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HHILAIDQGTSGTKAVVDIRDGTAGRVLATAEVSLRPDYLPGGGVEQDPEALFASVVTAGRQALQQAGVP VAAVALANQGETVLAWDRHTGTPLTPAIVWQDRRAETLCAALAEHATTVAGRTGLVLDPYFSAPKMAWIR ANLTRDGVVTTTDTWLVHRLCGAFVTDASTASRSLLTSLDDSRGQRWDPDLRALFGLDAEEMPEIVASDE IVGTTDVFGTTLPVAGLIVDQQAALFAESCLHAGSAKCTYGTGAFLLAQLGTEPVRSSSGLTTSVAWRLR GQTSYCIDGQVYTAASAIRWAVDLGLIPSADQIDSAAAESSDGVVCVPALAGLAAPWWDSAATASLSGMT LSTGRGQLVRAMVEGIAAQVAALTDLVSADLGRPLTRLRVDGGLTRSEALMQAQADLSQIPVDVYPSLHA TALGAAACARLALEPGLSPADAAGTWSPRRTYEPHWSADRAADFLARWRRAAESTLAPPHQRKESMS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2650 | - | - | 100% (488) | carbohydrate kinase, FGGY |
| M. gilvum PYR-GCK | Mflv_1327 | glpK | 1e-71 | 35.26% (502) | glycerol kinase |
| M. gilvum PYR-GCK | Mflv_3774 | - | 9e-18 | 26.49% (453) | carbohydrate kinase, FGGY |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3722c | glpKa | 5e-17 | 32.37% (173) | glycerol kinase |
| M. tuberculosis H37Rv | Rv3696c | glpK | 5e-69 | 34.13% (501) | glycerol kinase |
| M. leprae Br4923 | MLBr_02314 | glpK | 8e-70 | 35.19% (503) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 7e-65 | 33.53% (501) | glycerol kinase |
| M. marinum M | MMAR_5208 | glpK | 2e-69 | 34.13% (501) | glycerol kinase GlpK |
| M. avium 104 | MAV_0406 | glpK | 6e-66 | 33.33% (501) | glycerol kinase |
| M. smegmatis MC2 155 | MSMEG_6229 | glpK | 9e-71 | 36.83% (505) | glycerol kinase |
| M. thermoresistible (build 8) | TH_1719 | glpK | 2e-65 | 32.81% (506) | PROBABLE GLYCEROL KINASE GLPK (ATP:GLYCEROL |
| M. ulcerans Agy99 | MUL_4281 | glpK | 3e-69 | 34.86% (502) | glycerol kinase |
| M. vanbaalenii PYR-1 | Mvan_3929 | - | 0.0 | 85.45% (488) | carbohydrate kinase, FGGY |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3722c|M.bovis_AF2122/97 MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHG---AEVARHQLEHE
Rv3696c|M.tuberculosis_H37Rv MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHG---AEVARHQLEHE
MMAR_5208|M.marinum_M ---------MADSPDFVAAIDQGTTSTRCMIFDHQG---AEIARHQLEHE
MUL_4281|M.ulcerans_Agy99 ---------MADSPDFVAAIDQGTTSTRCMIFDHQG---AEIARHQLVHE
MLBr_02314|M.leprae_Br4923 ---------MAEFAEFIAAIDQGTTSTRCVIFDHNG---AEVARHQLEHE
MAV_0406|M.avium_104 ---------MAEFAEFIAAIDQGTTSTRCMIFDHQG---AEVARHQLEHE
MSMEG_6229|M.smegmatis_MC2_155 ------------MADFVAAIDQGTTSTRCMIFDHDG---AEVGRHQLEHE
TH_1719|M.thermoresistible__bu ------------VAEFVAAIDQGTTSTRCMIFDHAG---TEVGRHQLEHQ
MAB_0382|M.abscessus_ATCC_1997 ------------MADFVASIDQGTTSTRAMIFNHRG---EEVGRHQLEHQ
Mflv_2650|M.gilvum_PYR-GCK -------------MHHILAIDQGTSGTKAVVDIRDGTAGRVLATAEVSLR
Mvan_3929|M.vanbaalenii_PYR-1 -------------MHHILAIDQGTSGTKAVV--VDG-AGRVLATAEVSLR
..: :*****:.*:.:: * :. :: .
