For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MHHILAIDQGTSGTKAVVVDGAGRVLATAEVSLRPAYLAGGGVEQDPEALFDSVVTAGRRALAQADVPVA AVALANQGETVLAWDRATGRALTPAVVWQDRRAESLCAAVADRAEEVARRTGLVLDPYFSAPKMAWIRSH LTRAGVVTTTDTWLVHRLCGAFVTDASTASRSLLISLDSAQWDQDLLTLFGLDDEAMPEIVGSDEIVGTT DVFGPTLPVAGLIVDQQAALLAESCLEAGSAKCTYGTGAFLLAQLGSEPVRSTSGLTTSVAWRLRGATSY CIDGQVYTAASAVRWAVELGLVPAADQIDSAAAESSDGVLCVPALAGLAAPWWDSAATASFSGMTLSSGR GQLVRALVEGIAAQVTALTDLVSADLGRPLTRLRVDGGLTRSTALMQAQADLARMPVDVYPSLHATALGA AACARLALEPGTSAADAVGTWFPHHTYEPRWSADRAADFLDRWRRAAEMTLAQHDSHKESTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3929 | - | - | 100% (482) | carbohydrate kinase, FGGY |
| M. vanbaalenii PYR-1 | Mvan_5467 | glpK | 9e-72 | 34.75% (495) | glycerol kinase |
| M. vanbaalenii PYR-1 | Mvan_5296 | - | 2e-19 | 26.33% (490) | xylulokinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0750 | xylB | 7e-18 | 27.31% (465) | D-xylulose kinase XylB |
| M. gilvum PYR-GCK | Mflv_2650 | - | 0.0 | 85.45% (488) | carbohydrate kinase, FGGY |
| M. tuberculosis H37Rv | Rv3696c | glpK | 7e-71 | 34.75% (495) | glycerol kinase |
| M. leprae Br4923 | MLBr_02314 | glpK | 1e-73 | 35.61% (497) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 1e-67 | 32.73% (495) | glycerol kinase |
| M. marinum M | MMAR_5208 | glpK | 2e-72 | 34.14% (495) | glycerol kinase GlpK |
| M. avium 104 | MAV_0406 | glpK | 8e-69 | 33.54% (495) | glycerol kinase |
| M. smegmatis MC2 155 | MSMEG_6229 | glpK | 4e-75 | 36.75% (498) | glycerol kinase |
| M. thermoresistible (build 8) | TH_1719 | glpK | 1e-70 | 33.60% (500) | PROBABLE GLYCEROL KINASE GLPK (ATP:GLYCEROL |
| M. ulcerans Agy99 | MUL_4281 | glpK | 4e-72 | 34.14% (495) | glycerol kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3929|M.vanbaalenii_PYR-1 -------------MHHILAIDQGTSGTKAVV--VDG-AGRVLATAEVSLR
Mflv_2650|M.gilvum_PYR-GCK -------------MHHILAIDQGTSGTKAVVDIRDGTAGRVLATAEVSLR
MSMEG_6229|M.smegmatis_MC2_155 ------------MADFVAAIDQGTTSTRCMIFDHDG---AEVGRHQLEHE
TH_1719|M.thermoresistible__bu ------------VAEFVAAIDQGTTSTRCMIFDHAG---TEVGRHQLEHQ
Rv3696c|M.tuberculosis_H37Rv MSDAILGEQLAESSDFIAAIDQGTTSTRCMIFDHHG---AEVARHQLEHE
MLBr_02314|M.leprae_Br4923 ---------MAEFAEFIAAIDQGTTSTRCVIFDHNG---AEVARHQLEHE
MMAR_5208|M.marinum_M ---------MADSPDFVAAIDQGTTSTRCMIFDHQG---AEIARHQLEHE
MUL_4281|M.ulcerans_Agy99 ---------MADSPDFVAAIDQGTTSTRCMIFDHQG---AEIARHQLVHE
MAV_0406|M.avium_104 ---------MAEFAEFIAAIDQGTTSTRCMIFDHQG---AEVARHQLEHE
MAB_0382|M.abscessus_ATCC_1997 ------------MADFVASIDQGTTSTRAMIFNHRG---EEVGRHQLEHQ
Mb0750|M.bovis_AF2122/97 ----------MSRDDVTIGIDIGTTAVKAVAADDNG---RVTARVRIGHQ
. .** **:..:.: * . .: .
