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VSREDATIGIDIGTTAVKALVADADGNVTARLRIPHQLRVGAPDQLEHDADQAWRRGPLTALERLAGPDI RAVAVSAMVPSMTAVDSGGVPITPGLLYGDSRGWVPGAANQRAQPLPSVGEAAQFLRWTAAQAPEAAGYW PAAAVANYAMSGEPVIDFATAITSLPLFDGTGWNPQACADCGASADRMPRVETFGTAVGQVHGTDAVLGA GGIDAVCEQIVAGADHHGDVLVLCGTTLIVWTTISGSRQVPGLWTIPHTAPGKSQIGGASNAGGLFLSWV DRVTGPADRDGEQDRVDPRRVPIWLPYIRGERTPFHDPDRRASLEGLDLTQGAAAVRRAAYEVSGFVVRH LVELSGAPVLRIVASGGGTCVRPWMQAIADVTGRPVHVSAVAEGAALGAAFLARMAAGLES
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0824 | xylB | - | 100% (411) | D-xylulose-kinase (xylulokinase), XylB |
| M. ulcerans Agy99 | MUL_4281 | glpK | 2e-05 | 29.23% (130) | glycerol kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0750 | xylB | 0.0 | 77.37% (411) | D-xylulose kinase XylB |
| M. gilvum PYR-GCK | Mflv_3774 | - | 1e-27 | 26.92% (442) | carbohydrate kinase, FGGY |
| M. tuberculosis H37Rv | Rv0729 | xylB | 0.0 | 77.13% (411) | D-xylulose kinase XylB |
| M. leprae Br4923 | MLBr_02314 | glpK | 6e-07 | 21.76% (455) | glycerol kinase |
| M. abscessus ATCC 19977 | MAB_0382 | glpK | 1e-07 | 21.96% (460) | glycerol kinase |
| M. marinum M | MMAR_1066 | xylB | 0.0 | 98.30% (411) | D-xylulose-kinase (xylulokinase), XylB |
| M. avium 104 | MAV_4437 | - | 1e-166 | 70.87% (412) | carbohydrate kinase, FGGY family protein |
| M. smegmatis MC2 155 | MSMEG_3113 | - | 4e-33 | 29.57% (443) | carbohydrate kinase, FGGY |
| M. thermoresistible (build 8) | TH_0046 | xylB | 3e-14 | 26.07% (445) | xylulokinase |
| M. vanbaalenii PYR-1 | Mvan_2625 | - | 6e-26 | 27.49% (451) | carbohydrate kinase, FGGY |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3774|M.gilvum_PYR-GCK ---MSRYTIGVDIGTTGTKTVLLDT---------TSGIVATASRETALHS
Mvan_2625|M.vanbaalenii_PYR-1 ---MSRYTIGVDIGTTGIKTVLLDTTAAGRASNTTAGIVATANRENTLYS
MSMEG_3113|M.smegmatis_MC2_155 ---MPEFTIGVDIGTTGTKTVLVDVD--------AARIVAQSTGETTLHS
MUL_0824|M.ulcerans_Agy99 -MSREDATIGIDIGTTAVKALVADAD---------GNVTARLRIPHQLRV
MMAR_1066|M.marinum_M -MSREDATIGIDIGTTAVKAVVADAD---------GNVTARLRIPHQLRV
Mb0750|M.bovis_AF2122/97 -MSRDDVTIGIDIGTTAVKAVAADDN---------GRVTARVRIGHQLAV
Rv0729|M.tuberculosis_H37Rv -MSRDDVTIGIDIGTTAVKAVAADDN---------GRVTARVRIGHQLAV
MAV_4437|M.avium_104 -MSRKDVTIGIDVGSTAVKALAADAD---------GRVMARVRIPHELRI
MLBr_02314|M.leprae_Br4923 MAEFAEFIAAIDQGTTSTRCVIFDHN---------GAEVARHQLEHEQIL
