVSAVEEAGALGAATLAARACGAIGPHEHLGVT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1376 | - | - | 100% (415) | putative xylulose kinase |
| M. smegmatis MC2 155 | MSMEG_3257 | xylB | 5e-16 | 29.14% (453) | xylulokinase |
| M. smegmatis MC2 155 | MSMEG_6756 | glpK | 4e-15 | 26.62% (293) | glycerol kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0750 | xylB | 1e-09 | 26.23% (427) | D-xylulose kinase XylB |
| M. gilvum PYR-GCK | Mflv_2650 | - | 1e-17 | 28.19% (454) | carbohydrate kinase, FGGY |
| M. tuberculosis H37Rv | Rv0729 | xylB | 4e-09 | 26.53% (426) | D-xylulose kinase XylB |
| M. leprae Br4923 | MLBr_02314 | glpK | 3e-08 | 22.12% (339) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 1e-09 | 24.64% (276) | glycerol kinase |
| M. marinum M | MMAR_1066 | xylB | 2e-13 | 26.34% (429) | D-xylulose-kinase (xylulokinase), XylB |
| M. avium 104 | MAV_4437 | - | 4e-13 | 27.25% (433) | carbohydrate kinase, FGGY family protein |
| M. thermoresistible (build 8) | TH_0046 | xylB | 9e-14 | 29.59% (338) | xylulokinase |
| M. ulcerans Agy99 | MUL_0824 | xylB | 1e-12 | 25.87% (429) | D-xylulose-kinase (xylulokinase), XylB |
| M. vanbaalenii PYR-1 | Mvan_3929 | - | 1e-20 | 27.78% (450) | carbohydrate kinase, FGGY |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0750|M.bovis_AF2122/97 -MSRDDVTIGIDIGTTAVKAVAADDNG---RVTARVRIGHQLAVPAPDRL
Rv0729|M.tuberculosis_H37Rv -MSRDDVTIGIDIGTTAVKAVAADDNG---RVTARVRIGHQLAVPAPDRL
MMAR_1066|M.marinum_M -MSREDATIGIDIGTTAVKAVVADADG---NVTARLRIPHQLRVGAPDQL
MUL_0824|M.ulcerans_Agy99 -MSREDATIGIDIGTTAVKALVADADG---NVTARLRIPHQLRVGAPDQL
MAV_4437|M.avium_104 -MSRKDVTIGIDVGSTAVKALAADADG---RVMARVRIPHELRIPAPDRL
Mflv_2650|M.gilvum_PYR-GCK ----MHHILAIDQGTSGTKAVVDIRDGTAGRVLATAEVSLRPDYLPGGGV
Mvan_3929|M.vanbaalenii_PYR-1 ----MHHILAIDQGTSGTKAVV--VDG-AGRVLATAEVSLRPAYLAGGGV
MLBr_02314|M.leprae_Br4923 MAEFAEFIAAIDQGTTSTRCVIFDHNG---AEVARHQLEHEQILPRSGWV
MAB_0382|M.abscessus_ATCC_1997 ---MADFVASIDQGTTSTRAMIFNHRG---EEVGRHQLEHQQLLPRAGWV
TH_0046|M.thermoresistible__bu ----MTLVAGIDSSTQSCKVLICDADT--------GAVVREGRAAHPDGT
MSMEG_1376|M.smegmatis_MC2_155 -----MAFAGLDVGTTSSKAVVYDGEG---TVLGTGRAPMHWDTGSFG-T
.:* .: . : : . .