Mvan_3929|M.vanbaalenii_PYR-1 PAYLAGGGVEQDPEALFDSVVTAGRRALAQADVP---VAAVALANQGETV
Mflv_2650|M.gilvum_PYR-GCK PDYLPGGGVEQDPEALFASVVTAGRQALQQAGVP---VAAVALANQGETV
MSMEG_6229|M.smegmatis_MC2_155 QILPRAGWVEHNPVEIWERTASVVMTALNRTNLQASDLAALGITNQRETS
TH_1719|M.thermoresistible__bu QIMPQAGWVEHNPIEIWERTSAVIMSALNETRLSATDLAALGVTNQRETT
Rv3696c|M.tuberculosis_H37Rv QILPRAGWVEHNPVEIWERTASVLISVLNATNLSPKDIAALGITNQRETT
MLBr_02314|M.leprae_Br4923 QILPRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETT
MMAR_5208|M.marinum_M QILPRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQRETT
MUL_4281|M.ulcerans_Agy99 QILPRAGWVEHNPVEIWERTASVLMSVLNATDLSPKNIAALGITNQRETT
MAV_0406|M.avium_104 QILPRAGWVEHDPIEIWERTSSVLTSVLNRANLSAENLAALGITNQRETT
MAB_0382|M.abscessus_ATCC_1997 QLLPRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETT
Mb0750|M.bovis_AF2122/97 LAVPAPDRLEHDADEAWRRGPLAALDRLVGPDTRALAVAAMVPS------
. :*::. : . * . :**: :
Mvan_3929|M.vanbaalenii_PYR-1 LAWDRATGRALTPAVVWQDRRAESLCAAVADR--AEEVARRTGLVLDPYF
Mflv_2650|M.gilvum_PYR-GCK LAWDRHTGTPLTPAIVWQDRRAETLCAALAEH--ATTVAGRTGLVLDPYF
MSMEG_6229|M.smegmatis_MC2_155 LVWNRHTGRPYYNAIVWQDTRTDSIAAALDRDGRGDVIRRKAGLPPATYF
TH_1719|M.thermoresistible__bu LVWNKRTGRPYYNAIVWQDTRTDRIASALERDGRGEVIRQKAGLPPATYF
Rv3696c|M.tuberculosis_H37Rv LVWNRHTGRPYYNAIVWQDTRTDRIASALDRDGRGNLIRRKAGLPPATYF
MLBr_02314|M.leprae_Br4923 LVWNRNTGRPYCNAIVWQDTRTDRIAVALDRDGRGEVIRRKAGLPPATYF
MMAR_5208|M.marinum_M LVWNKRTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRRKAGLPPATYF
MUL_4281|M.ulcerans_Agy99 LVWNKRTGRPYYNAIVWQDTRTDRIASALDRDGRGDVIRRKAGLPPATYF
MAV_0406|M.avium_104 LVWNRKTGRPYYNAIVWQDTRTDRIASALDRDGRGQVIRRKAGLPPATYF
MAB_0382|M.abscessus_ATCC_1997 LVWNRHTGRPYCNAIVWQDTRTDKIAAALDRDGRGDIIRRKAGLPPATYF
Mb0750|M.bovis_AF2122/97 LTAVDPAGRPITPGLLYGDARGRVPNASVARAQSVPSVG----------E
*. :* . .::: * * :: :
