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TERYIAALDQGTTSTRCIVYDHHGRLVSVAQREHRQYYPRPGWVEHDPTEIWEIVRRIIPQALADADVEP RQIMALGITNQRETTVVWDRHTGKPAHRAIVWQDNRTAGLLPAIAAELDDEILLARCGLPLATYFSGPKL RWLLDNDRDLRARAESGDLLFGTVDSWLLWNLTGGIDGGVHATDVTNASRTMLMNLETLDWDDELLAGMH VPRRMMPEIRPTNGPFPSTVDPIAGIPITAVIGDQQASLFGQTAFEAGEAKCTFGTGSFVLLNTGKDIVR SQRGLLTTVARKFDGEPAVYALEGSVAVAGALVAWSRDNLGLVKTPAEIETLARTVEDNGGCYIVPAFSG LYSPYWATEARGLVVGLTSYVTKGHIARAVLEATAWQIRDVIDAMKDDSDIAVRSLHVDGGMTADNLLMQ LVADILDAPVVRPMMAETVALGAAYAAGLAAGYWPDRAVLRSNWRRAAEWRPSMDPTRRQRELDDWHRAV QLAISWGDGRRETV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6756 | glpK | - | 100% (505) | glycerol kinase |
| M. smegmatis MC2 155 | MSMEG_6229 | glpK | e-162 | 54.42% (498) | glycerol kinase |
| M. smegmatis MC2 155 | MSMEG_6759 | glpK | e-157 | 53.80% (500) | glycerol kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3722c | glpKa | 3e-56 | 55.68% (176) | glycerol kinase |
| M. gilvum PYR-GCK | Mflv_1327 | glpK | 1e-160 | 54.20% (500) | glycerol kinase |
| M. tuberculosis H37Rv | Rv3696c | glpK | 1e-160 | 54.80% (500) | glycerol kinase |
| M. leprae Br4923 | MLBr_02314 | glpK | 1e-155 | 53.60% (500) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 1e-151 | 51.40% (500) | glycerol kinase |
| M. marinum M | MMAR_5208 | glpK | 1e-159 | 53.80% (500) | glycerol kinase GlpK |
| M. avium 104 | MAV_0406 | glpK | 1e-163 | 55.80% (500) | glycerol kinase |
| M. thermoresistible (build 8) | TH_1719 | glpK | 1e-161 | 54.65% (505) | PROBABLE GLYCEROL KINASE GLPK (ATP:GLYCEROL |
| M. ulcerans Agy99 | MUL_4281 | glpK | 1e-158 | 53.40% (500) | glycerol kinase |
| M. vanbaalenii PYR-1 | Mvan_5467 | glpK | 1e-164 | 56.00% (500) | glycerol kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1327|M.gilvum_PYR-GCK ------------MADFVAAIDQGTTSTRCMIFDHDGAEVGRHQLEHEQIL
Mvan_5467|M.vanbaalenii_PYR-1 ------------MADFVAAIDQGTTSTRCMIFDHDGAEVGRHQLEHEQIL
MAB_0382|M.abscessus_ATCC_1997 ------------MADFVASIDQGTTSTRAMIFNHRGEEVGRHQLEHQQLL
TH_1719|M.thermoresistible__bu ------------VAEFVAAIDQGTTSTRCMIFDHAGTEVGRHQLEHQQIM
Mb3722c|M.bovis_AF2122/97 MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQIL
Rv3696c|M.tuberculosis_H37Rv MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHGAEVARHQLEHEQIL
MMAR_5208|M.marinum_M ---------MADSPDFVAAIDQGTTSTRCMIFDHQGAEIARHQLEHEQIL
MUL_4281|M.ulcerans_Agy99 ---------MADSPDFVAAIDQGTTSTRCMIFDHQGAEIARHQLVHEQIL
MLBr_02314|M.leprae_Br4923 ---------MAEFAEFIAAIDQGTTSTRCVIFDHNGAEVARHQLEHEQIL
MAV_0406|M.avium_104 ---------MAEFAEFIAAIDQGTTSTRCMIFDHQGAEVARHQLEHEQIL
MSMEG_6756|M.smegmatis_MC2_155 -----------MTERYIAALDQGTTSTRCIVYDHHGRLVSVAQREHRQYY
::*::********.::::* * :. * *.*
Mflv_1327|M.gilvum_PYR-GCK PKAGWVEHNPVEIWERTGSVLATALNATKLATTDLAALGITNQRETSLVW
Mvan_5467|M.vanbaalenii_PYR-1 PRAGWVEHNPVEIWERTGSVLATALNKTKLSTSDLVALGITNQRETSLVW
MAB_0382|M.abscessus_ATCC_1997 PRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETTLVW
TH_1719|M.thermoresistible__bu PQAGWVEHNPIEIWERTSAVIMSALNETRLSATDLAALGVTNQRETTLVW
Mb3722c|M.bovis_AF2122/97 PRAGWVEHNPVEIWERTASVLISVLNATNLSPKDIAALGITNQRETTLVW
Rv3696c|M.tuberculosis_H37Rv PRAGWVEHNPVEIWERTASVLISVLNATNLSPKDIAALGITNQRETTLVW
MMAR_5208|M.marinum_M PRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQRETTLVW
MUL_4281|M.ulcerans_Agy99 PRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQRETTLVW
MLBr_02314|M.leprae_Br4923 PRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETTLVW
MAV_0406|M.avium_104 PRAGWVEHDPIEIWERTSSVLTSVLNRANLSAENLAALGITNQRETTLVW
MSMEG_6756|M.smegmatis_MC2_155 PRPGWVEHDPTEIWEIVRRIIPQALADADVEPRQIMALGITNQRETTVVW
*:.*****:* **** . :: * : : . :: *:*:******::**
Mflv_1327|M.gilvum_PYR-GCK NRHTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRRKAGLPPATYFSGG
Mvan_5467|M.vanbaalenii_PYR-1 NRHTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRQKAGLPPATYFSGG
MAB_0382|M.abscessus_ATCC_1997 NRHTGRPYCNAIVWQDTRTDKIAAALDRDGRGDIIRRKAGLPPATYFSGG
TH_1719|M.thermoresistible__bu NKRTGRPYYNAIVWQDTRTDRIASALERDGRGEVIRQKAGLPPATYFSGG
Mb3722c|M.bovis_AF2122/97 NRHTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYFSGG
Rv3696c|M.tuberculosis_H37Rv NRHTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYFSGG
MMAR_5208|M.marinum_M NKRTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRRKAGLPPATYFSGG
MUL_4281|M.ulcerans_Agy99 NKRTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRRKAGLPPATYFSGG
MLBr_02314|M.leprae_Br4923 NRNTGRPYCNAIVWQDTRTDRIAVALDRDGRGEVIRRKAGLPPATYFSGG
MAV_0406|M.avium_104 NRKTGRPYYNAIVWQDTRTDRIASALDRDGRGQVIRRKAGLPPATYFSGA
MSMEG_6756|M.smegmatis_MC2_155 DRHTGKPAHRAIVWQDNRTAGLLPAIAAELDDEILLARCGLPLATYFSGP
::.**:* .******.** : *: : .::: :.*** ******
Mflv_1327|M.gilvum_PYR-GCK KLQWLLENVDGLRADAANGDALFGTTDTWVLWNLTGGHRGGVHVTDVTNA
Mvan_5467|M.vanbaalenii_PYR-1 KLQWLLENVDGLRADAEKGDALFGTTDTWVLWNLTGGHRGGVHVTDVTNA
MAB_0382|M.abscessus_ATCC_1997 KLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGVRSGVHVTDVTNA
TH_1719|M.thermoresistible__bu KLQWMLENVDGLRADAEKGEALFGTPDTWLVWNLTGGVRGGRHITDVTNA
Mb3722c|M.bovis_AF2122/97 KLQWILENVDGVRAAAENGDALFGTPDTWVLWNLTGGPRGGCACHRCNQR
Rv3696c|M.tuberculosis_H37Rv KLQWILENVDGVRAAAENGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNA
MMAR_5208|M.marinum_M KLQWILENVDGVRAAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNA
MUL_4281|M.ulcerans_Agy99 KLQWILEDVDGVRAAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDVTNA
MLBr_02314|M.leprae_Br4923 KLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGPRGGVHVTDVTNA
MAV_0406|M.avium_104 KLQWILDNVDGVREAAERGDALFGTADSWVLWQLTGGPRGGVHATDVTNA
MSMEG_6756|M.smegmatis_MC2_155 KLRWLLDNDRDLRARAESGDLLFGTVDSWLLWNLTGGIDGGVHATDVTNA
**:*:*:: .: * *: **** *:*::*:**** .* .:
Mflv_1327|M.gilvum_PYR-GCK SRTMLMNLETLDWDDELLGFFDIPRQMLPEIRPSSSPQPYGVTVETGPAD
Mvan_5467|M.vanbaalenii_PYR-1 SRTMLMNLETLDWDDELLGFFDIPRQMLPEIRPSSSPEPHGVTVDWGPAD
MAB_0382|M.abscessus_ATCC_1997 SRTMLMNLETLDWDDELLSFFSIPRQMLPPIKASSPVEPFGFTTQLGPLG
TH_1719|M.thermoresistible__bu SRTMLMNLETLDWDDELLSFFGIPRAMLPEIKPSSYPQSYGITLDDGPVA
Mb3722c|M.bovis_AF2122/97 Q-------------------------------------------------
Rv3696c|M.tuberculosis_H37Rv SRTMLMDLETLDWDDELLSLFSIPRAMLPEIASSAPSEPYGVTLATGPVG
MMAR_5208|M.marinum_M SRTMLMNLETLDWDDELLSFFSIPRAMLPAIEPSSPLQPYGITQDTGPVG
MUL_4281|M.ulcerans_Agy99 SRTMLMNLETLDWDDELLSFFSIPRAMLPAIEPSSPLQPYGITQDTGPVG
MLBr_02314|M.leprae_Br4923 SRTMLMDLEKLDWDDELLSFFSIPRAMLPAIASSSPLQPYGVTLADGPVG
MAV_0406|M.avium_104 SRTMLMDLETLDWDDELLSFFTIPRAMLPEIGPSSSPRPFGVTSDTGPAG
MSMEG_6756|M.smegmatis_MC2_155 SRTMLMNLETLDWDDELLAGMHVPRRMMPEIRPTNGPFPSTVDPIAG---
.