MAB_0382|M.abscessus_ATCC_1997 ---MADFVASIDQGTTSTRAMIFNHR---------GEEVGRHQLEHQQLL
TH_0046|M.thermoresistible__bu ----MTLVAGIDSSTQSCKVLICDAD--------------TGAVVREGRA
.:* .: . : : :
Mflv_3774|M.gilvum_PYR-GCK PAPGFAEADTTQWHANVIDSVREVLAHSGVAPDEIGALATSGMVPAVVPI
Mvan_2625|M.vanbaalenii_PYR-1 PGPGFAEADPAQWYRNVVESIREVLAVSGVAPDQIGALATSGMVPAVVAV
MSMEG_3113|M.smegmatis_MC2_155 DAPGHAEADPWQWLANTHAGIRAVLAESGISPDRVGAVATTGMVPAVVAV
MUL_0824|M.ulcerans_Agy99 GAPDQLEHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAV
MMAR_1066|M.marinum_M GAPDQLEHDADQAWRRGPLTALERLAG-----PDIRAVAVSAMVPSMTAV
Mb0750|M.bovis_AF2122/97 PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV
Rv0729|M.tuberculosis_H37Rv PAPDRLEHDADEAWRRGPLAALDRLVG-----PDTRALAVAAMVPSLTAV
MAV_4437|M.avium_104 PAPDRLEHDAEAAWRRGPSAALDELLHQ----PGVAAVAVAAMVPSMTAV
MLBr_02314|M.leprae_Br4923 PRSGWVEHNPVEIWERTASVLMSVLNATNLSAKDIAALGITNQRETTLVW
MAB_0382|M.abscessus_ATCC_1997 PRAGWVEHNPVEIWERTWSVLATSLNVTGLSAGDLAAVGVTNQRETTLVW
TH_0046|M.thermoresistible__bu AHPDGTEIDPAFWESAAHDAVRAAGGL-----DDVAAVAVGAQQHGMVCL
.. * :. *:.
Mflv_3774|M.gilvum_PYR-GCK D-DAGKPLRRAILQNDARAHREVDDLAGALAD-VDLVTLTGSALTQQSVA
Mvan_2625|M.vanbaalenii_PYR-1 D-QTGKPLRRAILQNDARAHREVAGLAAKLAS-VDLVTLTGSALTQQSVA
MSMEG_3113|M.smegmatis_MC2_155 D-RDGNPVRRAILQNDARATREIDTLKERIDD-ETVLAATGSAITQQSVA
MUL_0824|M.ulcerans_Agy99 D-SGGVPITPGLLYGDSRGW--------------VPGAANQRAQPLPSVG
MMAR_1066|M.marinum_M D-SGGVPITPGLLYGDSRGW--------------VPGAANQRAQPLPSVG
Mb0750|M.bovis_AF2122/97 D-PAGRPITPGLLYGDARGR--------------VPNASVARAQSVPSVG
Rv0729|M.tuberculosis_H37Rv D-PAGRPITPGLLYGDARGR--------------VPNASVARAQSVPSVG
MAV_4437|M.avium_104 D-DSGTPITPGLLYGDGRGR--------------TPGGPQN--QPLPALG
MLBr_02314|M.leprae_Br4923 NRNTGRPYCNAIVWQDTRTDRIAVALDRDGRG-EVIRRKAGLPPATYFSG
MAB_0382|M.abscessus_ATCC_1997 NRHTGRPYCNAIVWQDTRTDKIAAALDRDGRG-DIIRRKAGLPPATYFSG
TH_0046|M.thermoresistible__bu D-EAGKVVRDALLWNDVRSAGAAAALVDELGGPQAWAEAVGVVPLAAITV
: * .:: * *
Mflv_3774|M.gilvum_PYR-GCK PTTVWLREHEP----EVYARTAHWVGSYDWVLSALGADV-----HVEQNW
Mvan_2625|M.vanbaalenii_PYR-1 PTTVWLRDHEP----GVYARTAHWIGSYDWVLSALGAPI-----HVEQNW
MSMEG_3113|M.smegmatis_MC2_155 PTALWLRGNEP----DCWQRTARLVGSYDWVLMALGAAP-----HVELNW
MUL_0824|M.ulcerans_Agy99 EAAQFLRWTAA----QAPEAAGYWP-AAAVANYAMSGEP-----VIDFAT
