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SRKDVTIGIDVGSTAVKALAADADGRVMARVRIPHELRIPAPDRLEHDAEAAWRRGPSAALDELLHQPGV AAVAVAAMVPSMTAVDDSGTPITPGLLYGDGRGRTPGGPQNQPLPALGEAAEFLRWTAARAPGAAGYWPA PAVANHALAGQAVIDVATAATAFPLFDGTGWDAAACAERGARVEQMPRVHSMGAVVGQLPGGAALATGAI DALCEQLVAGADRDGDVLVMCGTTLIVWATISQARQMPGLWTIPHTTPGKSQIGGASNAGGLFLGWVDRV VAQADPASAQPGRVPVFAPYLRGERSPFHDPDRRGVLEALDLTHDAAALRRAAYEASGFVVRQLIELSGA PVSRIVATGGGTRVGPWLQAIADATGHPVEVSAVAEGAALGAAFLARMAAGLETTLTDAARWVRTERVVE PDPAWAAPVQDRYQRFLELGNRPCPAVVAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4437 | - | - | 100% (451) | carbohydrate kinase, FGGY family protein |
| M. avium 104 | MAV_0406 | glpK | 2e-10 | 24.74% (481) | glycerol kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0750 | xylB | 0.0 | 72.01% (443) | D-xylulose kinase XylB |
| M. gilvum PYR-GCK | Mflv_3774 | - | 1e-35 | 26.47% (476) | carbohydrate kinase, FGGY |
| M. tuberculosis H37Rv | Rv0729 | xylB | 0.0 | 71.78% (443) | D-xylulose kinase XylB |
| M. leprae Br4923 | MLBr_02314 | glpK | 2e-10 | 23.85% (478) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 5e-08 | 31.43% (140) | glycerol kinase |
| M. marinum M | MMAR_1066 | xylB | 0.0 | 69.18% (451) | D-xylulose-kinase (xylulokinase), XylB |
| M. smegmatis MC2 155 | MSMEG_3263 | - | 7e-40 | 30.41% (467) | xylulose kinase |
| M. thermoresistible (build 8) | TH_0046 | xylB | 1e-15 | 27.86% (481) | xylulokinase |
| M. ulcerans Agy99 | MUL_0824 | xylB | 1e-166 | 70.87% (412) | D-xylulose-kinase (xylulokinase), XylB |
| M. vanbaalenii PYR-1 | Mvan_2625 | - | 5e-33 | 26.55% (501) | carbohydrate kinase, FGGY |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0750|M.bovis_AF2122/97 -MSRDDVTIGIDIGTTAVKAVAADD---------NGRVTARVRIGHQLAV
Rv0729|M.tuberculosis_H37Rv -MSRDDVTIGIDIGTTAVKAVAADD---------NGRVTARVRIGHQLAV
MMAR_1066|M.marinum_M -MSREDATIGIDIGTTAVKAVVADA---------DGNVTARLRIPHQLRV
MUL_0824|M.ulcerans_Agy99 -MSREDATIGIDIGTTAVKALVADA---------DGNVTARLRIPHQLRV
MAV_4437|M.avium_104 -MSRKDVTIGIDVGSTAVKALAADA---------DGRVMARVRIPHELRI
Mflv_3774|M.gilvum_PYR-GCK -MSR--YTIGVDIGTTGTKTVLLDT---------TSGIVATASRETALHS
Mvan_2625|M.vanbaalenii_PYR-1 -MSR--YTIGVDIGTTGIKTVLLDTTAAGRASNTTAGIVATANRENTLYS