Mb0750|M.bovis_AF2122/97 EHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAVD-PAGR
Rv0729|M.tuberculosis_H37Rv EHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAVD-PAGR
MMAR_1066|M.marinum_M EHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAVD-SGGV
MUL_0824|M.ulcerans_Agy99 EHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAVD-SGGV
MAV_4437|M.avium_104 EHDAEAAWRRGPSAALDELLHQ----PGVAAVAVAAMVPSMTAVD-DSGT
Mflv_2650|M.gilvum_PYR-GCK EQDPEALFA---SVVTAGRQALQQAGVPVAAVALANQGETVLAWDRHTGT
Mvan_3929|M.vanbaalenii_PYR-1 EQDPEALFD---SVVTAGRRALAQADVPVAAVALANQGETVLAWDRATGR
MLBr_02314|M.leprae_Br4923 EHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETTLVWNRNTGR
MAB_0382|M.abscessus_ATCC_1997 EHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETTLVWNRHTGR
TH_0046|M.thermoresistible__bu EIDP-AFWESAAHDAVRAAGG----LDDVAAVAVGAQQHGMVCLD-EAGK
MSMEG_1376|M.smegmatis_MC2_155 QTDSERLCRSAFDALNAAAQAAG---VPVQAVGVTSMGESGVLVD-AQGQ
: :. *:.: : *
Mb0750|M.bovis_AF2122/97 PITPGLLYGDARGR-VPNASVARAQSVPSVG----------ETAEFLRWT
Rv0729|M.tuberculosis_H37Rv PITPGLLYGDARGR-VPNASVARAQSVPSVG----------ETAEFLRWT
MMAR_1066|M.marinum_M PITPGLLYGDSRGW-VPGAANQRAQPLPSVG----------EAAQFLRWT
MUL_0824|M.ulcerans_Agy99 PITPGLLYGDSRGW-VPGAANQRAQPLPSVG----------EAAQFLRWT
MAV_4437|M.avium_104 PITPGLLYGDGRGR-TPGGPQN--QPLPALG----------EAAEFLRWT
Mflv_2650|M.gilvum_PYR-GCK PLTPAIVWQDRRAE-TLCAALAEH--ATTVAGRTGLVLDPYFSAPKMAWI
Mvan_3929|M.vanbaalenii_PYR-1 ALTPAVVWQDRRAE-SLCAAVADR--AEEVARRTGLVLDPYFSAPKMAWI
MLBr_02314|M.leprae_Br4923 PYCNAIVWQDTRTD-RIAVALDRDGRGEVIRRKAGLPPATYFSGGKLQWI
MAB_0382|M.abscessus_ATCC_1997 PYCNAIVWQDTRTD-KIAAALDRDGRGDIIRRKAGLPPATYFSGGKLQWI
TH_0046|M.thermoresistible__bu VVRDALLWNDVRSAGAAAALVDELGGPQAWAEAVGVVPLAAITVAKLRWL
MSMEG_1376|M.smegmatis_MC2_155 SLTPVIAWHDDRDG-AEVADLVATIGPDTFGGVAGKPLRGQWSLTKHRWL
: : * * : *
Mb0750|M.bovis_AF2122/97 AGQAP-------------DASGYWPAPAVANYALSGEAVIDYATAVTTLP
Rv0729|M.tuberculosis_H37Rv AGQAL-------------DASGYWPAPAVANYALSGEAVIDYATAVTTLP
MMAR_1066|M.marinum_M AAQAP-------------EAAGYWPAAAVANYAMSGEPVIDFATAITSLP
MUL_0824|M.ulcerans_Agy99 AAQAP-------------EAAGYWPAAAVANYAMSGEPVIDFATAITSLP
MAV_4437|M.avium_104 AARAP-------------GAAGYWPAPAVANHALAGQAVIDVATAATAFP
Mflv_2650|M.gilvum_PYR-GCK RANLT--------RDGVVTTTDTWLVHRLCG-----AFVTDASTASRSLL
Mvan_3929|M.vanbaalenii_PYR-1 RSHLT--------RAGVVTTTDTWLVHRLCG-----AFVTDASTASRSLL
MLBr_02314|M.leprae_Br4923 LENVDGVGAAAENGEALFGTPDTWLLWNLTGGPRGGVHVTDVTNASRTML
MAB_0382|M.abscessus_ATCC_1997 LENVEGVRRDAENGDALFGTPDSWVIWNLTGGVRSGVHVTDVTNASRTML
TH_0046|M.thermoresistible__bu ADHEP----QHADRTAAVCLPHDWLTWRLRGSTDIAELTTDRSDASGTGY
MSMEG_1376|M.smegmatis_MC2_155 LTHDP----------AARAAVRRFDVAGWVVHRLGGDPALEMSLAGRTGW
. : . : : * :
Mb0750|M.bovis_AF2122/97 LFDGTG----WNATACAD-CGVTVDRMPRVETFG-------VGVGQVRGT
Rv0729|M.tuberculosis_H37Rv LFDGTG----WNATACAD-CGVTVDRMPRVETFG-------VGVGQVRGT
MMAR_1066|M.marinum_M LFDGTG----WNPQACAD-CGASADRMPRVETFG-------TAVGQVHGA
MUL_0824|M.ulcerans_Agy99 LFDGTG----WNPQACAD-CGASADRMPRVETFG-------TAVGQVHGT
MAV_4437|M.avium_104 LFDGTG----WDAAACAE-RGARVEQMPRVHSMG-------AVVGQLPG-
Mflv_2650|M.gilvum_PYR-GCK TSLDDSRGQRWDPDLRAL-FGLDAEEMPEIVASD-----EIVGTTDVFGT
Mvan_3929|M.vanbaalenii_PYR-1 ISLDS---AQWDQDLLTL-FGLDDEAMPEIVGSD-----EIVGTTDVFGP
MLBr_02314|M.leprae_Br4923 MDLEK---LDWDDELLSF-FSIPRAMLPAIASSSPLQPYGVTLADGPVGG
MAB_0382|M.abscessus_ATCC_1997 MNLET---LDWDDELLSF-FSIPRQMLPPIKASSPVEPFGFTTQLGPLGG
TH_0046|M.thermoresistible__bu YDASGD---DYRLDLLELGLRGRRPHLPAVLGPS----------DATRGG
MSMEG_1376|M.smegmatis_MC2_155 FDIAAG---DWWDDALAW-SGATRSLMPPVVPAGAPVGMITSDDVNLLLR
: :* : .