MMAR_1066|M.marinum_M EAAQFLRWTAA----QAPEAAGYWP-AAAVANYAMSGEP-----VIDFAT
Mb0750|M.bovis_AF2122/97 ETAEFLRWTAG----QAPDASGYWP-APAVANYALSGEA-----VIDYAT
Rv0729|M.tuberculosis_H37Rv ETAEFLRWTAG----QALDASGYWP-APAVANYALSGEA-----VIDYAT
MAV_4437|M.avium_104 EAAEFLRWTAA----RAPGAAGYWP-APAVANHALAGQA-----VIDVAT
MLBr_02314|M.leprae_Br4923 GKLQWILENVDGVGAAAENGEALFGTPDTWLLWNLTGGPRGGVHVTDVTN
MAB_0382|M.abscessus_ATCC_1997 GKLQWILENVEGVRRDAENGDALFGTPDSWVIWNLTGGVRSGVHVTDVTN
TH_0046|M.thermoresistible__bu AKLRWLADHEP----QHADRTAAVCLPHDWLTWRLRGSTDIAELTTDRSD
:: . . : . :
Mflv_3774|M.gilvum_PYR-GCK ALESGLFSIV-GDTADAVLGA-AGLDPATLAPLRRPG-----TRVGELSA
Mvan_2625|M.vanbaalenii_PYR-1 ALESGLFEID-GDVATDVVQA-AALEPVTLAPVRRPG-----TQVGELSR
MSMEG_3113|M.smegmatis_MC2_155 AIESGLGMLD-GGRFDPMFAA-AGLSTDLVPQVLSPG-----QRAGELSP
MUL_0824|M.ulcerans_Agy99 AITSLPLFDG-TGWNPQACAD-CGASADRMPRVETFG-----TAVGQVHG
MMAR_1066|M.marinum_M AITSLPLFDG-TGWNPQACAD-CGASADRMPRVETFG-----TAVGQVHG
Mb0750|M.bovis_AF2122/97 AVTTLPLFDG-TGWNATACAD-CGVTVDRMPRVETFG-----VGVGQVRG
Rv0729|M.tuberculosis_H37Rv AVTTLPLFDG-TGWNATACAD-CGVTVDRMPRVETFG-----VGVGQVRG
MAV_4437|M.avium_104 AATAFPLFDG-TGWDAAACAE-RGARVEQMPRVHSMG-----AVVGQLPG
MLBr_02314|M.leprae_Br4923 ASRTMLMDLEKLDWDDELLSF-FSIPRAMLPAIASSSPLQPYGVTLADGP
MAB_0382|M.abscessus_ATCC_1997 ASRTMLMNLETLDWDDELLSF-FSIPRQMLPPIKASSPVEPFGFTTQLGP
TH_0046|M.thermoresistible__bu ASGTGYYDASGDDYRLDLLELGLRGRRPHLPAVLGPS--------DATRG
* : . :. : .
Mflv_3774|M.gilvum_PYR-GCK AAADATGLRAGTPLVVGGADHVLSAYAAGVNGAGDALVKLGGAGDILVAS
Mvan_2625|M.vanbaalenii_PYR-1 RAADETGLRAGTALVVGGADHVLSAYAAGVNDPGDALVKLGGAGDILVAS
MSMEG_3113|M.smegmatis_MC2_155 AAAEATGLLAGLPLIVGGADHVLSAYAAGVNRPGDCLVKLGGAGDILAAS
MUL_0824|M.ulcerans_Agy99 TDAVLG---------AGGIDAVCEQIVAGADHHGDVLVLCGTTLIVWTTI
MMAR_1066|M.marinum_M ADAVLG---------AGGIDAVCEQIVAGADHHGDVLVLCGTTLIVWTTI
Mb0750|M.bovis_AF2122/97 TGAVLA---------VGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTI
Rv0729|M.tuberculosis_H37Rv TGAVLA---------VGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTI
MAV_4437|M.avium_104 -GAALA---------TGAIDALCEQLVAGADRDGDVLVMCGTTLIVWATI
MLBr_02314|M.leprae_Br4923 VGGEVPITGVLGDQHAAMVGQVCLDAGEAKNTYGTGNFLLLNTGEAIVRS
MAB_0382|M.abscessus_ATCC_1997 LGGEVPIAGDLGDQQAAMVGQVCLNPGEAKNTYGTGNFLLLNTGEELVHS
TH_0046|M.thermoresistible__bu GDRVFG----------AGLGDNAAAALGLAAEPGDVIVSVGTSGVVSAVA
. . * . : .