MLBr_02314|M.leprae_Br4923 MAEFAEFIAAIDQGTTSTRCVIFDH---------NGAEVARHQLEHEQIL
MAB_0382|M.abscessus_ATCC_1997 ---MADFVASIDQGTTSTRAMIFNH---------RGEEVGRHQLEHQQLL
MSMEG_3263|M.smegmatis_MC2_155 -------------------------------------MIATETVSHSMDL
TH_0046|M.thermoresistible__bu ----MTLVAGIDSSTQSCKVLICDA--------------DTGAVVREGRA
Mb0750|M.bovis_AF2122/97 PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV
Rv0729|M.tuberculosis_H37Rv PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV
MMAR_1066|M.marinum_M GAPDQLEHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAV
MUL_0824|M.ulcerans_Agy99 GAPDQLEHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAV
MAV_4437|M.avium_104 PAPDRLEHDAEAAWRRGPSAALDELLHQ----PGVAAVAVAAMVPSMTAV
Mflv_3774|M.gilvum_PYR-GCK PAPGFAEADTTQWHANVIDSVREVLAHSGVAPDEIGALATSGMVPAVVPI
Mvan_2625|M.vanbaalenii_PYR-1 PGPGFAEADPAQWYRNVVESIREVLAVSGVAPDQIGALATSGMVPAVVAV
MLBr_02314|M.leprae_Br4923 PRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETTLVW
MAB_0382|M.abscessus_ATCC_1997 PRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETTLVW
MSMEG_3263|M.smegmatis_MC2_155 PRPGWAEVDAEKLWWAEVCQIASKLMAQMPSGGVLAGMCVSGVGPCLVLC
TH_0046|M.thermoresistible__bu AHPDGTEIDP-AFWESAAHDAVRAAGG----LDDVAAVAVGAQQHGMVCL
.. * :. .:
Mb0750|M.bovis_AF2122/97 D-PAGRPITPGLLYG-DARGRVPNA-------------SVARAQSVPSVG
Rv0729|M.tuberculosis_H37Rv D-PAGRPITPGLLYG-DARGRVPNA-------------SVARAQSVPSVG
MMAR_1066|M.marinum_M D-SGGVPITPGLLYG-DSRGWVPGA-------------ANQRAQPLPSVG
MUL_0824|M.ulcerans_Agy99 D-SGGVPITPGLLYG-DSRGWVPGA-------------ANQRAQPLPSVG
MAV_4437|M.avium_104 D-DSGTPITPGLLYG-DGRGRTPGG-------------PQN--QPLPALG
Mflv_3774|M.gilvum_PYR-GCK D-DAGKPLRRAILQN-DARAHREVDDLAGALADVDLVTLTGSALTQQSVA
Mvan_2625|M.vanbaalenii_PYR-1 D-QTGKPLRRAILQN-DARAHREVAGLAAKLASVDLVTLTGSALTQQSVA
MLBr_02314|M.leprae_Br4923 NRNTGRPYCNAIVWQ-DTRTDRIAVALDRDGRGEVIRRKAGLPPATYFSG
MAB_0382|M.abscessus_ATCC_1997 NRHTGRPYCNAIVWQ-DTRTDKIAAALDRDGRGDIIRRKAGLPPATYFSG
MSMEG_3263|M.smegmatis_MC2_155 D-DDLRPLRPAILYGIDTRASEEIEALTAEFGAEAILDRAGTVLSSQAVG
TH_0046|M.thermoresistible__bu D-EAGKVVRDALLWNDVRSAGAAAALVDELGGPQAWAEAVGVVPLAAITV
: .::
Mb0750|M.bovis_AF2122/97 ETAEFLRWTAG----------QAPDASGYWPAPAVANYA-LSGEAVIDYA
Rv0729|M.tuberculosis_H37Rv ETAEFLRWTAG----------QALDASGYWPAPAVANYA-LSGEAVIDYA