Mb0750|M.bovis_AF2122/97 GAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTISAA--RQVPG
Rv0729|M.tuberculosis_H37Rv GAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTISAA--RQVPG
MMAR_1066|M.marinum_M DAVLGAGGIDAVCEQIVAGADHHGDVLVLCGTTLIVWTTISGS--RQVPG
MUL_0824|M.ulcerans_Agy99 DAVLGAGGIDAVCEQIVAGADHHGDVLVLCGTTLIVWTTISGS--RQVPG
MAV_4437|M.avium_104 GAALATGAIDALCEQLVAGADRDGDVLVMCGTTLIVWATISQA--RQMPG
Mflv_2650|M.gilvum_PYR-GCK TLPVAGLIVDQQAALFAESCLHAGSAKCTYGTGAFLLAQLGTEPVRSSSG
Mvan_3929|M.vanbaalenii_PYR-1 TLPVAGLIVDQQAALLAESCLEAGSAKCTYGTGAFLLAQLGSEPVRSTSG
MLBr_02314|M.leprae_Br4923 EVPITGVLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEAIVRSGNG
MAB_0382|M.abscessus_ATCC_1997 EVPIAGDLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEELVHSSNG
TH_0046|M.thermoresistible__bu DRVFGAGLGDNAAAALGLAAE-PGDVIVSVGTSGVVSAVATAP-VRDGTG
MSMEG_1376|M.smegmatis_MC2_155 NAVLTFAGHDHQASALGARATGPGHELDSSGTAEALVRTIDALPSRGDVA
. * . . . * *: : : .
Mb0750|M.bovis_AF2122/97 LWTIPHTAPGK----SQIGGASNAGGLFLNWVDRVIGPGD----PALADP
Rv0729|M.tuberculosis_H37Rv LWTIPHTAPGK----SQIGGASNAGGLFLNWVDRVIGPGD----PALADP
MMAR_1066|M.marinum_M LWTIPHTAPGK----SQIGGASNAGGLFLSWVDRLIGPADRDGEQDRVDP
MUL_0824|M.ulcerans_Agy99 LWTIPHTAPGK----SQIGGASNAGGLFLSWVDRVTGPADRDGEQDRVDP
MAV_4437|M.avium_104 LWTIPHTTPGK----SQIGGASNAGGLFLGWVDRVVAQAD----PASAQP
Mflv_2650|M.gilvum_PYR-GCK LTTSVAWRLRG-QTSYCIDGQVYTAASAIRWA-VDLGLIPSADQIDSAAA
Mvan_3929|M.vanbaalenii_PYR-1 LTTSVAWRLRG-ATSYCIDGQVYTAASAVRWA-VELGLVPAADQIDSAAA
MLBr_02314|M.leprae_Br4923 LLTTVCYQFGDAKPVYALEGSIAVTGSAVQWLRDQLGIISGAAQSESLAR
MAB_0382|M.abscessus_ATCC_1997 LLTTVCYQFGDNKPVYALEGSIAVTGSAVQWLRDQLGIISGASQSEDLAR
TH_0046|M.thermoresistible__bu FVAGFADGTGR-----HLPLVCTLNGARVLDAAAAMLQVDHAELSRLALS
MSMEG_1376|M.smegmatis_MC2_155 RLAEAGITTDP--------SVEAGHWSLLGGTEGGLAQQR----------
: :
Mb0750|M.bovis_AF2122/97 RRVP----VWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-ASVRRAAYEA
Rv0729|M.tuberculosis_H37Rv RRVP----VWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-ASVRRAAYEA
MMAR_1066|M.marinum_M RRVP----IWLPYIRGERTPFHDPDRRASLEGLDLTQGA-AAVRRAAYEA
MUL_0824|M.ulcerans_Agy99 RRVP----IWLPYIRGERTPFHDPDRRASLEGLDLTQGA-AAVRRAAYEV
MAV_4437|M.avium_104 GRVP----VFAPYLRGERSPFHDPDRRGVLEALDLTHDA-AALRRAAYEA
Mflv_2650|M.gilvum_PYR-GCK ESSD--GVVCVPALAGLAAPWWDSAATASLSGMTLSTGR-GQLVRAMVEG
Mvan_3929|M.vanbaalenii_PYR-1 ESSD--GVLCVPALAGLAAPWWDSAATASFSGMTLSSGR-GQLVRALVEG
MLBr_02314|M.leprae_Br4923 QVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNTN-AHLARATLEA
MAB_0382|M.abscessus_ATCC_1997 QVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTN-AHLARATLEA