Mb3722c|M.bovis_AF2122/97 QILPRAGWVEHNPVEIWERTASVLISVLNATNLSPKDIAALGITNQRETT
Rv3696c|M.tuberculosis_H37Rv QILPRAGWVEHNPVEIWERTASVLISVLNATNLSPKDIAALGITNQRETT
MMAR_5208|M.marinum_M QILPRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQRETT
MUL_4281|M.ulcerans_Agy99 QILPRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQRETT
MLBr_02314|M.leprae_Br4923 QILPRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETT
MAV_0406|M.avium_104 QILPRAGWVEHDPIEIWERTSSVLTSVLNRANLSAENLAALGITNQRETT
MSMEG_6229|M.smegmatis_MC2_155 QILPRAGWVEHNPVEIWERTASVVMTALNRTNLQASDLAALGITNQRETS
TH_1719|M.thermoresistible__bu QIMPQAGWVEHNPIEIWERTSAVIMSALNETRLSATDLAALGVTNQRETT
MAB_0382|M.abscessus_ATCC_1997 QLLPRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETT
Mflv_2650|M.gilvum_PYR-GCK PDYLPGGGVEQDPEALFASVVTAGRQALQQAGVP---VAAVALANQGETV
Mvan_3929|M.vanbaalenii_PYR-1 PAYLAGGGVEQDPEALFDSVVTAGRRALAQADVP---VAAVALANQGETV
.* **::* :: . :. * : : :**:.::** **
Mb3722c|M.bovis_AF2122/97 LVWNRHTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYF
Rv3696c|M.tuberculosis_H37Rv LVWNRHTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYF
MMAR_5208|M.marinum_M LVWNKRTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRRKAGLPPATYF
MUL_4281|M.ulcerans_Agy99 LVWNKRTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRRKAGLPPATYF
MLBr_02314|M.leprae_Br4923 LVWNRNTGRPYCNAIVWQDTRTDRIAVALDRDGRGEVIRRKAGLPPATYF
MAV_0406|M.avium_104 LVWNRKTGRPYYNAIVWQDTRTDRIASALDRDGRGQVIRRKAGLPPATYF
MSMEG_6229|M.smegmatis_MC2_155 LVWNRHTGRPYYNAIVWQDTRTDSIAAALDRDGRGDVIRRKAGLPPATYF
TH_1719|M.thermoresistible__bu LVWNKRTGRPYYNAIVWQDTRTDRIASALERDGRGEVIRQKAGLPPATYF
MAB_0382|M.abscessus_ATCC_1997 LVWNRHTGRPYCNAIVWQDTRTDKIAAALDRDGRGDIIRRKAGLPPATYF
Mflv_2650|M.gilvum_PYR-GCK LAWDRHTGTPLTPAIVWQDRRAETLCAALAEH--ATTVAGRTGLVLDPYF
Mvan_3929|M.vanbaalenii_PYR-1 LAWDRATGRALTPAVVWQDRRAESLCAAVADR--AEEVARRTGLVLDPYF
*.*:: ** . *:**** *:: :. *: . : ::** .**
Mb3722c|M.bovis_AF2122/97 SGGKLQWILENVDGVRAAAENGDALFGTPDTWVLWNLTGGPRGGCACHRC
Rv3696c|M.tuberculosis_H37Rv SGGKLQWILENVDGVRAAAENGDALFGTPDTWVLWNLTGGPRGGVHVTDV
MMAR_5208|M.marinum_M SGGKLQWILENVDGVRAAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDV
MUL_4281|M.ulcerans_Agy99 SGGKLQWILEDVDGVRAAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDV
MLBr_02314|M.leprae_Br4923 SGGKLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGPRGGVHVTDV
MAV_0406|M.avium_104 SGAKLQWILDNVDGVREAAERGDALFGTADSWVLWQLTGGPRGGVHATDV
MSMEG_6229|M.smegmatis_MC2_155 SGGKIQWILDNVPGVREDAEKGDAIFGTADSWLVWNLTGGTRGGVHVTDV
TH_1719|M.thermoresistible__bu SGGKLQWMLENVDGLRADAEKGEALFGTPDTWLVWNLTGGVRGGRHITDV
MAB_0382|M.abscessus_ATCC_1997 SGGKLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGVRSGVHVTDV
Mflv_2650|M.gilvum_PYR-GCK SAPKMAWIRANLT--------RDGVVTTTDTWLVHRLCG-----AFVTDA
Mvan_3929|M.vanbaalenii_PYR-1 SAPKMAWIRSHLT--------RAGVVTTTDTWLVHRLCG-----AFVTDA
*. *: *: .: .:. *.*:*:: .* *
Mb3722c|M.bovis_AF2122/97 NQRQ----------------------------------------------
Rv3696c|M.tuberculosis_H37Rv TNASRTMLMDLET---LDWDDELLSLFSIPRAMLPEIASSAPSEPYGVTL
MMAR_5208|M.marinum_M TNASRTMLMNLET---LDWDDELLSFFSIPRAMLPAIEPSSPLQPYGITQ
MUL_4281|M.ulcerans_Agy99 TNASRTMLMNLET---LDWDDELLSFFSIPRAMLPAIEPSSPLQPYGITQ
MLBr_02314|M.leprae_Br4923 TNASRTMLMDLEK---LDWDDELLSFFSIPRAMLPAIASSSPLQPYGVTL
MAV_0406|M.avium_104 TNASRTMLMDLET---LDWDDELLSFFTIPRAMLPEIGPSSSPRPFGVTS
MSMEG_6229|M.smegmatis_MC2_155 TNASRTMLMNLET---LDWDDELLSFFGIPRRMLPEIKPSSYPESYGITR
TH_1719|M.thermoresistible__bu TNASRTMLMNLET---LDWDDELLSFFGIPRAMLPEIKPSSYPQSYGITL
MAB_0382|M.abscessus_ATCC_1997 TNASRTMLMNLET---LDWDDELLSFFSIPRQMLPPIKASSPVEPFGFTT
Mflv_2650|M.gilvum_PYR-GCK STASRSLLTSLDDSRGQRWDPDLRALFGLDAEEMPEIVASDE-----IVG
Mvan_3929|M.vanbaalenii_PYR-1 STASRSLLISLDS---AQWDQDLLTLFGLDDEAMPEIVGSDE-----IVG
. .