MMAR_1066|M.marinum_M EAAQFLRWTAA----------QAPEAAGYWPAAAVANYA-MSGEPVIDFA
MUL_0824|M.ulcerans_Agy99 EAAQFLRWTAA----------QAPEAAGYWPAAAVANYA-MSGEPVIDFA
MAV_4437|M.avium_104 EAAEFLRWTAA----------RAPGAAGYWPAPAVANHA-LAGQAVIDVA
Mflv_3774|M.gilvum_PYR-GCK PTTVWLREHEP----------EVYARTAHWVGSYDWVLS-ALGADVHVEQ
Mvan_2625|M.vanbaalenii_PYR-1 PTTVWLRDHEP----------GVYARTAHWIGSYDWVLS-ALGAPIHVEQ
MLBr_02314|M.leprae_Br4923 GKLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGP-RGGVHVTDVT
MAB_0382|M.abscessus_ATCC_1997 GKLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGV-RSGVHVTDVT
MSMEG_3263|M.smegmatis_MC2_155 PKLEWVRRHEP----------EVFERATGWYGSNSYIAAKLTGEYVMDHH
TH_0046|M.thermoresistible__bu AKLRWLADHEP----------QHADRTAAVCLPHDWLTWRLRGSTDIAEL
:: . *
Mb0750|M.bovis_AF2122/97 TAVTTLPLFDGTGWNATACADCG-VTVDRMPRVETFG--------VGVGQ
Rv0729|M.tuberculosis_H37Rv TAVTTLPLFDGTGWNATACADCG-VTVDRMPRVETFG--------VGVGQ
MMAR_1066|M.marinum_M TAITSLPLFDGTGWNPQACADCG-ASADRMPRVETFG--------TAVGQ
MUL_0824|M.ulcerans_Agy99 TAITSLPLFDGTGWNPQACADCG-ASADRMPRVETFG--------TAVGQ
MAV_4437|M.avium_104 TAATAFPLFDGTGWDAAACAERG-ARVEQMPRVHSMG--------AVVGQ
Mflv_3774|M.gilvum_PYR-GCK NWALESGLFSIVGDTADAVLGAAGLDPATLAPLRRPG--------TRVGE
Mvan_2625|M.vanbaalenii_PYR-1 NWALESGLFEIDGDVATDVVQAAALEPVTLAPVRRPG--------TQVGE
MLBr_02314|M.leprae_Br4923 NASRTMLMDLEKLDWDDELLSFFSIPRAMLPAIASSSPLQPYGVTLADGP
MAB_0382|M.abscessus_ATCC_1997 NASRTMLMNLETLDWDDELLSFFSIPRQMLPPIKASSPVEPFGFTTQLGP
MSMEG_3263|M.smegmatis_MC2_155 TASQCDPLYATRRFEWNKPWAQRICGHLPLPRLVWPA--------DVVGT
TH_0046|M.thermoresistible__bu TTDRSDASGTGYYDASGDDYRLDLLELGLRGRRPHLP--------AVLGP
. *
Mb0750|M.bovis_AF2122/97 VRGT---------GAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVW
Rv0729|M.tuberculosis_H37Rv VRGT---------GAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVW
MMAR_1066|M.marinum_M VHGA---------DAVLGAGGIDAVCEQIVAGADHHGDVLVLCGTTLIVW
MUL_0824|M.ulcerans_Agy99 VHGT---------DAVLGAGGIDAVCEQIVAGADHHGDVLVLCGTTLIVW
MAV_4437|M.avium_104 LPG----------GAALATGAIDALCEQLVAGADRDGDVLVMCGTTLIVW
Mflv_3774|M.gilvum_PYR-GCK LSAAAADATGLRAGTPLVVGGADHVLSAYAAGVNGAGDALVKLGGAGDIL
Mvan_2625|M.vanbaalenii_PYR-1 LSRRAADETGLRAGTALVVGGADHVLSAYAAGVNDPGDALVKLGGAGDIL