Mvan_3929|M.vanbaalenii_PYR-1 SAPKMAWIRSHLT--------RAGVVTTTDTWLVHRLCG-----AFVTDA
Mflv_2650|M.gilvum_PYR-GCK SAPKMAWIRANLT--------RDGVVTTTDTWLVHRLCG-----AFVTDA
MSMEG_6229|M.smegmatis_MC2_155 SGGKIQWILDNVPGVREDAEKGDAIFGTADSWLVWNLTGGTRGGVHVTDV
TH_1719|M.thermoresistible__bu SGGKLQWMLENVDGLRADAEKGEALFGTPDTWLVWNLTGGVRGGRHITDV
Rv3696c|M.tuberculosis_H37Rv SGGKLQWILENVDGVRAAAENGDALFGTPDTWVLWNLTGGPRGGVHVTDV
MLBr_02314|M.leprae_Br4923 SGGKLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGPRGGVHVTDV
MMAR_5208|M.marinum_M SGGKLQWILENVDGVRAAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDV
MUL_4281|M.ulcerans_Agy99 SGGKLQWILEDVDGVRAAAERGDALFGTPDTWVLWNLTGGPRGGVHVTDV
MAV_0406|M.avium_104 SGAKLQWILDNVDGVREAAERGDALFGTADSWVLWQLTGGPRGGVHATDV
MAB_0382|M.abscessus_ATCC_1997 SGGKLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGVRSGVHVTDV
Mb0750|M.bovis_AF2122/97 TAEFLRWTAGQAP-------------DASGYWPAPAVANYALSGEAVIDY
:. : * . :.. * : . *
Mvan_3929|M.vanbaalenii_PYR-1 STASRSLLISLDS---AQWDQDLLTLFGLDDEAMPEIVGSDE-----IVG
Mflv_2650|M.gilvum_PYR-GCK STASRSLLTSLDDSRGQRWDPDLRALFGLDAEEMPEIVASDE-----IVG
MSMEG_6229|M.smegmatis_MC2_155 TNASRTMLMNLET---LDWDDELLSFFGIPRRMLPEIKPSSYPESYGITR
TH_1719|M.thermoresistible__bu TNASRTMLMNLET---LDWDDELLSFFGIPRAMLPEIKPSSYPQSYGITL
Rv3696c|M.tuberculosis_H37Rv TNASRTMLMDLET---LDWDDELLSLFSIPRAMLPEIASSAPSEPYGVTL
MLBr_02314|M.leprae_Br4923 TNASRTMLMDLEK---LDWDDELLSFFSIPRAMLPAIASSSPLQPYGVTL
MMAR_5208|M.marinum_M TNASRTMLMNLET---LDWDDELLSFFSIPRAMLPAIEPSSPLQPYGITQ
MUL_4281|M.ulcerans_Agy99 TNASRTMLMNLET---LDWDDELLSFFSIPRAMLPAIEPSSPLQPYGITQ
MAV_0406|M.avium_104 TNASRTMLMDLET---LDWDDELLSFFTIPRAMLPEIGPSSSPRPFGVTS
MAB_0382|M.abscessus_ATCC_1997 TNASRTMLMNLET---LDWDDELLSFFSIPRQMLPPIKASSPVEPFGFTT
Mb0750|M.bovis_AF2122/97 ATAVTTLPLFDGT----GWNATACADCGVTVDRMPRVETFGVG-----VG
:.* :: *: : : :* : .