TH_0046|M.thermoresistible__bu APPGSEGLVLVPYLEGERTPNR-PNASGALHGLRVSNATPANLARAAVEG
MSMEG_1376|M.smegmatis_MC2_155 ------------AMERLGMDLAELDRAAESPGSEAGAQWRAVVEKAADEA
: . . . : :* *
Mb0750|M.bovis_AF2122/97 SGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAIADATGRPVEVS
Rv0729|M.tuberculosis_H37Rv SGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAIADATGRPVEVS
MMAR_1066|M.marinum_M SGFVVRHLVELS----GAPVLRIVASGGGTCVQPWMQAIADVTGRPVHVS
MUL_0824|M.ulcerans_Agy99 SGFVVRHLVELS----GAPVLRIVASGGGTCVRPWMQAIADVTGRPVHVS
MAV_4437|M.avium_104 SGFVVRQLIELS----GAPVSRIVATGGGTRVGPWLQAIADATGHPVEVS
Mflv_2650|M.gilvum_PYR-GCK IAAQVAALTDLVSADLGRPLTRLRVDGGLTRSEALMQAQADLSQIPVDVY
Mvan_3929|M.vanbaalenii_PYR-1 IAAQVTALTDLVSADLGRPLTRLRVDGGLTRSTALMQAQADLARMPVDVY
MLBr_02314|M.leprae_Br4923 ICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQADVLGVDVVRS
MAB_0382|M.abscessus_ATCC_1997 ICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQADTLGVDVVKP
TH_0046|M.thermoresistible__bu LLCALADGIAHLTG-HGIPLRRVLLIGGAARSEAVRAIAPQVFGVPVLVP
MSMEG_1376|M.smegmatis_MC2_155 LTLHRAMDEVVG------PAARVVVTGGWRHSSEVMRAKRSRFAN-LEVS
: ** . :
Mb0750|M.bovis_AF2122/97 RVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEP--SADWAGPTK
Rv0729|M.tuberculosis_H37Rv RVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEP--SADWAGPTK
MMAR_1066|M.marinum_M DVAEGAALGAAFLARMAAGLESSIADADRWARTDRIVEP--RPDWVGPTK
MUL_0824|M.ulcerans_Agy99 AVAEGAALGAAFLARMAAGLES----------------------------
MAV_4437|M.avium_104 AVAEGAALGAAFLARMAAGLETTLTDAARWVRTERVVEP--DPAWAAPVQ
Mflv_2650|M.gilvum_PYR-GCK PSLHATALGAAACARLALEPGLSPADAAGTWSPRRTYEPHWSADRAADFL
Mvan_3929|M.vanbaalenii_PYR-1 PSLHATALGAAACARLALEPGTSAADAVGTWFPHHTYEPRWSADRAADFL
MLBr_02314|M.leprae_Br4923 VVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTPTWGEDQRAAAY
MAB_0382|M.abscessus_ATCC_1997 VVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSSSITDEKRAEGF
TH_0046|M.thermoresistible__bu DPAEYVALGAARQAAWALRGTPEPP----SWQPPR--TDRYEADPVPAVR
MSMEG_1376|M.smegmatis_MC2_155 AVEEAGALGAATLAARACGAIGPHEHLGVT--------------------
. ***:* . *
Mb0750|M.bovis_AF2122/97 ERYRRFLALSGSKLA-------
Rv0729|M.tuberculosis_H37Rv ERYRRFLALSGSKLA-------
MMAR_1066|M.marinum_M DRYRRFLELSGSPLA-------
MUL_0824|M.ulcerans_Agy99 ----------------------
MAV_4437|M.avium_104 DRYQRFLELGNRPCPAVVAR--
Mflv_2650|M.gilvum_PYR-GCK ARWRRAAESTLAPPHQRKESMS
Mvan_3929|M.vanbaalenii_PYR-1 DRWRRAAEMTLAQHDSHKESTS
MLBr_02314|M.leprae_Br4923 AGWRKAVQRTLDWVDVS-----
MAB_0382|M.abscessus_ATCC_1997 AGWKKAVQRTLDGVDV------
TH_0046|M.thermoresistible__bu ERYAEVRDLTEGVE--------
MSMEG_1376|M.smegmatis_MC2_155 ----------------------