MLBr_02314|M.leprae_Br4923 VGGEVPITG---VLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEAI
MAB_0382|M.abscessus_ATCC_1997 LGGEVPIAG---DLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEEL
MSMEG_3263|M.smegmatis_MC2_155 VTPEAAAATGVPAGTPVSAGTVDAYSEAFSVGVRRPGDQMLMYGSTMFLV
TH_0046|M.thermoresistible__bu SDATR-------GGDRVFGAGLGDNAAAALGLAAEPGDVIVSVGTSGVVS
. . * . :
Mb0750|M.bovis_AF2122/97 TTISAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVDRVIGPGD---
Rv0729|M.tuberculosis_H37Rv TTISAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVDRVIGPGD---
MMAR_1066|M.marinum_M TTISGSRQVPGLWTIPHTAPGKSQIGGASNAGGLFLSWVDRLIGPADRDG
MUL_0824|M.ulcerans_Agy99 TTISGSRQVPGLWTIPHTAPGKSQIGGASNAGGLFLSWVDRVTGPADRDG
MAV_4437|M.avium_104 ATISQARQMPGLWTIPHTTPGKSQIGGASNAGGLFLGWVDRVVAQAD---
Mflv_3774|M.gilvum_PYR-GCK VASDTEIVDERLYLDAHPVPGRWLPNGCMATSGSLIRWFQTLIGG---AE
Mvan_2625|M.vanbaalenii_PYR-1 VASDTQVVDERLYLDAHPIPGHWLPNGCMATSGSLIRWFQALIGGPEAVE
MLBr_02314|M.leprae_Br4923 VRSGNGLLTTVCYQFGDAKP-VYALEGSIAVTGSAVQWLRDQLGIIS-GA
MAB_0382|M.abscessus_ATCC_1997 VHSSNGLLTTVCYQFGDNKP-VYALEGSIAVTGSAVQWLRDQLGIIS-GA
MSMEG_3263|M.smegmatis_MC2_155 QVIDAYHSDPVLWTTAGIEHDTLALAAGTSTAGSLINWLQSVTGGASFDE
TH_0046|M.thermoresistible__bu AVATAPVRDGTGFVAGFADGTGRHLPLVCTLNGARVLDAAAAMLQVDHAE
: * :
Mb0750|M.bovis_AF2122/97 -PALADPRRVP-----VWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-AS
Rv0729|M.tuberculosis_H37Rv -PALADPRRVP-----VWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-AS
MMAR_1066|M.marinum_M EQDRVDPRRVP-----IWLPYIRGERTPFHDPDRRASLEGLDLTQGA-AA
MUL_0824|M.ulcerans_Agy99 EQDRVDPRRVP-----IWLPYIRGERTPFHDPDRRASLEGLDLTQGA-AA
MAV_4437|M.avium_104 -PASAQPGRVP-----VFAPYLRGERSPFHDPDRRGVLEALDLTHDA-AA
Mflv_3774|M.gilvum_PYR-GCK LTELDDEAAQRAPGEILCLPYFLGEKSPVHDPDLRGVFAGMHLGHTR-AD
Mvan_2625|M.vanbaalenii_PYR-1 LTTLDDEAALRSPAEVLCLPYFLGEKSPIHDPDLRGVFAGMHLGHTR-AD
MLBr_02314|M.leprae_Br4923 AQSESLARQVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNTN-AH
MAB_0382|M.abscessus_ATCC_1997 SQSEDLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTN-AH
MSMEG_3263|M.smegmatis_MC2_155 LMAEAADVPPGSEG-LLVLPYLAGERTPVFDPQARGVVAGLTLRHGR-GH
TH_0046|M.thermoresistible__bu LSRLALSAPPGSEG-LVLVPYLEGERTPNR-PNASGALHGLRVSNATPAN
* : * :* .: . . .: : .