Mflv_3774|M.gilvum_PYR-GCK DTEIVDERLYLDAHPVPGRWLPNGCMATSGSLIRWFQTLIGG---AELTE
Mvan_2625|M.vanbaalenii_PYR-1 DTQVVDERLYLDAHPIPGHWLPNGCMATSGSLIRWFQALIGGPEAVELTT
MSMEG_3113|M.smegmatis_MC2_155 ERPVVDARLYLDAHPVPGRWLPNGCMATSGSLIRWFQTLSGG---HDLVA
MUL_0824|M.ulcerans_Agy99 SGSRQVPGLWTIPHTAPGKSQIGGASNAGGLFLSWVDRVTGPADRDGEQD
MMAR_1066|M.marinum_M SGSRQVPGLWTIPHTAPGKSQIGGASNAGGLFLSWVDRLIGPADRDGEQD
Mb0750|M.bovis_AF2122/97 SAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVDRVIGPGD----PA
Rv0729|M.tuberculosis_H37Rv SAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVDRVIGPGD----PA
MAV_4437|M.avium_104 SQARQMPGLWTIPHTTPGKSQIGGASNAGGLFLGWVDRVVAQAD----PA
MLBr_02314|M.leprae_Br4923 GNGLLTTVCYQFGDAKP-VYALEGSIAVTGSAVQWLRDQLGIIS-GAAQS
MAB_0382|M.abscessus_ATCC_1997 SNGLLTTVCYQFGDNKP-VYALEGSIAVTGSAVQWLRDQLGIIS-GASQS
TH_0046|M.thermoresistible__bu TAPVRDGTGFVAGFADGTGRHLPLVCTLNGARVLDAAAAMLQVDHAELSR
: * :
Mflv_3774|M.gilvum_PYR-GCK LDDEAAQRAPGEILCLPYFLGEKSPVHDPDLRGVFAGMHLGHTR-ADMYR
Mvan_2625|M.vanbaalenii_PYR-1 LDDEAALRSPAEVLCLPYFLGEKSPIHDPDLRGVFAGMHLGHTR-ADMYR
MSMEG_3113|M.smegmatis_MC2_155 LDDEAQTRSPAEVLCLPYFLGEKSPLHDPDLRGAFVGLDLSHTR-ADMYR
MUL_0824|M.ulcerans_Agy99 RVDPRRVP-----IWLPYIRGERTPFHDPDRRASLEGLDLTQGA-AAVRR
MMAR_1066|M.marinum_M RVDPRRVP-----IWLPYIRGERTPFHDPDRRASLEGLDLTQGA-AAVRR
Mb0750|M.bovis_AF2122/97 LADPRRVP-----VWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-ASVRR
Rv0729|M.tuberculosis_H37Rv LADPRRVP-----VWLPYIRGERTPFHEPDRRAVLDGVDLSQDA-ASVRR
MAV_4437|M.avium_104 SAQPGRVP-----VFAPYLRGERSPFHDPDRRGVLEALDLTHDA-AALRR
MLBr_02314|M.leprae_Br4923 ESLARQVVDNGGVYFVPAFSGLFSPYWRSDARGAIVGLSRFNTN-AHLAR
MAB_0382|M.abscessus_ATCC_1997 EDLARQVEDNGGVYFVPAFSGLFAPYWRSDARGAIVGLSRFNTN-AHLAR
TH_0046|M.thermoresistible__bu LALSAPPGSEG-LVLVPYLEGERTPNR-PNASGALHGLRVSNATPANLAR
* : * :* .: . : .: : * : *
Mflv_3774|M.gilvum_PYR-GCK SVLEAIAFGFRHHVDVFGEI-GIPFTRVMITNGGSRSTLWKQIHADVLGC
Mvan_2625|M.vanbaalenii_PYR-1 SVLEAIAFGFRHHVDVFAEI-GIPLRRVMITNGGSKSTLWKQIHADVLGQ
MSMEG_3113|M.smegmatis_MC2_155 SVLEAIAFGFRHHTEVFAHM-GVSLERAMVTNGGSRSVLWKQILADVLGT
MUL_0824|M.ulcerans_Agy99 AAYEVSGFVVRHLVELS----GAPVLRIVASGGGTCVRPWMQAIADVTGR