Mvan_3929|M.vanbaalenii_PYR-1 TTDVFGPTLPVAGLIVDQQAALLAESCLEAGSAKCTYGTGAFLLAQLGSE
Mflv_2650|M.gilvum_PYR-GCK TTDVFGTTLPVAGLIVDQQAALFAESCLHAGSAKCTYGTGAFLLAQLGTE
MSMEG_6229|M.smegmatis_MC2_155 DDGPLAGQVPLTGILGDQQAAMVGQVCLEAGEAKNTYGTGNFLLLNTGEK
TH_1719|M.thermoresistible__bu DDGPVAGQVPLTGILGDQQAAMVGQVCLSAGEAKNTYGTGNFLLLNTGEN
Rv3696c|M.tuberculosis_H37Rv ATGPVGGEVPITGVLGDQHAAMVGQVCLAPGEAKNTYGTGNFLLLNTGET
MLBr_02314|M.leprae_Br4923 ADGPVGGEVPITGVLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEA
MMAR_5208|M.marinum_M DTGPVGGEVPITGMLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGET
MUL_4281|M.ulcerans_Agy99 DTGPVGGEVPITGMLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGET
MAV_0406|M.avium_104 DTGPAGGRIPITAVLGDQHAAMVGQVCLAEGEAKNTYGTGNFLLLNTGES
MAB_0382|M.abscessus_ATCC_1997 QLGPLGGEVPIAGDLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEE
Mb0750|M.bovis_AF2122/97 QVRGTGAVLAVG--AVDALCEQIVAGADRDGDVLVLCG--ATLIVWTTIS
. :.: * . . . *.. * *:
Mvan_3929|M.vanbaalenii_PYR-1 PVRSTSGLTTSVAWRLRGA------TSYCIDGQVYTAASAVRWA-VELGL
Mflv_2650|M.gilvum_PYR-GCK PVRSSSGLTTSVAWRLRGQ------TSYCIDGQVYTAASAIRWA-VDLGL
MSMEG_6229|M.smegmatis_MC2_155 IVRSDNGLLTTVCYQFGDS-----KPVYALEGSIAVTGSAVQWLRDQLGI
TH_1719|M.thermoresistible__bu IVRSKNGLITTVCYQFTGADGRPAEPVYALEGSIAVTGAAVQWLRDQLGI
Rv3696c|M.tuberculosis_H37Rv IVRSNNGLLTTVCYQFGNA-----KPVYALEGSIAVTGSAVQWLRDQLGI
MLBr_02314|M.leprae_Br4923 IVRSGNGLLTTVCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGI
MMAR_5208|M.marinum_M IVRSSNGLLTTLCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGI
MUL_4281|M.ulcerans_Agy99 IVRSSNGLLTTLCYQFGDA-----KPVYALEGSIAVTGSAVQWLRDQLGI
MAV_0406|M.avium_104 IVRSEHGLLTTVCYQFGDA-----KPVYALEGSIAVTGAAVQWLRDQLGI
MAB_0382|M.abscessus_ATCC_1997 LVHSSNGLLTTVCYQFGDN-----KPVYALEGSIAVTGSAVQWLRDQLGI
Mb0750|M.bovis_AF2122/97 AARQVPGLWTIPHTAPGKS---------QIGGASNAGGLFLNWVDRVIGP
.:. ** * : * . . :.* :*
Mvan_3929|M.vanbaalenii_PYR-1 VPAADQIDSAAAESSD--GVLCVPALAGLAAPWWDSAATASFSGMTLSSG
Mflv_2650|M.gilvum_PYR-GCK IPSADQIDSAAAESSD--GVVCVPALAGLAAPWWDSAATASLSGMTLSTG
MSMEG_6229|M.smegmatis_MC2_155 ISGASQSESLARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNT
TH_1719|M.thermoresistible__bu ISGAAQSESLARQVPDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNT
Rv3696c|M.tuberculosis_H37Rv ISGAAQSEALARQVPDNGGMYFVPAFSGLFAPYWRSDARGAIVGLSRFNT
MLBr_02314|M.leprae_Br4923 ISGAAQSESLARQVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNT
MMAR_5208|M.marinum_M ISGASQSEALARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNN
MUL_4281|M.ulcerans_Agy99 ISGASQSEALARQVSDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNN
MAV_0406|M.avium_104 ISGAAQSESLARQVDDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFDT
MAB_0382|M.abscessus_ATCC_1997 ISGASQSEDLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNT
Mb0750|M.bovis_AF2122/97 GDPALADPRRVP--------VWLPYIRGERTPFHEPDRRAVLDGVDLSQD
* . :* : * :*: . . : *:
Mvan_3929|M.vanbaalenii_PYR-1 RGQLVRALVEGIAAQVTALTDLVSADLGRPLTRLRVDGGLTRSTALMQAQ
Mflv_2650|M.gilvum_PYR-GCK RGQLVRAMVEGIAAQVAALTDLVSADLGRPLTRLRVDGGLTRSEALMQAQ
MSMEG_6229|M.smegmatis_MC2_155 NAHLARATLESICYQSRDVVDAMEADSGVHLEVLKVDGGITANALCMQIQ
TH_1719|M.thermoresistible__bu NAHIARATLEAICYQSRDVVDAMVADSGVRMESLKVDGGITANELCMQIQ
Rv3696c|M.tuberculosis_H37Rv NAHLARATLEAICYQSRDVVDAMEADSGVRLQVLKVDGGITGNDLCMQIQ
MLBr_02314|M.leprae_Br4923 NAHLARATLEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQ
MMAR_5208|M.marinum_M NAHLARATLEAICYQSRDVVDAMEADSGVRLEVLKVDGGITSNDLCMQIQ
MUL_4281|M.ulcerans_Agy99 NAHLARATLEAICYQSRDVVDAMEADSGVRLEVLKVDGGITSNDLCMQIQ
MAV_0406|M.avium_104 NAHLARATLEAICYQSRDVVDAMAADSGVRLEVLKVDGGITGNDLCMQIQ
MAB_0382|M.abscessus_ATCC_1997 NAHLARATLEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQ
Mb0750|M.bovis_AF2122/97 AASVRRAAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAI
. : ** *. : : * : : . ** * **
Mvan_3929|M.vanbaalenii_PYR-1 ADLARMPVDVYPSLHATALGAAACARLALEPGTSAADAVGTWFPHHTYEP
Mflv_2650|M.gilvum_PYR-GCK ADLSQIPVDVYPSLHATALGAAACARLALEPGLSPADAAGTWSPRRTYEP
MSMEG_6229|M.smegmatis_MC2_155 ADVLGVDVVKPLVAETTALGAAYAAGLAVGFWENADDLRANWQEDKRWSP
TH_1719|M.thermoresistible__bu ADVLGVDVIKPVVSETTALGAAYAAGLAVGFWEDADDLRTNWQEGRRWTP
Rv3696c|M.tuberculosis_H37Rv ADVLGVDVVRPVVAETTALGVAYAAGLAVGFWAAPSDLRANWREDKRWTP
MLBr_02314|M.leprae_Br4923 ADVLGVDVVRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTP
MMAR_5208|M.marinum_M ADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPSDLRANWQEDKRWTP
MUL_4281|M.ulcerans_Agy99 ADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPSDLRANWQEDKRWTP
MAV_0406|M.avium_104 ADVLGVDVVRPVVAETTALGAAYAAGLAVGFWADPGELRANWREDKRWTP
MAB_0382|M.abscessus_ATCC_1997 ADTLGVDVVKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSS
Mb0750|M.bovis_AF2122/97 ADATGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEP
** * . :*** * . ** : . .
Mvan_3929|M.vanbaalenii_PYR-1 RWSADRAADFLDRWRRAAEMTLAQHDSHKESTS
Mflv_2650|M.gilvum_PYR-GCK HWSADRAADFLARWRRAAESTLAPPHQRKESMS
MSMEG_6229|M.smegmatis_MC2_155 QWSDEQREKGYAGWQKAVQRTLDWVEIE-----
TH_1719|M.thermoresistible__bu QWTDEQREAGYRGWKKAVQRTLDWVDVG-----
Rv3696c|M.tuberculosis_H37Rv TWDDDERAAGYAGWRKAVQRTLDWVDVS-----
MLBr_02314|M.leprae_Br4923 TWGEDQRAAAYAGWRKAVQRTLDWVDVS-----
MMAR_5208|M.marinum_M QWTDDQRAAGYAGWRKAVQRTLDWVDVS-----
MUL_4281|M.ulcerans_Agy99 QWTDDQRAAGYAGWRKAVQRTLDWVDVS-----
MAV_0406|M.avium_104 AWSDEQRAAGYAGWRKAVQRTLDWADVT-----
MAB_0382|M.abscessus_ATCC_1997 SITDEKRAEGFAGWKKAVQRTLDGVDV------
Mb0750|M.bovis_AF2122/97 --SADWAGPTKERYRRFLALSGSKLA-------
: ::: :