Mb0750|M.bovis_AF2122/97 VRRAAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAIADA
Rv0729|M.tuberculosis_H37Rv VRRAAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAIADA
MMAR_1066|M.marinum_M VRRAAYEASGFVVRHLVELS----GAPVLRIVASGGGTCVQPWMQAIADV
MUL_0824|M.ulcerans_Agy99 VRRAAYEVSGFVVRHLVELS----GAPVLRIVASGGGTCVRPWMQAIADV
MAV_4437|M.avium_104 LRRAAYEASGFVVRQLIELS----GAPVSRIVATGGGTRVGPWLQAIADA
Mflv_3774|M.gilvum_PYR-GCK MYRSVLEAIAFGFRHHVDVFGEI-GIPFTRVMITNGGSRSTLWKQIHADV
Mvan_2625|M.vanbaalenii_PYR-1 MYRSVLEAIAFGFRHHVDVFAEI-GIPLRRVMITNGGSKSTLWKQIHADV
MLBr_02314|M.leprae_Br4923 LARATLEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQADV
MAB_0382|M.abscessus_ATCC_1997 LARATLEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQADT
MSMEG_3263|M.smegmatis_MC2_155 LFRAAYEGISFGIRQILERFDD--AHTASRTVAVGGGLRSPIWAQTVSDV
TH_0046|M.thermoresistible__bu LARAAVEGLLCALADGIAHLTG-HGIPLRRVLLIGGAARSEAVRAIAPQV
: *:. * . : . .* .:.
Mb0750|M.bovis_AF2122/97 TGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEPSAD
Rv0729|M.tuberculosis_H37Rv TGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEPSAD
MMAR_1066|M.marinum_M TGRPVHVSDVAEGAALGAAFLARMAAGLESSIADADRWARTDRIVEPRPD
MUL_0824|M.ulcerans_Agy99 TGRPVHVSAVAEGAALGAAFLARMAAGLES--------------------
MAV_4437|M.avium_104 TGHPVEVSAVAEGAALGAAFLARMAAGLETTLTDAARWVRTERVVEPDPA
Mflv_3774|M.gilvum_PYR-GCK LGCEMNPVIGHPGASLGAAVIAAIGVGALDDWADADRFITLDAPYRPDPA
Mvan_2625|M.vanbaalenii_PYR-1 LGQEMHPVRGHPGASLGAAVIAAIGVGALADWSDAARFITLDDPYIPDPA
MLBr_02314|M.leprae_Br4923 LGVDVVRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTP-TW
MAB_0382|M.abscessus_ATCC_1997 LGVDVVKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSS-SI
MSMEG_3263|M.smegmatis_MC2_155 TGRPQLVPEQAIGASYGDALLAAIGVGLVPADTDWAKIAAEIK---PDPR
TH_0046|M.thermoresistible__bu FGVPVLVPDPAEYVALGAARQAAWALRGTPEPPSWQPPRTDRYEADPVPA
* .: * * . .
Mb0750|M.bovis_AF2122/97 WAGPTKERYRRFLALSGSKLA-----------
Rv0729|M.tuberculosis_H37Rv WAGPTKERYRRFLALSGSKLA-----------
MMAR_1066|M.marinum_M WVGPTKDRYRRFLELSGSPLA-----------
MUL_0824|M.ulcerans_Agy99 --------------------------------
MAV_4437|M.avium_104 WAAPVQDRYQRFLELGNRPCPAVVAR------
Mflv_3774|M.gilvum_PYR-GCK RRHAYDDAYQTWRELGAVMTPVSHKIARTTR-
Mvan_2625|M.vanbaalenii_PYR-1 RRDIYDQAYATWRELSSAMTPISHAIARTTR-
MLBr_02314|M.leprae_Br4923 GEDQRAAAYAGWRKAVQRTLDWVDVS------
MAB_0382|M.abscessus_ATCC_1997 TDEKRAEGFAGWKKAVQRTLDGVDV-------
MSMEG_3263|M.smegmatis_MC2_155 NHALYEDLYATWQELYPATRDQVHRLAGQPIV
TH_0046|M.thermoresistible__bu VR----ERYAEVRDLTEGVE------------