MMAR_1066|M.marinum_M AAYEASGFVVRHLVELS----GAPVLRIVASGGGTCVQPWMQAIADVTGR
Mb0750|M.bovis_AF2122/97 AAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAIADATGR
Rv0729|M.tuberculosis_H37Rv AAYEASGFVVRQLIELS----GAPVARIVAAGGGTRIQPWMQAIADATGR
MAV_4437|M.avium_104 AAYEASGFVVRQLIELS----GAPVSRIVATGGGTRVGPWLQAIADATGH
MLBr_02314|M.leprae_Br4923 ATLEAICYQSRDVVDAMAADSGVRLDVLKVDGGITSNDLCMQIQADVLGV
MAB_0382|M.abscessus_ATCC_1997 ATLEAICYQSREVVEAMEADSGVRMEVLKVDGGITANKLCMQIQADTLGV
TH_0046|M.thermoresistible__bu AAVEGLLCALADGIAHLTGH-GIPLRRVLLIGGAARSEAVRAIAPQVFGV
:. * . * . .* : .:. *
Mflv_3774|M.gilvum_PYR-GCK EMNPVIGHPGASLGAAVIAAIGVGALDDWADADRFITLDAPYRPDPARRH
Mvan_2625|M.vanbaalenii_PYR-1 EMHPVRGHPGASLGAAVIAAIGVGALADWSDAARFITLDDPYIPDPARRD
MSMEG_3113|M.smegmatis_MC2_155 PLIPVIGHPGASLGAAVIAAVGIGLLGDWDSTQAFQTLGDPVVPDARHVD
MUL_0824|M.ulcerans_Agy99 PVHVSAVAEGAALGAAFLARMAAGLES-----------------------
MMAR_1066|M.marinum_M PVHVSDVAEGAALGAAFLARMAAGLESSIADADRWARTDRIVEPRPDWVG
Mb0750|M.bovis_AF2122/97 PVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEPSADWAG
Rv0729|M.tuberculosis_H37Rv PVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEPSADWAG
MAV_4437|M.avium_104 PVEVSAVAEGAALGAAFLARMAAGLETTLTDAARWVRTERVVEPDPAWAA
MLBr_02314|M.leprae_Br4923 DVVRSVVAETTALGSAYAAGLAVGFWAGPSDLRANWQEDKRWTP-TWGED
MAB_0382|M.abscessus_ATCC_1997 DVVKPVVAETTALGAAYAAGLAVGFWKDADDLRRNWQEDERWSS-SITDE
TH_0046|M.thermoresistible__bu PVLVPDPAEYVALGAARQAAWALRGTPEPPSWQPPRTDRYEADPVPAVR-
: .:**:* . .
Mflv_3774|M.gilvum_PYR-GCK AYDDAYQTWRELGAVMTPVSHKIARTTR-
Mvan_2625|M.vanbaalenii_PYR-1 IYDQAYATWRELSSAMTPISHAIARTTR-
MSMEG_3113|M.smegmatis_MC2_155 RYAEAYAEWRTLGDVLTPVSHRMARKARS
MUL_0824|M.ulcerans_Agy99 -----------------------------
MMAR_1066|M.marinum_M PTKDRYRRFLELSGSPLA-----------
Mb0750|M.bovis_AF2122/97 PTKERYRRFLALSGSKLA-----------
Rv0729|M.tuberculosis_H37Rv PTKERYRRFLALSGSKLA-----------
MAV_4437|M.avium_104 PVQDRYQRFLELGNRPCPAVVAR------
MLBr_02314|M.leprae_Br4923 QRAAAYAGWRKAVQRTLDWVDVS------
MAB_0382|M.abscessus_ATCC_1997 KRAEGFAGWKKAVQRTLDGVDV-------
TH_0046|M.thermoresistible__bu ---ERYAEVRDLTEGVE------------