Mflv_1327|M.gilvum_PYR-GCK GEIPITGILGDQQAAMVGQVCLDVGEAKNTYGTGNFLLLNTGEKIVRSDN
Mvan_5467|M.vanbaalenii_PYR-1 GEIPVTGILGDQQAAMVGQVCLDAGEAKNTYGTGNFLLLNTGENIVRSKN
MAB_0382|M.abscessus_ATCC_1997 GEVPIAGDLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEELVHSSN
TH_1719|M.thermoresistible__bu GQVPLTGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGENIVRSKN
Mb3722c|M.bovis_AF2122/97 -----------------------PDHVDGSRDAG----------------
Rv3696c|M.tuberculosis_H37Rv GEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGETIVRSNN
MMAR_5208|M.marinum_M GEVPITGMLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGETIVRSSN
MUL_4281|M.ulcerans_Agy99 GEVPITGMLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGETIVRSSN
MLBr_02314|M.leprae_Br4923 GEVPITGVLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEAIVRSGN
MAV_0406|M.avium_104 GRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGESIVRSEH
MSMEG_6756|M.smegmatis_MC2_155 --IPITAVIGDQQASLFGQTAFEAGEAKCTFGTGSFVLLNTGKDIVRSQR
.... : .:*
Mflv_1327|M.gilvum_PYR-GCK GLLTTVCYQFGDS-----KPVYALEGSIAVTGSAVQWLRDQLGIISGASQ
Mvan_5467|M.vanbaalenii_PYR-1 GLLTTVCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGIISGAAQ
MAB_0382|M.abscessus_ATCC_1997 GLLTTVCYQFGDN-----KPVYALEGSIAVTGSAVQWLRDQLGIISGASQ
TH_1719|M.thermoresistible__bu GLITTVCYQFTGADGRPAEPVYALEGSIAVTGAAVQWLRDQLGIISGAAQ
Mb3722c|M.bovis_AF2122/97 ---------LG---------------------------------------
Rv3696c|M.tuberculosis_H37Rv GLLTTVCYQFGNA-----KPVYALEGSIAVTGSAVQWLRDQLGIISGAAQ
MMAR_5208|M.marinum_M GLLTTLCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGIISGASQ
MUL_4281|M.ulcerans_Agy99 GLLTTLCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGIISGASQ
MLBr_02314|M.leprae_Br4923 GLLTTVCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGIISGAAQ
MAV_0406|M.avium_104 GLLTTVCYQFGDA-----KPVYALEGSIAVTGAAVQWLRDQLGIISGAAQ
MSMEG_6756|M.smegmatis_MC2_155 GLLTTVARKFDGE-----PAVYALEGSVAVAGALVAWSRDNLGLVKTPAE
:
Mflv_1327|M.gilvum_PYR-GCK SESLARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHVAR
Mvan_5467|M.vanbaalenii_PYR-1 SESLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHVAR
MAB_0382|M.abscessus_ATCC_1997 SEDLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLAR
TH_1719|M.thermoresistible__bu SESLARQVPDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHIAR
Mb3722c|M.bovis_AF2122/97 --------------------------------RRAVV--VVFDTSGHAAR
Rv3696c|M.tuberculosis_H37Rv SEALARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNTNAHLAR
MMAR_5208|M.marinum_M SEALARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNNNAHLAR
MUL_4281|M.ulcerans_Agy99 SEALARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNNNAHLAR
MLBr_02314|M.leprae_Br4923 SESLARQVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNTNAHLAR
MAV_0406|M.avium_104 SESLARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFDTNAHLAR
MSMEG_6756|M.smegmatis_MC2_155 IETLARTVEDNGGCYIVPAFSGLYSPYWATEARGLVVGLTSYVTKGHIAR
* :* : ...* **
Mflv_1327|M.gilvum_PYR-GCK ATLEAICYQSRDVVDAMAADSGVPLEVLKVDGGITANDLCMQIQADVLGV
Mvan_5467|M.vanbaalenii_PYR-1 ATLEAICYQSRDVVDAMAADSGVHLEVLKVDGGITANDLCMQIQADVLGV
MAB_0382|M.abscessus_ATCC_1997 ATLEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQADTLGV
TH_1719|M.thermoresistible__bu ATLEAICYQSRDVVDAMVADSGVRMESLKVDGGITANELCMQIQADVLGV
Mb3722c|M.bovis_AF2122/97 -------------------------------DRIVG--------------
Rv3696c|M.tuberculosis_H37Rv ATLEAICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQADVLGV
MMAR_5208|M.marinum_M ATLEAICYQSRDVVDAMEADSGVRLEVLKVDGGITSNDLCMQIQADVLGV
MUL_4281|M.ulcerans_Agy99 ATLEAICYQSRDVVDAMEADSGVRLEVLKVDGGITSNDLCMQIQADVLGV
MLBr_02314|M.leprae_Br4923 ATLEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQADVLGV
MAV_0406|M.avium_104 ATLEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQADVLGV
MSMEG_6756|M.smegmatis_MC2_155 AVLEATAWQIRDVIDAMKDDSDIAVRSLHVDGGMTADNLLMQLVADILDA
. :..
Mflv_1327|M.gilvum_PYR-GCK DVVKPVVAETTALGAAYAAGLAVGFWEGADDLRANWQEGRRWSPQWSDEQ
Mvan_5467|M.vanbaalenii_PYR-1 DVVRPVVAETTALGAAYAAGLAVGFWDGADDLRANWQEDKRWSPTWSDDQ
MAB_0382|M.abscessus_ATCC_1997 DVVKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSSSITDEK
TH_1719|M.thermoresistible__bu DVIKPVVSETTALGAAYAAGLAVGFWEDADDLRTNWQEGRRWTPQWTDEQ
Mb3722c|M.bovis_AF2122/97 ---------------------AVGALRCHAGDRACRR-------------
Rv3696c|M.tuberculosis_H37Rv DVVRPVVAETTALGVAYAAGLAVGFWAAPSDLRANWREDKRWTPTWDDDE
MMAR_5208|M.marinum_M DVVRPVVAETTALGAAYAAGLAVGFWADPSDLRANWQEDKRWTPQWTDDQ
MUL_4281|M.ulcerans_Agy99 DVVRPVVAETTALGAAYAAGLAVGFWADPSDLRANWQEDKRWTPQWTDDQ
MLBr_02314|M.leprae_Br4923 DVVRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTPTWGEDQ
MAV_0406|M.avium_104 DVVRPVVAETTALGAAYAAGLAVGFWADPGELRANWREDKRWTPAWSDEQ
MSMEG_6756|M.smegmatis_MC2_155 PVVRPMMAETVALGAAYAAGLAAGYWPDRAVLRSNWRRAAEWRPSMDPTR
*.* * :
Mflv_1327|M.gilvum_PYR-GCK RAEGYAGWQKAVHRTLDWVDVE----
Mvan_5467|M.vanbaalenii_PYR-1 RAAGYAGWRKAVQRTMDWVDVD----
MAB_0382|M.abscessus_ATCC_1997 RAEGFAGWKKAVQRTLDGVDV-----
TH_1719|M.thermoresistible__bu REAGYRGWKKAVQRTLDWVDVG----
Mb3722c|M.bovis_AF2122/97 --------------------------
Rv3696c|M.tuberculosis_H37Rv RAAGYAGWRKAVQRTLDWVDVS----
MMAR_5208|M.marinum_M RAAGYAGWRKAVQRTLDWVDVS----
MUL_4281|M.ulcerans_Agy99 RAAGYAGWRKAVQRTLDWVDVS----
MLBr_02314|M.leprae_Br4923 RAAAYAGWRKAVQRTLDWVDVS----
MAV_0406|M.avium_104 RAAGYAGWRKAVQRTLDWADVT----
MSMEG_6756|M.smegmatis_MC2_155 RQRELDDWHRAVQLAISWGDGRRETV