Mb3722c|M.bovis_AF2122/97 -----------------------------PDHVDGSRDAG----------
Rv3696c|M.tuberculosis_H37Rv ATGPVGGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGET
MMAR_5208|M.marinum_M DTGPVGGEVPITGMLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGET
MUL_4281|M.ulcerans_Agy99 DTGPVGGEVPITGMLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGET
MLBr_02314|M.leprae_Br4923 ADGPVGGEVPITGVLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEA
MAV_0406|M.avium_104 DTGPAGGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGES
MSMEG_6229|M.smegmatis_MC2_155 DDGPLAGQVPLTGILGDQQAAMVGQVCLEAGEAKNTYGTGNFLLLNTGEK
TH_1719|M.thermoresistible__bu DDGPVAGQVPLTGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGEN
MAB_0382|M.abscessus_ATCC_1997 QLGPLGGEVPIAGDLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEE
Mflv_2650|M.gilvum_PYR-GCK TTDVFGTTLPVAGLIVDQQAALFAESCLHAGSAKCTYGTGAFLLAQLGTE
Mvan_3929|M.vanbaalenii_PYR-1 TTDVFGPTLPVAGLIVDQQAALLAESCLEAGSAKCTYGTGAFLLAQLGSE
. .. : .:*
Mb3722c|M.bovis_AF2122/97 ---------------LG---------------------------------
Rv3696c|M.tuberculosis_H37Rv IVRSNNGLLTTVCYQFGNA-----KPVYALEGSIAVTGSAVQWLRDQLGI
MMAR_5208|M.marinum_M IVRSSNGLLTTLCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGI
MUL_4281|M.ulcerans_Agy99 IVRSSNGLLTTLCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGI
MLBr_02314|M.leprae_Br4923 IVRSGNGLLTTVCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGI
MAV_0406|M.avium_104 IVRSEHGLLTTVCYQFGDA-----KPVYALEGSIAVTGAAVQWLRDQLGI
MSMEG_6229|M.smegmatis_MC2_155 IVRSDNGLLTTVCYQFGDS-----KPVYALEGSIAVTGSAVQWLRDQLGI
TH_1719|M.thermoresistible__bu IVRSKNGLITTVCYQFTGADGRPAEPVYALEGSIAVTGAAVQWLRDQLGI
MAB_0382|M.abscessus_ATCC_1997 LVHSSNGLLTTVCYQFGDN-----KPVYALEGSIAVTGSAVQWLRDQLGI
Mflv_2650|M.gilvum_PYR-GCK PVRSSSGLTTSVAWRLRGQ------TSYCIDGQVYTAASAIRWAVD-LGL
Mvan_3929|M.vanbaalenii_PYR-1 PVRSTSGLTTSVAWRLRGA------TSYCIDGQVYTAASAVRWAVE-LGL
:
Mb3722c|M.bovis_AF2122/97 --------------------------------------RRAVV--VVFDT
Rv3696c|M.tuberculosis_H37Rv ISGAAQSEALARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNT
MMAR_5208|M.marinum_M ISGASQSEALARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNN
MUL_4281|M.ulcerans_Agy99 ISGASQSEALARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNN
MLBr_02314|M.leprae_Br4923 ISGAAQSESLARQVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNT
MAV_0406|M.avium_104 ISGAAQSESLARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFDT
MSMEG_6229|M.smegmatis_MC2_155 ISGASQSESLARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNT
TH_1719|M.thermoresistible__bu ISGAAQSESLARQVPDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNT
MAB_0382|M.abscessus_ATCC_1997 ISGASQSEDLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNT
Mflv_2650|M.gilvum_PYR-GCK IPSADQIDSAAAESSD--GVVCVPALAGLAAPWWDSAATASLSGMTLSTG
Mvan_3929|M.vanbaalenii_PYR-1 VPAADQIDSAAAESSD--GVLCVPALAGLAAPWWDSAATASFSGMTLSSG
:.
Mb3722c|M.bovis_AF2122/97 SGHAAR-------------------------------DRIVG--------
Rv3696c|M.tuberculosis_H37Rv NAHLARATLEAICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQ
MMAR_5208|M.marinum_M NAHLARATLEAICYQSRDVVDAMEADSGVRLEVLKVDGGITSNDLCMQIQ
MUL_4281|M.ulcerans_Agy99 NAHLARATLEAICYQSRDVVDAMEADSGVRLEVLKVDGGITSNDLCMQIQ
MLBr_02314|M.leprae_Br4923 NAHLARATLEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQ
MAV_0406|M.avium_104 NAHLARATLEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQ
MSMEG_6229|M.smegmatis_MC2_155 NAHLARATLESICYQSRDVVDAMEADSGVHLEVLKVDGGITANALCMQIQ
TH_1719|M.thermoresistible__bu NAHIARATLEAICYQSRDVVDAMVADSGVRMESLKVDGGITANELCMQIQ
MAB_0382|M.abscessus_ATCC_1997 NAHLARATLEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQ
Mflv_2650|M.gilvum_PYR-GCK RGQLVRAMVEGIAAQVAALTDLVSADLGRPLTRLRVDGGLTRSEALMQAQ
Mvan_3929|M.vanbaalenii_PYR-1 RGQLVRALVEGIAAQVTALTDLVSADLGRPLTRLRVDGGLTRSTALMQAQ
.: .* . :.
Mb3722c|M.bovis_AF2122/97 ---------------------------AVGALRCHAGDRACRR-------
Rv3696c|M.tuberculosis_H37Rv ADVLGVDVVRPVVAETTALGVAYAAGLAVGFWAAPSDLRANWREDKRWTP
MMAR_5208|M.marinum_M ADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPSDLRANWQEDKRWTP
MUL_4281|M.ulcerans_Agy99 ADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPSDLRANWQEDKRWTP
MLBr_02314|M.leprae_Br4923 ADVLGVDVVRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTP
MAV_0406|M.avium_104 ADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPGELRANWREDKRWTP
MSMEG_6229|M.smegmatis_MC2_155 ADVLGVDVVKPLVAETTALGAAYAAGLAVGFWENADDLRANWQEDKRWSP
TH_1719|M.thermoresistible__bu ADVLGVDVIKPVVSETTALGAAYAAGLAVGFWEDADDLRTNWQEGRRWTP
MAB_0382|M.abscessus_ATCC_1997 ADTLGVDVVKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSS
Mflv_2650|M.gilvum_PYR-GCK ADLSQIPVDVYPSLHATALGAAACARLALEPGLSPADAAGTWSPRRTYEP
Mvan_3929|M.vanbaalenii_PYR-1 ADLARMPVDVYPSLHATALGAAACARLALEPGTSAADAVGTWFPHHTYEP
*:
Mb3722c|M.bovis_AF2122/97 ---------------------------------
Rv3696c|M.tuberculosis_H37Rv TWDDDERAAGYAGWRKAVQRTLDWVDVS-----
MMAR_5208|M.marinum_M QWTDDQRAAGYAGWRKAVQRTLDWVDVS-----
MUL_4281|M.ulcerans_Agy99 QWTDDQRAAGYAGWRKAVQRTLDWVDVS-----
MLBr_02314|M.leprae_Br4923 TWGEDQRAAAYAGWRKAVQRTLDWVDVS-----
MAV_0406|M.avium_104 AWSDEQRAAGYAGWRKAVQRTLDWADVT-----
MSMEG_6229|M.smegmatis_MC2_155 QWSDEQREKGYAGWQKAVQRTLDWVEIE-----
TH_1719|M.thermoresistible__bu QWTDEQREAGYRGWKKAVQRTLDWVDVG-----
MAB_0382|M.abscessus_ATCC_1997 SITDEKRAEGFAGWKKAVQRTLDGVDV------
Mflv_2650|M.gilvum_PYR-GCK HWSADRAADFLARWRRAAESTLAPPHQRKESMS
Mvan_3929|M.vanbaalenii_PYR-1 RWSADRAADFLDRWRRAAEMTLAQHDSHKESTS